{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T22:00:18Z","timestamp":1791928818649,"version":"4.3.4"},"reference-count":46,"publisher":"Association for Research in Vision and Ophthalmology (ARVO)","issue":"11","license":[{"start":{"date-parts":[[2023,8,4]],"date-time":"2023-08-04T00:00:00Z","timestamp":1691107200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Invest. Ophthalmol. Vis. Sci."],"published-print":{"date-parts":[[2023,8,4]]},"DOI":"10.1167\/iovs.64.11.8","type":"journal-article","created":{"date-parts":[[2023,8,4]],"date-time":"2023-08-04T10:43:38Z","timestamp":1691145818000},"page":"8","source":"Crossref","is-referenced-by-count":14,"title":["SYVN1 Promotes STAT3 Protein Ubiquitination and Exerts Antiangiogenesis Effects in Retinopathy of Prematurity Development"],"prefix":"10.1167","volume":"64","author":[{"given":"Shimei","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai Key Laboratory of Ocular Fundus Diseases, Shanghai Engineering Center for Visual Science and Photomedicine, National Clinical Research Center for Eye Diseases, Shanghai Engineering Center for Precise Diagnosis and Treatment of Eye Diseases, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai Key Laboratory of Ocular Fundus Diseases, Shanghai Engineering Center for Visual Science and Photomedicine, National Clinical Research Center for Eye Diseases, Shanghai Engineering Center for Precise Diagnosis and Treatment of Eye Diseases, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dandan","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai Key Laboratory of Ocular Fundus Diseases, Shanghai Engineering Center for Visual Science and Photomedicine, National Clinical Research Center for Eye Diseases, Shanghai Engineering Center for Precise Diagnosis and Treatment of Eye Diseases, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yidong","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai Key Laboratory of Ocular Fundus Diseases, Shanghai Engineering Center for Visual Science and Photomedicine, National Clinical Research Center for Eye Diseases, Shanghai Engineering Center for Precise Diagnosis and Treatment of Eye Diseases, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junwei","family":"Fang","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai Key Laboratory of Ocular Fundus Diseases, Shanghai Engineering Center for Visual Science and Photomedicine, National Clinical Research Center for Eye Diseases, Shanghai Engineering Center for Precise Diagnosis and Treatment of Eye Diseases, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoling","family":"Wan","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai Key Laboratory of Ocular Fundus Diseases, Shanghai Engineering Center for Visual Science and Photomedicine, National Clinical Research Center for Eye Diseases, Shanghai Engineering Center for Precise Diagnosis and Treatment of Eye Diseases, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shenping","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai Key Laboratory of Ocular Fundus Diseases, Shanghai Engineering Center for Visual Science and Photomedicine, National Clinical Research Center for Eye Diseases, Shanghai Engineering Center for Precise Diagnosis and Treatment of Eye Diseases, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuchang","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai Key Laboratory of Ocular Fundus Diseases, Shanghai Engineering Center for Visual Science and Photomedicine, National Clinical Research Center for Eye Diseases, Shanghai Engineering Center for Precise Diagnosis and Treatment of Eye Diseases, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Gu","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai Key Laboratory of Ocular Fundus Diseases, Shanghai Engineering Center for Visual Science and Photomedicine, National Clinical Research Center for Eye Diseases, Shanghai Engineering Center for Precise Diagnosis and Treatment of Eye Diseases, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Shao","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Shanghai