{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:59:37Z","timestamp":1791928777379,"version":"4.3.4"},"reference-count":60,"publisher":"Association for Research in Vision and Ophthalmology (ARVO)","issue":"6","license":[{"start":{"date-parts":[[2022,6,27]],"date-time":"2022-06-27T00:00:00Z","timestamp":1656288000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Invest. Ophthalmol. Vis. Sci."],"published-print":{"date-parts":[[2022,6,27]]},"DOI":"10.1167\/iovs.63.6.28","type":"journal-article","created":{"date-parts":[[2022,6,27]],"date-time":"2022-06-27T10:31:01Z","timestamp":1656325861000},"page":"28","source":"Crossref","is-referenced-by-count":8,"title":["Inhibition of Heat Shock Protein B8 Alleviates Retinal Dysfunction and Ganglion Cells Loss Via Autophagy Suppression in Mouse Axonal Damage"],"prefix":"10.1167","volume":"63","author":[{"given":"Feijia","family":"Xie","sequence":"first","affiliation":[{"name":"Eye Center, RenMin Hospital of Wuhan University, Wuhan, Hubei Province, People's Republic of China"},{"name":"State Key Laboratory Cultivation Base, Shandong Provincial Key Laboratory of Ophthalmology, Eye Institute of Shandong First Medical University, Qingdao, Shandong Province, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zongyuan","family":"Li","sequence":"additional","affiliation":[{"name":"Eye Center, RenMin Hospital of Wuhan University, Wuhan, Hubei Province, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ning","family":"Yang","sequence":"additional","affiliation":[{"name":"Eye Center, RenMin Hospital of Wuhan University, Wuhan, Hubei Province, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiayi","family":"Yang","sequence":"additional","affiliation":[{"name":"Eye Center, RenMin Hospital of Wuhan University, Wuhan, Hubei Province, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dihao","family":"Hua","sequence":"additional","affiliation":[{"name":"Eye Center, RenMin Hospital of Wuhan University, Wuhan, Hubei Province, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinyuan","family":"Luo","sequence":"additional","affiliation":[{"name":"Eye Center, RenMin Hospital of Wuhan University, Wuhan, Hubei Province, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"He","sequence":"additional","affiliation":[{"name":"Eye Center, RenMin Hospital of Wuhan University, Wuhan, Hubei Province, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiqiao","family":"Xing","sequence":"additional","affiliation":[{"name":"Eye Center, RenMin Hospital of Wuhan University, Wuhan, Hubei Province, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"27","reference":[{"issue":"pt 10","key":"bib1","doi-asserted-by":"crossref","first-page":"2606","DOI":"10.1093\/brain\/awn196","article-title":"BAG1 promotes axonal outgrowth and regeneration in vivo via Raf-1 and reduction of ROCK activity","volume":"131","author":"Planchamp","year":"2008","journal-title":"Brain"},{"issue":"10","key":"bib2","doi-asserted-by":"publisher","first-page":"2540","DOI":"10.1016\/j.celrep.2018.07.105","article-title":"Lin28 signaling supports mammalian PNS and CNS axon regeneration","volume":"24","author":"Wang","year":"2018","journal-title":"Cell Rep"},{"key":"bib3","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1016\/j.exer.2015.08.016","article-title":"The role of autophagy in axonal degeneration of the optic nerve","volume":"144","author":"Koch","year":"2016","journal-title":"Exp Eye Res"},{"issue":"32","key":"bib4","doi-asserted-by":"publisher","first-page":"13469","DOI":"10.1073\/pnas.0906678106","article-title":"Experimental and clinical evidence of neuroprotection by nerve growth factor eye drops: implications for glaucoma","volume":"106","author":"Lambiase","year":"2009","journal-title":"Proc Natl Acad Sci USA"},{"key":"bib5","doi-asserted-by":"publisher","first-page":"194","DOI":"10.1186\/s12974-014-0194-3","article-title":"Tumor necrosis factor alpha has an early protective effect on retinal ganglion cells after optic nerve crush","volume":"11","author":"Mac Nair","year":"2014","journal-title":"J Neuroinflammation"},{"issue":"1","key":"bib6","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1167\/iovs.15-17841","article-title":"Apoptotic retinal