{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T22:00:30Z","timestamp":1791928830609,"version":"4.3.4"},"reference-count":62,"publisher":"Association for Research in Vision and Ophthalmology (ARVO)","issue":"10","license":[{"start":{"date-parts":[[2023,7,13]],"date-time":"2023-07-13T00:00:00Z","timestamp":1689206400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Invest. Ophthalmol. Vis. Sci."],"published-print":{"date-parts":[[2023,7,13]]},"DOI":"10.1167\/iovs.64.10.13","type":"journal-article","created":{"date-parts":[[2023,7,13]],"date-time":"2023-07-13T11:31:09Z","timestamp":1689247869000},"page":"13","source":"Crossref","is-referenced-by-count":12,"title":["Obstruction of the Tear Drainage Altered Lacrimal Gland Structure and Function"],"prefix":"10.1167","volume":"64","author":[{"given":"Bing","family":"Xiao","sequence":"first","affiliation":[{"name":"State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dianlei","family":"Guo","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ren","family":"Liu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengqian","family":"Tu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziyan","family":"Chen","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingfeng","family":"Zheng","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunqiao","family":"Liu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangzhou, China"},{"name":"Guangdong Province Key Laboratory of Brain Function and Disease, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingyi","family":"Liang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"27","reference":[{"key":"bib1","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1001\/archopht.1973.01000050241013","article-title":"Eyelids, lacrimal apparatus, and conjunctiva","volume":"90","author":"Boniuk","year":"1973","journal-title":"Arch Ophthalmol"},{"key":"bib2","doi-asserted-by":"publisher","first-page":"438","DOI":"10.1016\/j.jtos.2017.05.011","article-title":"TFOS DEWS II pathophysiology report","volume":"15","author":"Bron","year":"2017","journal-title":"The Ocular Surf"},{"key":"bib3","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1016\/j.exer.2003.09.003","article-title":"The role of the lacrimal functional unit in the pathophysiology of dry eye","volume":"78","author":"Stern","year":"2004","journal-title":"Exp Eye Res"},{"key":"bib4","doi-asserted-by":"publisher","first-page":"1807","DOI":"10.1167\/iovs.02-0744","article-title":"Characterization of mucins in human lacrimal sac and nasolacrimal duct","volume":"44","author":"Paulsen","year":"2003","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib5","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1001\/archopht.1961.00960010113025","article-title":"An anatomical approach to problems of the eyelids and lacrimal apparatus","volume":"66","author":"Jones","year":"1961","journal-title":"Arch Ophthalmol"},{"key":"bib6","first-page":"411","article-title":"Lacrimal drainage - A dynamic evaluation. Part I - mechanics of tear transport","volume":"9","author":"Hill","year":"1974","journal-title":"Canadian J Ophthalmol Journal Canadien D'ophtalmologie"},{"key":"bib7","doi-asserted-by":"publisher","first-page":"844","DOI":"10.1016\/S0161-6420(81)34940-9","article-title":"Blinking and the mechanics of the lacrimal drainage system","volume":"88","author":"Doane","year":"1981","journal-title":"Ophthalmology"},{"key":"bib8","doi-asserted-by":"publisher","first-page":"674","DOI":"10.1007\/s004170050140","article-title":"Functional anatomy of the human efferent tear ducts: a new theory of tear outflow mechanism","volume":"236","author":"Thale","year":"1998","journal-title":"Graefe's Arch Clinic Exp Ophthalmol = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie"},{"key":"bib9","doi-asserted-by":"publisher","first-page":"705","DOI":"10.1136\/bjo.39.12.705","article-title":"Experience in clinical examination of corneal sensitivity; corneal sensitivity and the naso-lacrimal reflex after retrobulbar anaesthesia","volume":"39","author":"Boberg-Ans","year":"1955","journal-title":"The