{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T22:00:20Z","timestamp":1791928820054,"version":"4.3.4"},"reference-count":42,"publisher":"Association for Research in Vision and Ophthalmology (ARVO)","issue":"12","license":[{"start":{"date-parts":[[2023,9,15]],"date-time":"2023-09-15T00:00:00Z","timestamp":1694736000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Invest. Ophthalmol. Vis. Sci."],"published-print":{"date-parts":[[2023,9,15]]},"DOI":"10.1167\/iovs.64.12.28","type":"journal-article","created":{"date-parts":[[2023,9,15]],"date-time":"2023-09-15T11:30:52Z","timestamp":1694777452000},"page":"28","source":"Crossref","is-referenced-by-count":33,"title":["Therapeutic Effects of Upadacitinib on Experimental Autoimmune Uveitis: Insights From Single-Cell Analysis"],"prefix":"10.1167","volume":"64","author":[{"given":"Zhaohao","family":"Huang","sequence":"first","affiliation":[{"name":"State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Jiang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junjie","family":"Chen","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiuxing","family":"Liu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenyang","family":"Gu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianyu","family":"Tao","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianjie","family":"Lv","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaohuai","family":"Li","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zuohong","family":"Li","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenru","family":"Su","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"27","reference":[{"key":"bib1","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1016\/j.ophtha.2003.06.014","article-title":"Incidence and prevalence of uveitis in Northern California; the Northern California Epidemiology of Uveitis Study","volume":"111","author":"Gritz","year":"2004","journal-title":"Ophthalmology"},{"key":"bib2","doi-asserted-by":"publisher","first-page":"2503","DOI":"10.1016\/S0140-6736(18)31115-2","article-title":"Safety and efficacy of upadacitinib in patients with rheumatoid arthritis and inadequate response to conventional synthetic disease-modifying anti-rheumatic drugs (SELECT-NEXT): a randomised, double-blind, placebo-controlled phase 3 trial","volume":"391","author":"Burmester","year":"2018","journal-title":"Lancet"},{"key":"bib3","doi-asserted-by":"publisher","first-page":"1227","DOI":"10.1056\/NEJMoa2022516","article-title":"Trial of upadacitinib and adalimumab for psoriatic arthritis","volume":"384","author":"McInnes","year":"2021","journal-title":"N Engl J Med"},{"key":"bib4","doi-asserted-by":"publisher","first-page":"1047","DOI":"10.1001\/jamadermatol.2021.3023","article-title":"Efficacy and safety of upadacitinib vs dupilumab in adults with moderate-to-severe atopic dermatitis: a randomized clinical trial","volume":"157","author":"Blauvelt","year":"2021","journal-title":"JAMA Dermatol"},{"key":"bib5","doi-asserted-by":"publisher","first-page":"2427","DOI":"10.1016\/j.cgh.2023.03.040","article-title":"Comparative effectiveness of upadacitinib and tofacitinib in inducing remission in ulcerative colitis: real-world data","volume":"21","author":"Boneschansker","year":"2023","journal-title":"Clin Gastroenterol Hepatol"},{"key":"bib6","doi-asserted-by":"publisher","first-page":"1966","DOI":"10.1056\/NEJMoa2212728","article-title":"Upadacitinib Induction and Maintenance Therapy for Crohn's Disease","volume":"388","author":"Loftus","year":"2023","journal-title":"N Engl J Med"},{"key":"bib7","doi-asserted-by":"publisher","first-page":"2108","DOI":"10.1016\/S0140-6736(19)32534-6","article-title":"Efficacy