{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:59:52Z","timestamp":1791928792996,"version":"4.3.4"},"reference-count":53,"publisher":"Association for Research in Vision and Ophthalmology (ARVO)","issue":"1","license":[{"start":{"date-parts":[[2023,1,30]],"date-time":"2023-01-30T00:00:00Z","timestamp":1675036800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Invest. Ophthalmol. Vis. Sci."],"published-print":{"date-parts":[[2023,1,30]]},"DOI":"10.1167\/iovs.64.1.21","type":"journal-article","created":{"date-parts":[[2023,1,30]],"date-time":"2023-01-30T10:31:05Z","timestamp":1675074665000},"page":"21","source":"Crossref","is-referenced-by-count":25,"title":["Role of FGF10\/FGFR2b Signaling in Homeostasis and Regeneration of Adult Lacrimal Gland and Corneal Epithelium Proliferation"],"prefix":"10.1167","volume":"64","author":[{"given":"Emma N.","family":"Finburgh","sequence":"first","affiliation":[{"name":"Viterbi Family Department of Ophthalmology, Shiley Eye Institute, University of California San Diego, La Jolla, California, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Mauduit","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine, The Scripps Research Institute, La Jolla, California, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takako","family":"Noguchi","sequence":"additional","affiliation":[{"name":"Viterbi Family Department of Ophthalmology, Shiley Eye Institute, University of California San Diego, La Jolla, California, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer J.","family":"Bu","sequence":"additional","affiliation":[{"name":"Viterbi Family Department of Ophthalmology, Shiley Eye Institute, University of California San Diego, La Jolla, California, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anser A.","family":"Abbas","sequence":"additional","affiliation":[{"name":"Viterbi Family Department of Ophthalmology, Shiley Eye Institute, University of California San Diego, La Jolla, California, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominic F.","family":"Hakim","sequence":"additional","affiliation":[{"name":"Viterbi Family Department of Ophthalmology, Shiley Eye Institute, University of California San Diego, La Jolla, California, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saverio","family":"Bellusci","sequence":"additional","affiliation":[{"name":"Cardio-Pulmonary Institute and Department of Pulmonary and Critical Care Medicine and Infectious Diseases, Universities of Giessen and Marburg Lung Center, German Center for Lung Research, Justus Liebig University Giessen, Giessen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robyn","family":"Meech","sequence":"additional","affiliation":[{"name":"Discipline of Clinical Pharmacology, College of Medicine and Public Health, Flinders University, Adelaide, South Australia, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helen P.","family":"Makarenkova","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine, The Scripps Research Institute, La Jolla, California, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalie A.","family":"Afshari","sequence":"additional","affiliation":[{"name":"Viterbi Family Department of Ophthalmology, Shiley Eye Institute, University of California San Diego, La Jolla, California, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"27","reference":[{"key":"bib1","first-page":"1137","article-title":"Direct interactions between Gli3, Wnt8b, and Fgfs underlie patterning of the dorsal telencephalon","volume":"27","author":"Hasenpusch-Theil","year":"2017","journal-title":"Cereb Cortex"},{"key":"bib2","doi-asserted-by":"publisher","first-page":"L1116","DOI":"10.1152\/ajplung.00033.2004","article-title":"FGF-10 induces SP-C and Bmp4 and regulates proximal-distal patterning in embryonic tracheal