Br J Ophthalmol"},{"key":"bib10","doi-asserted-by":"publisher","first-page":"645","DOI":"10.1097\/00003226-199711000-00008","article-title":"Nasolacrimal stimulation of aqueous tear production","volume":"16","author":"Gupta","year":"1997","journal-title":"Cornea"},{"key":"bib11","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1016\/S1542-0124(12)70146-5","article-title":"Dysfunctional neural regulation of lacrimal gland secretion and its role in the pathogenesis of dry eye syndromes","volume":"2","author":"Dartt","year":"2004","journal-title":"The Ocular Surf"},{"key":"bib12","doi-asserted-by":"publisher","first-page":"904","DOI":"10.1038\/sj.ejhg.5201640","article-title":"Delineation of the ADULT syndrome phenotype due to arginine 298 mutations of the p63 gene","volume":"14","author":"Rinne","year":"2006","journal-title":"Eur J Human Genetics: EJHG"},{"key":"bib13","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1111\/j.1755-3768.1966.tb06427.x","article-title":"Tear secretion in diseased eyes. Keratoconjunctivitis sicca, diseases of the lacrimal system, ectropion, lagophthalmos, conjunctivitis, etc., studied by a new method: lacrimal streak dilution test","volume":"44","author":"Norn","year":"1966","journal-title":"Acta Ophthalmologica"},{"key":"bib14","doi-asserted-by":"publisher","first-page":"314","DOI":"10.1016\/S0002-9394(00)00822-9","article-title":"The effect of punctal occlusion on tear production, tear clearance, and ocular surface sensation in normal subjects","volume":"131","author":"Yen","year":"2001","journal-title":"Am J Ophthalmol"},{"key":"bib15","doi-asserted-by":"publisher","first-page":"4425","DOI":"10.1167\/iovs.15-16873","article-title":"Lacrimal gland volume changes in unilateral primary acquired nasolacrimal obstruction","volume":"56","author":"Yazici","year":"2015","journal-title":"Invest Ophthalmol Visual Sci"},{"key":"bib16","doi-asserted-by":"publisher","first-page":"802","DOI":"10.1016\/j.jtos.2017.08.003","article-title":"TFOS DEWS II Report Executive Summary","volume":"15","author":"Craig","year":"2017","journal-title":"The Ocular Surf"},{"key":"bib17","doi-asserted-by":"publisher","first-page":"1204","DOI":"10.1136\/ard.2002.003889","article-title":"Oral pilocarpine for the treatment of ocular symptoms in patients with Sjogren's syndrome: A randomised 12 week controlled study","volume":"62","author":"Tsifetaki","year":"2003","journal-title":"Ann Rheumatic Dis"},{"key":"bib18","doi-asserted-by":"publisher","first-page":"777","DOI":"10.1080\/02713683.2020.1833349","article-title":"Changes in corneal subbasal nerves after punctal occlusion in dry eye disease","volume":"46","author":"Latifi","year":"2021","journal-title":"Current Eye Res"},{"key":"bib19","doi-asserted-by":"publisher","first-page":"895","DOI":"10.1016\/j.ophtha.2003.09.034","article-title":"Punctal occlusion in the management of chronic Stevens-Johnson syndrome","volume":"111","author":"Kaido","year":"2004","journal-title":"Ophthalmology"},{"key":"bib20","doi-asserted-by":"publisher","first-page":"208","DOI":"10.1007\/s10384-012-0125-8","article-title":"Punctal plugs for treatment of post-LASIK dry eye","volume":"56","author":"Yung","year":"2012","journal-title":"Japanese J Ophthalmol"},{"key":"bib21","doi-asserted-by":"publisher","first-page":"2103","DOI":"10.1007\/s00417-018-4129-z","article-title":"Pathological changes of the nasolacrimal duct in rabbit models of chronic dacryocystitis: correlation with lacrimal endoscopic findings","volume":"256","author":"Liu","year":"2018","journal-title":"Graefe's Arch Clinic Exp Ophthalmol = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie"},{"key":"bib22","doi-asserted-by":"publisher","first-page":"623186","DOI":"10.1155\/2011\/623186","article-title":"Development of the lacrimal apparatus in the rabbit (Oryctolagus cuniculus) and its potential role as an animal model for humans","volume":"2011","author":"Rehorek","year":"2011","journal-title":"Anatomy Res Intl"},{"key":"bib23","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1186\/s12865-018-0242-3","article-title":"Co-localization