{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T22:00:22Z","timestamp":1791928822951,"version":"4.3.4"},"reference-count":76,"publisher":"Association for Research in Vision and Ophthalmology (ARVO)","issue":"12","license":[{"start":{"date-parts":[[2023,9,26]],"date-time":"2023-09-26T00:00:00Z","timestamp":1695686400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Invest. Ophthalmol. Vis. Sci."],"published-print":{"date-parts":[[2023,9,26]]},"DOI":"10.1167\/iovs.64.12.40","type":"journal-article","created":{"date-parts":[[2023,9,26]],"date-time":"2023-09-26T09:31:16Z","timestamp":1695720676000},"page":"40","source":"Crossref","is-referenced-by-count":13,"title":["Role of Fibroblast Growth Factor Receptor 2 (FGFR2) in Corneal Stromal Thinning"],"prefix":"10.1167","volume":"64","author":[{"given":"Roy","family":"Joseph","sequence":"first","affiliation":[{"name":"Department of Optometry and Vision Science, School of Optometry, University of Alabama at Birmingham, Birmingham, Alabama, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akosua","family":"Boateng","sequence":"additional","affiliation":[{"name":"Department of Optometry and Vision Science, School of Optometry, University of Alabama at Birmingham, Birmingham, Alabama, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Om P.","family":"Srivastava","sequence":"additional","affiliation":[{"name":"Department of Optometry and Vision Science, School of Optometry, University of Alabama at Birmingham, Birmingham, Alabama, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roswell R.","family":"Pfister","sequence":"additional","affiliation":[{"name":"The Eye Research Foundation, Birmingham, Alabama, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"27","reference":[{"key":"bib2","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/0002-9394(86)90817-2","article-title":"A 48-year old clinical epidemiological study of keratoconus","volume":"10","author":"Kennedy","year":"1986","journal-title":"Am J Ophthalmol"},{"key":"bib3","doi-asserted-by":"publisher","first-page":"3685","DOI":"10.1167\/iovs.16-19105","article-title":"Modeling keratoconus using induced pluripotent stem cellsmodeling keratoconus using iPSC","volume":"57","author":"Joseph","year":"2016","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib4","doi-asserted-by":"publisher","first-page":"520","DOI":"10.1016\/j.stemcr.2014.03.001","article-title":"Detailed analysis of the genetic and epigenetic signatures of iPSC-derived mesodiencephalic dopaminergic neurons","volume":"2","author":"Roessler","year":"2014","journal-title":"Stem Cell Reports"},{"key":"bib5","doi-asserted-by":"publisher","first-page":"5672","DOI":"10.1073\/pnas.95.10.5672","article-title":"Neuronal defects and delayed wound healing in mice lacking fibroblast growth factor 2","volume":"95","author":"Ortega","year":"1998","journal-title":"Proc Natl Acad Sci USA"},{"key":"bib6","doi-asserted-by":"publisher","first-page":"166","DOI":"10.1038\/nrm3528","article-title":"Exploring mechanisms of FGF signalling through the lens of structural biology","volume":"14","author":"Goetz","year":"2013","journal-title":"Nat Rev Mol Cell Biol"},{"key":"bib7","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1016\/j.cytogfr.2005.01.001","article-title":"Cellular signaling by fibroblast growth factor receptors","volume":"16","author":"Eswarakumar","year":"2005","journal-title":"Cytokine Growth Factor Rev"},{"key":"bib8","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1038\/nrc2780","article-title":"Fibroblast growth factor signalling: from development to cancer","volume":"10","author":"Turner","year":"2010","journal-title":"Nat Rev Cancer"},{"key":"bib9","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1038\/nrd2792","article-title":"The FGF family: biology, pathophysiology and therapy","volume":"8","author":"Beenken","year":"2009","journal-title":"Nat Rev Drug