epithelium","volume":"287","author":"Hyatt","year":"2004","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"bib3","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1038\/nrd2792","article-title":"The FGF family: biology, pathophysiology and therapy","volume":"8","author":"Beenken","year":"2009","journal-title":"Nat Rev Drug Discov"},{"key":"bib4","doi-asserted-by":"publisher","first-page":"11895","DOI":"10.1073\/pnas.96.21.11895","article-title":"Fgfr2 is required for limb outgrowth and lung-branching morphogenesis","volume":"96","author":"Arman","year":"1999","journal-title":"Proc Natl Acad Sci U S A"},{"key":"bib5","doi-asserted-by":"publisher","first-page":"643","DOI":"10.1006\/bbrc.2000.3721","article-title":"FGF10 acts as a major ligand for FGF receptor 2 IIIb in mouse multi-organ development","volume":"277","author":"Ohuchi","year":"2000","journal-title":"Biochem Biophys Res Commun"},{"key":"bib6","doi-asserted-by":"publisher","first-page":"4867","DOI":"10.1242\/dev.124.23.4867","article-title":"Fibroblast growth factor 10 (FGF10) and branching morphogenesis in the embryonic mouse lung","volume":"124","author":"Bellusci","year":"1997","journal-title":"Development"},{"key":"bib7","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1186\/1471-213X-5-11","article-title":"FGF10\/FGFR2b signaling plays essential roles during in vivo embryonic submandibular salivary gland morphogenesis","volume":"5","author":"Jaskoll","year":"2005","journal-title":"BMC Dev Biol"},{"key":"bib8","doi-asserted-by":"publisher","first-page":"102","DOI":"10.3389\/fgene.2019.00102","article-title":"Structural biology of the FGF7 subfamily","volume":"10","author":"Zinkle","year":"2019","journal-title":"Front Genet"},{"key":"bib9","doi-asserted-by":"publisher","first-page":"256","DOI":"10.1111\/nyas.1991.638.issue-1","article-title":"The role of fibroblast growth factor in eye lens development","volume":"638","author":"McAvoy","year":"1991","journal-title":"Ann N Y Acad Sci"},{"key":"bib10","doi-asserted-by":"publisher","first-page":"5075","DOI":"10.1242\/dev.128.24.5075","article-title":"FGF-induced lens cell proliferation and differentiation is dependent on MAPK (ERK1\/2) signalling","volume":"128","author":"Lovicu","year":"2001","journal-title":"Development"},{"key":"bib11","doi-asserted-by":"publisher","first-page":"3947","DOI":"10.1074\/jbc.M115.705103","article-title":"Regulation of c-Maf and aA-crystallin in ocular lens by fibroblast growth factor signaling","volume":"291","author":"Xie","year":"2016","journal-title":"J Biol Chem"},{"key":"bib12","doi-asserted-by":"publisher","first-page":"3307","DOI":"10.1242\/dev.066241","article-title":"Barx2 and Fgf10 regulate ocular glands branching morphogenesis by controlling extracellular matrix remodeling","volume":"138","author":"Tsau","year":"2011","journal-title":"Development"},{"key":"bib13","doi-asserted-by":"publisher","first-page":"ra55","DOI":"10.1126\/scisignal.2000304","article-title":"Differential interactions of FGFs with heparan sulfate control gradient formation and branching morphogenesis","volume":"2","author":"Makarenkova","year":"2009","journal-title":"Sci Signal"},{"key":"bib14","doi-asserted-by":"publisher","first-page":"e0117089","DOI":"10.1371\/journal.pone.0117089","article-title":"Fibroblast growth factor receptor 2 (FGFR2) is required for corneal epithelial cell proliferation and differentiation during embryonic development","volume":"10","author":"Zhang","year":"2015","journal-title":"PLoS One"},{"key":"bib15","doi-asserted-by":"publisher","first-page":"687","DOI":"10.1111\/dgd.2009.51.issue-8","article-title":"Anterior-posterior patterning of neural differentiated embryonic stem cells by canonical Wnts, Fgfs, Bmp4 and their respective antagonists","volume":"51","author":"Hendrickx","year":"2009","journal-title":"Dev Growth Differ"},{"key":"bib16","doi-asserted-by":"publisher","first-page":"2563","DOI":"10.1242\/dev.127.12.2563","article-title":"FGF10 is an