{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T22:21:45Z","timestamp":1792448505306,"version":"4.5.0"},"reference-count":27,"publisher":"Association for Research in Vision and Ophthalmology (ARVO)","issue":"5","license":[{"start":{"date-parts":[[2022,5,16]],"date-time":"2022-05-16T00:00:00Z","timestamp":1652659200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Invest. Ophthalmol. Vis. Sci."],"published-print":{"date-parts":[[2022,5,16]]},"DOI":"10.1167\/iovs.63.5.14","type":"journal-article","created":{"date-parts":[[2022,5,16]],"date-time":"2022-05-16T11:33:25Z","timestamp":1652700805000},"page":"14","source":"Crossref","is-referenced-by-count":2,"title":["Ablation of\n                    <i>Ctrp9<\/i>\n                    , Ligand of AdipoR1, and Lower Number of Cone Photoreceptors in Mouse Retina"],"prefix":"10.1167","volume":"63","author":[{"given":"Daiki","family":"Inooka","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Nagoya University Graduate School of Medicine, Nagoya, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshihiro","family":"Omori","sequence":"additional","affiliation":[{"name":"Laboratory of Functional Genomics, Graduate School of Bioscience, Nagahama Institute of Bioscience and Technology, Shiga, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noriyuki","family":"Ouchi","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine and Cardiology, Nagoya University Graduate School of Medicine, Nagoya, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koji","family":"Ohashi","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine and Cardiology, Nagoya University Graduate School of Medicine, Nagoya, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuto","family":"Kawakami","sequence":"additional","affiliation":[{"name":"Laboratory of Functional Genomics, Graduate School of Bioscience, Nagahama Institute of Bioscience and Technology, Shiga, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshito","family":"Koyanagi","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Nagoya University Graduate School of Medicine, Nagoya, Japan"},{"name":"Department of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chieko","family":"Koike","sequence":"additional","affiliation":[{"name":"College of Pharmaceutical Sciences, Ritsumeikan University, Kusatsu, Shiga, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroko","family":"Terasaki","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Nagoya University Graduate School of Medicine, Nagoya, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koji M.","family":"Nishiguchi","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Nagoya University Graduate School of Medicine, Nagoya, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinji","family":"Ueno","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Nagoya University Graduate School of Medicine, Nagoya, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"27","reference":[{"key":"bib1","doi-asserted-by":"publisher","first-page":"3066","DOI":"10.1161\/CIRCULATIONAHA.112.114181","article-title":"Cardiovascular and metabolic regulation by the adiponectin\/C1q\/tumor necrosis factor-related protein family of proteins","volume":"125","author":"Ouchi","year":"2012","journal-title":"Circulation"},{"key":"bib2","doi-asserted-by":"publisher","first-page":"194","DOI":"10.1016\/j.tem.2011.12.003","article-title":"CTRP family: linking immunity to metabolism","volume":"23","author":"Sch\u00e4ffler","year":"2012","journal-title":"Trends Endocrinol Metab"},{"key":"bib3","doi-asserted-by":"publisher","first-page":"R130","DOI":"10.1186\/gb-2009-10-11-r130","article-title":"BioGPS: an extensible and customizable portal for querying and organizing gene annotation resources","volume":"10","author":"Wu","year":"2009","journal-title":"Genome Biology"},{"key":"bib4","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1096\/fsb2.v23.1","article-title":"Identification and