ganglion cell death after optic nerve transection or crush in mice: delayed RGCs loss with BDNF or a caspase 3 inhibitor","volume":"57","author":"Sanchez-Migallon","year":"2016","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"6","key":"bib7","doi-asserted-by":"crossref","first-page":"565","DOI":"10.4103\/1673-5374.130093","article-title":"Mechanisms of secondary degeneration after partial optic nerve transection","volume":"9","author":"Li","year":"2014","journal-title":"Neural Regen Res"},{"issue":"10","key":"bib8","doi-asserted-by":"publisher","first-page":"842","DOI":"10.1038\/nsmb993","article-title":"Some like it hot: the structure and function of small heat-shock proteins","volume":"12","author":"Haslbeck","year":"2005","journal-title":"Nat Struct Mol Biol"},{"issue":"2","key":"bib9","doi-asserted-by":"publisher","first-page":"237","DOI":"10.4161\/auto.5407","article-title":"HspB8 and Bag3: a new chaperone complex targeting misfolded proteins to macroautophagy","volume":"4","author":"Carra","year":"2008","journal-title":"Autophagy"},{"issue":"1","key":"bib10","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.abb.2011.06.014","article-title":"Biochemical characterization of small heat shock protein HspB8 (Hsp22)\u2013Bag3 interaction","volume":"513","author":"Shemetov","year":"2011","journal-title":"Arch Biochem Biophys"},{"issue":"3","key":"bib11","doi-asserted-by":"publisher","first-page":"1437","DOI":"10.1074\/jbc.M706304200","article-title":"HspB8 chaperone activity toward poly(Q)-containing proteins depends on its association with Bag3, a stimulator of macroautophagy","volume":"283","author":"Carra","year":"2008","journal-title":"J Biol Chem"},{"issue":"1","key":"bib12","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1111\/nan.2012.38.issue-1","article-title":"The HSPB8-BAG3 chaperone complex is upregulated in astrocytes in the human brain affected by protein aggregation diseases","volume":"38","author":"Seidel","year":"2012","journal-title":"Neuropathol Appl Neurobiol"},{"issue":"4","key":"bib13","doi-asserted-by":"publisher","first-page":"1492","DOI":"10.1159\/000492259","article-title":"Heat shock protein B8 (HSPB8) reduces oxygen-glucose deprivation\/reperfusion injury via the induction of mitophagy","volume":"48","author":"Li","year":"2018","journal-title":"Cell Physiol Biochem"},{"issue":"pt 2","key":"bib14","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1042\/BJ20041314","article-title":"H11 has dose-dependent and dual hypertrophic and proapoptotic functions in cardiac myocytes","volume":"388","author":"Hase","year":"2005","journal-title":"Biochem J"},{"issue":"10","key":"bib15","doi-asserted-by":"publisher","first-page":"1622","DOI":"10.1016\/j.biocel.2012.04.002","article-title":"Small heat shock proteins HSP27 (HspB1), alphaB-crystallin (HspB5) and HSP22 (HspB8) as regulators of cell death","volume":"44","author":"Acunzo","year":"2012","journal-title":"Int J Biochem Cell Biol"},{"issue":"7","key":"bib16","doi-asserted-by":"publisher","first-page":"713","DOI":"10.1038\/ncb2788","article-title":"Emerging regulation and functions of autophagy","volume":"15","author":"Boya","year":"2013","journal-title":"Nat Cell Biol"},{"key":"bib17","doi-asserted-by":"publisher","first-page":"206","DOI":"10.1016\/j.preteyeres.2016.08.001","article-title":"Autophagy in the eye: development, degeneration, and aging","volume":"55","author":"Boya","year":"2016","journal-title":"Prog Retin Eye Res"},{"issue":"13","key":"bib18","doi-asserted-by":"publisher","first-page":"6064","DOI":"10.1073\/pnas.0909794107","article-title":"Mechanisms of acute axonal degeneration in the optic nerve in vivo","volume":"107","author":"Knoferle","year":"2010","journal-title":"Proc Natl Acad Sci USA"},{"issue":"2","key":"bib19","doi-asserted-by":"publisher","first-page":"286","DOI":"10.4161\/auto.8.2.18982","article-title":"Axonal damage, autophagy and neuronal survival","volume":"8","author":"Rodriguez-Muela","year":"2012","journal-title":"Autophagy"},{"issue":"2","key":"bib20","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1007\/s00417-019-04580-z","article-title":"SIRT1 is required for the neuroprotection of resveratrol on retinal ganglion cells after