Aier Eye Hospital, Xuhui District, Shanghai Aier Eye Institute, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Dong","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Shanghai Aier Eye Hospital, Xuhui District, Shanghai Aier Eye Institute, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xun","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai Key Laboratory of Ocular Fundus Diseases, Shanghai Engineering Center for Visual Science and Photomedicine, National Clinical Research Center for Eye Diseases, Shanghai Engineering Center for Precise Diagnosis and Treatment of Eye Diseases, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai Key Laboratory of Ocular Fundus Diseases, Shanghai Engineering Center for Visual Science and Photomedicine, National Clinical Research Center for Eye Diseases, Shanghai Engineering Center for Precise Diagnosis and Treatment of Eye Diseases, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiao","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai Key Laboratory of Ocular Fundus Diseases, Shanghai Engineering Center for Visual Science and Photomedicine, National Clinical Research Center for Eye Diseases, Shanghai Engineering Center for Precise Diagnosis and Treatment of Eye Diseases, Shanghai, China"},{"name":"Department of Ophthalmology, Shanghai Aier Eye Hospital, Xuhui District, Shanghai Aier Eye Institute, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"27","reference":[{"issue":"9902","key":"bib1","doi-asserted-by":"publisher","first-page":"1445","DOI":"10.1016\/S0140-6736(13)60178-6","article-title":"Retinopathy of prematurity","volume":"382","author":"Hellstr\u00f6m","year":"2013","journal-title":"Lancet"},{"issue":"Suppl 1","key":"bib2","doi-asserted-by":"crossref","first-page":"S5","DOI":"10.1186\/1742-4755-10-S1-S5","article-title":"Born too soon: care for the preterm baby","volume":"10","author":"Lawn","year":"2013","journal-title":"Reprod Health"},{"issue":"1","key":"bib3","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1055\/s-0040-1713181","article-title":"Update in the treatment of retinopathy of prematurity","volume":"39","author":"Bancalari","year":"2022","journal-title":"Am J Perinatol"},{"issue":"Suppl 1","key":"bib4","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1038\/pr.2013.205","article-title":"Preterm-associated visual impairment and estimates of retinopathy of prematurity at regional and global levels for 2010","volume":"74","author":"Blencowe","year":"2013","journal-title":"Pediatr Res"},{"issue":"9","key":"bib5","first-page":"514","article-title":"Retinopathy of prematurity\u2013epidemics, incidence, prevalence, blindness","volume":"111","author":"Gergely","year":"2010","journal-title":"Bratisl Lek Listy"},{"key":"bib6","doi-asserted-by":"publisher","first-page":"735335","DOI":"10.3389\/fped.2022.735335","article-title":"Prevalence, years lived with disability, and time trends for 16 causes of blindness and vision impairment: findings highlight retinopathy of prematurity","volume":"10","author":"Zhang","year":"2022","journal-title":"Front Pediatr"},{"key":"bib7","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1016\/j.preteyeres.2017.09.002","article-title":"Pathophysiology, screening and treatment of ROP: a multi-disciplinary perspective","volume":"62","author":"Chan-Ling","year":"2018","journal-title":"Prog Retin Eye Res"},{"issue":"4","key":"bib8","doi-asserted-by":"publisher","first-page":"541","DOI":"10.1136\/bjophthalmol-2019-314429","article-title":"Visual function is reduced in young adults formerly born prematurely: a population-based study","volume":"104","author":"P\u00e9tursd\u00f3ttir","year":"2020","journal-title":"Br J Ophthalmol"},{"issue":"8","key":"bib9","doi-asserted-by":"publisher","first-page":"1041","DOI":"10.1136\/bjophthalmol-2017-311345","article-title":"Vision in former very low birthweight young adults with and without retinopathy of prematurity compared with term born controls: the NZ 1986 VLBW