and safety of upadacitinib in patients with active ankylosing spondylitis (SELECT-AXIS 1): a multicentre, randomised, double-blind, placebo-controlled, phase 2\/3 trial","volume":"394","author":"van der Heijde","year":"2019","journal-title":"Lancet"},{"key":"bib8","doi-asserted-by":"publisher","first-page":"2139","DOI":"10.1053\/j.gastro.2020.02.030","article-title":"Efficacy of upadacitinib in a randomized trial of patients with active ulcerative colitis","volume":"158","author":"Sandborn","year":"2020","journal-title":"Gastroenterology"},{"key":"bib9","doi-asserted-by":"publisher","first-page":"2123","DOI":"10.1053\/j.gastro.2020.01.047","article-title":"Efficacy and safety of upadacitinib in a randomized trial of patients with Crohn's disease","volume":"158","author":"Sandborn","year":"2020","journal-title":"Gastroenterology"},{"key":"bib10","doi-asserted-by":"publisher","first-page":"1511","DOI":"10.1056\/NEJMoa2008250","article-title":"Trial of upadacitinib or abatacept in rheumatoid arthritis","volume":"383","author":"Rubbert-Roth","year":"2020","journal-title":"N Engl J Med"},{"key":"bib11","doi-asserted-by":"publisher","first-page":"8597","DOI":"10.1021\/acs.jmedchem.8b00917","article-title":"Dual inhibition of TYK2 and JAK1 for the treatment of autoimmune diseases: discovery of ((S)-2,2-difluorocyclopropyl)((1R,5S)-3-(2-((1-methyl-1H-pyrazol-4-yl)amino)pyrimidin-4-yl)-3,8-diazabicyclo[3.2.1]octan-8-yl)methanone (PF-06700841)","volume":"61","author":"Fensome","year":"2018","journal-title":"J Med Chem"},{"key":"bib12","doi-asserted-by":"publisher","first-page":"262","DOI":"10.1111\/exd.v30.2","article-title":"The inflammation in cutaneous lichen planus is dominated by IFN-? and IL-21-A basis for therapeutic JAK1 inhibition","volume":"30","author":"Pietschke","year":"2021","journal-title":"Exp Dermatol"},{"key":"bib13","doi-asserted-by":"publisher","first-page":"1888","DOI":"10.1016\/j.cell.2019.05.031","article-title":"Comprehensive integration of single-cell data","volume":"177","author":"Stuart","year":"2019","journal-title":"Cell"},{"key":"bib14","doi-asserted-by":"publisher","first-page":"423","DOI":"10.1038\/s41579-018-0020-5","article-title":"ISG15 in antiviral immunity and beyond","volume":"16","author":"Perng","year":"2018","journal-title":"Nat Rev Microbiol"},{"key":"bib15","doi-asserted-by":"publisher","first-page":"647","DOI":"10.1016\/S0002-9394(01)00925-4","article-title":"Revised diagnostic criteria for Vogt-Koyanagi-Harada disease: report of an international committee on nomenclature","volume":"131","author":"Read","year":"2001","journal-title":"Am J Ophthalmol"},{"key":"bib16","first-page":"395","article-title":"Rodent models of experimental autoimmune uveitis","volume":"102","author":"Agarwal","year":"2004","journal-title":"Methods Mol Med"},{"key":"bib17","doi-asserted-by":"publisher","first-page":"3573","DOI":"10.1016\/j.cell.2021.04.048","article-title":"Integrated analysis of multimodal single-cell data","volume":"184","author":"Hao","year":"2021","journal-title":"Cell"},{"key":"bib18","doi-asserted-by":"publisher","first-page":"1523","DOI":"10.1038\/s41467-019-09234-6","article-title":"Metascape provides a biologist-oriented resource for the analysis of systems-level datasets","volume":"10","author":"Zhou","year":"2019","journal-title":"Nat Commun"},{"key":"bib19","doi-asserted-by":"publisher","first-page":"1","DOI":"10.18637\/jss.v035.b01","article-title":"ggplot2: elegant graphics for data analysis","volume":"35","author":"Valero-Mora","year":"2010","journal-title":"J Stat