of lymphoid aggregates and lymphatic networks in nose- (NALT) and lacrimal duct-associated lymphoid tissue (LDALT) of mice","volume":"19","author":"Lohrberg","year":"2018","journal-title":"BMC Immunol"},{"key":"bib24","doi-asserted-by":"publisher","first-page":"2351","DOI":"10.1084\/jem.20091436","article-title":"Id2-, RORgammat-, and LTbetaR-independent initiation of lymphoid organogenesis in ocular immunity","volume":"206","author":"Nagatake","year":"2009","journal-title":"The J Exp Med"},{"key":"bib25","first-page":"1","article-title":"Ontogenesis of the tear drainage system requires Prickle1-driven polarized basement membrane deposition","volume":"147","author":"Guo","year":"2020","journal-title":"Development"},{"key":"bib26","doi-asserted-by":"publisher","first-page":"952","DOI":"10.1167\/iovs.17-22947","article-title":"A spatiotemporal requirement for Prickle 1-mediated PCP signaling in eyelid morphogenesis and homeostasis","volume":"59","author":"Guo","year":"2018","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib27","doi-asserted-by":"publisher","first-page":"208","DOI":"10.1016\/j.exer.2018.12.012","article-title":"Ocular surface pathogenesis associated with precocious eyelid opening and necrotic autologous tissue in mouse with disruption of Prickle 1 gene","volume":"180","author":"Guo","year":"2019","journal-title":"Exp Eye Res"},{"key":"bib28","doi-asserted-by":"publisher","first-page":"2234","DOI":"10.1093\/hmg\/ddt075","article-title":"Prickle1 is expressed in distinct cell populations of the central nervous system and contributes to neuronal morphogenesis","volume":"22","author":"Liu","year":"2013","journal-title":"Human Molec Genetics"},{"key":"bib29","doi-asserted-by":"publisher","first-page":"861","DOI":"10.1242\/bio.20148375","article-title":"Null and hypomorph Prickle1 alleles in mice phenocopy human Robinow syndrome and disrupt signaling downstream of Wnt5a","volume":"3","author":"Liu","year":"2014","journal-title":"Biology Open"},{"key":"bib30","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1167\/iovs.63.3.14","article-title":"Lacrimal gland microenvironment changes after obstruction of lacrimal gland ducts","volume":"63","author":"He","year":"2022","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib31","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1167\/tvst.8.6.34","article-title":"Assessment of corneal fluorescein staining in different dry eye subtypes using digital image analysis","volume":"8","author":"Pellegrini","year":"2019","journal-title":"Transl Vis Sci Technol"},{"key":"bib32","doi-asserted-by":"publisher","first-page":"e3","DOI":"10.4110\/in.2019.19.e3","article-title":"Age-related autoimmune changes in lacrimal glands","volume":"19","author":"de Souza","year":"2019","journal-title":"Immune Network"},{"key":"bib33","doi-asserted-by":"publisher","first-page":"3626","DOI":"10.1167\/iovs.13-12955","article-title":"Effects of the loss of conjunctival Muc16 on corneal epithelium and stroma in mice","volume":"55","author":"Shirai","year":"2014","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib34","first-page":"111","article-title":"A significant role of stromal fibroblasts in rapidly progressive dry eye in patients with chronic GVHD","volume":"42","author":"Ogawa","year":"2001","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib35","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1167\/iovs.61.13.6","article-title":"Malformation of tear ducts underlies the epiphora and precocious eyelid opening in Prickle 1 mutant mice: genetic implications for tear duct genesis","volume":"61","author":"Ru","year":"2020","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib36","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"bib37","doi-asserted-by":"publisher","first-page":"C360","DOI":"10.1152\/ajpcell.00298.2001","article-title":"Calcium dependence of exocytosis in lacrimal gland acinar cells","volume":"282","author":"Sundermeier","year":"2002","journal-title":"Am J Physiol Cell