follow-up study","volume":"102","author":"Darlow","year":"2018","journal-title":"Br J Ophthalmol"},{"issue":"11","key":"bib10","doi-asserted-by":"publisher","first-page":"2212","DOI":"10.1016\/j.ophtha.2014.05.015","article-title":"Intravitreal bevacizumab versus laser treatment in type 1 retinopathy of prematurity: report on fluorescein angiographic findings","volume":"121","author":"Lepore","year":"2014","journal-title":"Ophthalmology"},{"issue":"26","key":"bib11","doi-asserted-by":"publisher","first-page":"2515","DOI":"10.1056\/NEJMra1208129","article-title":"Mechanisms and management of retinopathy of prematurity","volume":"367","author":"Hartnett","year":"2012","journal-title":"N Engl J Med"},{"key":"bib12","doi-asserted-by":"publisher","first-page":"101018","DOI":"10.1016\/j.preteyeres.2021.101018","article-title":"Assessment and management of retinopathy of prematurity in the era of anti-vascular endothelial growth factor (VEGF)","volume":"88","author":"Tsai","year":"2022","journal-title":"Prog Retin Eye Res"},{"issue":"4","key":"bib13","doi-asserted-by":"publisher","first-page":"391","DOI":"10.1001\/jamaophthalmol.2014.5373","article-title":"Serum levels of vascular endothelial growth factor and related factors after intravitreous bevacizumab injection for retinopathy of prematurity","volume":"133","author":"Wu","year":"2015","journal-title":"JAMA Ophthalmol"},{"key":"bib14","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1016\/j.preteyeres.2014.06.001","article-title":"The \u00df-adrenergic system as a possible new target for pharmacologic treatment of neovascular retinal diseases","volume":"42","author":"Casini","year":"2014","journal-title":"Prog Retin Eye Res"},{"issue":"4","key":"bib15","doi-asserted-by":"publisher","first-page":"e20153218","DOI":"10.1542\/peds.2015-3218","article-title":"Neurodevelopmental outcomes following bevacizumab injections for retinopathy of prematurity","volume":"137","author":"Morin","year":"2016","journal-title":"Pediatrics"},{"key":"bib16","doi-asserted-by":"publisher","first-page":"113113","DOI":"10.1016\/j.biopha.2022.113113","article-title":"Combination of pigment epithelium derived factor with anti-vascular endothelial growth factor therapy protects the neuroretina from ischemic damage","volume":"151","author":"Xi","year":"2022","journal-title":"Biomed Pharmacother"},{"issue":"14","key":"bib17","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1167\/iovs.61.14.9","article-title":"Stress signal regulation by Na\/K-ATPase as a new approach to promote physiological revascularization in a mouse model of ischemic retinopathy","volume":"61","author":"Wang","year":"2020","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib18","doi-asserted-by":"publisher","first-page":"110856","DOI":"10.1016\/j.biopha.2020.110856","article-title":"C-CBL is required for inhibition of angiogenesis through modulating JAK2\/STAT3 activity in ROP development","volume":"132","author":"Chen","year":"2020","journal-title":"Biomed Pharmacother"},{"issue":"9","key":"bib19","doi-asserted-by":"publisher","first-page":"651","DOI":"10.1038\/nrm909","article-title":"Stats: transcriptional control and biological impact","volume":"3","author":"Levy","year":"2002","journal-title":"Nat Rev Mol Cell Biol"},{"key":"bib20","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1016\/j.semcancer.2020.03.016","article-title":"Targeting STAT3 signaling pathway in cancer by agents derived from Mother Nature","volume":"80","author":"Mohan","year":"2022","journal-title":"Semin Cancer Biol"},{"issue":"3","key":"bib21","doi-asserted-by":"publisher","first-page":"1243","DOI":"10.1016\/j.ajpath.2011.11.031","article-title":"VEGF-mediated STAT3 activation inhibits retinal vascularization by down-regulating local erythropoietin expression","volume":"180","author":"Wang","year":"2012","journal-title":"Am J Pathol"},{"issue":"4","key":"bib22","doi-asserted-by":"publisher","first-page":"751","DOI":"10.1007\/s10456-018-9618-5","article-title":"Gene therapy knockdown of VEGFR2 in retinal