{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T22:00:22Z","timestamp":1791928822056,"version":"4.3.4"},"reference-count":56,"publisher":"Association for Research in Vision and Ophthalmology (ARVO)","issue":"11","license":[{"start":{"date-parts":[[2023,8,7]],"date-time":"2023-08-07T00:00:00Z","timestamp":1691366400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Invest. Ophthalmol. Vis. Sci."],"published-print":{"date-parts":[[2023,8,7]]},"DOI":"10.1167\/iovs.64.11.9","type":"journal-article","created":{"date-parts":[[2023,8,7]],"date-time":"2023-08-07T11:30:54Z","timestamp":1691407854000},"page":"9","source":"Crossref","is-referenced-by-count":12,"title":["Impaired Direction Selectivity in the Nucleus of the Optic Tract of Albino Mice"],"prefix":"10.1167","volume":"64","author":[{"given":"Jorrit S.","family":"Montijn","sequence":"first","affiliation":[{"name":"Department of Circuits, Structure & Function, Netherlands Institute for Neuroscience, Royal Netherlands Academy of Arts and Sciences, Amsterdam, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentina","family":"Riguccini","sequence":"additional","affiliation":[{"name":"Department of Molecular Visual Plasticity, Netherlands Institute for Neuroscience, Amsterdam, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christiaan N.","family":"Levelt","sequence":"additional","affiliation":[{"name":"Department of Molecular Visual Plasticity, Netherlands Institute for Neuroscience, Amsterdam, the Netherlands"},{"name":"Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, VU University Amsterdam, Amsterdam, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. Alexander","family":"Heimel","sequence":"additional","affiliation":[{"name":"Department of Circuits, Structure & Function, Netherlands Institute for Neuroscience, Royal Netherlands Academy of Arts and Sciences, Amsterdam, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"27","reference":[{"key":"bib1","doi-asserted-by":"publisher","first-page":"212","DOI":"10.1186\/1471-2458-6-212","article-title":"Albinism in Africa as a public health issue","volume":"6","author":"Hong","year":"2006","journal-title":"BMC Public Health"},{"key":"bib2","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1016\/S0002-9394(01)01326-5","article-title":"Foveal hypoplasia in oculocutaneous albinism demonstrated by optical coherence tomography","volume":"133","author":"Meyer","year":"2002","journal-title":"Am J Ophthalmol"},{"key":"bib3","doi-asserted-by":"publisher","first-page":"623","DOI":"10.1097\/00006324-199208000-00005","article-title":"Vision defects in albinism","volume":"69","author":"P\u00e9rez-Carpinell","year":"1992","journal-title":"Optom Vis Sci"},{"key":"bib4","doi-asserted-by":"publisher","first-page":"659","DOI":"10.1097\/OPX.0b013e3181a5254c","article-title":"Albinism: classification, clinical characteristics, and recent findings","volume":"86","author":"Summers","year":"2009","journal-title":"Optom Vis Sci Off Publ Am Acad Optom"},{"key":"bib5","doi-asserted-by":"publisher","first-page":"362","DOI":"10.1016\/j.survophthal.2020.10.007","article-title":"Current and emerging treatments for albinism","volume":"66","author":"Liu","year":"2021","journal-title":"Surv Ophthalmol"},{"key":"bib6","doi-asserted-by":"publisher","first-page":"1351","DOI":"10.1126\/science.628845","article-title":"Optokinetic eye movements in albino rabbits: inversion in anterior visual field","volume":"199","author":"Collewijn","year":"1978","journal-title":"Science"},{"key":"bib7","doi-asserted-by":"publisher","first-page":"4061","DOI":"10.1523\/JNEUROSCI.0903-04.2004","article-title":"Optokinetic deficits in albino ferrets (Mustela putorius furo): a behavioral and electrophysiological study","volume":"24","author":"Hoffmann","year":"2004","journal-title":"J Neurosci"},{"key":"bib8","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1186\/1749-8104-9-11","article-title":"Delayed neurogenesis leads to altered specification of ventrotemporal retinal ganglion cells in albino mice","volume":"9","author":"Bhansali","year":"2014","journal-title":"Neural Dev"},{"key":"bib9","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1146\/vision.2020.6.issue-1","article-title":"Retinal ganglion cell axon wiring establishing the binocular circuit","volume":"6","author":"Mason","year":"2020","journal-title":"Annu Rev Vis