Discov"},{"key":"bib10","doi-asserted-by":"publisher","first-page":"678","DOI":"10.1038\/358678a0","article-title":"Point mutation of an FGF receptor abolishes phosphatidylinositol turnover and Ca2+ flux but not mitogenesis","volume":"358","author":"Peters","year":"1992","journal-title":"Nature"},{"key":"bib11","doi-asserted-by":"publisher","first-page":"246","DOI":"10.1126\/science.7809630","article-title":"Requirement of FGF-4 for postimplantation mouse development","volume":"267","author":"Feldman","year":"1995","journal-title":"Science"},{"key":"bib12","doi-asserted-by":"publisher","first-page":"5082","DOI":"10.1073\/pnas.95.9.5082","article-title":"Targeted disruption of fibroblast growth factor (FGF) receptor 2 suggests a role for FGF signaling in pregastrulation mammalian development","volume":"95","author":"Arman","year":"1998","journal-title":"Proc Natl Acad Sci USA"},{"key":"bib13","doi-asserted-by":"publisher","first-page":"793","DOI":"10.1016\/S0092-8674(00)81702-X","article-title":"Mammalian Grb2 regulates multiple steps in embryonic development and malignant transformation","volume":"95","author":"Cheng","year":"1998","journal-title":"Cell"},{"key":"bib14","doi-asserted-by":"publisher","first-page":"8578","DOI":"10.1073\/pnas.161259898","article-title":"Critical role for the docking-protein FRS2a in FGF receptor-mediated signal transduction pathways","volume":"98","author":"Hadari","year":"2001","journal-title":"Proc Natl Acad Sci USA"},{"key":"bib15","doi-asserted-by":"publisher","first-page":"964","DOI":"10.1038\/sj.embor.embor939","article-title":"An essential function of the mitogen-activated protein kinase Erk2 in mouse trophoblast development","volume":"4","author":"Saba-El-Leil","year":"2003","journal-title":"EMBO Rep"},{"key":"bib16","doi-asserted-by":"publisher","first-page":"847","DOI":"10.1046\/j.1365-2443.2003.00680.x","article-title":"Essential role for ERK2 mitogen-activated protein kinase in placental development","volume":"8","author":"Hatano","year":"2003","journal-title":"Genes to Cells"},{"key":"bib17","doi-asserted-by":"publisher","first-page":"11059","DOI":"10.1200\/jco.2014.32.15_suppl.11059","article-title":"The FGFR landscape in cancer: an analysis of 4,869 cases","volume":"32","author":"Helsten","year":"2014","journal-title":"J Clin Oncol"},{"key":"bib19","doi-asserted-by":"publisher","first-page":"1679","DOI":"10.1523\/JNEUROSCI.16-05-01679.1996","article-title":"Retinal degeneration in transgenic mice with photoreceptor-specific expression of a dominant-negative fibroblast growth factor receptor","volume":"16","author":"Campochiaro","year":"1996","journal-title":"J Neurosci"},{"key":"bib20","doi-asserted-by":"publisher","first-page":"2638","DOI":"10.1167\/iovs.16-21204","article-title":"Fibroblast growth factor receptor 2 (FGFR2) is required for meibomian gland homeostasis in the adult mousethe role of FGF receptor 2 in meibomian gland homeostasis","volume":"58","author":"Reneker","year":"2017","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib21","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1016\/j.brainres.2012.04.002","article-title":"Impaired motor coordination and disrupted cerebellar architecture in Fgfr1 and Fgfr2 double knockout mice","volume":"1460","author":"Smith","year":"2012","journal-title":"Brain Res"},{"key":"bib22","doi-asserted-by":"publisher","first-page":"516","DOI":"10.1002\/dvdy.v233:2","article-title":"Signaling through FGF receptor-2 is required for lens cell survival and for withdrawal from the cell cycle during lens fiber cell differentiation","volume":"233","author":"Garcia","year":"2005","journal-title":"Dev Dyn"},{"key":"bib23","doi-asserted-by":"publisher","first-page":"306","DOI":"10.1159\/000112521","article-title":"Fibroblast growth factor receptor 2 plays an essential role in telencephalic progenitors","volume":"30","author":"Ever","year":"2008","journal-title":"Dev