endothelial cells to treat retinopathy","volume":"21","author":"Simmons","year":"2018","journal-title":"Angiogenesis"},{"issue":"5","key":"bib23","doi-asserted-by":"publisher","first-page":"e121887","DOI":"10.1172\/jci.insight.121887","article-title":"The E3 ligase Hrd1 stabilizes Tregs by antagonizing inflammatory cytokine-induced ER stress response","volume":"4","author":"Xu","year":"2019","journal-title":"JCI Insight"},{"issue":"12","key":"bib24","doi-asserted-by":"publisher","first-page":"2331","DOI":"10.1038\/s41564-019-0542-2","article-title":"ER-localized Hrd1 ubiquitinates and inactivates Usp15 to promote TLR4-induced inflammation during bacterial infection","volume":"4","author":"Lu","year":"2019","journal-title":"Nat Microbiol"},{"issue":"5","key":"bib25","doi-asserted-by":"publisher","first-page":"480","DOI":"10.1038\/embor.2008.37","article-title":"Synoviolin promotes IRE1 ubiquitination and degradation in synovial fibroblasts from mice with collagen-induced arthritis","volume":"9","author":"Gao","year":"2008","journal-title":"EMBO Rep"},{"issue":"1","key":"bib26","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1186\/s13024-022-00528-w","article-title":"Cellular stress signaling and the unfolded protein response in retinal degeneration: mechanisms and therapeutic implications","volume":"17","author":"McLaughlin","year":"2022","journal-title":"Mol Neurodegener"},{"key":"bib27","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1016\/j.preteyeres.2014.12.001","article-title":"The unfolded protein response in retinal vascular diseases: implications and therapeutic potential beyond protein folding","volume":"45","author":"Zhang","year":"2015","journal-title":"Prog Retin Eye Res"},{"key":"bib28","doi-asserted-by":"publisher","first-page":"100860","DOI":"10.1016\/j.preteyeres.2020.100860","article-title":"Endoplasmic reticulum stress: new insights into the pathogenesis and treatment of retinal degenerative diseases","volume":"79","author":"Gorbatyuk","year":"2020","journal-title":"Prog Retin Eye Res"},{"issue":"1","key":"bib29","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1038\/ncb2383","article-title":"Defining human ERAD networks through an integrative mapping strategy","volume":"14","author":"Christianson","year":"2011","journal-title":"Nat Cell Biol"},{"key":"bib30","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1016\/j.abb.2017.06.006","article-title":"Ubiquitin-proteasome system and ER stress in the retina of diabetic rats","volume":"627","author":"Shruthi","year":"2017","journal-title":"Arch Biochem Biophys"},{"key":"bib31","doi-asserted-by":"publisher","first-page":"14036","DOI":"10.1038\/srep14036","article-title":"Experimental study of the protective effects of SYVN1 against diabetic retinopathy","volume":"5","author":"Yang","year":"2015","journal-title":"Sci Rep"},{"issue":"2","key":"bib32","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1530\/JME-21-0123","article-title":"Synoviolin inhibits the inflammatory cytokine secretion of M\u00fcller cells by reducing NLRP3","volume":"68","author":"Zhang","year":"2022","journal-title":"J Mol Endocrinol"},{"issue":"2","key":"bib33","doi-asserted-by":"publisher","first-page":"218","DOI":"10.1016\/j.ophtha.2017.08.005","article-title":"Follow-up to age 4 years of treatment of type 1 retinopathy of prematurity intravitreal bevacizumab injection versus laser: fluorescein angiographic findings","volume":"125","author":"Lepore","year":"2018","journal-title":"Ophthalmology"},{"issue":"10208","key":"bib34","doi-asserted-by":"publisher","first-page":"1551","DOI":"10.1016\/S0140-6736(19)31344-3","article-title":"Ranibizumab versus laser therapy for the treatment of very low birthweight infants with retinopathy of prematurity (RAINBOW): an open-label randomised controlled trial","volume":"394","author":"Stahl","year":"2019","journal-title":"Lancet"},{"issue":"9","key":"bib35","doi-asserted-by":"publisher","first-page":"1083","DOI":"10.3109\/10715762.2011.595408","article-title":"Endoplasmic reticulum