Softw"},{"key":"bib20","doi-asserted-by":"publisher","first-page":"1088","DOI":"10.1038\/s41467-021-21246-9","article-title":"Inference and analysis of cell-cell communication using CellChat","volume":"12","author":"Jin","year":"2021","journal-title":"Nat Commun"},{"key":"bib21","doi-asserted-by":"publisher","first-page":"1333","DOI":"10.1038\/s41592-021-01282-5","article-title":"Single-cell chromatin state analysis with Signac","volume":"18","author":"Stuart","year":"2021","journal-title":"Nat Methods"},{"key":"bib22","doi-asserted-by":"publisher","first-page":"472","DOI":"10.1016\/j.stem.2020.11.015","article-title":"Integrative single-cell RNA-seq and ATAC-seq analysis of human developmental hematopoiesis","volume":"28","author":"Ranzoni","year":"2021","journal-title":"Cell Stem Cell"},{"key":"bib23","doi-asserted-by":"publisher","first-page":"2938","DOI":"10.1093\/bioinformatics\/btx364","article-title":"UpSetR: an R package for the visualization of intersecting sets and their properties","volume":"33","author":"Conway","year":"2017","journal-title":"Bioinformatics"},{"key":"bib24","doi-asserted-by":"publisher","first-page":"9848","DOI":"10.3390\/ijms23179848","article-title":"Potential application of leelamine as a novel regulator of chemokine-induced epithelial-to-mesenchymal transition in breast cancer cells","volume":"23","author":"Jung","year":"2022","journal-title":"Int J Mol Sci"},{"key":"bib25","doi-asserted-by":"publisher","first-page":"e141573","DOI":"10.1172\/JCI141573","article-title":"Congenital deficiency reveals critical role of ISG15 in skin homeostasis","volume":"132","author":"Malik","year":"2022","journal-title":"J Clin Invest"},{"key":"bib26","doi-asserted-by":"publisher","first-page":"5866","DOI":"10.1038\/s41467-022-33502-7","article-title":"Multicellular immune dynamics implicate PIM1 as a potential therapeutic target for uveitis","volume":"13","author":"Li","year":"2022","journal-title":"Nat Commun"},{"key":"bib27","doi-asserted-by":"publisher","first-page":"2498","DOI":"10.1101\/gr.1239303","article-title":"Cytoscape: a software environment for integrated models of biomolecular interaction networks","volume":"13","author":"Shannon","year":"2003","journal-title":"Genome Res"},{"key":"bib28","doi-asserted-by":"publisher","first-page":"23356","DOI":"10.1038\/s41598-021-02642-z","article-title":"PCBP1 regulates the transcription and alternative splicing of metastasis-related genes and pathways in hepatocellular carcinoma","volume":"11","author":"Huang","year":"2021","journal-title":"Sci Rep"},{"key":"bib29","doi-asserted-by":"publisher","first-page":"8398","DOI":"10.1038\/s41598-022-12594-7","article-title":"PCBP1 is associated with rheumatoid arthritis by affecting RNA products of genes involved in immune response in Th1 cells","volume":"12","author":"Cao","year":"2022","journal-title":"Sci Rep"},{"key":"bib30","doi-asserted-by":"publisher","first-page":"4459","DOI":"10.1096\/fsb2.v24.11","article-title":"A small-molecule inhibitor of macrophage migration inhibitory factor for the treatment of inflammatory disease","volume":"24","author":"Kithcart","year":"2010","journal-title":"FASEB J"},{"key":"bib31","doi-asserted-by":"publisher","first-page":"176","DOI":"10.1016\/j.semcancer.2019.12.007","article-title":"The CXCL12-CXCR4\/CXCR7 axis as a mechanism of immune resistance in gastrointestinal malignancies","volume":"65","author":"Daniel","year":"2020","journal-title":"Semin Cancer Biol"},{"key":"bib32","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1038\/s41392-021-00791-1","article-title":"The JAK\/STAT signaling pathway: from bench to clinic","volume":"6","author":"Hu","year":"2021","journal-title":"Signal Transduct Target