{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,7]],"date-time":"2026-11-07T07:17:10Z","timestamp":1794035830207,"version":"4.8.0"},"reference-count":71,"publisher":"Association for Research in Vision and Ophthalmology (ARVO)","issue":"10","license":[{"start":{"date-parts":[[2023,7,17]],"date-time":"2023-07-17T00:00:00Z","timestamp":1689552000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Invest. Ophthalmol. Vis. Sci."],"published-print":{"date-parts":[[2023,7,17]]},"DOI":"10.1167\/iovs.64.10.19","type":"journal-article","created":{"date-parts":[[2023,7,17]],"date-time":"2023-07-17T11:30:58Z","timestamp":1689593458000},"page":"19","source":"Crossref","is-referenced-by-count":37,"title":["Association of Behavioral and Clinical Risk Factors With Cataract: A Two-Sample Mendelian Randomization Study"],"prefix":"10.1167","volume":"64","author":[{"given":"Chen","family":"Jiang","sequence":"first","affiliation":[{"name":"Kaiser Permanente Northern California (KPNC), Division of Research, Oakland, California, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald B.","family":"Melles","sequence":"additional","affiliation":[{"name":"KPNC, Department of Ophthalmology, Redwood City, California, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Poorab","family":"Sangani","sequence":"additional","affiliation":[{"name":"KPNC, Department of Ophthalmology, South San Francisco,  California, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas J.","family":"Hoffmann","sequence":"additional","affiliation":[{"name":"Institute for Human Genetics, UCSF, San Francisco,  California, United States"},{"name":"Department of Epidemiology and Biostatistics, UCSF, San Francisco,  California, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pirro G.","family":"Hysi","sequence":"additional","affiliation":[{"name":"King's College London, Section of Ophthalmology, School of Life Course Sciences, London, United Kingdom"},{"name":"King's College London, Department of Twin Research and Genetic Epidemiology, London, United Kingdom"},{"name":"University College London, Great Ormond Street Hospital Institute of Child Health, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. Maria","family":"Glymour","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics, UCSF, San Francisco,  California, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Jorgenson","sequence":"additional","affiliation":[{"name":"Regeneron Genetics Center, Tarrytown, New York, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salil A.","family":"Lachke","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, University of Delaware, Newark, Delaware, United States"},{"name":"Center for Bioinformatics and Computational Biology, University of Delaware, Newark, Delaware, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H\u00e9l\u00e8ne","family":"Choquet","sequence":"additional","affiliation":[{"name":"Kaiser Permanente Northern California (KPNC), Division of Research, Oakland, California, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"27","reference":[{"issue":"4","key":"bib1","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1001\/archopht.122.4.487","article-title":"Prevalence of cataract and pseudophakia\/aphakia among adults in the United States","volume":"122","author":"Congdon","year":"2004","journal-title":"Arch Ophthalmol"},{"issue":"10094","key":"bib2","doi-asserted-by":"publisher","first-page":"600","DOI":"10.1016\/S0140-6736(17)30544-5","article-title":"Cataracts","volume":"390","author":"Liu","year":"2017","journal-title":"Lancet"},{"issue":"1","key":"bib3","first-page":"58","article-title":"The evolution of cataract surgery","volume":"113","author":"Davis","year":"2016","journal-title":"Mo Med"},{"issue":"4","key":"bib4","doi-asserted-by":"publisher","first-page":"552","DOI":"10.1038\/eye.2015.3","article-title":"The Royal College of Ophthalmologists\u2019 National Ophthalmology Database study of cataract surgery: report 1, visual outcomes and complications","volume":"29","author":"Day","year":"2015","journal-title":"Eye (Lond)"},{"issue":"1","key":"bib5","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1097\/ICU.0000000000000113","article-title":"Intraoperative