{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:59:47Z","timestamp":1791928787687,"version":"4.3.4"},"reference-count":34,"publisher":"Association for Research in Vision and Ophthalmology (ARVO)","issue":"6","license":[{"start":{"date-parts":[[2022,6,2]],"date-time":"2022-06-02T00:00:00Z","timestamp":1654128000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Invest. Ophthalmol. Vis. Sci."],"published-print":{"date-parts":[[2022,6,2]]},"DOI":"10.1167\/iovs.63.6.3","type":"journal-article","created":{"date-parts":[[2022,6,2]],"date-time":"2022-06-02T11:31:16Z","timestamp":1654169476000},"page":"3","source":"Crossref","is-referenced-by-count":24,"title":["Potential Mechanisms of Intraocular Pressure Reduction by Micropulse Transscleral Cyclophotocoagulation in Rabbit Eyes"],"prefix":"10.1167","volume":"63","author":[{"given":"Hotaka","family":"Nemoto","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Megumi","family":"Honjo","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michiaki","family":"Okamoto","sequence":"additional","affiliation":[{"name":"Tomey Corporation, Nagoya, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koichiro","family":"Sugimoto","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Makoto","family":"Aihara","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"27","reference":[{"key":"bib1","doi-asserted-by":"publisher","first-page":"262","DOI":"10.1136\/bjo.2005.081224","article-title":"The number of people with glaucoma worldwide in 2010 and 2020","volume":"90","author":"Quigley","year":"2006","journal-title":"Br J Ophthalmol"},{"issue":"4","key":"bib2","doi-asserted-by":"publisher","first-page":"398","DOI":"10.1007\/s10384-020-00748-x","article-title":"Intraocular pressure-lowering effect of omidenepag isopropyl in latanoprost non-\/low-responder patients with primary open-angle glaucoma or ocular hypertension: the FUJI study","volume":"64","author":"Aihara","year":"2020","journal-title":"Jpn J Ophthalmol"},{"key":"bib3","doi-asserted-by":"publisher","first-page":"271","DOI":"10.7326\/0003-4819-158-4-201302190-00008","article-title":"Comparative effectiveness of treatments for open-angle glaucoma: a systematic review for the U.S. Preventive Services Task Force","volume":"158","author":"Boland","year":"2013","journal-title":"Ann Intern Med"},{"key":"bib4","doi-asserted-by":"publisher","first-page":"1113","DOI":"10.1056\/NEJMra0804630","article-title":"Primary open-angle glaucoma","volume":"360","author":"Kwon","year":"2009","journal-title":"N Engl J Med"},{"issue":"9422","key":"bib5","doi-asserted-by":"publisher","first-page":"1711","DOI":"10.1016\/S0140-6736(04)16257-0","article-title":"Primary open-angle glaucoma","volume":"363","author":"Weinreb","year":"2004","journal-title":"Lancet"},{"key":"bib6","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1016\/S0002-9394(14)75758-7","article-title":"Semiconductor diode laser transscleral cyclophotocoagulation in patients with glaucoma","volume":"113","author":"Hennis","year":"1992","journal-title":"Am J Ophthalmol"},{"key":"bib7","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1046\/j.1442-9071.2002.00553.x","article-title":"Effect of diode laser contact transscleral pars plana photocoagulation on intraocular pressure in glaucoma","volume":"30","author":"Ho","year":"2002","journal-title":"Clin Exp Ophthalmol"},{"key":"bib8","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1097\/IJG.0b013e318207091a","article-title":"Risk factors for hypotony after transscleral diode cyclophotocoagulation","volume":"21","author":"Ramli","year":"2012","journal-title":"J Glaucoma"},{"key":"bib9","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1111\/ceo.2015.43.issue-1","article-title":"Micropulse versus continuous wave transscleral diode cyclophotocoagulation in refractory glaucoma: