{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T18:30:03Z","timestamp":1793212203992,"version":"4.5.0"},"reference-count":88,"publisher":"Association for Research in Vision and Ophthalmology (ARVO)","issue":"12","license":[{"start":{"date-parts":[[2023,9,8]],"date-time":"2023-09-08T00:00:00Z","timestamp":1694131200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Invest. Ophthalmol. Vis. Sci."],"published-print":{"date-parts":[[2023,9,8]]},"DOI":"10.1167\/iovs.64.12.13","type":"journal-article","created":{"date-parts":[[2023,9,8]],"date-time":"2023-09-08T11:30:51Z","timestamp":1694172651000},"page":"13","source":"Crossref","is-referenced-by-count":9,"title":["Sympathetic Nerves Coordinate Corneal Epithelial Wound Healing by Controlling the Mobilization of Ly6C\n                    <sup>hi<\/sup>\n                    Monocytes From the Spleen to the Injured Cornea"],"prefix":"10.1167","volume":"64","author":[{"given":"Siyu","family":"He","sequence":"first","affiliation":[{"name":"Key Laboratory of Regenerative Medicine of Ministry of Education, Department of Developmental & Regenerative Biology, Jinan University, Guangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Liu","sequence":"additional","affiliation":[{"name":"International Ocular Surface Research Center, Institute of Ophthalmology, and Jinan University Medical School, Guangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunxia","family":"Xue","sequence":"additional","affiliation":[{"name":"International Ocular Surface Research Center, Institute of Ophthalmology, and Jinan University Medical School, Guangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"Fu","sequence":"additional","affiliation":[{"name":"International Ocular Surface Research Center, Institute of Ophthalmology, and Jinan University Medical School, Guangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhijie","family":"Li","sequence":"additional","affiliation":[{"name":"Key Laboratory of Regenerative Medicine of Ministry of Education, Department of Developmental & Regenerative Biology, Jinan University, Guangzhou, China"},{"name":"International Ocular Surface Research Center, Institute of Ophthalmology, and Jinan University Medical School, Guangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"27","reference":[{"key":"bib1","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1016\/j.clae.2021.02.009","article-title":"CLEAR - Anatomy and physiology of the anterior eye","volume":"44","author":"Downie","year":"2021","journal-title":"Cont Lens Anterior Eye"},{"key":"bib2","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/j.preteyeres.2015.07.002","article-title":"Progress in corneal wound healing","volume":"49","author":"Ljubimov","year":"2015","journal-title":"Prog Retin Eye Res"},{"key":"bib3","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1016\/S1350-9462(99)00007-5","article-title":"Growth factors: importance in wound healing and maintenance of transparency of the cornea","volume":"19","author":"Imanishi","year":"2000","journal-title":"Prog Retin Eye Res"},{"key":"bib4","doi-asserted-by":"publisher","first-page":"108089","DOI":"10.1016\/j.exer.2020.108089","article-title":"Corneal wound healing","volume":"197","author":"Wilson","year":"2020","journal-title":"Exp Eye Res"},{"key":"bib5","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1016\/j.addr.2018.01.006","article-title":"Wound healing in the eye: therapeutic prospects","volume":"126","author":"Ziaei","year":"2018","journal-title":"Adv Drug Deliv Rev"},{"key":"bib6","doi-asserted-by":"publisher","first-page":"100956","DOI":"10.1016\/j.preteyeres.2021.100956","article-title":"Human limbal epithelial stem cell regulation, bioengineering and function.","volume":"85","author":"Bonnet","year":"2021","journal-title":"Prog Retin Eye Res."