{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T22:00:06Z","timestamp":1791928806179,"version":"4.3.4"},"reference-count":63,"publisher":"Association for Research in Vision and Ophthalmology (ARVO)","issue":"11","license":[{"start":{"date-parts":[[2023,8,11]],"date-time":"2023-08-11T00:00:00Z","timestamp":1691712000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Invest. Ophthalmol. Vis. Sci."],"published-print":{"date-parts":[[2023,8,11]]},"DOI":"10.1167\/iovs.64.11.17","type":"journal-article","created":{"date-parts":[[2023,8,11]],"date-time":"2023-08-11T11:31:14Z","timestamp":1691753474000},"page":"17","source":"Crossref","is-referenced-by-count":14,"title":["PERK Inhibition Suppresses Neovascularization and Protects Neurons During Ischemia-Induced Retinopathy"],"prefix":"10.1167","volume":"64","author":[{"given":"Shuizhen","family":"Shi","sequence":"first","affiliation":[{"name":"Department of Ophthalmology & Visual Sciences, University of Texas Medical Branch, Galveston, Texas, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun","family":"Ding","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology & Visual Sciences, University of Texas Medical Branch, Galveston, Texas, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuang","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology & Visual Sciences, University of Texas Medical Branch, Galveston, Texas, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fan","family":"Xia","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology & Visual Sciences, University of Texas Medical Branch, Galveston, Texas, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seth E.","family":"Buscho","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology & Visual Sciences, University of Texas Medical Branch, Galveston, Texas, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shengguo","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology & Visual Sciences, University of Texas Medical Branch, Galveston, Texas, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Massoud","family":"Motamedi","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology & Visual Sciences, University of Texas Medical Branch, Galveston, Texas, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology & Visual Sciences, University of Texas Medical Branch, Galveston, Texas, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenbo","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology & Visual Sciences, University of Texas Medical Branch, Galveston, Texas, United States"},{"name":"Departments of Neurobiology, University of Texas Medical Branch, Galveston, Texas, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"27","reference":[{"key":"bib1","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1016\/j.preteyeres.2015.06.002","article-title":"Molecular pathogenesis of retinal and choroidal vascular diseases","volume":"49","author":"Campochiaro","year":"2015","journal-title":"Prog Retin Eye Res"},{"issue":"1","key":"bib2","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1007\/s10633-009-9201-x","article-title":"Understanding ischemic retinopathies: emerging concepts from oxygen-induced retinopathy","volume":"120","author":"Kermorvant-Duchemin","year":"2010","journal-title":"Doc Ophthalmol"},{"key":"bib3","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1016\/j.cophys.2018.12.008","article-title":"Molecular mechanisms of retinal ischemia","volume":"7","author":"Fortmann","year":"2019","journal-title":"Curr Opin Physiol"},{"issue":"2","key":"bib4","doi-asserted-by":"publisher","first-page":"376","DOI":"10.1016\/j.ajpath.2012.06.006","article-title":"A brief history of anti-VEGF for the treatment of ocular angiogenesis","volume":"181","author":"Kim","year":"2012","journal-title":"Am J Pathol"},{"issue":"1","key":"bib5","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1016\/j.mayocp.2011.10.001","article-title":"The expanding role of vascular endothelial growth factor inhibitors in ophthalmology","volume":"87","author":"Stewart","year":"2012","journal-title":"Mayo Clin Proc"},{"issue":"6059","key":"bib6","doi-asserted-by":"publisher","first-page":"1081","DOI":"10.1126\/science.1209038","article-title":"The unfolded protein response: from stress pathway to homeostatic regulation","volume":"334","author":"Walter","year":"2011","journal-title":"Science"},{"issue":"2","key":"bib7","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1038\/nrm3270","article-title":"The unfolded protein response: controlling cell fate decisions under ER stress and