Physiol"},{"key":"bib38","doi-asserted-by":"publisher","first-page":"C713","DOI":"10.1152\/ajpcell.1995.268.3.C713","article-title":"Cholinergic activation of phospholipase D in lacrimal gland acini is independent of protein kinase C and calcium","volume":"268","author":"Zoukhri","year":"1995","journal-title":"The Am J Physiol"},{"key":"bib39","doi-asserted-by":"publisher","first-page":"2675","DOI":"10.1007\/s00125-005-0010-9","article-title":"Increased expression of advanced glycation end-products and their receptor, and activation of nuclear factor kappa-B in lacrimal glands of diabetic rats","volume":"48","author":"Alves","year":"2005","journal-title":"Diabetologia"},{"key":"bib40","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1007\/s00296-007-0411-9","article-title":"EGF activates PI3K-Akt and NF-kappaB via distinct pathways in salivary epithelial cells in Sjogren's syndrome","volume":"28","author":"Nakamura","year":"2007","journal-title":"Rheumatol Intl"},{"key":"bib41","doi-asserted-by":"publisher","first-page":"565","DOI":"10.1016\/S1350-9462(98)00004-4","article-title":"Tear dynamics and dry eye","volume":"17","author":"Tsubota","year":"1998","journal-title":"Prog Retin Eye Res"},{"key":"bib42","doi-asserted-by":"publisher","first-page":"2691","DOI":"10.1242\/dev.108944","article-title":"FGF signaling activates a Sox9-Sox10 pathway for the formation and branching morphogenesis of mouse ocular glands","volume":"141","author":"Chen","year":"2014","journal-title":"Development"},{"key":"bib43","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1111\/joa.2005.206.issue-3","article-title":"The role of eye-associated lymphoid tissue in corneal immune protection","volume":"206","author":"Knop","year":"2005","journal-title":"Journal of Anatomy"},{"key":"bib44","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1016\/S1542-0124(12)70013-7","article-title":"Drainage of tears: impact on the ocular surface and lacrimal system","volume":"1","author":"Paulsen","year":"2003","journal-title":"The Ocular Surface"},{"key":"bib45","doi-asserted-by":"publisher","first-page":"8290","DOI":"10.1038\/s41598-017-08197-2","article-title":"Lacrimal gland repair after short-term obstruction of excretory duct in rabbits","volume":"7","author":"Lin","year":"2017","journal-title":"Scientific Rep"},{"key":"bib46","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1016\/j.exer.2018.03.026","article-title":"Comparative analysis on the dynamic of lacrimal gland damage and regeneration after Interleukin-1alpha or duct ligation induced dry eye disease in mice","volume":"172","author":"Dietrich","year":"2018","journal-title":"Exp Eye Res"},{"key":"bib47","doi-asserted-by":"publisher","first-page":"487","DOI":"10.1016\/S0962-8924(01)02147-X","article-title":"Rab GTPases: specifying and deciphering organelle identity and function","volume":"11","author":"Pfeffer","year":"2001","journal-title":"Trends in Cell Biology"},{"key":"bib48","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1080\/0968768031000104953","article-title":"Regulated exocytosis and SNARE function (Review)","volume":"20","author":"Sollner","year":"2003","journal-title":"Molecular Membrane Biology"},{"key":"bib49","doi-asserted-by":"publisher","first-page":"40919","DOI":"10.1074\/jbc.M203704200","article-title":"Localization versus function of Rab3 proteins. Evidence for a common regulatory role in controlling fusion","volume":"277","author":"Schluter","year":"2002","journal-title":"J Biolog Chem"},{"key":"bib50","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1152\/physrev.2001.81.1.153","article-title":"Small GTP-binding proteins","volume":"81","author":"Takai","year":"2001","journal-title":"Physiological Rev"},{"key":"bib51","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1016\/j.exer.2005.11.009","article-title":"Molecular mechanisms of lacrimal acinar secretory vesicle exocytosis","volume":"83","author":"Wu","year":"2006","journal-title":"Experimental Eye Res"},{"key":"bib52","doi-asserted-by":"publisher","first-page":"3126","DOI":"10.1002\/art.30500","article-title":"Changes