},{"key":"bib7","doi-asserted-by":"publisher","first-page":"1248","DOI":"10.1016\/j.stem.2021.04.003","article-title":"Discrete limbal epithelial stem cell populations mediate corneal homeostasis and wound healing","volume":"28","author":"Altshuler","year":"2021","journal-title":"Cell Stem Cell"},{"key":"bib8","doi-asserted-by":"publisher","first-page":"1947","DOI":"10.1167\/iovs.05-1193","article-title":"Two waves of neutrophil emigration in response to corneal epithelial abrasion: distinct adhesion molecule requirements","volume":"47","author":"Li","year":"2006","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib9","doi-asserted-by":"publisher","first-page":"2659","DOI":"10.1096\/fsb2.v25.8","article-title":"CCL20, ?d T cells, and IL-22 in corneal epithelial healing","volume":"25","author":"Li","year":"2011","journal-title":"FASEB J"},{"key":"bib10","doi-asserted-by":"publisher","first-page":"1145","DOI":"10.1038\/mi.2016.139","article-title":"CCR2- and CCR2+ corneal macrophages exhibit distinct characteristics and balance inflammatory responses after epithelial abrasion","volume":"10","author":"Liu","year":"2017","journal-title":"Mucosal Immunol"},{"key":"bib11","doi-asserted-by":"publisher","first-page":"1313","DOI":"10.1016\/j.ajpath.2017.02.010","article-title":"Local group 2 innate lymphoid cells promote corneal regeneration after epithelial abrasion","volume":"187","author":"Liu","year":"2017","journal-title":"Am J Pathol"},{"key":"bib12","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1016\/j.it.2018.11.007","article-title":"The mononuclear phagocyte system: the relationship between monocytes and macrophages","volume":"40","author":"Hume","year":"2019","journal-title":"Trends Immunol"},{"key":"bib13","doi-asserted-by":"publisher","first-page":"571","DOI":"10.1038\/nri3712","article-title":"Dendritic cells, monocytes and macrophages: a unified nomenclature based on ontogeny","volume":"14","author":"Guilliams","year":"2014","journal-title":"Nat Rev Immunol"},{"key":"bib14","doi-asserted-by":"publisher","first-page":"595","DOI":"10.1016\/j.immuni.2018.10.005","article-title":"Developmental and functional heterogeneity of monocytes","volume":"49","author":"Guilliams","year":"2018","journal-title":"Immunity"},{"key":"bib15","doi-asserted-by":"publisher","first-page":"1102","DOI":"10.1161\/ATVBAHA.118.310703","article-title":"Ly6CHi blood monocyte\/macrophage drive chronic inflammation and impair wound healing in diabetes mellitus","volume":"38","author":"Kimball","year":"2018","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"bib16","doi-asserted-by":"publisher","first-page":"1205","DOI":"10.1016\/j.immuni.2016.12.001","article-title":"The heterogeneity of Ly6Chi monocytes controls their differentiation into iNOS+ macrophages or monocyte-derived dendritic cells","volume":"45","author":"Menezes","year":"2016","journal-title":"Immunity"},{"key":"bib17","doi-asserted-by":"publisher","first-page":"762","DOI":"10.1038\/nri3070","article-title":"Monocyte recruitment during infection and inflammation","volume":"11","author":"Shi","year":"2011","journal-title":"Nat Rev Immunol"},{"key":"bib18","doi-asserted-by":"publisher","first-page":"1231","DOI":"10.1084\/jem.20032152","article-title":"Role of CCR8 and other chemokine pathways in the migration of monocyte-derived dendritic cells to lymph nodes","volume":"200","author":"Qu","year":"2004","journal-title":"J Exp Med"},{"key":"bib19","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1161\/ATVBAHA.116.308198","article-title":"Monocyte conversion during inflammation and injury","volume":"37","author":"Kratofil","year":"2017","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"bib20","doi-asserted-by":"publisher","first-page":"e86660","DOI":"10.1371\/journal.pone.0086660","article-title":"The monocyte to macrophage transition in the murine sterile wound","volume":"9","author":"Crane","year":"2014","journal-title":"PLoS ONE"},{"key":"bib21","doi-asserted-by":"publisher","first-page":"447","DOI":"10.1084\/jem.20141539","article-title":"A dynamic spectrum of monocytes arising