beyond","volume":"13","author":"Hetz","year":"2012","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"8","key":"bib8","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1038\/s41580-020-0250-z","article-title":"Mechanisms, regulation and functions of the unfolded protein response","volume":"21","author":"Hetz","year":"2020","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"9","key":"bib9","doi-asserted-by":"publisher","first-page":"5995","DOI":"10.1167\/iovs.13-12117","article-title":"Modulation of angiogenesis by genetic manipulation of ATF4 in mouse model of oxygen-induced retinopathy [corrected]","volume":"54","author":"Wang","year":"2013","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"4","key":"bib10","doi-asserted-by":"publisher","first-page":"1412","DOI":"10.1016\/j.ajpath.2012.12.020","article-title":"Targeting the IRE1alpha\/XBP1 and ATF6 arms of the unfolded protein response enhances VEGF blockade to prevent retinal and choroidal neovascularization","volume":"182","author":"Liu","year":"2013","journal-title":"Am J Pathol"},{"issue":"8","key":"bib11","doi-asserted-by":"publisher","first-page":"530","DOI":"10.1002\/iub.v66.8","article-title":"Endoplasmic reticulum stress and endothelial dysfunction","volume":"66","author":"Lenna","year":"2014","journal-title":"IUBMB Life"},{"issue":"9","key":"bib12","doi-asserted-by":"publisher","first-page":"1521","DOI":"10.1016\/j.febslet.2009.04.007","article-title":"Endoplasmic reticulum stress is implicated in retinal inflammation and diabetic retinopathy","volume":"583","author":"Li","year":"2009","journal-title":"FEBS Lett"},{"issue":"4","key":"bib13","doi-asserted-by":"publisher","first-page":"306","DOI":"10.1080\/15376516.2020.1727596","article-title":"Morin supplementation modulates PERK branch of UPR and mitigates 1,2-dimethylhydrazine-induced angiogenesis and oxidative stress in the colon of experimental rats","volume":"30","author":"Sharma","year":"2020","journal-title":"Toxicol Mech Methods"},{"key":"bib14","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1016\/j.exer.2014.04.015","article-title":"Endoplasmic reticulum stress and the unfolded protein responses in retinal degeneration","volume":"125","author":"Zhang","year":"2014","journal-title":"Exp Eye Res"},{"key":"bib15","doi-asserted-by":"publisher","first-page":"100860","DOI":"10.1016\/j.preteyeres.2020.100860","article-title":"Endoplasmic reticulum stress: new insights into the pathogenesis and treatment of retinal degenerative diseases","volume":"79","author":"Gorbatyuk","year":"2020","journal-title":"Prog Retin Eye Res"},{"issue":"11-12","key":"bib16","doi-asserted-by":"publisher","first-page":"535","DOI":"10.2119\/molmed.2010.00070","article-title":"Endoplasmic reticulum stress in age-related macular degeneration: trigger for neovascularization","volume":"16","author":"Salminen","year":"2010","journal-title":"Mol Med"},{"issue":"7","key":"bib17","doi-asserted-by":"publisher","first-page":"519","DOI":"10.1038\/nrm2199","article-title":"Signal integration in the endoplasmic reticulum unfolded protein response","volume":"8","author":"Ron","year":"2007","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"5","key":"bib18","doi-asserted-by":"publisher","first-page":"897","DOI":"10.1016\/S1097-2765(00)80330-5","article-title":"Perk is essential for translational regulation and cell survival during the unfolded protein response","volume":"5","author":"Harding","year":"2000","journal-title":"Mol Cell"},{"issue":"Pt 5","key":"bib19","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1107\/S0907444911006445","article-title":"The structure of the PERK kinase domain suggests the mechanism for its activation","volume":"67","author":"Cui","year":"2011","journal-title":"Acta Crystallogr D Biol Crystallogr"},{"issue":"16","key":"bib20","doi-asserted-by":"publisher","first-page":"16579","DOI":"10.18632\/aging.v12i16","article-title":"Suppressing endoplasmic reticulum stress-related autophagy attenuates retinal light injury","volume":"12","author":"Song","year":"2020","journal-title":"Aging (Albany NY)"},{"issue":"3","key":"bib21","doi-asserted-by":"publisher","first-page":"354","DOI":"10.3390\/biom11030354","article-title":"PERK pathway and neurodegenerative disease: to inhibit or to activate?","volume":"11","author":"Shacham","year":"2021","journal-title":"Biomolecules"},{"issue":"14","key":"bib22","doi-asserted-by":"publisher","first-page":"2477","DOI":"10.1093\/hmg\/ddy152","article-title":"PERK inhibition delays neurodegeneration and improves motor function in a mouse model of Marinesco-Sjogren