Neurosci"},{"key":"bib24","doi-asserted-by":"publisher","first-page":"4800","DOI":"10.1167\/iovs.17-22661","article-title":"Generation and characterization of a novel mouse line, keratocan-rtTA (KeraRT), for corneal stroma and tendon research","volume":"58","author":"Zhang","year":"2017","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib25","doi-asserted-by":"publisher","first-page":"3063","DOI":"10.1242\/dev.00491","article-title":"Conditional inactivation of FGF receptor 2 reveals an essential role for FGF signaling in the regulation of osteoblast function and bone growth","volume":"130","author":"Yu","year":"2003","journal-title":"Development"},{"key":"bib26","doi-asserted-by":"publisher","first-page":"4032","DOI":"10.1167\/iovs.11-9062","article-title":"Downregulation of \u00df-Actin gene and human antigen R in human keratoconus","volume":"53","author":"Joseph","year":"2012","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib27","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1016\/j.exer.2011.04.013","article-title":"Assessment of postnatal corneal development in the C57BL\/6 mouse using spectral domain optical coherence tomography and microwave-assisted histology","volume":"93","author":"Hanlon","year":"2011","journal-title":"Exp Eye Res"},{"key":"bib28","doi-asserted-by":"crossref","first-page":"4971572","DOI":"10.1155\/2016\/4971572","article-title":"Applications of anterior segment optical coherence tomography in cornea and ocular surface diseases","volume":"2016","author":"Han","year":"2016","journal-title":"J Ophthalmol"},{"key":"bib29","doi-asserted-by":"publisher","first-page":"4545","DOI":"10.1167\/iovs.17-21947","article-title":"Absence of sigma 1 receptor accelerates photoreceptor cell death in a murine model of retinitis pigmentosa","volume":"58","author":"Wang","year":"2017","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib30","doi-asserted-by":"publisher","first-page":"1138","DOI":"10.1017\/S1431927610055170","article-title":"Enhancing Serial Block-Face Scanning Electron Microscopy to Enable High Resolution 3-D Nanohistology of Cells and Tissues","volume":"16","author":"Deerinck","year":"2010","journal-title":"Microsc Microanal"},{"key":"bib31","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1177\/14.4.291","article-title":"THF early stages of absorption of injected horseradish peroxidase in the proximal tubules of mouse kidney: ultrastructural cytochemistry by a new technique","volume":"14","author":"Graham","year":"1966","journal-title":"J Histochem Cytochem"},{"issue":"6","key":"bib32","doi-asserted-by":"publisher","first-page":"e144799","DOI":"10.1172\/jci.insight.144799","article-title":"Myofibroblast dedifferentiation proceeds via distinct transcriptomic and phenotypic transitions.","volume":"6","author":"Fortier","year":"2021","journal-title":"JCI Insight."},{"key":"bib33","doi-asserted-by":"publisher","first-page":"107868","DOI":"10.1016\/j.exer.2019.107868","article-title":"Topography and pachymetry maps for mouse corneas using optical coherence tomography","volume":"190","author":"Liu","year":"2020","journal-title":"Exp Eye Res"},{"key":"bib34","first-page":"12","article-title":"Attenuation of lysyl oxidase and collagen gene expression in keratoconus patient corneal epithelium corresponds to disease severity","volume":"21","author":"Shetty","year":"2015","journal-title":"Mol Vis"},{"key":"bib35","doi-asserted-by":"publisher","first-page":"475","DOI":"10.1006\/exer.1999.0719","article-title":"Keratocyte apoptosis associated with keratoconus","volume":"69","author":"Kim","year":"1999","journal-title":"Exp Eye Res"},{"key":"bib36","doi-asserted-by":"publisher","first-page":"1738","DOI":"10.1016\/S0161-6420(94)31110-9","article-title":"Acute corneal hydrops in keratoconus","volume":"101","author":"Tuft","year":"1994","journal-title":"Ophthalmology"},{"key":"bib37","doi-asserted-by":"crossref","first-page":"461","DOI":"10.4103\/0301-4738.116062","article-title":"Acute