from the in situ reprogramming of CCR2+ monocytes at a site of sterile injury","volume":"212","author":"Dal-Secco","year":"2015","journal-title":"J Exp Med"},{"key":"bib22","doi-asserted-by":"publisher","first-page":"eaau6085","DOI":"10.1126\/sciimmunol.aau6085","article-title":"Structure-function of the immune system in the spleen","volume":"4","author":"Lewis","year":"2019","journal-title":"Sci Immunol"},{"key":"bib23","doi-asserted-by":"publisher","first-page":"806","DOI":"10.1016\/j.immuni.2013.10.010","article-title":"The spleen in local and systemic regulation of immunity","volume":"39","author":"Bronte","year":"2013","journal-title":"Immunity"},{"key":"bib24","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1161\/CIRCRESAHA.118.314331","article-title":"The spleen in myocardial infarction","volume":"124","author":"Heusch","year":"2019","journal-title":"Circ Res"},{"key":"bib25","doi-asserted-by":"publisher","first-page":"612","DOI":"10.1126\/science.1175202","article-title":"Identification of splenic reservoir monocytes and their deployment to inflammatory sites","volume":"325","author":"Swirski","year":"2009","journal-title":"Science"},{"key":"bib26","doi-asserted-by":"publisher","first-page":"2833","DOI":"10.1172\/JCI98436","article-title":"Spleen-derived classical monocytes mediate lung ischemia-reperfusion injury through IL-1beta","volume":"128","author":"Hsiao","year":"2018","journal-title":"J Clin Invest"},{"key":"bib27","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.pharmthera.2017.05.002","article-title":"Cholinergic modulation of the immune system presents new approaches for treating inflammation","volume":"179","author":"Hoover","year":"2017","journal-title":"Pharmacol Ther"},{"key":"bib28","doi-asserted-by":"publisher","first-page":"783","DOI":"10.1146\/immunol.2018.36.issue-1","article-title":"Molecular and functional neuroscience in immunity","volume":"36","author":"Pavlov","year":"2018","journal-title":"Annu Rev Immunol"},{"key":"bib29","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1146\/immunol.2019.37.issue-1","article-title":"Neuro-immune cell units: a new paradigm in physiology","volume":"37","author":"Godinho-Silva","year":"2019","journal-title":"Annu Rev Immunol"},{"key":"bib30","doi-asserted-by":"publisher","first-page":"464","DOI":"10.1016\/j.immuni.2020.02.017","article-title":"Neuro-immune interactions in the tissues","volume":"52","author":"Chu","year":"2020","journal-title":"Immunity"},{"key":"bib31","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1038\/s41583-021-00555-4","article-title":"Somatosensory and autonomic neuronal regulation of the immune response","volume":"23","author":"Udit","year":"2022","journal-title":"Nat Rev Neurosci"},{"key":"bib32","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1146\/neuro.2022.45.issue-1","article-title":"Neuroimmune interactions in peripheral organs","volume":"45","author":"Klein Wolterink","year":"2022","journal-title":"Annu Rev Neurosci"},{"key":"bib33","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1016\/j.bbi.2018.12.009","article-title":"Innervation of the human spleen: a complete hilum-embedding approach","volume":"77","author":"Verlinden","year":"2019","journal-title":"Brain Behav Immun"},{"key":"bib34","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1002\/(ISSN)1097-4547","article-title":"Noradrenergic sympathetic innervation of the spleen: II. Tyrosine hydroxylase (TH)-positive nerve terminals form synapticlike contacts on lymphocytes in the splenic white pulp","volume":"18","author":"Felten","year":"1987","journal-title":"J Neurosci Res"},{"key":"bib35","doi-asserted-by":"publisher","first-page":"e0182416","DOI":"10.1371\/journal.pone.0182416","article-title":"Neuroanatomy of the spleen: mapping the relationship between sympathetic neurons and lymphocytes","volume":"12","author":"Murray","year":"2017","journal-title":"PLoS