management of posterior capsular rupture","volume":"26","author":"Hong","year":"2015","journal-title":"Curr Opin Ophthalmol"},{"issue":"8","key":"bib6","doi-asserted-by":"publisher","first-page":"1208","DOI":"10.1002\/(ISSN)1096-8628","article-title":"Genetic etiology of nuclear cataract: evidence for a major gene","volume":"47","author":"Heiba","year":"1993","journal-title":"Am J Med Genet"},{"issue":"24","key":"bib7","doi-asserted-by":"publisher","first-page":"1786","DOI":"10.1056\/NEJM200006153422404","article-title":"Genetic and environmental factors in age-related nuclear cataracts in monozygotic and dizygotic twins","volume":"342","author":"Hammond","year":"2000","journal-title":"N Engl J Med"},{"issue":"3","key":"bib8","first-page":"601","article-title":"The heritability of age-related cortical cataract: the twin eye study","volume":"42","author":"Hammond","year":"2001","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"7","key":"bib9","doi-asserted-by":"publisher","first-page":"2182","DOI":"10.1167\/iovs.03-1163","article-title":"Nuclear cataract shows significant familial aggregation in an older population after adjustment for possible shared environmental factors","volume":"45","author":"Congdon","year":"2004","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"6","key":"bib10","doi-asserted-by":"publisher","first-page":"561","DOI":"10.1016\/j.survophthal.2010.07.003","article-title":"The heritability of ocular traits","volume":"55","author":"Sanfilippo","year":"2010","journal-title":"Surv Ophthalmol"},{"issue":"6","key":"bib11","doi-asserted-by":"publisher","first-page":"1237","DOI":"10.1016\/j.ophtha.2016.01.036","article-title":"Genetic and dietary factors influencing the progression of nuclear cataract","volume":"123","author":"Yonova-Doing","year":"2016","journal-title":"Ophthalmology"},{"issue":"1","key":"bib12","doi-asserted-by":"publisher","first-page":"3595","DOI":"10.1038\/s41467-021-23873-8","article-title":"A large multiethnic GWAS meta-analysis of cataract identifies new risk loci and sex-specific effects","volume":"12","author":"Choquet","year":"2021","journal-title":"Nat Commun"},{"issue":"2","key":"bib13","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1016\/j.oftal.2018.10.020","article-title":"Risk of cataract in smokers: a meta-analysis of observational studies","volume":"94","author":"Beltr\u00e1n-Zambrano","year":"2019","journal-title":"Arch Soc Esp Oftalmol (Engl Ed)"},{"issue":"11","key":"bib14","doi-asserted-by":"publisher","first-page":"2113","DOI":"10.1016\/j.ophtha.2011.03.032","article-title":"Risk factors associated with incident cataracts and cataract surgery in the Age-Related Eye Disease Study (AREDS): AREDS report number 32","volume":"118","author":"Chang","year":"2011","journal-title":"Ophthalmology"},{"issue":"8","key":"bib15","doi-asserted-by":"publisher","first-page":"1704","DOI":"10.1016\/j.ophtha.2016.04.037","article-title":"Risk factors for cataracts treated surgically in postmenopausal women","volume":"123","author":"Floud","year":"2016","journal-title":"Ophthalmology"},{"issue":"4","key":"bib16","doi-asserted-by":"publisher","first-page":"471","DOI":"10.1097\/OPX.0000000000000558","article-title":"Different amounts of alcohol consumption and cataract: a meta-analysis","volume":"92","author":"Gong","year":"2015","journal-title":"Optom Vis Sci"},{"issue":"3","key":"bib17","doi-asserted-by":"publisher","first-page":"226","DOI":"10.2174\/1874473710902030226","article-title":"Alcohol use and cataract","volume":"2","author":"Hiratsuka","year":"2009","journal-title":"Curr Drug Abuse Rev"},{"issue":"4","key":"bib18","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1080\/03009734.2020.1802375","article-title":"Prevalence and risk factors for age-related cataract in Sweden","volume":"125","author":"Hugosson","year":"2020","journal-title":"Ups J Med Sci"},{"key":"bib19","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1186\/1471-2415-14-94","article-title":"Meta-analysis of the risk of cataract in type 2 diabetes","volume":"14","author":"Li","year":"2014","journal-title":"BMC