inducer and Pax6 a competence factor for lacrimal gland development","volume":"127","author":"Makarenkova","year":"2000","journal-title":"Development"},{"key":"bib17","doi-asserted-by":"publisher","first-page":"362","DOI":"10.3389\/fgene.2019.00362","article-title":"FGF gradient controls boundary position between proliferating and differentiating cells and regulates lacrimal gland growth dynamics","volume":"10","author":"Thotakura","year":"2019","journal-title":"Front Genet"},{"key":"bib18","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1159\/000046183","article-title":"Embryonic submandibular gland morphogenesis: stage-specific protein localization of FGFs, BMPs, Pax6 and Pax9 in normal mice and abnormal SMG phenotypes in FgfR2-IIIc(+\/Delta), BMP7(-\/-) and Pax6(-\/-) mice","volume":"170","author":"Jaskoll","year":"2002","journal-title":"Cells Tissues Organs"},{"key":"bib19","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1111\/(ISSN)1399-0004","article-title":"LADD syndrome is caused by FGF10 mutations","volume":"69","author":"Milunsky","year":"2006","journal-title":"Clin Genet"},{"key":"bib20","doi-asserted-by":"publisher","first-page":"414","DOI":"10.1038\/ng1757","article-title":"Mutations in different components of FGF signaling in LADD syndrome","volume":"38","author":"Rohmann","year":"2006","journal-title":"Nat Genet"},{"key":"bib21","doi-asserted-by":"publisher","first-page":"6903","DOI":"10.1128\/MCB.00544-07","article-title":"Lacrimo-auriculo-dento-digital syndrome is caused by reduced activity of the fibroblast growth factor 10 (FGF10)-FGF receptor 2 signaling pathway","volume":"27","author":"Shams","year":"2007","journal-title":"Mol Cell Biol"},{"key":"bib22","doi-asserted-by":"publisher","first-page":"999","DOI":"10.1136\/bjophthalmol-2019-314466","article-title":"Histopathology and selective biomarker expression in human meibomian glands","volume":"104","author":"Reneker","year":"2020","journal-title":"Br J Ophthalmol"},{"key":"bib23","doi-asserted-by":"publisher","first-page":"2638","DOI":"10.1167\/iovs.16-21204","article-title":"Fibroblast growth factor receptor 2 (FGFR2) is required for meibomian gland homeostasis in the adult mouse","volume":"58","author":"Reneker","year":"2017","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib24","doi-asserted-by":"publisher","first-page":"526","DOI":"10.1016\/j.jtos.2019.02.011","article-title":"Prevalence of dry eye disease in Ontario, Canada: a population-based survey","volume":"17","author":"Caffery","year":"2019","journal-title":"Ocul Surf"},{"key":"bib25","doi-asserted-by":"publisher","first-page":"1089","DOI":"10.1097\/OPX.0000000000001610","article-title":"Prevalence of dry eye disease in Africa: a systematic review and meta-analysis","volume":"97","author":"Akowuah","year":"2020","journal-title":"Optom Vis Sci"},{"key":"bib26","doi-asserted-by":"publisher","first-page":"852","DOI":"10.2174\/1389450120666190112145409","article-title":"Implications of fibroblast growth factors (FGFs) in cancer: from prognostic to therapeutic applications","volume":"20","author":"Dianat-Moghadam","year":"2019","journal-title":"Curr Drug Targets"},{"key":"bib27","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1016\/j.semcdb.2015.09.007","article-title":"Therapeutic uses of FGFs","volume":"53","author":"Zhang","year":"2016","journal-title":"Semin Cell Dev Biol"},{"key":"bib28","doi-asserted-by":"crossref","first-page":"218142","DOI":"10.4061\/2010\/218142","article-title":"Fibroblast growth factors: biology, function, and application for tissue regeneration","volume":"2010","author":"Yun","year":"2010","journal-title":"J Tissue Eng"},{"key":"bib29","first-page":"2789","article-title":"Fibroblast growth factor 10 upregulates the expression of mucins in rat conjunctival epithelial cells","volume":"17","author":"Ma","year":"2011","journal-title":"Mol