ONE"},{"key":"bib36","doi-asserted-by":"publisher","first-page":"1188","DOI":"10.3390\/ijms19041188","article-title":"Sympathetic nerve hyperactivity in the spleen: causal for nonpathogenic-driven chronic immune-mediated inflammatory diseases (IMIDs)?","volume":"19","author":"Bellinger","year":"2018","journal-title":"Int J Mol Sci"},{"key":"bib37","first-page":"1827","article-title":"Central injection of leptin increases sympathetic nerve outflows to the stomach and spleen in anesthetized rats","volume":"33","author":"Tanida","year":"2019","journal-title":"In Vivo (Athens, Greece)"},{"key":"bib38","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1016\/j.immuni.2018.05.004","article-title":"Sympathetic neuronal activation triggers myeloid progenitor proliferation and differentiation","volume":"49","author":"Vasamsetti","year":"2018","journal-title":"Immunity"},{"key":"bib39","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1016\/j.semcdb.2016.08.010","article-title":"It takes nerve to fight back: the significance of neural innervation of the bone marrow and spleen for immune function","volume":"61","author":"Jung","year":"2017","journal-title":"Semin Cell Dev Biol"},{"key":"bib40","doi-asserted-by":"publisher","first-page":"3799","DOI":"10.1016\/j.celrep.2019.05.082","article-title":"Panicle-shaped sympathetic architecture in the spleen parenchyma modulates antibacterial innate immunity","volume":"27","author":"Ding","year":"2019","journal-title":"Cell Rep"},{"key":"bib41","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1126\/science.1209985","article-title":"Acetylcholine-synthesizing T cells relay neural signals in a vagus nerve circuit","volume":"334","author":"Rosas-Ballina","year":"2011","journal-title":"Science"},{"key":"bib42","doi-asserted-by":"publisher","first-page":"282","DOI":"10.1186\/s12974-020-01945-8","article-title":"Splenic sympathetic signaling contributes to acute neutrophil infiltration of the injured spinal cord","volume":"17","author":"Monteiro","year":"2020","journal-title":"J Neuroinflammation"},{"key":"bib43","doi-asserted-by":"publisher","first-page":"109065","DOI":"10.1016\/j.exer.2022.109065","article-title":"Autonomic nervous system receptor-mediated regulation of mast cell degranulation modulates the inflammation after corneal epithelial abrasion","volume":"219","author":"Li","year":"2022","journal-title":"Exp Eye Res"},{"key":"bib44","doi-asserted-by":"publisher","first-page":"1496","DOI":"10.1038\/s41385-018-0031-6","article-title":"The mouse autonomic nervous system modulates inflammation and epithelial renewal after corneal abrasion through the activation of distinct local macrophages","volume":"11","author":"Xue","year":"2018","journal-title":"Mucosal Immunol"},{"key":"bib45","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1038\/s42003-018-0270-9","article-title":"Acute tobacco smoke exposure exacerbates the inflammatory response to corneal wounds in mice via the sympathetic nervous system","volume":"2","author":"Xiao","year":"2019","journal-title":"Commun Biol"},{"key":"bib46","doi-asserted-by":"publisher","first-page":"1106","DOI":"10.1016\/j.ajpath.2010.12.001","article-title":"IL-17 and VEGF are necessary for efficient corneal nerve regeneration","volume":"178","author":"Li","year":"2011","journal-title":"Am J Pathol"},{"key":"bib47","doi-asserted-by":"publisher","first-page":"452","DOI":"10.1016\/j.ajpath.2012.04.010","article-title":"NK cells modulate the inflammatory response to corneal epithelial abrasion and thereby support wound healing","volume":"181","author":"Liu","year":"2012","journal-title":"Am J Pathol"},{"key":"bib48","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1016\/j.bbi.2014.01.007","article-title":"The sympathetic nervous system modulates CD4(+)Foxp3(+) regulatory T cells via noradrenaline-dependent apoptosis in a murine model of lymphoproliferative disease","volume":"38","author":"Wirth","year":"2014","journal-title":"Brain Behav