Sci"},{"key":"bib10","doi-asserted-by":"publisher","first-page":"1953","DOI":"10.1016\/j.ophtha.2018.08.003","article-title":"The phenotypic spectrum of albinism","volume":"125","author":"Kruijt","year":"2018","journal-title":"Ophthalmology"},{"key":"bib11","doi-asserted-by":"publisher","first-page":"761","DOI":"10.1001\/jamaophthalmol.2013.5833","article-title":"Unifying neurologic mechanism for infantile nystagmus","volume":"132","author":"Brodsky","year":"2014","journal-title":"JAMA Ophthalmol"},{"key":"bib12","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1146\/neuro.1984.7.issue-1","article-title":"The accessory optic system","volume":"7","author":"Simpson","year":"1984","journal-title":"Annu Rev Neurosci"},{"key":"bib13","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1016\/0006-8993(88)90809-8","article-title":"The human accessory optic system","volume":"454","author":"Fredericks","year":"1988","journal-title":"Brain Res"},{"key":"bib15","doi-asserted-by":"publisher","first-page":"5737","DOI":"10.1167\/iovs.12-10137","article-title":"Albino mice as an animal model for infantile nystagmus syndrome","volume":"53","author":"Traber","year":"2012","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib16","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1146\/vision.2015.1.issue-1","article-title":"Contributions of retinal ganglion cells to subcortical visual processing and behaviors","volume":"1","author":"Dhande","year":"2015","journal-title":"Annu Rev Vis Sci"},{"key":"bib17","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1038\/nature19818","article-title":"Cortico-fugal output from visual cortex promotes plasticity of innate motor behaviour","volume":"538","author":"Liu","year":"2016","journal-title":"Nature"},{"key":"bib18","doi-asserted-by":"publisher","first-page":"1241","DOI":"10.1016\/j.neuron.2018.11.031","article-title":"Whole-brain functional ultrasound imaging reveals brain modules for visuomotor integration","volume":"100","author":"Mac\u00e9","year":"2018","journal-title":"Neuron"},{"key":"bib19","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1523\/JNEUROSCI.1784-18.2018","article-title":"Molecular fingerprinting of on\u2013off direction-selective retinal ganglion cells across species and relevance to primate visual circuits","volume":"39","author":"Dhande","year":"2019","journal-title":"J Neurosci"},{"key":"bib20","doi-asserted-by":"publisher","first-page":"2529","DOI":"10.1016\/j.cub.2022.04.056","article-title":"Conserved circuits for direction selectivity in the primate retina","volume":"32","author":"Patterson","year":"2022","journal-title":"Curr Biol"},{"key":"bib21","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1016\/0006-8993(81)90209-2","article-title":"Inversion of direction-selectivity to anterior fields in neurons of nucleus of the optic tract in rabbits with ocular albinism","volume":"220","author":"Winterson","year":"1981","journal-title":"Brain Res"},{"key":"bib22","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1007\/s00221-008-1690-4","article-title":"Retinal projections to the accessory optic system in pigmented and albino ferrets (Mustela putorius furo)","volume":"199","author":"Distler","year":"2009","journal-title":"Exp Brain Res"},{"key":"bib23","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/0006-8993(83)90076-8","article-title":"Retinopretectal projections in albino and pigmented rabbits: an autoradiographic study","volume":"288","author":"Klooster","year":"1983","journal-title":"Brain Res"},{"key":"bib24","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1002\/(ISSN)1096-9861","article-title":"Retinopretectal and accessory optic projections of normal mice and the OKN-defective mutant mice beige, beige-J, and pearl","volume":"258","author":"Pak","year":"1987","journal-title":"J Comp Neurol"},{"key":"bib25","doi-asserted-by":"publisher","first-page":"985","DOI":"10.1016\/j.neuron.2015.04.005","article-title":"Contactin-4 mediates axon-target specificity and functional development of the accessory optic system","volume":"86","author":"Osterhout","year":"2015","journal-title":"Neuron"},{"key":"bib26","doi-asserted-by":"publisher","first-page":"2058","DOI":"10.1016\/j.celrep.2017.01.075","article-title":"Diverse central projection patterns of retinal ganglion cells","volume":"18","author":"Martersteck","year":"2017","journal-title":"Cell