syndrome","volume":"27","author":"Grande","year":"2018","journal-title":"Hum Mol Genet"},{"issue":"1","key":"bib23","doi-asserted-by":"publisher","first-page":"eaay3566","DOI":"10.1126\/sciadv.aay3566","article-title":"Epac1 inhibition ameliorates pathological angiogenesis through coordinated activation of Notch and suppression of VEGF signaling","volume":"6","author":"Liu","year":"2020","journal-title":"Sci Adv"},{"issue":"4","key":"bib24","doi-asserted-by":"publisher","first-page":"965","DOI":"10.1167\/iovs.18-26216","article-title":"Neuroprotective effects of HSF1 in retinal ischemia-reperfusion injury","volume":"60","author":"Liu","year":"2019","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"2","key":"bib25","doi-asserted-by":"publisher","first-page":"801","DOI":"10.1167\/iovs.13-12812","article-title":"TWEAK\/Fn14 pathway is a novel mediator of retinal neovascularization","volume":"55","author":"Ameri","year":"2014","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"3","key":"bib26","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1007\/s10456-009-9155-3","article-title":"Computer-aided quantification of retinal neovascularization","volume":"12","author":"Stahl","year":"2009","journal-title":"Angiogenesis"},{"issue":"4","key":"bib27","doi-asserted-by":"publisher","first-page":"e20190930","DOI":"10.1084\/jem.20190930","article-title":"Neuronal Epac1 mediates retinal neurodegeneration in mouse models of ocular hypertension","volume":"217","author":"Liu","year":"2020","journal-title":"J Exp Med"},{"issue":"2","key":"bib28","doi-asserted-by":"publisher","first-page":"e1075","DOI":"10.1038\/cddis.2014.23","article-title":"Arginase 2 deficiency reduces hyperoxia-mediated retinal neurodegeneration through the regulation of polyamine metabolism","volume":"5","author":"Narayanan","year":"2014","journal-title":"Cell Death Dis"},{"issue":"7","key":"bib29","doi-asserted-by":"publisher","first-page":"e22460","DOI":"10.1371\/journal.pone.0022460","article-title":"Arginase 2 deletion reduces neuro-glial injury and improves retinal function in a model of retinopathy of prematurity","volume":"6","author":"Narayanan","year":"2011","journal-title":"PLoS One"},{"issue":"7","key":"bib30","doi-asserted-by":"publisher","first-page":"3002","DOI":"10.1167\/iovs.15-18555","article-title":"Hydrogen sulfide contributes to retinal neovascularization in ischemia-induced retinopathy","volume":"57","author":"Gersztenkorn","year":"2016","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"7","key":"bib31","doi-asserted-by":"publisher","first-page":"860","DOI":"10.1161\/CIRCRESAHA.110.218271","article-title":"Notch3 is critical for proper angiogenesis and mural cell investment","volume":"107","author":"Liu","year":"2010","journal-title":"Circ Res"},{"issue":"6","key":"bib32","doi-asserted-by":"publisher","first-page":"1993","DOI":"10.1158\/0008-5472.CAN-12-3109","article-title":"Characterization of a novel PERK kinase inhibitor with antitumor and antiangiogenic activity","volume":"73","author":"Atkins","year":"2013","journal-title":"Cancer Res"},{"issue":"644","key":"bib33","doi-asserted-by":"publisher","first-page":"eabb4749","DOI":"10.1126\/scisignal.abb4749","article-title":"Targeting the kinase insert loop of PERK selectively modulates PERK signaling without systemic toxicity in mice","volume":"13","author":"Hughes","year":"2020","journal-title":"Sci Signal"},{"issue":"16","key":"bib34","doi-asserted-by":"publisher","first-page":"7193","DOI":"10.1021\/jm300713s","article-title":"Discovery of 7-methyl-5-(1-[3-(trifluoromethyl)phenyl]acetyl-2,3-dihydro-1H-indol-5-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine (GSK2606414), a potent and selective first-in-class inhibitor of protein kinase R (PKR)-like endoplasmic reticulum kinase (PERK)","volume":"55","author":"Axten","year":"2012","journal-title":"J Med Chem"},{"key":"bib35","doi-asserted-by":"publisher","first-page":"238","DOI":"10.1016\/j.omto.2020.01.001","article-title":"The PERK inhibitor GSK2606414 enhances reovirus infection in head and neck squamous cell carcinoma via an ATF4-dependent mechanism","volume":"16","author":"McLaughlin","year":"2020","journal-title":"Mol Ther Oncolytics"},{"issue":"5","key":"bib36","doi-asserted-by":"publisher","first-page":"3105","DOI":"10.3892\/mmr.2017.6418","article-title":"Effects of GSK2606414 on cell proliferation and endoplasmic reticulum stress-associated gene expression in retinal pigment epithelial cells","volume":"15","author":"Jiang","year":"2017","journal-title":"Mol Med