Immun"},{"key":"bib49","doi-asserted-by":"publisher","first-page":"855","DOI":"10.1089\/hum.2018.197","article-title":"Salmeterol with liver depot gene therapy enhances the skeletal muscle response in murine Pompe disease","volume":"30","author":"Han","year":"2019","journal-title":"Hum Gene Ther"},{"issue":"3","key":"bib50","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1016\/j.biopsych.2009.02.029","article-title":"Reward processing after catecholamine depletion in unmedicated, remitted subjects with major depressive disorder.","volume":"66","author":"Hasler","year":"2009","journal-title":"Biol Psychiatry"},{"key":"bib51","doi-asserted-by":"publisher","first-page":"2364","DOI":"10.1002\/hep.30510","article-title":"Ly6C(+) monocytes and Kupffer cells orchestrate liver immune responses against hepatitis B virus in mice","volume":"69","author":"Wu","year":"2019","journal-title":"Hepatology"},{"key":"bib52","doi-asserted-by":"publisher","first-page":"1443","DOI":"10.2337\/db20-1121","article-title":"Fgf15 neurons of the dorsomedial hypothalamus control glucagon secretion and hepatic gluconeogenesis","volume":"70","author":"Picard","year":"2021","journal-title":"Diabetes"},{"key":"bib53","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1038\/s41586-020-2235-7","article-title":"Brain control of humoral immune responses amenable to behavioural modulation","volume":"581","author":"Zhang","year":"2020","journal-title":"Nature"},{"key":"bib54","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1007\/978-1-0716-1425-9","article-title":"Flow cytometry-based analysis of the mouse bone marrow stromal and perivascular compartment","volume":"2308","author":"Matsushita","year":"2021","journal-title":"Methods Mol Biol"},{"key":"bib55","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1007\/978-1-4939-8570-8","article-title":"Isolation and characterization of mouse neutrophils","volume":"1809","author":"Ubags","year":"2018","journal-title":"Methods Mol Biol"},{"key":"bib56","doi-asserted-by":"publisher","first-page":"306","DOI":"10.1590\/S0102-865020150050000001","article-title":"Effect of total splenectomy in the lipid profile in mice","volume":"30","author":"Demuner","year":"2015","journal-title":"Acta Cir Bras"},{"key":"bib57","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1016\/j.bpsgos.2021.05.004","article-title":"Splenic denervation attenuates repeated social defeat stress-induced T-lymphocyte inflammation","volume":"1","author":"Elkhatib","year":"2021","journal-title":"Biol Psychiatry Glob Open Sci"},{"key":"bib58","doi-asserted-by":"publisher","first-page":"R31","DOI":"10.1186\/ar3735","article-title":"Direct transplantation of mesenchymal stem cells into the knee joints of Hartley strain guinea pigs with spontaneous osteoarthritis","volume":"14","author":"Sato","year":"2012","journal-title":"Arthritis Res Ther"},{"key":"bib59","doi-asserted-by":"publisher","first-page":"2038","DOI":"10.1167\/iovs.18-26030","article-title":"Short-term high fructose intake reprograms the transcriptional clock rhythm of the murine extraorbital lacrimal gland","volume":"60","author":"Lu","year":"2019","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib60","doi-asserted-by":"publisher","first-page":"1044","DOI":"10.1080\/02713683.2019.1625408","article-title":"Transcriptional profiling of daily patterns of mRNA expression in the C57BL\/6J mouse cornea","volume":"44","author":"Jiao","year":"2019","journal-title":"Curr Eye Res"},{"key":"bib61","doi-asserted-by":"publisher","first-page":"550","DOI":"10.1186\/s13059-014-0550-8","article-title":"Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2","volume":"15","author":"Love","year":"2014","journal-title":"Genome Biol"},{"key":"bib62","doi-asserted-by":"publisher","first-page":"284","DOI":"10.1089\/omi.2011.0118","article-title":"clusterProfiler: an R package for comparing biological themes among gene