Vis"},{"key":"bib30","doi-asserted-by":"publisher","first-page":"3217","DOI":"10.1242\/dev.01892","article-title":"A dual role of FGF10 in proliferation and coordinated migration of epithelial leading edge cells during mouse eyelid development","volume":"132","author":"Tao","year":"2005","journal-title":"Development"},{"key":"bib31","doi-asserted-by":"publisher","first-page":"2264","DOI":"10.3390\/ijms18112264","article-title":"Regenerative therapies in dry eye disease: from growth factors to cell therapy","volume":"18","author":"Villatoro","year":"2017","journal-title":"Int J Mol Sci"},{"key":"bib32","doi-asserted-by":"publisher","first-page":"108517","DOI":"10.1016\/j.exer.2021.108517","article-title":"Multiple roles of FGF10 in the regulation of corneal endothelial wound healing","volume":"205","author":"Wang","year":"2021","journal-title":"Exp Eye Res"},{"key":"bib33","doi-asserted-by":"publisher","first-page":"100818","DOI":"10.1016\/j.ajoc.2020.100818","article-title":"Trichiasis and dry eye syndrome in two patients on novel fibroblast growth factor receptor inhibitor therapies","volume":"19","author":"Vinson","year":"2020","journal-title":"Am J Ophthalmol Case Rep"},{"key":"bib34","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1186\/s12886-019-1285-9","article-title":"Markedly increased ocular side effect causing severe vision deterioration after chemotherapy using new or investigational epidermal or fibroblast growth factor receptor inhibitors","volume":"20","author":"Shin","year":"2020","journal-title":"BMC Ophthalmol"},{"key":"bib35","doi-asserted-by":"publisher","first-page":"656883","DOI":"10.3389\/fcell.2021.656883","article-title":"Cross-talk between inflammation and fibroblast growth factor 10 during organogenesis and pathogenesis: lessons learnt from the lung and other organs","volume":"9","author":"Marega","year":"2021","journal-title":"Front Cell Dev Biol"},{"key":"bib36","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1016\/j.ydbio.2008.02.014","article-title":"Terminal end bud maintenance in mammary gland is dependent upon FGFR2b signaling","volume":"317","author":"Parsa","year":"2008","journal-title":"Dev Biol"},{"key":"bib37","doi-asserted-by":"publisher","first-page":"894","DOI":"10.1016\/j.exer.2007.01.015","article-title":"A single injection of interleukin-1 induces reversible aqueous-tear deficiency, lacrimal gland inflammation, and acinar and ductal cell proliferation","volume":"84","author":"Zoukhri","year":"2007","journal-title":"Exp Eye Res"},{"key":"bib38","doi-asserted-by":"publisher","first-page":"5654","DOI":"10.1167\/iovs.17-22071","article-title":"Manipulation of Panx1 activity increases the engraftment of transplanted lacrimal gland epithelial progenitor cells","volume":"58","author":"Basova","year":"2017","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib39","doi-asserted-by":"publisher","first-page":"88","DOI":"10.5966\/sctm.2016-0191","article-title":"Lacrimal gland repair using progenitor cells","volume":"6","author":"Gromova","year":"2017","journal-title":"Stem Cells Transl Med"},{"key":"bib40","doi-asserted-by":"publisher","first-page":"1011125","DOI":"10.3389\/fimmu.2022.1011125","article-title":"Spatial transcriptomics of the lacrimal gland features macrophage activity and epithelium metabolism as key alterations during chronic inflammation","volume":"13","author":"Mauduit","year":"2022","journal-title":"Front Immunol"},{"key":"bib41","first-page":"1011125","article-title":"Isolation of myoepithelial cells from adult murine lacrimal and submandibular glands","volume":"13","author":"Zyrianova","year":"2019","journal-title":"J Vis Exp"},{"key":"bib42","first-page":"e59602","article-title":"Evaluation of 4 Presurgical Skin Preparation Methods in Mice","volume":"148","author":"Kick","year":"2019","journal-title":"J Am Assoc Lab Anim