Ther"},{"key":"bib33","doi-asserted-by":"publisher","first-page":"2002","DOI":"10.3390\/cancers11122002","article-title":"JAK-STAT signaling: a double-edged sword of immune regulation and cancer progression","volume":"11","author":"Owen","year":"2019","journal-title":"Cancers (Basel)"},{"key":"bib34","doi-asserted-by":"publisher","first-page":"1504","DOI":"10.1136\/ard-2022-222605","article-title":"Age-associated B cells contribute to the pathogenesis of rheumatoid arthritis by inducing activation of fibroblast-like synoviocytes via TNF-a-mediated ERK1\/2 and JAK-STAT1 pathways","volume":"81","author":"Qin","year":"2022","journal-title":"Ann Rheum Dis"},{"key":"bib35","doi-asserted-by":"publisher","first-page":"ii3","DOI":"10.1093\/rheumatology\/keab024","article-title":"JAK1: number one in the family; number one in inflammation?","volume":"60","author":"Spinelli","year":"2021","journal-title":"Rheumatology (Oxford)"},{"key":"bib36","doi-asserted-by":"publisher","first-page":"962393","DOI":"10.3389\/fimmu.2022.962393","article-title":"Identification of key interferon-stimulated genes for indicating the condition of patients with systemic lupus erythematosus","volume":"13","author":"Shen","year":"2022","journal-title":"Front Immunol"},{"key":"bib37","doi-asserted-by":"publisher","first-page":"6458","DOI":"10.1038\/s41467-022-34145-4","article-title":"Single-cell profiling reveals distinct adaptive immune hallmarks in MDA5+ dermatomyositis with therapeutic implications","volume":"13","author":"Ye","year":"2022","journal-title":"Nat Commun"},{"key":"bib38","doi-asserted-by":"publisher","first-page":"25712","DOI":"10.1073\/pnas.2002476117","article-title":"Genetic landscape and autoimmunity of monocytes in developing Vogt-Koyanagi-Harada disease","volume":"117","author":"Hu","year":"2020","journal-title":"Proc Natl Acad Sci USA"},{"key":"bib39","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1136\/bjo.70.1.60","article-title":"Complement activation in uveitis","volume":"70","author":"Vergani","year":"1986","journal-title":"Br J Ophthalmol"},{"key":"bib40","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1016\/j.molimm.2010.08.006","article-title":"Suppression of complement activation by recombinant Crry inhibits experimental autoimmune anterior uveitis (EAAU)","volume":"48","author":"Manickam","year":"2010","journal-title":"Mol Immunol"},{"key":"bib41","doi-asserted-by":"publisher","first-page":"902","DOI":"10.1038\/s41590-019-0398-x","article-title":"The immune cell landscape in kidneys of patients with lupus nephritis","volume":"20","author":"Arazi","year":"2019","journal-title":"Nat Immunol"},{"key":"bib42","doi-asserted-by":"publisher","first-page":"726747","DOI":"10.3389\/fimmu.2021.726747","article-title":"Identifying immune cell infiltration and effective diagnostic biomarkers in rheumatoid arthritis by bioinformatics analysis","volume":"12","author":"Zhou","year":"2021","journal-title":"Front Immunol"}],"container-title":["Investigative Opthalmology & Visual Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/iovs.arvojournals.org\/article.aspx?articleid=2792759","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:31:42Z","timestamp":1791927102000},"score":1,"resource":{"primary":{"URL":"https:\/\/iovs.arvojournals.org\/article.aspx?articleid=2792759"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9,15]]},"references-count":42,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2023,9,1]]}},"URL":"https:\/\/doi.org\/10.1167\/iovs.64.12.28","relation":{},"ISSN":["1552-5783"],"issn-type":[{"value":"1552-5783","type":"print"}],"subject":[],"published":{"date-parts":[[2023,9,15]]}}}