stress induces retinal endothelial permeability of extracellular-superoxide dismutase","volume":"45","author":"Adachi","year":"2011","journal-title":"Free Radic Res"},{"issue":"33","key":"bib36","first-page":"3148","article-title":"Role of endoplasmic reticulum stress in the loss of retinal ganglion cells in diabetic retinopathy","volume":"8","author":"Yang","year":"2013","journal-title":"Neural Regen Res"},{"issue":"10","key":"bib37","doi-asserted-by":"publisher","first-page":"1007","DOI":"10.1002\/cac2.v41.10","article-title":"Integrative proteomics reveals the role of E3 ubiquitin ligase SYVN1 in hepatocellular carcinoma metastasis","volume":"41","author":"Ji","year":"2021","journal-title":"Cancer Commun (Lond)"},{"issue":"12","key":"bib38","doi-asserted-by":"publisher","first-page":"3202","DOI":"10.1038\/s41419-017-0002-y","article-title":"HRD1 prevents apoptosis in renal tubular epithelial cells by mediating eIF2a ubiquitylation and degradation","volume":"8","author":"Huang","year":"2017","journal-title":"Cell Death Dis"},{"issue":"7","key":"bib39","doi-asserted-by":"publisher","first-page":"e00257","DOI":"10.1128\/MCB.00257-19","article-title":"E3 ubiquitin ligase HRD1 promotes lung tumorigenesis by promoting sirtuin 2 ubiquitination and degradation","volume":"40","author":"Liu","year":"2020","journal-title":"Mol Cell Biol"},{"issue":"10","key":"bib40","doi-asserted-by":"publisher","first-page":"776","DOI":"10.1038\/nrc1994","article-title":"Ubiquitin and ubiquitin-like proteins in cancer pathogenesis","volume":"6","author":"Hoeller","year":"2006","journal-title":"Nat Rev Cancer"},{"key":"bib41","doi-asserted-by":"publisher","first-page":"3940241","DOI":"10.1155\/2017\/3940241","article-title":"Ischemic retinopathies: oxidative stress and inflammation","volume":"2017","author":"Rivera","year":"2017","journal-title":"Oxid Med Cell Longev"},{"issue":"11","key":"bib42","doi-asserted-by":"publisher","first-page":"1565","DOI":"10.1038\/nprot.2009.187","article-title":"Quantification of oxygen-induced retinopathy in the mouse: a model of vessel loss, vessel regrowth and pathological angiogenesis","volume":"4","author":"Connor","year":"2009","journal-title":"Nat Protoc"},{"issue":"6","key":"bib43","doi-asserted-by":"publisher","first-page":"869","DOI":"10.1083\/jcb.201312042","article-title":"Quality control: ER-associated degradation: protein quality control and beyond","volume":"204","author":"Ruggiano","year":"2014","journal-title":"J Cell Biol"},{"issue":"6","key":"bib44","doi-asserted-by":"publisher","first-page":"430","DOI":"10.1016\/j.tcb.2016.12.002","article-title":"New Insights into the physiological role of endoplasmic reticulum-associated degradation","volume":"27","author":"Qi","year":"2017","journal-title":"Trends Cell Biol"},{"issue":"6","key":"bib45","doi-asserted-by":"publisher","first-page":"3957","DOI":"10.1167\/iovs.13-13532","article-title":"The vasoneuronal effects of AT1 receptor blockade in a rat model of retinopathy of prematurity","volume":"55","author":"Hatzopoulos","year":"2014","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib46","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1016\/j.preteyeres.2016.09.004","article-title":"The neural retina in retinopathy of prematurity","volume":"56","author":"Hansen","year":"2017","journal-title":"Prog Retin Eye Res"}],"container-title":["Investigative Opthalmology & Visual Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/iovs.arvojournals.org\/article.aspx?articleid=2791372","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:31:45Z","timestamp":1791927105000},"score":1,"resource":{"primary":{"URL":"https:\/\/iovs.arvojournals.org\/article.aspx?articleid=2791372"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8,4]]},"references-count":46,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2023,8,1]]}},"URL":"https:\/\/doi.org\/10.1167\/iovs.64.11.8","relation":{},"ISSN":["1552-5783"],"issn-type":[{"value":"1552-5783","type":"print"}],"subject":[],"published":{"date-parts":[[2023,8,4]]}}}