corneal hydrops in keratoconus","volume":"61","author":"Maharana","year":"2013","journal-title":"Indian J Ophthalmol"},{"key":"bib38","doi-asserted-by":"publisher","first-page":"921","DOI":"10.1016\/j.ajo.2014.01.017","article-title":"Acute corneal hydrops in keratoconus\u2014new perspectives","volume":"157","author":"Fan Gaskin","year":"2014","journal-title":"Am J Ophthalmol"},{"key":"bib39","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1038\/eye.2014.333","article-title":"Acute corneal hydrops in keratoconus: a national prospective study of incidence and management","volume":"29","author":"Barsam","year":"2015","journal-title":"Eye (London, England)"},{"key":"bib40","doi-asserted-by":"publisher","first-page":"e190960","DOI":"10.1001\/jamaophthalmol.2019.0960","article-title":"Acute corneal hydrops in a young man","volume":"138","author":"Ng","year":"2020","journal-title":"JAMA Ophthalmol"},{"key":"bib41","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1097\/00003226-200303000-00019","article-title":"Spontaneous corneal hydrops and perforation in keratoconus and pellucid marginal degeneration","volume":"22","author":"Aldave","year":"2003","journal-title":"Cornea"},{"key":"bib42","doi-asserted-by":"publisher","first-page":"bcr2014205782","DOI":"10.1136\/bcr-2014-205782","article-title":"Acute corneal hydrops in a patient with intellectual disability","volume":"2014","author":"Makino","year":"2014","journal-title":"BMJ Case Rep"},{"key":"bib43","doi-asserted-by":"publisher","first-page":"1382","DOI":"10.1167\/iovs.09-3860","article-title":"Human corneal fibrosis: an in vitro model","volume":"51","author":"Karamichos","year":"2010","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib44","doi-asserted-by":"publisher","first-page":"1948","DOI":"10.1167\/iovs.04-1253","article-title":"Changes in collagen orientation and distribution in keratoconus corneas","volume":"46","author":"Meek","year":"2005","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib45","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1016\/0039-6257(84)90094-8","article-title":"Keratoconus and related noninflammatory corneal thinning disorders","volume":"28","author":"Krachmer","year":"1984","journal-title":"Surv Ophthalmol"},{"key":"bib46","doi-asserted-by":"publisher","first-page":"843","DOI":"10.1038\/eye.2015.63","article-title":"Keratoconus: an inflammatory disorder?","volume":"29","author":"Galvis","year":"2015","journal-title":"Eye (Lond)"},{"key":"bib47","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/09273948.2023.2176325","article-title":"In vitro expression analysis of cytokines and ROS-related genes in human corneal fibroblasts and keratocytes of healthy and keratoconus corneas","author":"Berger","year":"2023","journal-title":"Ocul Immunol Inflamm"},{"key":"bib48","doi-asserted-by":"publisher","first-page":"326","DOI":"10.1016\/j.exer.2010.06.021","article-title":"The molecular basis of corneal transparency","volume":"91","author":"Hassell","year":"2010","journal-title":"Exp Eye Res"},{"key":"bib49","doi-asserted-by":"publisher","first-page":"483","DOI":"10.1242\/dev.127.3.483","article-title":"An important role for the IIIb isoform of fibroblast growth factor receptor 2 (FGFR2) in mesenchymal-epithelial signalling during mouse organogenesis","volume":"127","author":"De Moerlooze","year":"2000","journal-title":"Development"},{"key":"bib50","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1006\/dbio.2000.0144","article-title":"Fibroblast growth factor receptor 2-IIIb acts upstream of Shh and Fgf4 and is required for limb bud maintenance but not for the induction of Fgf8, Fgf10, Msx1, or Bmp4","volume":"231","author":"Revest","year":"2001","journal-title":"Dev Biol"},{"key":"bib51","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1016\/j.cytogfr.2005.01.003","article-title":"Fibroblast growth factor signaling in