characterization of CTRP9, a novel secreted glycoprotein, from adipose tissue that reduces serum glucose in mice and forms heterotrimers with adiponectin","volume":"23","author":"Wong","year":"2009","journal-title":"FASEB J"},{"key":"bib5","doi-asserted-by":"publisher","first-page":"2616","DOI":"10.1161\/ATVBAHA.111.231050","article-title":"C1q\/TNF-related proteins, a family of novel adipokines, induce vascular relaxation through the adiponectin receptor-1\/AMPK\/eNOS\/nitric oxide signaling pathway","volume":"31","author":"Zheng","year":"2011","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"bib6","doi-asserted-by":"publisher","first-page":"2173","DOI":"10.1128\/MCB.01518-14","article-title":"C1q\/Tumor Necrosis Factor-Related Protein 9 Protects against Acute Myocardial Injury through an Adiponectin Receptor I-AMPK-Dependent Mechanism","volume":"35","author":"Kambara","year":"2015","journal-title":"Mol Cell Biol"},{"key":"bib7","doi-asserted-by":"publisher","first-page":"762","DOI":"10.1038\/nature01705","article-title":"Cloning of adiponectin receptors that mediate antidiabetic metabolic effects","volume":"423","author":"Yamauchi","year":"2003","journal-title":"Nature"},{"key":"bib8","doi-asserted-by":"publisher","first-page":"246","DOI":"10.1002\/humu.2016.37.issue-3","article-title":"ADIPOR1 Is Mutated in Syndromic Retinitis Pigmentosa","volume":"37","author":"Xu","year":"2016","journal-title":"Hum Mutat"},{"key":"bib9","doi-asserted-by":"publisher","first-page":"1375","DOI":"10.1007\/s00439-016-1730-2","article-title":"A mutation in ADIPOR1 causes nonsyndromic autosomal dominant retinitis pigmentosa","volume":"135","author":"Zhang","year":"2016","journal-title":"Hum Genet"},{"key":"bib10","doi-asserted-by":"publisher","first-page":"14339","DOI":"10.1038\/s41598-018-32579-9","article-title":"ADIPOR1 is essential for vision and its RPE expression is lost in the Mfrp(rd6) mouse","volume":"8","author":"Sluch","year":"2018","journal-title":"Sci Rep"},{"key":"bib11","doi-asserted-by":"publisher","first-page":"6228","DOI":"10.1038\/ncomms7228","article-title":"Adiponectin receptor 1 conserves docosahexaenoic acid and promotes photoreceptor cell survival","volume":"6","author":"Rice","year":"2015","journal-title":"Nat Commun"},{"key":"bib12","doi-asserted-by":"publisher","first-page":"963689720962052","DOI":"10.1177\/0963689720962052","article-title":"C1q\/TNF-related Protein 9 Inhibits High Glucose-Induced Oxidative Stress and Apoptosis in Retinal Pigment Epithelial Cells Through the Activation of AMPK\/Nrf2 Signaling Pathway","volume":"29","author":"Cheng","year":"2020","journal-title":"Cell Transplantation"},{"key":"bib13","doi-asserted-by":"publisher","first-page":"652","DOI":"10.1038\/nbt822","article-title":"High-throughput engineering of the mouse genome coupled with high-resolution expression analysis","volume":"21","author":"Valenzuela","year":"2003","journal-title":"Nature Biotechnology"},{"key":"bib14","doi-asserted-by":"publisher","first-page":"751","DOI":"10.1016\/j.exer.2005.04.013","article-title":"Physiological function of S-cone system is not enhanced in rd7 mice","volume":"81","author":"Ueno","year":"2005","journal-title":"Exp Eye Res"},{"key":"bib15","doi-asserted-by":"publisher","first-page":"332","DOI":"10.1073\/pnas.0912730107","article-title":"TRPM1 is a component of the retinal ON bipolar cell transduction channel in the mGluR6 cascade","volume":"107","author":"Koike","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"bib16","doi-asserted-by":"crossref","first-page":"E8264","DOI":"10.1073\/pnas.1707021114","article-title":"Samd7 is a cell type-specific PRC1 component essential for establishing retinal rod photoreceptor identity","volume":"114","author":"Omori","year":"2017","journal-title":"Proc National Acad Sci USA"},{"key":"bib17","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1111\/gtc.12233","article-title":"Mef2d is essential for the maturation and integrity of