retinal ischemia-reperfusion injury in mice","volume":"258","author":"Luo","year":"2020","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"key":"bib21","doi-asserted-by":"publisher","first-page":"108281","DOI":"10.1016\/j.exer.2020.108281","article-title":"Overexpression of S100A4 protects retinal ganglion cells against retinal ischemia-reperfusion injury in mice","volume":"201","author":"Yang","year":"2020","journal-title":"Exp Eye Res"},{"key":"bib22","doi-asserted-by":"publisher","first-page":"107972","DOI":"10.1016\/j.exer.2020.107972","article-title":"Essential contribution of macrophage Tie2 signal mediated autophagy in laser-induced choroidal neovascularization","volume":"193","author":"Zhang","year":"2020","journal-title":"Exp Eye Res"},{"key":"bib23","doi-asserted-by":"publisher","first-page":"e860","DOI":"10.1038\/cddis.2013.391","article-title":"Axonal protection by Nmnat3 overexpression with involvement of autophagy in optic nerve degeneration","volume":"4","author":"Kitaoka","year":"2013","journal-title":"Cell Death Dis"},{"issue":"12","key":"bib24","doi-asserted-by":"publisher","first-page":"4611","DOI":"10.1167\/iovs.04-0541","article-title":"Rapid quantification of adult and developing mouse spatial vision using a virtual optomotor system","volume":"45","author":"Prusky","year":"2004","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib25","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.exer.2017.02.015","article-title":"Silencing of galectin-1 inhibits retinal neovascularization and ameliorates retinal hypoxia in a murine model of oxygen-induced ischemic retinopathy","volume":"159","author":"Yang","year":"2017","journal-title":"Exp Eye Res"},{"issue":"21","key":"bib26","doi-asserted-by":"publisher","first-page":"5720","DOI":"10.1093\/emboj\/19.21.5720","article-title":"LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing","volume":"19","author":"Kabeya","year":"2000","journal-title":"EMBO J"},{"issue":"6","key":"bib27","doi-asserted-by":"publisher","first-page":"1001","DOI":"10.1016\/j.cell.2009.05.023","article-title":"p62 at the crossroads of autophagy, apoptosis, and cancer","volume":"137","author":"Moscat","year":"2009","journal-title":"Cell"},{"issue":"1","key":"bib28","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1038\/cdd.2011.88","article-title":"Autophagy promotes survival of retinal ganglion cells after optic nerve axotomy in mice","volume":"19","author":"Rodriguez-Muela","year":"2012","journal-title":"Cell Death Differ"},{"issue":"13","key":"bib29","doi-asserted-by":"publisher","first-page":"2943","DOI":"10.1002\/jnr.v86:13","article-title":"Activation of autophagy in retinal ganglion cells","volume":"86","author":"Kim","year":"2008","journal-title":"J Neurosci Res"},{"issue":"pt B","key":"bib30","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.brainres.2016.03.047","article-title":"Mechanisms of neuronal homeostasis: autophagy in the axon","volume":"1649","author":"Maday","year":"2016","journal-title":"Brain Res"},{"issue":"9","key":"bib31","doi-asserted-by":"publisher","first-page":"1395","DOI":"10.18240\/ijo","article-title":"Activation of autophagy in the retina after optic nerve crush injury in rats","volume":"12","author":"Kang","year":"2019","journal-title":"Int J Ophthalmol"},{"issue":"5","key":"bib32","doi-asserted-by":"publisher","first-page":"652","DOI":"10.1016\/j.exer.2010.08.011","article-title":"Transduction of the inner mouse retina using AAVrh8 and AAVrh10 via intravitreal injection","volume":"91","author":"Giove","year":"2010","journal-title":"Exp Eye Res"},{"issue":"1","key":"bib33","doi-asserted-by":"publisher","first-page":"6966","DOI":"10.1038\/s41598-017-07294-6","article-title":"Hypothermia prevents retinal damage generated by optic nerve trauma in the rat","volume":"7","author":"Rey-Funes","year":"2017","journal-title":"Sci Rep"},{"issue":"12","key":"bib34","doi-asserted-by":"publisher","first-page":"905","DOI":"10.1038\/s41419-019-2140-x","article-title":"Rod bipolar cells dysfunction occurs before ganglion cells loss in excitotoxin-damaged mouse retina","volume":"10","author":"Shen","year":"2019","journal-title":"Cell Death