clusters","volume":"16","author":"Yu","year":"2012","journal-title":"Omics"},{"key":"bib63","first-page":"100141","article-title":"clusterProfiler 4.0: a universal enrichment tool for interpreting omics data","volume":"2","author":"Wu","year":"2021","journal-title":"Innovation (Camb)"},{"key":"bib64","doi-asserted-by":"publisher","first-page":"1865","DOI":"10.1167\/iovs.16-21154","article-title":"Modulation of circadian rhythms affects corneal epithelium renewal and repair in mice","volume":"58","author":"Xue","year":"2017","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib65","doi-asserted-by":"publisher","first-page":"1947","DOI":"10.1167\/iovs.05-1193","article-title":"Two waves of neutrophil emigration in response to corneal epithelial abrasion: distinct adhesion molecule requirements","volume":"47","author":"Li","year":"2006","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib66","doi-asserted-by":"publisher","first-page":"641","DOI":"10.1152\/japplphysiol.00200.2004","article-title":"Hindlimb unloading depresses corneal epithelial wound healing in mice","volume":"97","author":"Li","year":"2004","journal-title":"J Appl Physiol"},{"key":"bib67","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1007\/978-1-0716-0385-7","article-title":"Assessing immune responses in the nonobese diabetic mouse model of type 1 diabetes","volume":"2128","author":"Thayer","year":"2020","journal-title":"Methods Mol Biol"},{"key":"bib68","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1007\/978-1-0716-0266-9","article-title":"Characterization of immune cell subset expansion in response to therapeutic treatment in mice","volume":"2111","author":"Tomala","year":"2020","journal-title":"Methods Mol Biol"},{"key":"bib69","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1097\/00003226-199209000-00009","article-title":"Subconjunctival injection of purified blood mononuclear cells into alkali-injured rabbit eyes","volume":"11","author":"John","year":"1992","journal-title":"Cornea"},{"key":"bib70","first-page":"199","article-title":"Pharmacological actions of 6-hydroxydopamine","volume":"26","author":"Kostrzewa","year":"1974","journal-title":"Pharmacologic Rev"},{"key":"bib71","doi-asserted-by":"publisher","first-page":"635","DOI":"10.1016\/j.it.2019.05.001","article-title":"The healing power of neutrophils","volume":"40","author":"Phillipson","year":"2019","journal-title":"Trends Immunol"},{"key":"bib72","doi-asserted-by":"publisher","first-page":"2983","DOI":"10.1172\/JCI124618","article-title":"Innate immune cell-epithelial crosstalk during wound repair","volume":"129","author":"Brazil","year":"2019","journal-title":"J Clin Invest"},{"key":"bib73","doi-asserted-by":"publisher","first-page":"1076","DOI":"10.1016\/j.immuni.2012.08.026","article-title":"Ly6C hi monocytes in the inflamed colon give rise to proinflammatory effector cells and migratory antigen-presenting cells","volume":"37","author":"Zigmond","year":"2012","journal-title":"Immunity"},{"key":"bib74","doi-asserted-by":"publisher","first-page":"e130807","DOI":"10.1172\/jci.insight.130807","article-title":"Splenic Ly6Chi monocytes are critical players in dystrophic muscle injury and repair","volume":"5","author":"Rizzo","year":"2020","journal-title":"JCI Insight"},{"key":"bib75","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1016\/j.immuni.2018.05.004","article-title":"Sympathetic neuronal activation triggers myeloid progenitor proliferation and differentiation","volume":"49","author":"Vasamsetti","year":"2018","journal-title":"Immunity"},{"key":"bib76","doi-asserted-by":"publisher","first-page":"3425","DOI":"10.1172\/JCI97973","article-title":"Spleen mediates a distinct hematopoietic progenitor response supporting tumor-promoting myelopoiesis","volume":"128","author":"Wu","year":"2018","journal-title":"J Clin Invest"},{"key":"bib77","doi-asserted-by":"publisher","first-page":"e20211498","DOI":"10.1084\/jem.20211498","article-title":"PERK reprograms hematopoietic progenitor cells to direct tumor-promoting