{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T08:08:40Z","timestamp":1793261320021,"version":"4.5.0"},"reference-count":20,"publisher":"Association for Research in Vision and Ophthalmology (ARVO)","issue":"1","license":[{"start":{"date-parts":[[2023,1,19]],"date-time":"2023-01-19T00:00:00Z","timestamp":1674086400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Invest. Ophthalmol. Vis. Sci."],"published-print":{"date-parts":[[2023,1,19]]},"DOI":"10.1167\/iovs.64.1.15","type":"journal-article","created":{"date-parts":[[2023,1,19]],"date-time":"2023-01-19T11:35:12Z","timestamp":1674128112000},"page":"15","source":"Crossref","is-referenced-by-count":14,"title":["Cytogenetic Abnormalities for Predicting the Risk of Metastases in Choroidal and Ciliary Body Melanoma"],"prefix":"10.1167","volume":"64","author":[{"given":"An-Ning","family":"Chao","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Linkou Chang Gung Memorial Hospital, and College of Medicine, Chang Gung University, Taoyuan, Taiwan"},{"name":"Department of Ophthalmology and Visual Sciences, Princess Margaret Cancer Centre, University Health Network, Ocular Oncology Service, University of Toronto, Toronto, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kalpana","family":"Rose","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology and Visual Sciences, Princess Margaret Cancer Centre, University Health Network, Ocular Oncology Service, University of Toronto, Toronto, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hilary","family":"Racher","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology and Visual Sciences, Princess Margaret Cancer Centre, University Health Network, Ocular Oncology Service, University of Toronto, Toronto, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Filiberto","family":"Altomare","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology and Visual Sciences, Princess Margaret Cancer Centre, University Health Network, Ocular Oncology Service, University of Toronto, Toronto, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hatem","family":"Krema","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology and Visual Sciences, Princess Margaret Cancer Centre, University Health Network, Ocular Oncology Service, University of Toronto, Toronto, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"27","reference":[{"key":"bib1","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1016\/0039-6257(88)90173-7","article-title":"Epidemiologic aspects of uveal melanoma","volume":"32","author":"Egan","year":"1988","journal-title":"Surv Ophthalmol"},{"key":"bib2","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1159\/000480640","article-title":"Uveal Melanoma: 5-Year Update on Incidence, Treatment, and Survival (SEER 1973-2013)","volume":"4","author":"Aronow","year":"2018","journal-title":"Ocul Oncol Pathol"},{"key":"bib3","doi-asserted-by":"publisher","first-page":"1523","DOI":"10.1016\/j.ophtha.2017.04.003","article-title":"Personalized Prognosis of Uveal Melanoma Based on Cytogenetic Profile in 1059 Patients over an 8-Year Period: The 2017 Harry S. Gradle Lecture","volume":"124","author":"Shields","year":"2017","journal-title":"Ophthalmology"},{"key":"bib4","first-page":"833","article-title":"The prognostic value of AJCC staging in uveal melanoma is enhanced by adding chromosome 3 and 8q status","volume":"58","author":"Dogrus\u00f6z","year":"2017","journal-title":"Med Image Comput Comput Assist Interv"},{"key":"bib5","doi-asserted-by":"publisher","first-page":"1881","DOI":"10.1016\/j.ophtha.2011.01.040","article-title":"Uveal melanoma: trends in incidence, treatment, and survival","volume":"118","author":"Singh","year":"2011","journal-title":"Ophthalmology"},{"key":"bib6","doi-asserted-by":"publisher","first-page":"605","DOI":"10.1001\/jamaophthalmol.2014.77","article-title":"Age, survival predictors, and metastatic death in patients with choroidal melanoma: tentative evidence of a therapeutic effect on survival","volume":"132","author":"Damato","year":"2014","journal-title":"JAMA Ophthalmol"},{"key":"bib7","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1016\/S0039-6257(96)80024-5","article-title":"Prognostic parameters in uveal melanoma: a review","volume":"41","author":"Mooy","year":"1996","journal-title":"Surv Ophthalmol"},{"key":"bib8","doi-asserted-by":"publisher","first-page":"477","DOI":"10.3390\/cancers12020477","article-title":"Multicenter External Validation