{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T22:00:04Z","timestamp":1791928804999,"version":"4.3.4"},"reference-count":50,"publisher":"Association for Research in Vision and Ophthalmology (ARVO)","issue":"9","license":[{"start":{"date-parts":[[2022,8,26]],"date-time":"2022-08-26T00:00:00Z","timestamp":1661472000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Invest. Ophthalmol. Vis. Sci."],"published-print":{"date-parts":[[2022,8,26]]},"DOI":"10.1167\/iovs.63.9.29","type":"journal-article","created":{"date-parts":[[2022,8,26]],"date-time":"2022-08-26T11:49:26Z","timestamp":1661514566000},"page":"29","source":"Crossref","is-referenced-by-count":6,"title":["Sensitivity of the Dorsal-Central Retinal Pigment Epithelium to Sodium Iodate-Induced Damage Is Associated With Overlying M-Cone Photoreceptors in Mice"],"prefix":"10.1167","volume":"63","author":[{"given":"Lili","family":"Lian","sequence":"first","affiliation":[{"name":"Laboratory of Developmental Cell Biology and Disease, School of Ophthalmology and Optometry and Eye Hospital, Wenzhou Medical University, Wenzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yifan","family":"Zhai","sequence":"additional","affiliation":[{"name":"Laboratory of Developmental Cell Biology and Disease, School of Ophthalmology and Optometry and Eye Hospital, Wenzhou Medical University, Wenzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuejiao","family":"Wan","sequence":"additional","affiliation":[{"name":"Laboratory of Developmental Cell Biology and Disease, School of Ophthalmology and Optometry and Eye Hospital, Wenzhou Medical University, Wenzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linxin","family":"Chen","sequence":"additional","affiliation":[{"name":"Laboratory of Developmental Cell Biology and Disease, School of Ophthalmology and Optometry and Eye Hospital, Wenzhou Medical University, Wenzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zuimeng","family":"Liu","sequence":"additional","affiliation":[{"name":"Laboratory of Developmental Cell Biology and Disease, School of Ophthalmology and Optometry and Eye Hospital, Wenzhou Medical University, Wenzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruona","family":"Liu","sequence":"additional","affiliation":[{"name":"Laboratory of Developmental Cell Biology and Disease, School of Ophthalmology and Optometry and Eye Hospital, Wenzhou Medical University, Wenzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shijia","family":"Li","sequence":"additional","affiliation":[{"name":"Laboratory of Developmental Cell Biology and Disease, School of Ophthalmology and Optometry and Eye Hospital, Wenzhou Medical University, Wenzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiajia","family":"Zhou","sequence":"additional","affiliation":[{"name":"Laboratory of Developmental Cell Biology and Disease, School of Ophthalmology and Optometry and Eye Hospital, Wenzhou Medical University, Wenzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Chen","sequence":"additional","affiliation":[{"name":"Laboratory of Developmental Cell Biology and Disease, School of Ophthalmology and Optometry and Eye Hospital, Wenzhou Medical University, Wenzhou, China"},{"name":"State Key Laboratory of Ophthalmology, Optometry and Vision Science, Wenzhou Medical University, Wenzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Hou","sequence":"additional","affiliation":[{"name":"Laboratory of Developmental Cell Biology and Disease, School of Ophthalmology and Optometry and Eye Hospital, Wenzhou Medical University, Wenzhou, China"},{"name":"State Key Laboratory of Ophthalmology, Optometry and Vision Science, Wenzhou Medical University, Wenzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huirong","family":"Li","sequence":"additional","affiliation":[{"name":"Laboratory of Developmental Cell Biology and Disease, School of Ophthalmology and Optometry and Eye Hospital, Wenzhou Medical University, Wenzhou, China"},{"name":"State Key Laboratory of Ophthalmology, Optometry and Vision Science, Wenzhou Medical University, Wenzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"27","reference":[{"key":"bib1","doi-asserted-by":"publisher","first-page":"845","DOI":"10.1152\/physrev.00021.2004","article-title":"The retinal pigment epithelium in visual function","volume":"85","author":"Strauss","year":"2005","journal-title":"Physiol Rev"},{"key":"bib2","doi-asserted-by":"publisher","first-page":"100766","DOI":"10.1016\/j.preteyeres.2019.06.002","article-title":"The transcription factor MITF in RPE function and dysfunction","volume":"73","author":"Ma","year":"2019","journal-title":"Prog Retin Eye Res"},{"key":"bib3","doi-asserted-by":"publisher","first-page":"615","DOI":"10.1038\/nrn3767","article-title":"Intrinsically different retinal progenitor cells produce specific types of progeny","volume":"15","author":"Cepko","year":"2014","journal-title":"Nat Rev Neurosci"},{"key":"bib4","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1146\/neuro.2019.42.issue-1","article-title":"Probing Computation in the Primate Visual System at Single-Cone Resolution","volume":"42","author":"Kling","year":"2019","journal-title":"Annu Rev Neurosci"},{"key":"bib5","article-title":"The cell biology of the retinal pigment epithelium [published online ahead of print February 24, 2020]","author":"Lakkaraju","journal-title":"Prog Retin Eye Res."