tumorigenesis","volume":"16","author":"Grose","year":"2005","journal-title":"Cytokine Growth Factor Rev"},{"key":"bib52","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1016\/j.cytogfr.2005.03.001","article-title":"Bad bones, absent smell, selfish testes: the pleiotropic consequences of human FGF receptor mutations","volume":"16","author":"Wilkie","year":"2005","journal-title":"Cytokine Growth Factor Rev"},{"key":"bib53","first-page":"233","article-title":"Cancer genomics and genetics of FGFR2 (review)","volume":"33","author":"Katoh","year":"2008","journal-title":"Int J Oncol"},{"key":"bib54","doi-asserted-by":"publisher","first-page":"e0117089","DOI":"10.1371\/journal.pone.0117089","article-title":"Fibroblast growth factor receptor 2 (FGFR2) is required for corneal epithelial cell proliferation and differentiation during embryonic development","volume":"10","author":"Zhang","year":"2015","journal-title":"PLoS ONE"},{"key":"bib55","doi-asserted-by":"publisher","first-page":"25541","DOI":"10.1074\/jbc.M500249200","article-title":"Keratocan, a cornea-specific keratan sulfate proteoglycan, is regulatedby lumican*","volume":"280","author":"Carlson","year":"2005","journal-title":"J Biol Chem"},{"key":"bib56","doi-asserted-by":"publisher","first-page":"475","DOI":"10.1006\/dbio.1993.1205","article-title":"Developmental localization of the splicing alternatives of fibroblast growth factor receptor-2 (FGFR2)","volume":"158","author":"Orr-Urtreger","year":"1993","journal-title":"Dev Biol"},{"key":"bib57","doi-asserted-by":"publisher","first-page":"1887","DOI":"10.1002\/jcp.24649","article-title":"Isoforms of receptors of fibroblast growth factors","volume":"229","author":"Gong","year":"2014","journal-title":"J Cell Physiol"},{"key":"bib58","doi-asserted-by":"publisher","first-page":"22584","DOI":"10.1074\/jbc.273.35.22584","article-title":"The cloning of mouse keratocan cDNA and genomic DNA and the characterization of its expression during eye development*","volume":"273","author":"Liu","year":"1998","journal-title":"J Biol Chem"},{"key":"bib59","doi-asserted-by":"publisher","first-page":"1871","DOI":"10.1016\/j.jcrs.2011.05.027","article-title":"Corneal topographic analysis in patients with keratoconus using 3-dimensional anterior segment optical coherence tomography","volume":"37","author":"Nakagawa","year":"2011","journal-title":"J Cataract Refract Surg"},{"key":"bib60","doi-asserted-by":"publisher","first-page":"1178","DOI":"10.1126\/science.1957169","article-title":"Optical coherence tomography","volume":"254","author":"Huang","year":"1991","journal-title":"Science"},{"key":"bib61","doi-asserted-by":"publisher","first-page":"244","DOI":"10.1016\/j.lfs.2015.10.025","article-title":"Men and mice: relating their ages","volume":"152","author":"Dutta","year":"2016","journal-title":"Life Sci"},{"key":"bib62","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1097\/ICO.0b013e31825240d7","article-title":"Central and peripheral corneal thinning in keratoconus","volume":"32","author":"Brautaset","year":"2013","journal-title":"Cornea"},{"key":"bib63","doi-asserted-by":"publisher","first-page":"19406","DOI":"10.1038\/s41598-019-55866-5","article-title":"PPIP5K2 and PCSK1 are candidate genetic contributors to familial keratoconus","volume":"9","author":"Khaled","year":"2019","journal-title":"Sci Rep"},{"key":"bib64","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1016\/j.preteyeres.2004.04.002","article-title":"Collagens and collagen-related matrix components in the human and mouse eye","volume":"23","author":"Ihanam\u00e4ki","year":"2004","journal-title":"Prog Retin Eye Res"},{"key":"bib65","first-page":"15","article-title":"Extracellular matrix components in retrocorneal fibrous membrane in comparison to corneal endothelium and Descemet's membrane","volume":"6","author":"Leung","year":"2000","journal-title":"Mol Vis"},{"key":"bib66","first-page":"2427","article-title":"Corneal endothelial