Rep"},{"key":"bib27","doi-asserted-by":"publisher","first-page":"4392","DOI":"10.1073\/pnas.85.12.4392","article-title":"A cDNA encoding tyrosinase-related protein maps to the brown locus in mouse","volume":"85","author":"Jackson","year":"1988","journal-title":"Proc Natl Acad Sci USA"},{"key":"bib28","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1016\/j.preteyeres.2007.01.001","article-title":"Tyrosinase and ocular diseases: some novel thoughts on the molecular basis of oculocutaneous albinism type 1","volume":"26","author":"Ray","year":"2007","journal-title":"Prog Retin Eye Res"},{"key":"bib29","first-page":"1145","article-title":"Mutation in and lack of expression of tyrosinase-related protein-1 (TRP-1) in melanocytes from an individual with brown oculocutaneous albinism: a new subtype of albinism classified as \u2018OCA3\u2019","volume":"58","author":"Boissy","year":"1996","journal-title":"Am J Hum Genet"},{"key":"bib30","doi-asserted-by":"publisher","first-page":"1095","DOI":"10.1086\/301603","article-title":"Rufous oculocutaneous albinism in southern African Blacks is caused by mutations in the TYRP1 gene","volume":"61","author":"Manga","year":"1997","journal-title":"Am J Hum Genet"},{"key":"bib31","doi-asserted-by":"publisher","first-page":"595","DOI":"10.1017\/S0952523800005794","article-title":"Origins of uncrossed retinofugal projections in normal and hypopigmented mice","volume":"4","author":"Balkema","year":"1990","journal-title":"Vis Neurosci"},{"key":"bib32","doi-asserted-by":"publisher","first-page":"795","DOI":"10.1111\/j.1460-9568.2007.05333.x","article-title":"Screening mouse vision with intrinsic signal optical imaging","volume":"25","author":"Heimel","year":"2007","journal-title":"Eur J Neurosci"},{"key":"bib33","doi-asserted-by":"publisher","first-page":"1577","DOI":"10.1016\/j.neurobiolaging.2006.07.023","article-title":"Age-related changes in visual acuity, learning and memory in C57BL\/6J and DBA\/2J mice","volume":"28","author":"Wong","year":"2007","journal-title":"Neurobiol Aging"},{"key":"bib34","doi-asserted-by":"publisher","first-page":"915","DOI":"10.1111\/gbb.2008.7.issue-8","article-title":"Genetic control of experience-dependent plasticity in the visual cortex","volume":"7","author":"Heimel","year":"2008","journal-title":"Genes Brain Behav"},{"key":"bib35","doi-asserted-by":"publisher","first-page":"2486","DOI":"10.1016\/j.celrep.2016.07.065","article-title":"Population-level neural codes are robust to single-neuron variability from a multidimensional coding perspective","volume":"16","author":"Montijn","year":"2016","journal-title":"Cell Rep"},{"key":"bib39","doi-asserted-by":"publisher","first-page":"436","DOI":"10.1016\/j.yebeh.2010.02.007","article-title":"DBA\/1 mice exhibit chronic susceptibility to audiogenic seizures followed by sudden death associated with respiratory arrest","volume":"17","author":"Faingold","year":"2010","journal-title":"Epilepsy Behav"},{"key":"bib40","first-page":"1","article-title":"What's new in psychtoolbox-3","volume":"36","author":"Kleiner","year":"2007","journal-title":"Perception"},{"key":"bib41","doi-asserted-by":"publisher","first-page":"e71969","DOI":"10.7554\/eLife.71969","article-title":"A parameter-free statistical test for neuronal responsiveness","volume":"10","author":"Montijn","year":"2021","journal-title":"eLife"},{"key":"bib42","doi-asserted-by":"publisher","first-page":"5639","DOI":"10.1523\/JNEUROSCI.22-13-05639.2002","article-title":"Orientation selectivity in macaque V1: diversity and laminar dependence","volume":"22","author":"Ringach","year":"2002","journal-title":"J Neurosci"},{"key":"bib44","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1016\/0006-8993(75)90154-7","article-title":"Direction-selective units in the rabbit's nucleus of the optic tract","volume":"100","author":"Collewijn","year":"1975","journal-title":"Brain Res"},{"key":"bib45","doi-asserted-by":"publisher","first-page":"17797","DOI":"10.1523\/JNEUROSCI.2778-13.2013","article-title":"Genetic dissection of retinal inputs to brainstem nuclei controlling image stabilization","volume":"33","author":"Dhande","year":"2013","journal-title":"J Neurosci"},{"key":"bib46","doi-asserted-by":"publisher","first-page":"1506","DOI":"10.1126\/science.149.3691.1506","article-title":"Uncrossed visual pathways of hooded and albino