Dis"},{"issue":"6","key":"bib35","doi-asserted-by":"publisher","first-page":"3766","DOI":"10.1167\/iovs.14-13895","article-title":"Monitoring retinal morphologic and functional changes in mice following optic nerve crush","volume":"55","author":"Liu","year":"2014","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"2","key":"bib36","doi-asserted-by":"publisher","first-page":"685","DOI":"10.1167\/iovs.03-0674","article-title":"The effect of retinal ganglion cell injury on light-induced photoreceptor degeneration","volume":"45","author":"Casson","year":"2004","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib37","first-page":"2373","article-title":"Short and long term axotomy-induced ERG changes in albino and pigmented rats","volume":"15","author":"Alarcon-Martinez","year":"2009","journal-title":"Mol Vis"},{"issue":"pt 1","key":"bib38","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1113\/jphysiol.2003.052738","article-title":"Ganglion cell contributions to the rat full-field electroretinogram","volume":"555","author":"Bui","year":"2004","journal-title":"J Physiol"},{"issue":"1","key":"bib39","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1007\/s10633-005-2629-8","article-title":"The decline of the photopic negative response (PhNR) in the rat after optic nerve transection","volume":"111","author":"Li","year":"2005","journal-title":"Doc Ophthalmol"},{"issue":"8","key":"bib40","doi-asserted-by":"publisher","first-page":"1175","DOI":"10.1016\/j.ophtha.2017.03.017","article-title":"Relative genetic and environmental contributions to variations in human retinal electrical responses quantified in a twin study","volume":"124","author":"Bhatti","year":"2017","journal-title":"Ophthalmology"},{"issue":"3","key":"bib41","doi-asserted-by":"publisher","first-page":"818","DOI":"10.1016\/j.ajpath.2017.11.015","article-title":"Alterations of ocular hemodynamics impair ophthalmic vascular and neuroretinal function","volume":"188","author":"Tsai","year":"2018","journal-title":"Am J Pathol"},{"issue":"6","key":"bib42","doi-asserted-by":"publisher","first-page":"2470","DOI":"10.1167\/iovs.18-24096","article-title":"RGCs neuroprotection following optic nerve trauma mediated by intranasal delivery of amnion cell secretome","volume":"59","author":"Grinblat","year":"2018","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"3","key":"bib43","doi-asserted-by":"publisher","first-page":"431","DOI":"10.4161\/auto.27344","article-title":"Expression of the autophagy substrate SQSTM1\/p62 is restored during prolonged starvation depending on transcriptional upregulation and autophagy-derived amino acids","volume":"10","author":"Sahani","year":"2014","journal-title":"Autophagy"},{"key":"bib44","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1186\/1750-1326-4-16","article-title":"All-you-can-eat: autophagy in neurodegeneration and neuroprotection","volume":"4","author":"Jaeger","year":"2009","journal-title":"Mol Neurodegener"},{"issue":"2","key":"bib45","doi-asserted-by":"crossref","first-page":"78","DOI":"10.2174\/156652408783769616","article-title":"To die or not to die: that is the autophagic question","volume":"8","author":"Galluzzi","year":"2008","journal-title":"Curr Mol Med"},{"issue":"9","key":"bib46","doi-asserted-by":"publisher","first-page":"5523","DOI":"10.1074\/jbc.M807440200","article-title":"HspB8 participates in protein quality control by a non-chaperone-like mechanism that requires eIF2{alpha} phosphorylation","volume":"284","author":"Carra","year":"2009","journal-title":"J Biol Chem"},{"issue":"3","key":"bib47","doi-asserted-by":"publisher","first-page":"428","DOI":"10.4161\/auto.5.3.7894","article-title":"The stress-inducible HspB8-Bag3 complex induces the eIF2alpha kinase pathway: implications for protein quality control and viral factory degradation?","volume":"5","author":"Carra","year":"2009","journal-title":"Autophagy"},{"issue":"2","key":"bib48","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1016\/j.cub.2009.11.022","article-title":"Chaperone-assisted selective autophagy is essential for muscle maintenance","volume":"20","author":"Arndt","year":"2010","journal-title":"Curr Biol"},{"issue":"13","key":"bib49","doi-asserted-by":"publisher","first-page":"1335","DOI":"10.7150\/ijms.20653","article-title":"HSPB8 