of the Liverpool Uveal Melanoma Prognosticator Online: An OOG Collaborative Study","volume":"12","author":"Cunha Rola","year":"2020","journal-title":"Cancers (Basel)"},{"key":"bib9","doi-asserted-by":"publisher","first-page":"769","DOI":"10.1136\/bjophthalmol-2013-303867","article-title":"Genome-wide profiling is a clinically relevant and affordable prognostic test in posterior uveal melanoma","volume":"98","author":"Cassoux","year":"2014","journal-title":"Br J Ophthalmol"},{"key":"bib10","doi-asserted-by":"publisher","first-page":"2825","DOI":"10.1200\/JCO.2012.45.2771","article-title":"Staging of ciliary body and choroidal melanomas based on anatomic extent","volume":"31","author":"Kujala","year":"2013","journal-title":"J Clin Oncol"},{"key":"bib11","doi-asserted-by":"publisher","first-page":"438","DOI":"10.1167\/iovs.14-15571","article-title":"The prognostic effect of American Joint Committee on Cancer staging and genetic status in patients with choroidal and ciliary body melanoma","volume":"56","author":"Bagger","year":"2014","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib12","doi-asserted-by":"publisher","first-page":"3331","DOI":"10.1167\/iovs.11-9027","article-title":"Chromosome 3 status in uveal melanoma: a comparison of fluorescence in situ hybridization and single-nucleotide polymorphism array","volume":"53","author":"Singh","year":"2012","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib13","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1097\/CMR.0b013e32834e6a67","article-title":"Multiplex ligation-dependent probe amplification equals fluorescence in-situ hybridization for the identification of patients at risk for metastatic disease in uveal melanoma","volume":"22","author":"Vaarwater","year":"2012","journal-title":"Melanoma Res"},{"key":"bib14","first-page":"313","article-title":"Concomitant loss of chromosome 3 and whole arm losses and gains of chromosome 1, 6, or 8 in metastasizing primary uveal melanoma","volume":"42","author":"Aalto","year":"2001","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib15","doi-asserted-by":"publisher","first-page":"1925","DOI":"10.1016\/j.ophtha.2007.06.012","article-title":"Cytogenetics of uveal melanoma: a 7-year clinical experience","volume":"114","author":"Damato","year":"2007","journal-title":"Ophthalmology"},{"key":"bib16","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1002\/(ISSN)1098-2264","article-title":"Abnormalities of chromosomes 3 and 8 in posterior uveal melanoma correlate with prognosis","volume":"19","author":"Sisley","year":"1997","journal-title":"Genes Chromosomes Cancer"},{"key":"bib17","doi-asserted-by":"publisher","first-page":"5721","DOI":"10.1167\/iovs.13-12195","article-title":"Genomic profile of 320 uveal melanoma cases: chromosome 8p-loss and metastatic outcome","volume":"54","author":"Ewens","year":"2013","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib18","doi-asserted-by":"publisher","first-page":"3703","DOI":"10.1167\/iovs.06-0101","article-title":"Clinical and cytogenetic analyses in uveal melanoma","volume":"47","author":"Kilic","year":"2006","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib19","doi-asserted-by":"publisher","first-page":"3737","DOI":"10.1158\/1078-0432.CCR-07-5144","article-title":"A metastasis modifier locus on human chromosome 8p in uveal melanoma identified by integrative genomic analysis","volume":"14","author":"Onken","year":"2008","journal-title":"Clin Cancer Res"},{"key":"bib20","doi-asserted-by":"publisher","first-page":"5316","DOI":"10.3390\/cancers13215316","article-title":"Radiological Patterns of Uveal Melanoma Liver Metastases in Correlation to Genetic Status","volume":"13","author":"Yavuzyigitoglu","year":"2021","journal-title":"Cancers (Basel)"}],"container-title":["Investigative Opthalmology & Visual Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/iovs.arvojournals.org\/article.aspx?articleid=2785295","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:31:38Z","timestamp":1791927098000},"score":1,"resource":{"primary":{"URL":"https:\/\/iovs.arvojournals.org\/article.aspx?articleid=2785295"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1,19]]},"references-count":20,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2023,1,3]]}},"URL":"https:\/\/doi.org\/10.1167\/iovs.64.1.15","relation":{},"ISSN":["1552-5783"],"issn-type":[{"value":"1552-5783","type":"print"}],"subject":[],"published":{"date-parts":[[2023,1,19]]}}}