Rep"},{"issue":"23","key":"bib37","doi-asserted-by":"publisher","first-page":"e93382","DOI":"10.1172\/jci.insight.93382","article-title":"Myeloid cell modulation by a GLP-1 receptor agonist regulates retinal angiogenesis in ischemic retinopathy","volume":"6","author":"Zhou","year":"2021","journal-title":"JCI Insight"},{"key":"bib38","doi-asserted-by":"publisher","first-page":"976729","DOI":"10.3389\/fimmu.2022.976729","article-title":"Ferulic acid alleviates retinal neovascularization by modulating microglia\/macrophage polarization through the ROS\/NF-kappaB axis","volume":"13","author":"Sun","year":"2022","journal-title":"Front Immunol"},{"key":"bib39","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1016\/j.exer.2017.08.012","article-title":"Norrin treatment improves ganglion cell survival in an oxygen-induced retinopathy model of retinal ischemia","volume":"164","author":"Dailey","year":"2017","journal-title":"Exp Eye Res"},{"issue":"3","key":"bib40","doi-asserted-by":"publisher","first-page":"1290","DOI":"10.1167\/iovs.08-1920","article-title":"The role of lysophosphatidic acid receptor (LPA1) in the oxygen-induced retinal ganglion cell degeneration","volume":"50","author":"Yang","year":"2009","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"11","key":"bib41","doi-asserted-by":"publisher","first-page":"3864","DOI":"10.1128\/MCB.22.11.3864-3874.2002","article-title":"The PERK eukaryotic initiation factor 2 alpha kinase is required for the development of the skeletal system, postnatal growth, and the function and viability of the pancreas","volume":"22","author":"Zhang","year":"2002","journal-title":"Mol Cell Biol"},{"issue":"6","key":"bib42","doi-asserted-by":"publisher","first-page":"1153","DOI":"10.1016\/S1097-2765(01)00264-7","article-title":"Diabetes mellitus and exocrine pancreatic dysfunction in perk-\/- mice reveals a role for translational control in secretory cell survival","volume":"7","author":"Harding","year":"2001","journal-title":"Mol Cell"},{"key":"bib43","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1016\/j.nbd.2018.01.004","article-title":"Targeting PERK signaling with the small molecule GSK2606414 prevents neurodegeneration in a model of Parkinson's disease","volume":"112","author":"Mercado","year":"2018","journal-title":"Neurobiol Dis"},{"issue":"3","key":"bib44","doi-asserted-by":"publisher","first-page":"1808","DOI":"10.1007\/s12035-016-9790-9","article-title":"Pharmacological inhibition of PERK attenuates early brain injury after subarachnoid hemorrhage in rats through the activation of Akt","volume":"54","author":"Yan","year":"2017","journal-title":"Mol Neurobiol"},{"issue":"5","key":"bib45","doi-asserted-by":"publisher","first-page":"633","DOI":"10.1007\/s00401-015-1487-z","article-title":"PERK inhibition prevents tau-mediated neurodegeneration in a mouse model of frontotemporal dementia","volume":"130","author":"Radford","year":"2015","journal-title":"Acta Neuropathol"},{"key":"bib46","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1016\/j.niox.2014.05.001","article-title":"PERK pathway are involved in NO-induced apoptosis in endothelial cells cocultured with RPE under high glucose conditions","volume":"40","author":"Zhang","year":"2014","journal-title":"Nitric Oxide"},{"key":"bib47","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.exer.2017.01.002","article-title":"PERK and XBP1 differentially regulate CXCL10 and CCL2 production","volume":"155","author":"Zhu","year":"2017","journal-title":"Exp Eye Res"},{"issue":"1","key":"bib48","doi-asserted-by":"publisher","first-page":"5594","DOI":"10.1038\/s41467-020-19352-1","article-title":"ATF4 leads to glaucoma by promoting protein synthesis and ER client protein load","volume":"11","author":"Kasetti","year":"2020","journal-title":"Nat Commun"},{"issue":"5","key":"bib49","doi-asserted-by":"publisher","first-page":"e0154779","DOI":"10.1371\/journal.pone.0154779","article-title":"Limited ATF4 expression in degenerating retinas with ongoing ER stress promotes photoreceptor survival in a mouse model of autosomal dominant retinitis pigmentosa","volume":"11","author":"Bhootada","year":"2016","journal-title":"PLoS One"},{"issue":"2","key":"bib50","doi-asserted-by":"publisher","first-page":"492","DOI":"10.2337\/db11-0315","article-title":"Activation of endoplasmic reticulum stress by hyperglycemia is essential for Muller cell-derived inflammatory cytokine production in diabetes","volume":"61","author":"Zhong","year":"2012","journal-title":"Diabetes"},{"key":"bib51","doi-asserted-by":"publisher","first-page":"108826","DOI":"10.1016\/j.exer.2021.108826","article-title":"CHOP