Ophthalmol"},{"issue":"1","key":"bib20","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1001\/archopht.124.1.79","article-title":"Development of cataract and associated risk factors: the Visual Impairment Project","volume":"124","author":"Mukesh","year":"2006","journal-title":"Arch Ophthalmol"},{"issue":"5","key":"bib21","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1080\/09286580802105806","article-title":"Influence of diabetes and cardiovascular disease on the long-term incidence of cataract: the Blue Mountains eye study","volume":"15","author":"Tan","year":"2008","journal-title":"Ophthalmic Epidemiol"},{"issue":"4","key":"bib22","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1111\/ceo.2018.46.issue-4","article-title":"Risk factors of age-related cataract in a Chinese adult population: the Taizhou Eye Study","volume":"46","author":"Tang","year":"2018","journal-title":"Clin Exp Ophthalmol"},{"issue":"7","key":"bib23","doi-asserted-by":"publisher","first-page":"3885","DOI":"10.1167\/iovs.12-9820","article-title":"Smoking and risk of age-related cataract: a meta-analysis","volume":"53","author":"Ye","year":"2012","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"12","key":"bib24","first-page":"3625","article-title":"Myopia and incident cataract and cataract surgery: the blue mountains eye study","volume":"43","author":"Younan","year":"2002","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"6","key":"bib25","doi-asserted-by":"publisher","first-page":"837","DOI":"10.1016\/j.ophtha.2021.02.007","article-title":"Alcohol consumption and incident cataract surgery in two large UK cohorts","volume":"128","author":"Chua","year":"2021","journal-title":"Ophthalmology"},{"issue":"6","key":"bib26","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1136\/bjo.71.6.405","article-title":"Cataract: the relation between myopia and cataract morphology","volume":"71","author":"Brown","year":"1987","journal-title":"Br J Ophthalmol"},{"issue":"8","key":"bib27","doi-asserted-by":"publisher","first-page":"1395","DOI":"10.1016\/j.ophtha.2005.02.017","article-title":"The association between myopia and various subtypes of lens opacity: SEE (Salisbury Eye Evaluation) project","volume":"112","author":"Chang","year":"2005","journal-title":"Ophthalmology"},{"issue":"7","key":"bib28","doi-asserted-by":"publisher","first-page":"914","DOI":"10.1001\/archopht.1993.01090070032014","article-title":"Axial dimension of the human cataractous lens","volume":"111","author":"Hoffer","year":"1993","journal-title":"Arch Ophthalmol"},{"issue":"5","key":"bib29","doi-asserted-by":"publisher","first-page":"1021","DOI":"10.1016\/j.ajo.2013.06.005","article-title":"Myopia and age-related cataract: a systematic review and meta-analysis","volume":"156","author":"Pan","year":"2013","journal-title":"Am J Ophthalmol"},{"issue":"2","key":"bib30","doi-asserted-by":"publisher","first-page":"284","DOI":"10.1016\/j.ophtha.2012.07.065","article-title":"Differential associations of myopia with major age-related eye diseases: the Singapore Indian Eye Study","volume":"120","author":"Pan","year":"2013","journal-title":"Ophthalmology"},{"issue":"2","key":"bib31","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1111\/ceo.v49.2","article-title":"Cataract and systemic disease: a review","volume":"49","author":"Ang","year":"2021","journal-title":"Clin Exp Ophthalmol"},{"issue":"1","key":"bib32","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1093\/ije\/dyg070","article-title":"Mendelian randomization\u2019: can genetic epidemiology contribute to understanding environmental determinants of disease?","volume":"32","author":"Smith","year":"2003","journal-title":"Int J Epidemiol"},{"issue":"5","key":"bib33","doi-asserted-by":"publisher","first-page":"1600","DOI":"10.1093\/ije\/dyw088","article-title":"Selecting instruments for Mendelian randomization in the wake of genome-wide association studies","volume":"45","author":"Swerdlow","year":"2016","journal-title":"Int J Epidemiol"},{"issue":"10","key":"bib34","doi-asserted-by":"publisher","first-page":"e1006944","DOI":"10.1371\/journal.pgen.1006944","article-title":"Genetic