myelopoiesis in the spleen","volume":"219","author":"Liu","year":"2022","journal-title":"J Exp Med"},{"key":"bib78","doi-asserted-by":"publisher","first-page":"282","DOI":"10.1111\/joa.v239.2","article-title":"Sympathetic nerve distribution in human lymph nodes","volume":"239","author":"Cleypool","year":"2021","journal-title":"J Anat"},{"key":"bib79","doi-asserted-by":"publisher","first-page":"736","DOI":"10.1016\/j.bbi.2007.03.008","article-title":"Autonomic innervation and regulation of the immune system (1987-2007)","volume":"21","author":"Nance","year":"2007","journal-title":"Brain Behav Immun"},{"key":"bib80","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1016\/j.autneu.2014.01.004","article-title":"Sympathetic nervous system and inflammation: a conceptual view","volume":"182","author":"J\u00e4nig","year":"2014","journal-title":"Auton Neurosci"},{"key":"bib81","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1016\/0889-1591(89)90028-7","article-title":"Innervation of the spleen in the rat: evidence for absence of afferent innervation","volume":"3","author":"Nance","year":"1989","journal-title":"Brain Behav Immun"},{"key":"bib82","doi-asserted-by":"publisher","first-page":"e0182416","DOI":"10.1371\/journal.pone.0182416","article-title":"Neuroanatomy of the spleen: mapping the relationship between sympathetic neurons and lymphocytes","volume":"12","author":"Murray","year":"2017","journal-title":"PLoS ONE"},{"key":"bib83","doi-asserted-by":"publisher","first-page":"447","DOI":"10.1038\/s41598-017-00477-1","article-title":"Non-classical monocytes are biased progenitors of wound healing macrophages during soft tissue injury","volume":"7","author":"Olingy","year":"2017","journal-title":"Sci Rep"},{"key":"bib84","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1055\/s-0039-3400959","article-title":"Ly6CLo monocyte\/macrophages are essential for thrombus resolution in a murine model of venous thrombosis","volume":"120","author":"Kimball","year":"2020","journal-title":"Thromb Haemost"},{"key":"bib85","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1038\/nature20611","article-title":"Identification of an atypical monocyte and committed progenitor involved in fibrosis","volume":"541","author":"Satoh","year":"2017","journal-title":"Nature"},{"key":"bib86","doi-asserted-by":"publisher","first-page":"1627","DOI":"10.1084\/jem.20180247","article-title":"Peripherally derived macrophages can engraft the brain independent of irradiation and maintain an identity distinct from microglia","volume":"215","author":"Cronk","year":"2018","journal-title":"J Exp Med"},{"key":"bib87","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1084\/jem.20101387","article-title":"Inflammation switches the differentiation program of Ly6Chi monocytes from antiinflammatory macrophages to inflammatory dendritic cells in the colon","volume":"209","author":"Rivollier","year":"2012","journal-title":"J Exp Med"},{"key":"bib88","doi-asserted-by":"publisher","first-page":"eaax6085","DOI":"10.1126\/sciimmunol.aax6085","article-title":"IRF5 guides monocytes toward an inflammatory CD11c(+) macrophage phenotype and promotes intestinal inflammation","volume":"5","author":"Corbin","year":"2020","journal-title":"Sci Immunol"}],"container-title":["Investigative Opthalmology &amp; Visual Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/iovs.arvojournals.org\/article.aspx?articleid=2792742","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:31:38Z","timestamp":1791927098000},"score":1,"resource":{"primary":{"URL":"https:\/\/iovs.arvojournals.org\/article.aspx?articleid=2792742"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9,8]]},"references-count":88,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2023,9,1]]}},"URL":"https:\/\/doi.org\/10.1167\/iovs.64.12.13","relation":{},"ISSN":["1552-5783"],"issn-type":[{"value":"1552-5783","type":"print"}],"subject":[],"published":{"date-parts":[[2023,9,8]]}}}