},{"key":"bib6","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1016\/j.neuron.2012.06.018","article-title":"Mechanisms of age-related macular degeneration","volume":"75","author":"Ambati","year":"2012","journal-title":"Neuron"},{"key":"bib7","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1038\/s41572-021-00265-2","article-title":"Age-related macular degeneration","volume":"7","author":"Fleckenstein","year":"2021","journal-title":"Nat Rev Dis primers"},{"key":"bib8","doi-asserted-by":"publisher","first-page":"8132","DOI":"10.1523\/JNEUROSCI.1671-20.2020","article-title":"Analysis of parvocellular and magnocellular visual pathways in human retina","volume":"40","author":"Masri","year":"2020","journal-title":"J Neurosci"},{"key":"bib9","doi-asserted-by":"publisher","first-page":"1222","DOI":"10.1016\/j.cell.2019.01.004","article-title":"Molecular classification and comparative taxonomics of foveal and peripheral cells in primate retina","volume":"176","author":"Peng","year":"2019","journal-title":"Cell"},{"key":"bib10","first-page":"145","article-title":"Retinal pigment epithelial lipofuscin and melanin and choroidal melanin in human eyes","volume":"27","author":"Weiter","year":"1986","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib11","first-page":"195","article-title":"Aging human RPE: morphometric analysis of macular, equatorial, and peripheral cells","volume":"25","author":"Feeney-Burns","year":"1984","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib12","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1167\/iovs.61.5.35","article-title":"Autofluorescent granules of the human retinal pigment epithelium: phenotypes, intracellular distribution, and age-related topography","volume":"61","author":"Bermond","year":"2020","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib13","doi-asserted-by":"publisher","first-page":"24100","DOI":"10.1073\/pnas.1914143116","article-title":"Single-cell transcriptomics of the human retinal pigment epithelium and choroid in health and macular degeneration","volume":"116","author":"Voigt","year":"2019","journal-title":"P Natl Acad Sci USA"},{"key":"bib14","doi-asserted-by":"publisher","first-page":"101537","DOI":"10.1016\/j.redox.2020.101537","article-title":"MITF protects against oxidative damage-induced retinal degeneration by regulating the NRF2 pathway in the retinal pigment epithelium","volume":"34","author":"Han","year":"2020","journal-title":"Redox Biol"},{"key":"bib15","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1038\/nm.4450","article-title":"cGAS drives noncanonical-inflammasome activation in age-related macular degeneration","volume":"24","author":"Kerur","year":"2018","journal-title":"Nat Med"},{"key":"bib16","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1016\/j.cell.2013.06.012","article-title":"Noncanonical autophagy promotes the visual cycle","volume":"154","author":"Kim","year":"2013","journal-title":"Cell"},{"key":"bib17","doi-asserted-by":"publisher","first-page":"100858","DOI":"10.1016\/j.preteyeres.2020.100858","article-title":"Mechanisms of mitochondrial dysfunction and their impact on age-related macular degeneration","volume":"79","author":"Kaarniranta","year":"2020","journal-title":"Prog Retin Eye Res"},{"key":"bib18","doi-asserted-by":"publisher","first-page":"310","DOI":"10.1016\/j.cub.2013.12.020","article-title":"Visual space is represented by nonmatching topographies of distinct mouse retinal ganglion cell types","volume":"24","author":"Bleckert","year":"2014","journal-title":"Curr Biol"},{"key":"bib19","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1038\/s41583-019-0242-1","article-title":"Understanding the retinal basis of vision across species","volume":"21","author":"Baden","year":"2020","journal-title":"Nat Rev Neurosci"},{"key":"bib20","doi-asserted-by":"publisher","first-page":"655","DOI":"10.1016\/j.cub.2018.01.016","article-title":"Inhomogeneous encoding of the visual field in the mouse retina","volume":"28","author":"Warwick","year":"2018","journal-title":"Curr Biol"},{"key":"bib21","doi-asserted-by":"publisher","first-page":"887","DOI":"10.1016\/j.exer.2004.06.031","article-title":"Why