modulation: bFGF as direct mediator and corneal endothelium modulation factor as inducer","volume":"35","author":"Kay","year":"1994","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib67","doi-asserted-by":"publisher","first-page":"206","DOI":"10.1097\/00003226-200203000-00017","article-title":"Evidence of apoptotic cell death in keratoconus","volume":"21","author":"Kaldawy","year":"2002","journal-title":"Cornea"},{"key":"bib68","doi-asserted-by":"publisher","first-page":"6902","DOI":"10.1158\/0008-5472.CAN-08-0770","article-title":"Inhibition of activated fibroblast growth factor receptor 2 in endometrial cancer cells induces cell death despite PTEN abrogation","volume":"68","author":"Byron","year":"2008","journal-title":"Cancer Res"},{"key":"bib69","doi-asserted-by":"publisher","first-page":"2340","DOI":"10.1158\/0008-5472.CAN-07-5229","article-title":"FGFR2-amplified gastric cancer cell lines require FGFR2 and Erbb3 signaling for growth and survival","volume":"68","author":"Kunii","year":"2008","journal-title":"Cancer Res"},{"key":"bib70","doi-asserted-by":"publisher","first-page":"587","DOI":"10.1111\/cas.v113.2","article-title":"FGFR2 loss sensitizes MYCN-amplified neuroblastoma CHP134 cells to CHK1 inhibitor-induced apoptosis","volume":"113","author":"Ando","year":"2022","journal-title":"Cancer Sci"},{"key":"bib71","first-page":"220","article-title":"Keratocyte apoptosis: implications on corneal wound healing, tissue organization, and disease","volume":"39","author":"Wilson","year":"1998","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib72","doi-asserted-by":"publisher","first-page":"e106556","DOI":"10.1371\/journal.pone.0106556","article-title":"Transforming growth factor \u00df and insulin signal changes in stromal fibroblasts of individual keratoconus patients","volume":"9","author":"Foster","year":"2014","journal-title":"PLoS ONE"},{"key":"bib73","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.preteyeres.2015.07.001","article-title":"Corneal structure and transparency","volume":"49","author":"Meek","year":"2015","journal-title":"Prog Retin Eye Res"},{"key":"bib74","doi-asserted-by":"publisher","first-page":"635","DOI":"10.1006\/exer.1993.1081","article-title":"Regulation of corneal collagen fibrillogenesis in vitro by corneal proteoglycan (lumican and decorin) core proteins","volume":"56","author":"Rada","year":"1993","journal-title":"Exp Eye Res"},{"key":"bib75","doi-asserted-by":"publisher","first-page":"19963","DOI":"10.1038\/s41598-019-56529-1","article-title":"Collagen fibrils and proteoglycans of peripheral and central stroma of the keratoconus cornea - Ultrastructure and 3D transmission electron tomography","volume":"9","author":"Alkanaan","year":"2019","journal-title":"Sci Rep"},{"key":"bib76","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1016\/0039-6257(76)90066-7","article-title":"Contributions of electron microscopy to the study of corneal pathology","volume":"20","author":"Polack","year":"1976","journal-title":"Surv Ophthalmol"},{"key":"bib1","article-title":"Facts about the cornea and corneal disease keratoconus"},{"key":"bib18","article-title":"Ocular side effects of systemically administered chemotherapy","author":"Liu","year":"2019"}],"container-title":["Investigative Opthalmology & Visual Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/iovs.arvojournals.org\/article.aspx?articleid=2792872","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:31:44Z","timestamp":1791927104000},"score":1,"resource":{"primary":{"URL":"https:\/\/iovs.arvojournals.org\/article.aspx?articleid=2792872"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9,26]]},"references-count":76,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2023,9,1]]}},"URL":"https:\/\/doi.org\/10.1167\/iovs.64.12.40","relation":{},"ISSN":["1552-5783"],"issn-type":[{"value":"1552-5783","type":"print"}],"subject":[],"published":{"date-parts":[[2023,9,26]]}}}