epidemiology and Mendelian randomization for informing disease therapeutics: conceptual and methodological challenges","volume":"13","author":"Paternoster","year":"2017","journal-title":"PLoS Genet"},{"issue":"6","key":"bib35","doi-asserted-by":"publisher","first-page":"589","DOI":"10.1001\/jama.2016.21189","article-title":"When will Mendelian randomization become relevant for clinical practice and public health?","volume":"317","author":"Davey Smith","year":"2017","journal-title":"JAMA"},{"issue":"2","key":"bib36","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1136\/jmedgenet-2014-102438","article-title":"Mendelian randomisation applied to drug development in cardiovascular disease: a review","volume":"52","author":"Mokry","year":"2015","journal-title":"J Med Genet"},{"issue":"9","key":"bib37","doi-asserted-by":"publisher","first-page":"864","DOI":"10.1001\/jamaophthalmol.2022.2762","article-title":"Association between myopic refractive error and primary open-angle glaucoma: a 2-sample Mendelian randomization study","volume":"140","author":"Choquet","year":"2022","journal-title":"JAMA Ophthalmol"},{"issue":"6","key":"bib38","doi-asserted-by":"publisher","first-page":"671","DOI":"10.1001\/jamaophthalmol.2020.1231","article-title":"Association of myopia and intraocular pressure with retinal detachment in European descent participants of the UK Biobank Cohort: a Mendelian randomization study","volume":"138","author":"Han","year":"2020","journal-title":"JAMA Ophthalmol"},{"issue":"12","key":"bib39","doi-asserted-by":"publisher","first-page":"1299","DOI":"10.1001\/jamaophthalmol.2021.4601","article-title":"Association of smoking, alcohol consumption, blood pressure, body mass index, and glycemic risk factors with age-related macular degeneration: a Mendelian randomization study","volume":"139","author":"Kuan","year":"2021","journal-title":"JAMA Ophthalmol"},{"issue":"4","key":"bib40","doi-asserted-by":"publisher","first-page":"969","DOI":"10.1093\/ajcn\/nqz167","article-title":"Evaluating the associations between obesity and age-related cataract: a Mendelian randomization study","volume":"110","author":"Tan","year":"2019","journal-title":"Am J Clin Nutr"},{"key":"bib41","doi-asserted-by":"publisher","first-page":"104154","DOI":"10.1016\/j.ebiom.2022.104154","article-title":"Appraising the causal role of smoking in multiple diseases: A systematic review and meta-analysis of Mendelian randomization studies","volume":"82","author":"Larsson","year":"2022","journal-title":"EBioMedicine"},{"issue":"6","key":"bib42","doi-asserted-by":"publisher","first-page":"2024","DOI":"10.1093\/ije\/dyab175","article-title":"Mendelian randomization study reveals a population-specific putative causal effect of type 2 diabetes in risk of cataract","volume":"50","author":"Zhang","year":"2022","journal-title":"Int J Epidemiol"},{"issue":"1","key":"bib43","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1038\/s41598-021-04515-x","article-title":"Metabolic and lifestyle factors in relation to senile cataract: a Mendelian randomization study","volume":"12","author":"Yuan","year":"2022","journal-title":"Sci Rep"},{"key":"bib44","doi-asserted-by":"publisher","first-page":"e34408","DOI":"10.7554\/eLife.34408","article-title":"The MR-Base platform supports systematic causal inference across the human phenome","volume":"7","author":"Hemani","year":"2018","journal-title":"eLife"},{"issue":"4","key":"bib45","doi-asserted-by":"publisher","first-page":"1051","DOI":"10.1534\/genetics.115.178905","article-title":"Genotyping informatics and quality control for 100,000 subjects in the Genetic Epidemiology Research on Adult Health and Aging (GERA) cohort","volume":"200","author":"Kvale","year":"2015","journal-title":"Genetics"},{"issue":"4","key":"bib46","doi-asserted-by":"publisher","first-page":"1285","DOI":"10.1534\/genetics.115.178616","article-title":"Characterizing race\/ethnicity and genetic ancestry for 100,000 subjects in the Genetic Epidemiology Research on Adult Health and Aging (GERA) cohort","volume":"200","author":"Banda","year":"2015","journal-title":"Genetics"},{"issue":"1","key":"bib47","doi-asserted-by":"publisher","first-page":"1258","DOI":"10.1038\/s41467-020-20851-4","article-title":"Genome-wide