retinal photoreceptor and bipolar cells","volume":"20","author":"Omori","year":"2015","journal-title":"Genes to Cells: Devoted to Molecular & Cellular Mechanisms"},{"key":"bib18","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1038\/s41419-018-0726-3","article-title":"Cardiac-derived CTRP9 protects against myocardial ischemia\/reperfusion injury via calreticulin-dependent inhibition of apoptosis","volume":"9","author":"Zhao","year":"2018","journal-title":"Cell Death & Dis"},{"key":"bib19","doi-asserted-by":"crossref","first-page":"2162","DOI":"10.1161\/CIRCULATIONAHA.117.029557","article-title":"C1q\/Tumor Necrosis Factor-Related Protein-9 Regulates the Fate of Implanted Mesenchymal Stem Cells and Mobilizes Their Protective Effects Against Ischemic Heart Injury via Multiple Novel Signaling Pathways","volume":"136","author":"Yan","year":"2017","journal-title":"Circulation"},{"key":"bib20","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.ygeno.2011.09.003","article-title":"Genome-wide transcriptome analysis in murine neural retina using high-throughput RNA sequencing","volume":"99","author":"Gamsiz","year":"2012","journal-title":"Genomics"},{"key":"bib21","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1038\/s41419-021-03741-5","article-title":"ADIPOR1 deficiency-induced suppression of retinal ELOVL2 and docosahexaenoic acid levels during photoreceptor degeneration and visual loss","volume":"12","author":"Osada","year":"2021","journal-title":"Cell Death & Dis"},{"key":"bib22","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.ejphar.2019.04.012","article-title":"C1q\/TNF-related protein-9 attenuates retinal inflammation and protects blood-retinal barrier in db\/db mice","volume":"853","author":"Li","year":"2019","journal-title":"Eur J Pharmacol"},{"key":"bib23","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1038\/83829","article-title":"A thyroid hormone receptor that is required for the development of green cone photoreceptors","volume":"27","author":"Ng","year":"2001","journal-title":"Nature Genetics"},{"key":"bib24","doi-asserted-by":"crossref","first-page":"4844","DOI":"10.1523\/JNEUROSCI.6181-10.2011","article-title":"Thyroid hormone controls cone opsin expression in the retina of adult rodents","volume":"31","author":"Glaschke","year":"2011","journal-title":"The Journal of Neuroscience: The Official Journal of the Society for Neuroscience"},{"key":"bib25","doi-asserted-by":"crossref","first-page":"1719","DOI":"10.1167\/iovs.09-3592","article-title":"Developmental changes of cone opsin expression but not retinal morphology in the hypothyroid Pax8 knockout mouse","volume":"51","author":"Glaschke","year":"2010","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib26","doi-asserted-by":"crossref","first-page":"16882","DOI":"10.1073\/pnas.1904783116","article-title":"Endocrine regulation of multichromatic color vision","volume":"116","author":"Mackin","year":"2019","journal-title":"Proc National Acad Sci USA"},{"key":"bib27","doi-asserted-by":"crossref","first-page":"e12804","DOI":"10.1111\/jne.12804","article-title":"Growth hormone regulates opsin expression in the retina of a salmonid fish","volume":"31","author":"Novales Flamarique","year":"2019","journal-title":"J. Neuroendocrinol"}],"container-title":["Investigative Opthalmology &amp; Visual Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/iovs.arvojournals.org\/article.aspx?articleid=2778824","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:31:31Z","timestamp":1791927091000},"score":1,"resource":{"primary":{"URL":"https:\/\/iovs.arvojournals.org\/article.aspx?articleid=2778824"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5,16]]},"references-count":27,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2022,5,2]]}},"URL":"https:\/\/doi.org\/10.1167\/iovs.63.5.14","relation":{},"ISSN":["1552-5783"],"issn-type":[{"value":"1552-5783","type":"print"}],"subject":[],"published":{"date-parts":[[2022,5,16]]}}}