a randomized exploratory study","volume":"43","author":"Aquino","year":"2015","journal-title":"Clin Exp Ophthalmol"},{"key":"bib10","doi-asserted-by":"publisher","first-page":"266","DOI":"10.1111\/ceo.2010.38.issue-3","article-title":"Micropulse transscleral diode laser cyclophotocoagulation in the treatment of refractory glaucoma","volume":"38","author":"Tan","year":"2010","journal-title":"Clin Exp Ophthalmol"},{"key":"bib11","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1002\/(ISSN)1096-9101","article-title":"Thermal modelling of micropulsed diode laser retinal photocoagulation","volume":"20","author":"Berger","year":"1997","journal-title":"Lasers Surg Med"},{"issue":"1","key":"bib12","doi-asserted-by":"publisher","first-page":"18703","DOI":"10.1038\/s41598-019-55102-0","article-title":"Transscleral cyclophotocoagulation and its histological effects on the conjunctiva","volume":"9","author":"Tan","year":"2019","journal-title":"Sci Rep"},{"key":"bib13","doi-asserted-by":"publisher","first-page":"1528","DOI":"10.1007\/s12325-017-0559-y","article-title":"A review of subthreshold micropulse laser for treatment of macular disorders","volume":"34","author":"Scholz","year":"2017","journal-title":"Adv Ther"},{"key":"bib14","doi-asserted-by":"publisher","first-page":"900","DOI":"10.1097\/IJG.0000000000001053","article-title":"Micropulse versus continuous wave transscleral cyclophotocoagulation in refractory pediatric glaucoma","volume":"27","author":"Abdelrahman","year":"2018","journal-title":"J Glaucoma"},{"key":"bib15","doi-asserted-by":"publisher","first-page":"920","DOI":"10.1097\/IJG.0000000000001023","article-title":"Patient outcomes following micropulse transscleral cyclophotocoagulation: intermediate-term results","volume":"27","author":"Yelenskiy","year":"2018","journal-title":"J Glaucoma"},{"key":"bib16","doi-asserted-by":"crossref","first-page":"144","DOI":"10.22336\/rjo.2018.21","article-title":"Choroidal thickness increase after micropulse transscleral cyclophotocoagulation","volume":"62","author":"Barac","year":"2018","journal-title":"Rom J Ophthalmol"},{"key":"bib19","first-page":"135","article-title":"Simultaneous measurement of changing intraocular pressure and outflow facility in the vervet monkey by constant pressure infusion","volume":"3","author":"Barany","year":"1964","journal-title":"Invest Ophthalmol"},{"key":"bib20","first-page":"2201","article-title":"Identification of the mouse uveoscleral outflow pathway using fluorescent dextran","volume":"43","author":"Lindsey","year":"2002","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib21","doi-asserted-by":"publisher","first-page":"108421","DOI":"10.1016\/j.exer.2020.108421","article-title":"Effects of mammalian target of rapamycin inhibitors on fibrosis after trabeculectomy","volume":"203","author":"Igarashi","year":"2021","journal-title":"Exp Eye Res"},{"key":"bib22","doi-asserted-by":"publisher","first-page":"426","DOI":"10.1097\/00061198-199712000-00013","article-title":"Diode laser transscleral cyclophotocoagulation","volume":"6","author":"Gupta","year":"1997","journal-title":"J Glaucoma"},{"issue":"3","key":"bib23","first-page":"94","article-title":"Micropulse Transscleral Cyclophotocoagulation: A Hypothesis for the Ideal Parameters","volume":"7","author":"Sanchez","year":"2018","journal-title":"Med Hypothesis Discov Innov Ophthalmol"},{"key":"bib24","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1159\/000267395","article-title":"Mechanism of intraocular pressure decrease after contact transscleral continuous-wave Nd:YAG laser cyclophotocoagulation","volume":"26","author":"Liu","year":"1994","journal-title":"Ophthalmic Res"},{"key":"bib25","article-title":"Morphological changes and potential mechanisms of intraocular pressure reduction after micropulse transscleral cyclophotocoagulation