promotes the fusion of autophagosome and lysosome during autophagy in diabetic neurons","volume":"14","author":"Li","year":"2017","journal-title":"Int J Med Sci"},{"issue":"6","key":"bib50","doi-asserted-by":"publisher","first-page":"1155","DOI":"10.1111\/jnc.2011.119.issue-6","article-title":"HspB8 mutation causing hereditary distal motor neuropathy impairs lysosomal delivery of autophagosomes","volume":"119","author":"Kwok","year":"2011","journal-title":"J Neurochem"},{"issue":"4","key":"bib51","doi-asserted-by":"publisher","first-page":"e35665","DOI":"10.1371\/journal.pone.0035665","article-title":"Inhibitors of phosphatidylinositol 3'-kinases promote mitotic cell death in HeLa cells","volume":"7","author":"Hou","year":"2012","journal-title":"PLoS One"},{"issue":"6","key":"bib52","doi-asserted-by":"publisher","first-page":"1889","DOI":"10.1073\/pnas.79.6.1889","article-title":"3-Methyladenine: specific inhibitor of autophagic\/lysosomal protein degradation in isolated rat hepatocytes","volume":"79","author":"Seglen","year":"1982","journal-title":"Proc Natl Acad Sci USA"},{"key":"bib53","doi-asserted-by":"publisher","first-page":"796","DOI":"10.3389\/fnins.2019.00796","article-title":"The regulation of the small heat shock protein b8 in misfolding protein diseases causing motoneuronal and muscle cell death","volume":"13","author":"Cristofani","year":"2019","journal-title":"Front Neurosci"},{"issue":"pt 5","key":"bib54","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1242\/jcs.091041","article-title":"NF-?B regulates protein quality control after heat stress through modulation of the BAG3\u2013HspB8 complex","volume":"125","author":"Nivon","year":"2012","journal-title":"J Cell Sci"},{"issue":"7","key":"bib55","doi-asserted-by":"publisher","first-page":"1576","DOI":"10.1093\/emboj\/19.7.1576","article-title":"The atypical PKC-interacting protein p62 channels NF-?B activation by the IL-1\u2013TRAF6 pathway","volume":"19","author":"Sanz","year":"2000","journal-title":"EMBO J"},{"issue":"5","key":"bib56","doi-asserted-by":"publisher","first-page":"631","DOI":"10.1016\/j.molcel.2006.08.002","article-title":"Cell signaling and function organized by PB1 domain interactions","volume":"23","author":"Moscat","year":"2006","journal-title":"Mol Cell"},{"issue":"7","key":"bib57","doi-asserted-by":"publisher","first-page":"3784","DOI":"10.1167\/iovs.09-4894","article-title":"Preconditioning with inhalative carbon monoxide protects rat retinal ganglion cells from ischemia\/reperfusion injury","volume":"51","author":"Biermann","year":"2010","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib58","first-page":"1275","article-title":"Inhalative preconditioning with hydrogen sulfide attenuated apoptosis after retinal ischemia\/reperfusion injury","volume":"17","author":"Biermann","year":"2011","journal-title":"Mol Vis"},{"issue":"8","key":"bib59","doi-asserted-by":"publisher","first-page":"3626","DOI":"10.1167\/iovs.15-18999R2","article-title":"Specific inner retinal layer cell damage in an autoimmune glaucoma model is induced by GDNF with or without HSP27","volume":"57","author":"Casola","year":"2016","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"1","key":"bib60","doi-asserted-by":"publisher","first-page":"325","DOI":"10.3390\/ijms19010325","article-title":"Heat shock proteins and autophagy pathways in neuroprotection: from molecular bases to pharmacological interventions","volume":"19","author":"Penke","year":"2018","journal-title":"Int J Mol Sci"}],"container-title":["Investigative Opthalmology & Visual Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/iovs.arvojournals.org\/article.aspx?articleid=2783436","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:31:34Z","timestamp":1791927094000},"score":1,"resource":{"primary":{"URL":"https:\/\/iovs.arvojournals.org\/article.aspx?articleid=2783436"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6,27]]},"references-count":60,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2022,6,1]]}},"URL":"https:\/\/doi.org\/10.1167\/iovs.63.6.28","relation":{},"ISSN":["1552-5783"],"issn-type":[{"value":"1552-5783","type":"print"}],"subject":[],"published":{"date-parts":[[2022,6,27]]}}}