meta-analysis identifies 127 open-angle glaucoma loci with consistent effect across ancestries","volume":"12","author":"Gharahkhani","year":"2021","journal-title":"Nat Commun"},{"issue":"4","key":"bib48","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1038\/s41588-020-0599-0","article-title":"Meta-analysis of 542,934 subjects of European ancestry identifies new genes and mechanisms predisposing to refractive error and myopia","volume":"52","author":"Hysi","year":"2020","journal-title":"Nat Genet"},{"issue":"11","key":"bib49","doi-asserted-by":"publisher","first-page":"1505","DOI":"10.1038\/s41588-018-0241-6","article-title":"Fine-mapping type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps","volume":"50","author":"Mahajan","year":"2018","journal-title":"Nat Genet"},{"issue":"1","key":"bib50","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1038\/ng.3715","article-title":"Genome-wide association analyses using electronic health records identify new loci influencing blood pressure variation","volume":"49","author":"Hoffmann","year":"2017","journal-title":"Nat Genet"},{"issue":"2","key":"bib51","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1534\/genetics.118.301479","article-title":"A large multiethnic genome-wide association study of adult body mass index identifies novel loci","volume":"210","author":"Hoffmann","year":"2018","journal-title":"Genetics"},{"issue":"7941","key":"bib52","doi-asserted-by":"publisher","first-page":"720","DOI":"10.1038\/s41586-022-05477-4","article-title":"Genetic diversity fuels gene discovery for tobacco and alcohol use","volume":"612","author":"Saunders","year":"2022","journal-title":"Nature"},{"issue":"14","key":"bib53","doi-asserted-by":"publisher","first-page":"2435","DOI":"10.1017\/S0033291719002678","article-title":"Evidence for causal effects of lifetime smoking on risk for depression and schizophrenia: a Mendelian randomisation study","volume":"50","author":"Wootton","year":"2020","journal-title":"Psychol Med"},{"issue":"2","key":"bib54","doi-asserted-by":"publisher","first-page":"512","DOI":"10.1093\/ije\/dyv080","article-title":"Mendelian randomization with invalid instruments: effect estimation and bias detection through Egger regression","volume":"44","author":"Bowden","year":"2015","journal-title":"Int J Epidemiol"},{"key":"bib55","doi-asserted-by":"publisher","first-page":"186","DOI":"10.12688\/wellcomeopenres","article-title":"Guidelines for performing Mendelian randomization investigations","volume":"4","author":"Burgess","year":"2019","journal-title":"Wellcome Open Res"},{"issue":"5","key":"bib56","doi-asserted-by":"publisher","first-page":"693","DOI":"10.1038\/s41588-018-0099-7","article-title":"Detection of widespread horizontal pleiotropy in causal relationships inferred from Mendelian randomization between complex traits and diseases","volume":"50","author":"Verbanck","year":"2018","journal-title":"Nat Genet"},{"issue":"11","key":"bib57","doi-asserted-by":"publisher","first-page":"e1007081","DOI":"10.1371\/journal.pgen.1007081","article-title":"Orienting the causal relationship between imprecisely measured traits using GWAS summary data","volume":"13","author":"Hemani","year":"2017","journal-title":"PLoS Genet"},{"issue":"4","key":"bib58","doi-asserted-by":"publisher","first-page":"394","DOI":"10.1016\/j.ophtha.2022.11.030","article-title":"Mendelian randomization implicates bidirectional association between myopia and primary open-angle glaucoma or intraocular pressure","volume":"130","author":"Chong","year":"2023","journal-title":"Ophthalmology"},{"issue":"3","key":"bib59","doi-asserted-by":"publisher","first-page":"713","DOI":"10.1093\/ije\/dyy262","article-title":"An examination of multivariable Mendelian randomization in the single-sample and two-sample summary data settings","volume":"48","author":"Sanderson","year":"2019","journal-title":"Int J Epidemiol"},{"issue":"4","key":"bib60","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1093\/aje\/kwu283","article-title":"Multivariable Mendelian randomization: the use of pleiotropic