rats","volume":"149","author":"Lund","year":"1965","journal-title":"Science"},{"key":"bib47","doi-asserted-by":"publisher","first-page":"2274","DOI":"10.1111\/ejn.12572","article-title":"Retinal ganglion cells projecting to the accessory optic system in optokinetic blind albinotic rats are direction-selective","volume":"40","author":"Krause","year":"2014","journal-title":"Eur J Neurosci"},{"key":"bib48","doi-asserted-by":"publisher","first-page":"3389","DOI":"10.1016\/S0042-6989(01)00184-5","article-title":"Directional effect of inactivation of the nucleus of the optic tract on optokinetic nystagmus in the cat","volume":"41","author":"Hoffmann","year":"2001","journal-title":"Vis Res"},{"key":"bib49","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1007\/s00221-009-1722-8","article-title":"Shift of chloride reversal potential in neurons of the accessory optic system in albinotic rats","volume":"199","author":"Krause","year":"2009","journal-title":"Exp Brain Res"},{"key":"bib50","doi-asserted-by":"publisher","first-page":"915","DOI":"10.1113\/jphysiol.2004.076695","article-title":"Identification of ON\u2013OFF direction-selective ganglion cells in the mouse retina","volume":"562","author":"Weng","year":"2005","journal-title":"J Physiol"},{"key":"bib51","doi-asserted-by":"publisher","first-page":"7753","DOI":"10.1523\/JNEUROSCI.0907-11.2011","article-title":"Retinal ganglion cells with distinct directional preferences differ in molecular identity, structure, and central projections","volume":"31","author":"Kay","year":"2011","journal-title":"J Neurosci"},{"key":"bib52","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1016\/j.neuron.2015.11.032","article-title":"Congenital nystagmus gene FRMD7 is necessary for establishing a neuronal circuit asymmetry for direction selectivity","volume":"89","author":"Yonehara","year":"2016","journal-title":"Neuron"},{"key":"bib53","doi-asserted-by":"publisher","first-page":"e3000174","DOI":"10.1371\/journal.pbio.3000174","article-title":"Nystagmus in patients with congenital stationary night blindness (CSNB) originates from synchronously firing retinal ganglion cells","volume":"17","author":"Winkelman","year":"2019","journal-title":"PLoS Biol"},{"key":"bib54","doi-asserted-by":"publisher","first-page":"4206","DOI":"10.1523\/JNEUROSCI.0496-06.2006","article-title":"Light-induced changes in spike synchronization between coupled ON direction selective ganglion cells in the mammalian retina","volume":"26","author":"Ackert","year":"2006","journal-title":"J Neurosci"},{"key":"bib55","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1017\/S095252380000119X","article-title":"Projections of the nucleus of the optic tract to the nucleus reticularis tegmenti pontis and prepositus hypoglossi nucleus in the pigmented rat as demonstrated by anterograde and retrograde transport methods","volume":"2","author":"Korp","year":"1989","journal-title":"Vis Neurosci"},{"key":"bib56","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1007\/s11940-011-0154-5","article-title":"Treatment of nystagmus","volume":"14","author":"Thurtell","year":"2012","journal-title":"Curr Treat Options Neurol"},{"key":"bib14","first-page":"379","article-title":"The pretectum: connections and oculomotor-related roles","volume-title":"Progress in Brain Research","author":"Gamlin","year":"2006"},{"key":"bib36","author":"Montijn"},{"key":"bib37","doi-asserted-by":"crossref","DOI":"10.1101\/2023.01.07.523036","article-title":"Solving the spike sorting problem with Kilosort","author":"Pachitariu","year":"2023"},{"key":"bib38","volume-title":"Allen Mouse Brain Atlas","author":"Allen Institute for Brain Science","year":"2017"},{"key":"bib43","volume-title":"Pattern Recognition and Machine Learning","author":"Bishop","year":"2006"}],"container-title":["Investigative Opthalmology & Visual Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/iovs.arvojournals.org\/article.aspx?articleid=2791377","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:31:46Z","timestamp":1791927106000},"score":1,"resource":{"primary":{"URL":"https:\/\/iovs.arvojournals.org\/article.aspx?articleid=2791377"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8,7]]},"references-count":56,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2023,8,1]]}},"URL":"https:\/\/doi.org\/10.1167\/iovs.64.11.9","relation":{},"ISSN":["1552-5783"],"issn-type":[{"value":"1552-5783","type":"print"}],"subject":[],"published":{"date-parts":[[2023,8,7]]}}}