in Rab3D expression and distribution in the acini of Sjogren's syndrome patients are associated with loss of cell polarity and secretory dysfunction","volume":"63","author":"Bahamondes","year":"2011","journal-title":"Arthritis and Rheumatism"},{"key":"bib53","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1016\/j.jaut.2012.01.011","article-title":"Aberrant localization of fusion receptors involved in regulated exocytosis in salivary glands of Sjogren's syndrome patients is linked to ectopic mucin secretion","volume":"39","author":"Barrera","year":"2012","journal-title":"J Autoimmunity"},{"key":"bib54","doi-asserted-by":"publisher","first-page":"2573","DOI":"10.1002\/art.11178","article-title":"Enhanced degradation of proteins of the basal lamina and stroma by matrix metalloproteinases from the salivary glands of Sjogren's syndrome patients: correlation with reduced structural integrity of acini and ducts","volume":"48","author":"Goicovich","year":"2003","journal-title":"Arthritis and Rheumatism"},{"key":"bib55","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1016\/j.exer.2005.04.019","article-title":"Male NOD mouse external lacrimal glands exhibit profound changes in the exocytotic pathway early in postnatal development","volume":"82","author":"da Costa","year":"2006","journal-title":"Exp Eye Res"},{"key":"bib56","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1016\/j.exer.2018.09.002","article-title":"NOD and NOR mice exhibit comparable development of lacrimal gland secretory dysfunction but NOD mice have more severe autoimmune dacryoadenitis","volume":"176","author":"Ju","year":"2018","journal-title":"Exp Eye Res"},{"key":"bib57","doi-asserted-by":"publisher","first-page":"714","DOI":"10.1111\/j.1755-3768.1993.tb04669.x","article-title":"The effect of dacryocystorhinostomy on tear film flow and stability in patients with chronic dacryocystitis","volume":"71","author":"Zengin","year":"1993","journal-title":"Acta Ophthalmologica"},{"key":"bib58","doi-asserted-by":"publisher","first-page":"625","DOI":"10.1136\/bjo.45.9.625","article-title":"Intra-Canalicular Gelatin Implants in the Treatment of Kerato-Conjunctivitis Sicca","volume":"45","author":"Foulds","year":"1961","journal-title":"Br J Ophthalmol"},{"key":"bib59","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1016\/j.preteyeres.2009.04.003","article-title":"Neural regulation of lacrimal gland secretory processes: relevance in dry eye diseases","volume":"28","author":"Dartt","year":"2009","journal-title":"Prog Retin Eye Res"},{"key":"bib60","doi-asserted-by":"publisher","first-page":"100540","DOI":"10.1016\/j.waojou.2021.100540","article-title":"Naso-ocular neuropeptide interactions in allergic rhinoconjunctivitis, rhinitis, and conjunctivitis","volume":"14","author":"Meng","year":"2021","journal-title":"The World Allergy Organization Journal"},{"key":"bib61","first-page":"47","article-title":"Tear levels of neuropeptides increase after specific allergen challenge in allergic conjunctivitis","volume":"17","author":"Sacchetti","year":"2011","journal-title":"Molecular Vision"},{"key":"bib62","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1016\/j.jtos.2018.11.002","article-title":"Neurostimulation in dry eye disease-past, present, and future","volume":"17","author":"Dieckmann","year":"2019","journal-title":"The Ocular Surface"}],"container-title":["Investigative Opthalmology &amp; Visual Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/iovs.arvojournals.org\/article.aspx?articleid=2791302","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:31:38Z","timestamp":1791927098000},"score":1,"resource":{"primary":{"URL":"https:\/\/iovs.arvojournals.org\/article.aspx?articleid=2791302"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7,13]]},"references-count":62,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2023,7,3]]}},"URL":"https:\/\/doi.org\/10.1167\/iovs.64.10.13","relation":{},"ISSN":["1552-5783"],"issn-type":[{"value":"1552-5783","type":"print"}],"subject":[],"published":{"date-parts":[[2023,7,13]]}}}