do mice have ultra-violet vision?","volume":"79","author":"Gouras","year":"2004","journal-title":"Exp Eye Res"},{"key":"bib22","doi-asserted-by":"publisher","first-page":"1206","DOI":"10.1016\/j.neuron.2013.09.030","article-title":"A tale of two retinal domains: near-optimal sampling of achromatic contrasts in natural scenes through asymmetric photoreceptor distribution","volume":"80","author":"Baden","year":"2013","journal-title":"Neuron"},{"key":"bib23","doi-asserted-by":"publisher","first-page":"e56840","DOI":"10.7554\/eLife.56840","article-title":"True S-cones are concentrated in the ventral mouse retina and wired for color detection in the upper visual field","volume":"9","author":"Nadal-Nicol\u00e1s","year":"2020","journal-title":"eLife"},{"key":"bib24","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1167\/iovs.62.2.32","article-title":"Morphometric analysis of retinal pigment epithelial cells from C57BL\/6J mice during aging","volume":"62","author":"Kim","year":"2021","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib25","first-page":"570","article-title":"Microscopic mammalian retinal pigment epithelium lesions induce widespread proliferation with differences in magnitude between center and periphery","volume":"16","author":"von Leithner","year":"2010","journal-title":"Mol Vis"},{"key":"bib26","doi-asserted-by":"publisher","first-page":"e18921","DOI":"10.1371\/journal.pone.0018921","article-title":"Mature peripheral RPE cells have an intrinsic capacity to proliferate; a potential regulatory mechanism for age-related cell loss","volume":"6","author":"Kokkinopoulos","year":"2011","journal-title":"PloS One"},{"key":"bib27","doi-asserted-by":"publisher","first-page":"1819","DOI":"10.1007\/s11064-010-0248-6","article-title":"Sodium iodate selectively injuries the posterior pole of the retina in a dose-dependent manner: morphological and electrophysiological study","volume":"35","author":"Machalinska","year":"2010","journal-title":"Neurochem Res"},{"key":"bib28","doi-asserted-by":"publisher","first-page":"100969","DOI":"10.1016\/j.preteyeres.2021.100969","article-title":"The retinal pigment epithelium: Development, injury responses, and regenerative potential in mammalian and non-mammalian systems","volume":"85","author":"George","year":"2021","journal-title":"Prog Retin Eye Res"},{"key":"bib29","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1186\/s13024-021-00437-4","article-title":"High dose expression of heme oxigenase-1 induces retinal degeneration through ER stress-related DDIT3","volume":"16","author":"Li","year":"2021","journal-title":"Mol Neurodegener"},{"key":"bib30","doi-asserted-by":"publisher","first-page":"1206","DOI":"10.1038\/nprot.2016.065","article-title":"Isolation, culture and characterization of primary mouse RPE cells","volume":"11","author":"Fernandez-Godino","year":"2016","journal-title":"Nat Protoc"},{"key":"bib31","doi-asserted-by":"publisher","first-page":"3259","DOI":"10.1167\/iovs.18-23965","article-title":"Hyperosmotic stress-induced TRPM2 channel activation stimulates NLRP3 inflammasome activity in primary human corneal epithelial cells","volume":"59","author":"Zheng","year":"2018","journal-title":"Invest Ophth Vis Sci"},{"key":"bib32","doi-asserted-by":"publisher","first-page":"e51698","DOI":"10.7554\/eLife.51698","article-title":"KIT ligand protects against both light-induced and genetic photoreceptor degeneration","volume":"9","author":"Li","year":"2020","journal-title":"eLife"},{"key":"bib33","doi-asserted-by":"publisher","first-page":"7272","DOI":"10.1038\/s41598-017-07683-x","article-title":"Epilation induces hair and skin pigmentation through an EDN3\/EDNRB-dependent regenerative response of melanocyte stem cells","volume":"7","author":"Li","year":"2017","journal-title":"Sci Rep-UK"},{"key":"bib34","doi-asserted-by":"publisher","first-page":"2152","DOI":"10.1167\/iovs.17-21557","article-title":"Multimodal fundus imaging of sodium iodate-treated mice informs RPE susceptibility and origins of increased fundus autofluorescence","volume":"58","author":"Zhao","year":"2017","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib35","doi-asserted-by":"publisher","first-page":"3476","DOI":"10.1167\/iovs.17-23532","article-title":"Irreversible photoreceptors and RPE cells damage by intravenous sodium iodate in mice is related to macrophage accumulation","volume":"59","author":"Moriguchi","year":"2018","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib36","doi-asserted-by":"publisher","first-page":"1163","DOI":"10.1038\/cr.2008.303","article-title":"Transcriptional and signaling regulation in neural crest stem cell-derived melanocyte development: do all roads lead to