in rabbits [published online July 31, 2020]","author":"Tsujisawa","journal-title":"Ophthalmic Res"},{"issue":"13","key":"bib26","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1167\/tvst.10.13.11","article-title":"Changes after a month following micropulse cyclophotocoagulation in normal porcine eyes","volume":"10","author":"Ahn","year":"2021","journal-title":"Transl Vis Sci Technol"},{"issue":"5","key":"bib27","doi-asserted-by":"publisher","first-page":"581","DOI":"10.1007\/s10384-021-00844-6","article-title":"Prostanoid receptor agonists for glaucoma treatment","volume":"65","author":"Aihara","year":"2021","journal-title":"Jpn J Ophthalmol"},{"key":"bib28","doi-asserted-by":"publisher","first-page":"208","DOI":"10.1089\/jop.2019.0146","article-title":"Matrix metalloproteinases and glaucoma treatment","volume":"36","author":"Weinreb","year":"2020","journal-title":"J Ocul Pharmacol Ther"},{"key":"bib29","first-page":"1514","article-title":"Increased human scleral permeability with prostaglandin exposure","volume":"42","author":"Kim","year":"2001","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib30","doi-asserted-by":"publisher","first-page":"1165","DOI":"10.1001\/archopht.119.8.1165","article-title":"Increased matrix metalloproteinases 1, 2, and 3 in the monkey uveoscleral outflow pathway after topical prostaglandin F(2 alpha)-isopropyl ester treatment","volume":"119","author":"Gaton","year":"2001","journal-title":"Arch Ophthalmol"},{"key":"bib31","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1159\/000181150","article-title":"Influence of conjunctival suture removal on the outcome of trabeculectomy","volume":"223","author":"Klink","year":"2009","journal-title":"Ophthalmologica"},{"key":"bib32","doi-asserted-by":"publisher","first-page":"694","DOI":"10.1016\/j.ophtha.2011.09.043","article-title":"A twenty-year follow-up study of trabeculectomy: risk factors and outcomes","volume":"119","author":"Landers","year":"2012","journal-title":"Ophthalmology"},{"key":"bib33","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1016\/j.exer.2016.01.017","article-title":"Unconventional aqueous humor outflow: a review","volume":"158","author":"Johnson","year":"2017","journal-title":"Exp Eye Res"},{"key":"bib34","doi-asserted-by":"publisher","first-page":"476","DOI":"10.1007\/BF02172902","article-title":"Effect of topical prostaglandin D2 on the aqueous humor dynamics in rabbits","volume":"227","author":"Goh","year":"1989","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"key":"bib17","first-page":"2825","article-title":"Microscope real-time video (MRTV), high-resolution OCT (HR-OCT) & histopathology (HP) to assess how transscleral micropulse laser (TML) affects the sclera, ciliary body (CB), muscle (CM), secretory epithelium (CBSE), suprachoroidal space (SCS) & aqueous","volume-title":"Invest Ophthalmol Vis Sci","author":"Johnstone","year":"2019"},{"key":"bib18","article-title":"Transscleral laser induces aqueous outflow pathway motion & reorganization","volume-title":"27th Annual Meeting of the American Glaucoma Society Annual Meeting","author":"Johnstone","year":"2017"}],"container-title":["Investigative Opthalmology & Visual Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/iovs.arvojournals.org\/article.aspx?articleid=2778878","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:31:35Z","timestamp":1791927095000},"score":1,"resource":{"primary":{"URL":"https:\/\/iovs.arvojournals.org\/article.aspx?articleid=2778878"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6,2]]},"references-count":34,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2022,6,1]]}},"URL":"https:\/\/doi.org\/10.1167\/iovs.63.6.3","relation":{},"ISSN":["1552-5783"],"issn-type":[{"value":"1552-5783","type":"print"}],"subject":[],"published":{"date-parts":[[2022,6,2]]}}}