Sci"},{"key":"bib43","doi-asserted-by":"publisher","first-page":"743","DOI":"10.1038\/mi.2016.83","article-title":"Age-related spontaneous lacrimal keratoconjunctivitis is accompanied by dysfunctional T regulatory cells","volume":"10","author":"Coursey","year":"2017","journal-title":"Mucosal Immunol"},{"key":"bib44","doi-asserted-by":"publisher","first-page":"3117","DOI":"10.3390\/ijms19103117","article-title":"Dysregulated marginal zone B cell compartment in a mouse model of Sj\u00f6gren's syndrome with ocular inflammation","volume":"19","author":"Singh","year":"2018","journal-title":"Int J Mol Sci"},{"key":"bib45","doi-asserted-by":"crossref","first-page":"45","DOI":"10.3390\/ijms21239172","article-title":"Innate immunity and biological therapies for the treatment of Sj\u00f6gren's syndrome","volume":"21","author":"Srivastava","year":"2020","journal-title":"Int J Mol Sci"},{"key":"bib46","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1038\/sj.ejhg.5201762","article-title":"FGF10 missense mutations in aplasia of lacrimal and salivary glands (ALSG)","volume":"15","author":"Entesarian","year":"2007","journal-title":"Eur J Hum Genet"},{"key":"bib47","doi-asserted-by":"publisher","first-page":"101230","DOI":"10.1016\/j.isci.2020.101230","article-title":"Origin and lineage plasticity of endogenous lacrimal gland epithelial stem\/progenitor cells","volume":"23","author":"Basova","year":"2020","journal-title":"iScience"},{"key":"bib48","doi-asserted-by":"publisher","first-page":"18299","DOI":"10.1038\/s41598-019-54840-5","article-title":"MSC transplantation improves lacrimal gland regeneration after surgically induced dry eye disease in mice","volume":"9","author":"Dietrich","year":"2019","journal-title":"Sci Rep"},{"key":"bib49","doi-asserted-by":"publisher","first-page":"8392","DOI":"10.1167\/iovs.15-17477","article-title":"Lacrimal gland inflammation deregulates extracellular matrix remodeling and alters molecular signature of epithelial stem\/progenitor cells","volume":"56","author":"Umazume","year":"2015","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib50","doi-asserted-by":"publisher","first-page":"14435","DOI":"10.1074\/jbc.M111.225003","article-title":"Lacrimal gland development and Fgf10-Fgfr2b signaling are controlled by 2-O- and 6-O-sulfated heparan sulfate","volume":"286","author":"Qu","year":"2011","journal-title":"J Biol Chem"},{"key":"bib51","first-page":"2517","article-title":"Defining epithelial cell dynamics and lineage relationships in the developing lacrimal gland","volume":"144","author":"Farmer","year":"2017","journal-title":"Development"},{"key":"bib52","doi-asserted-by":"publisher","first-page":"1011125","DOI":"10.3389\/fimmu.2022.1011125","article-title":"Spatial transcriptomics of the lacrimal gland features macrophage activity and epithelium metabolism as key alterations during chronic inflammation","volume":"13","author":"Mauduit","year":"2022","journal-title":"Front Immunol"},{"key":"bib53","doi-asserted-by":"publisher","first-page":"7344","DOI":"10.3892\/mmr.2015.4368","article-title":"Therapeutic efficacy of fibroblast growth factor 10 in a rabbit model of dry eye","volume":"12","author":"Zheng","year":"2015","journal-title":"Mol Med Rep"}],"container-title":["Investigative Opthalmology &amp; Visual Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/iovs.arvojournals.org\/article.aspx?articleid=2785317","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:31:40Z","timestamp":1791927100000},"score":1,"resource":{"primary":{"URL":"https:\/\/iovs.arvojournals.org\/article.aspx?articleid=2785317"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1,30]]},"references-count":53,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2023,1,3]]}},"URL":"https:\/\/doi.org\/10.1167\/iovs.64.1.21","relation":{},"ISSN":["1552-5783"],"issn-type":[{"value":"1552-5783","type":"print"}],"subject":[],"published":{"date-parts":[[2023,1,30]]}}}