genetic variants to estimate causal effects","volume":"181","author":"Burgess","year":"2015","journal-title":"Am J Epidemiol"},{"issue":"7","key":"bib61","doi-asserted-by":"publisher","first-page":"1303","DOI":"10.1016\/S0161-6420(02)01094-1","article-title":"Risk factors for incident nuclear opacities","volume":"109","author":"Leske","year":"2002","journal-title":"Ophthalmology"},{"issue":"12","key":"bib62","first-page":"3021","article-title":"Refractive associations with cataract: the Blue Mountains Eye Study","volume":"40","author":"Lim","year":"1999","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"2","key":"bib63","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1016\/0014-4835(89)90088-2","article-title":"Lipid peroxidation and human cataractogenesis in diabetes and severe myopia","volume":"49","author":"Simonelli","year":"1989","journal-title":"Exp Eye Res"},{"issue":"9","key":"bib64","doi-asserted-by":"publisher","first-page":"840","DOI":"10.1136\/bjo.80.9.840","article-title":"Role of lipid peroxidation in the pathogenesis of myopic and senile cataract","volume":"80","author":"Micelli-Ferrari","year":"1996","journal-title":"Br J Ophthalmol"},{"issue":"1","key":"bib65","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1016\/0003-9861(83)90018-8","article-title":"Effects of lipid peroxidation products on the rat lens in organ culture: a possible mechanism of cataract initiation in retinal degenerative disease","volume":"225","author":"Zigler","year":"1983","journal-title":"Arch Biochem Biophys"},{"issue":"9","key":"bib66","first-page":"2461","article-title":"Protein oxidation and lens opacity in humans","volume":"41","author":"Boscia","year":"2000","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"12","key":"bib67","doi-asserted-by":"publisher","first-page":"e81900","DOI":"10.1371\/journal.pone.0081900","article-title":"Epigenetic regulation of aA-crystallin in high myopia-induced dark nuclear cataract","volume":"8","author":"Zhu","year":"2013","journal-title":"PLoS One"},{"key":"bib68","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1016\/j.redox.2018.08.012","article-title":"DNA hypermethylation-mediated downregulation of antioxidant genes contributes to the early onset of cataracts in highly myopic eyes","volume":"19","author":"Zhu","year":"2018","journal-title":"Redox Biol"},{"issue":"1","key":"bib69","doi-asserted-by":"publisher","first-page":"2102","DOI":"10.1038\/s41467-021-22041-2","article-title":"Aberrant TGF-\u00df1 signaling activation by MAF underlies pathological lens growth in high myopia","volume":"12","author":"Zhu","year":"2021","journal-title":"Nat Commun"},{"key":"bib70","doi-asserted-by":"publisher","first-page":"2867","DOI":"10.2147\/IJGM.S354935","article-title":"Identification of the potential key genes and pathways involved in lens changes of high myopia","volume":"15","author":"Lai","year":"2022","journal-title":"Int J Gen Med"},{"issue":"1","key":"bib71","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1111\/fcp.2011.26.issue-1","article-title":"Biomarkers and special features of oxidative stress in the anterior segment of the eye linked to lens cataract and the trabecular meshwork injury in primary open-angle glaucoma: challenges of dual combination therapy with N-acetylcarnosine lubricant eye drops and oral formulation of nonhydrolyzed carnosine","volume":"26","author":"Babizhayev","year":"2012","journal-title":"Fundam Clin Pharmacol"}],"container-title":["Investigative Opthalmology &amp; Visual Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/iovs.arvojournals.org\/article.aspx?articleid=2791314","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:31:39Z","timestamp":1791927099000},"score":1,"resource":{"primary":{"URL":"https:\/\/iovs.arvojournals.org\/article.aspx?articleid=2791314"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7,17]]},"references-count":71,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2023,7,3]]}},"URL":"https:\/\/doi.org\/10.1167\/iovs.64.10.19","relation":{},"ISSN":["1552-5783"],"issn-type":[{"value":"1552-5783","type":"print"}],"subject":[],"published":{"date-parts":[[2023,7,17]]}}}