Mitf?","volume":"18","author":"Hou","year":"2008","journal-title":"Cell Res"},{"key":"bib37","first-page":"2088","article-title":"Photoreactivity of aged human RPE melanosomes: a comparison with lipofuscin","volume":"43","author":"R\u00f3zanowska","year":"2002","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib38","doi-asserted-by":"publisher","first-page":"3696","DOI":"10.1002\/cne.v524.18","article-title":"Retinal pigment epithelial integrity is compromised in the developing albino mouse retina","volume":"524","author":"Iwai-Takekoshi","year":"2016","journal-title":"J Comp Neurol"},{"key":"bib39","doi-asserted-by":"publisher","first-page":"1941","DOI":"10.1167\/iovs.13-13075","article-title":"Direct effect of sodium iodate on neurosensory retina","volume":"55","author":"Wang","year":"2014","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib40","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1016\/j.neuron.2012.12.012","article-title":"Chromatic coding from cone-type unselective circuits in the mouse retina","volume":"77","author":"Chang","year":"2013","journal-title":"Neuron"},{"key":"bib41","doi-asserted-by":"publisher","first-page":"1159","DOI":"10.1016\/0896-6273(94)90053-1","article-title":"Two different visual pigments in one retinal cone cell","volume":"13","author":"R\u00f6hlich","year":"1994","journal-title":"Neuron"},{"key":"bib42","doi-asserted-by":"publisher","first-page":"7274","DOI":"10.1167\/iovs.13-12450","article-title":"Functional principal component analysis reveals discriminating categories of retinal pigment epithelial morphology in mice","volume":"54","author":"Jiang","year":"2013","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib43","doi-asserted-by":"publisher","first-page":"727","DOI":"10.1172\/JCI79651","article-title":"CRALBP supports the mammalian retinal visual cycle and cone vision","volume":"125","author":"Xue","year":"2015","journal-title":"J Clin Invest"},{"key":"bib44","doi-asserted-by":"publisher","first-page":"1059","DOI":"10.1016\/j.ajpath.2020.01.005","article-title":"Deletion of M-opsin prevents M cone degeneration in a mouse model of Leber congenital amaurosis","volume":"190","author":"Xu","year":"2020","journal-title":"Am J Pathol"},{"key":"bib45","doi-asserted-by":"publisher","first-page":"eaba5614","DOI":"10.1126\/sciadv.aba5614","article-title":"A gene therapy for inherited blindness using dCas9-VPR-mediated transcriptional activation","volume":"6","author":"B\u00f6hm","year":"2020","journal-title":"Sci Adv"},{"key":"bib46","doi-asserted-by":"publisher","first-page":"2239","DOI":"10.1167\/iovs.16-21255","article-title":"Course of sodium iodate-induced retinal degeneration in albino and pigmented mice","volume":"58","author":"Chowers","year":"2017","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib47","doi-asserted-by":"publisher","first-page":"6473","DOI":"10.1242\/jcs.01580","article-title":"Role of myosin VIIa and Rab27a in the motility and localization of RPE melanosomes","volume":"117","author":"Gibbs","year":"2004","journal-title":"J Cell Sci"},{"key":"bib48","doi-asserted-by":"publisher","first-page":"2838","DOI":"10.1167\/iovs.08-1700","article-title":"Human RPE melanosomes protect from photosensitized and iron-mediated oxidation but become pro-oxidant in the presence of iron upon photodegradation","volume":"49","author":"R\u00f3zanowski","year":"2008","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib49","doi-asserted-by":"publisher","first-page":"1044","DOI":"10.3390\/antiox9111044","article-title":"The effect of antioxidants on photoreactivity and phototoxic potential of RPE melanolipofuscin granules from human donors of different age","volume":"9","author":"Olchawa","year":"2020","journal-title":"Antioxidants"},{"key":"bib50","doi-asserted-by":"publisher","first-page":"9218","DOI":"10.3390\/ijms22179218","article-title":"Sodium iodate-induced degeneration results in local complement changes and inflammatory processes in murine retina","volume":"22","author":"Enzbrenner","year":"2021","journal-title":"Int J Mol Sci"}],"container-title":["Investigative Opthalmology &amp; Visual Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/iovs.arvojournals.org\/article.aspx?articleid=2783600","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:31:35Z","timestamp":1791927095000},"score":1,"resource":{"primary":{"URL":"https:\/\/iovs.arvojournals.org\/article.aspx?articleid=2783600"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8,26]]},"references-count":50,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2022,8,2]]}},"URL":"https:\/\/doi.org\/10.1167\/iovs.63.9.29","relation":{},"ISSN":["1552-5783"],"issn-type":[{"value":"1552-5783","type":"print"}],"subject":[],"published":{"date-parts":[[2022,8,26]]}}}