deletion and anti-neuroinflammation treatment with hesperidin synergistically attenuate NMDA retinal injury in mice","volume":"213","author":"Sato","year":"2021","journal-title":"Exp Eye Res"},{"issue":"1","key":"bib52","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1167\/iovs.14-15447","article-title":"Role of C\/EBP homologous protein in retinal ganglion cell death after ischemia\/reperfusion injury","volume":"56","author":"Nashine","year":"2014","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"3","key":"bib53","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1016\/j.neuron.2011.11.026","article-title":"Differential effects of unfolded protein response pathways on axon injury-induced death of retinal ganglion cells","volume":"73","author":"Hu","year":"2012","journal-title":"Neuron"},{"issue":"9","key":"bib54","doi-asserted-by":"publisher","first-page":"6384","DOI":"10.1167\/iovs.11-7666","article-title":"Hyperoxia therapy of pre-proliferative ischemic retinopathy in a mouse model","volume":"52","author":"Zhang","year":"2011","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"21","key":"bib55","doi-asserted-by":"publisher","first-page":"20331","DOI":"10.1074\/jbc.M411275200","article-title":"The oxidative stressor arsenite activates vascular endothelial growth factor mRNA transcription by an ATF4-dependent mechanism","volume":"280","author":"Roybal","year":"2005","journal-title":"J Biol Chem"},{"issue":"44","key":"bib56","doi-asserted-by":"publisher","first-page":"77219","DOI":"10.18632\/oncotarget.v8i44","article-title":"Salubrinal attenuated retinal neovascularization by inhibiting CHOP-HIF1alpha-VEGF pathways","volume":"8","author":"Hu","year":"2017","journal-title":"Oncotarget"},{"key":"bib57","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1016\/j.exer.2013.08.021","article-title":"Retinal pigment epithelium cells produce VEGF in response to oxidized phospholipids through mechanisms involving ATF4 and protein kinase CK2","volume":"116","author":"Pollreisz","year":"2013","journal-title":"Exp Eye Res"},{"issue":"23","key":"bib58","doi-asserted-by":"publisher","first-page":"e160940","DOI":"10.1172\/jci.insight.160940","article-title":"Single-cell transcriptome analyses reveal microglia types associated with proliferative retinopathy","volume":"7","author":"Liu","year":"2022","journal-title":"JCI Insight"},{"issue":"8","key":"bib59","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1167\/iovs.63.8.25","article-title":"LGALS3BP in microglia promotes retinal angiogenesis through PI3K\/AKT pathway during hypoxia","volume":"63","author":"Zhao","year":"2022","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib60","doi-asserted-by":"publisher","first-page":"234","DOI":"10.3389\/fphar.2020.00234","article-title":"Targeting neuroinflammation in neovascular retinal diseases","volume":"11","author":"Wang","year":"2020","journal-title":"Front Pharmacol"},{"issue":"1","key":"bib61","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1111\/febs.v290.1","article-title":"Role of inflammasome activation in neovascular age-related macular degeneration","volume":"290","author":"Marneros","year":"2023","journal-title":"FEBS J"},{"issue":"16","key":"bib62","doi-asserted-by":"publisher","first-page":"5651","DOI":"10.1128\/MCB.23.16.5651-5663.2003","article-title":"Phosphorylation of the alpha subunit of eukaryotic initiation factor 2 is required for activation of NF-kappaB in response to diverse cellular stresses","volume":"23","author":"Jiang","year":"2003","journal-title":"Mol Cell Biol"},{"issue":"20","key":"bib63","doi-asserted-by":"publisher","first-page":"3911","DOI":"10.1128\/MCB.00980-14","article-title":"PERK-dependent activation of JAK1 and STAT3 contributes to endoplasmic reticulum stress-induced inflammation","volume":"34","author":"Meares","year":"2014","journal-title":"Mol Cell Biol"}],"container-title":["Investigative Opthalmology &amp; Visual Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/iovs.arvojournals.org\/article.aspx?articleid=2791393","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:31:39Z","timestamp":1791927099000},"score":1,"resource":{"primary":{"URL":"https:\/\/iovs.arvojournals.org\/article.aspx?articleid=2791393"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8,11]]},"references-count":63,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2023,8,1]]}},"URL":"https:\/\/doi.org\/10.1167\/iovs.64.11.17","relation":{},"ISSN":["1552-5783"],"issn-type":[{"value":"1552-5783","type":"print"}],"subject":[],"published":{"date-parts":[[2023,8,11]]}}}