{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T22:00:30Z","timestamp":1791928830560,"version":"4.3.4"},"reference-count":41,"publisher":"Association for Research in Vision and Ophthalmology (ARVO)","issue":"13","license":[{"start":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T00:00:00Z","timestamp":1696291200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Invest. Ophthalmol. Vis. Sci."],"published-print":{"date-parts":[[2023,10,3]]},"DOI":"10.1167\/iovs.64.13.1","type":"journal-article","created":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T11:30:51Z","timestamp":1696332651000},"page":"1","source":"Crossref","is-referenced-by-count":4,"title":["Optical Density Ratio of Subretinal Fluid in Choroidal Melanomas Versus Choroidal Naevi Assessed by Optical Coherence Tomography"],"prefix":"10.1167","volume":"64","author":[{"given":"Zachary","family":"Mahoun","sequence":"first","affiliation":[{"name":"Department of Ocular Oncology, Institut Curie, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denis","family":"Malaise","sequence":"additional","affiliation":[{"name":"Department of Ocular Oncology, Institut Curie, Paris, France"},{"name":"Laboratoire d'Imagerie Translationnelle en Oncologie, INSERM U1288, Institut Curie, PSL University, Orsay, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Livia","family":"Lumbroso-Le Rouic","sequence":"additional","affiliation":[{"name":"Department of Ocular Oncology, Institut Curie, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Levy-Gabriel","sequence":"additional","affiliation":[{"name":"Department of Ocular Oncology, Institut Curie, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathalie","family":"Cassoux","sequence":"additional","affiliation":[{"name":"Department of Ocular Oncology, Institut Curie, Paris, France"},{"name":"Universit\u00e9 Paris Cit\u00e9, Paris, France"},{"name":"INSERM UMR1138 \u201cFrom physiopathology of ocular diseases to clinical developments,\u201d Centre de Recherche des Cordeliers, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandre","family":"Matet","sequence":"additional","affiliation":[{"name":"Department of Ocular Oncology, Institut Curie, Paris, France"},{"name":"Universit\u00e9 Paris Cit\u00e9, Paris, France"},{"name":"INSERM UMR1138 \u201cFrom physiopathology of ocular diseases to clinical developments,\u201d Centre de Recherche des Cordeliers, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"27","reference":[{"issue":"3","key":"bib1","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1097\/ICU.0000000000000041","article-title":"Choroidal melanoma: clinical features, classification, and top 10 pseudomelanomas","volume":"25","author":"Shields","year":"2014","journal-title":"Curr Opin Ophthalmol"},{"issue":"7","key":"bib2","doi-asserted-by":"publisher","first-page":"1363","DOI":"10.1097\/IAE.0b013e31824d09a8","article-title":"Clinical spectrum and prognosis of uveal melanoma based on age at presentation in 8,033 cases","volume":"32","author":"Shields","year":"2012","journal-title":"Retina"},{"issue":"11","key":"bib3","doi-asserted-by":"publisher","first-page":"4651","DOI":"10.1167\/iovs.03-0538","article-title":"Very long-term prognosis of patients with malignant uveal melanoma","volume":"44","author":"Kujala","year":"2003","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"2","key":"bib4","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1111\/j.1755-3768.1982.tb08371.x","article-title":"Malignant melanomas of the human uvea: 25-year follow-up of cases in Denmark, 1943\u20131952","volume":"60","author":"Jensen","year":"1982","journal-title":"Acta Ophthalmol (Copenh)"},{"issue":"12","key":"bib5","doi-asserted-by":"crossref","first-page":"1639","DOI":"10.1001\/archopht.123.12.1639","article-title":"Development of metastatic disease after enrollment in the COMS trials for treatment of choroidal melanoma: collaborative Ocular Melanoma Study Group Report No. 26","volume":"123","author":"Diener-West","year":"2005","journal-title":"Arch Ophthalmol"},{"issue":"8","key":"bib6","doi-asserted-by":"publisher","first-page":"989","DOI":"10.1001\/archophthalmol.2009.208","article-title":"Metastasis of uveal melanoma millimeter-by-millimeter in 8033 consecutive eyes","volume":"127","author":"Shields","year":"2009","journal-title":"Arch Ophthalmol"},{"issue":"10","key":"bib7","doi-asserted-by":"publisher","first-page":"1840","DOI":"10.1097\/IAE.0000000000002440","article-title":"Choroidal nevus imaging features in 3,806 cases and risk factors for transformation into melanoma in 2,355 cases: the 2020 Taylor R. Smith and Victor T. Curtin Lecture","volume":"39","author":"Shields","year":"2019","journal-title":"Retina"},{"issue":"10","key":"bib8","doi-asserted-by":"publisher","first-page":"1441","DOI":"10.1136\/bjophthalmol-2018-312967","article-title":"Combination of multimodal imaging features predictive of choroidal nevus transformation into melanoma","volume":"103","author":"Dalvin","year":"2019","journal-title":"Br J Ophthalmol"},{"issue":"4","key":"bib9","doi-asserted-by":"publisher","first-page":"685","DOI":"10.1097\/IAE.0000000000001998","article-title":"Optical density ratio of the subretinal fluid in choroidal melanoma and metastasis","volume":"39","author":"Leshno","year":"2019","journal-title":"Retina"},{"issue":"4","key":"bib10","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1159\/000492948","article-title":"Subretinal fluid optical density and spectral-domain optical coherence tomography characteristics for the diagnosis of circumscribed choroidal hemangioma","volume":"241","author":"Zur","year":"2019","journal-title":"Ophthalmologica"},{"issue":"6","key":"bib11","doi-asserted-by":"publisher","first-page":"3104","DOI":"10.1167\/iovs.11-8700","article-title":"Differential optical density of subretinal spaces","volume":"53","author":"Neudorfer","year":"2012","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"8","key":"bib12","doi-asserted-by":"publisher","first-page":"3529","DOI":"10.1167\/iovs.07-1320","article-title":"Differential optical densities of intraretinal spaces","volume":"49","author":"Barthelmes","year":"2008","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"2","key":"bib13","doi-asserted-by":"publisher","first-page":"386","DOI":"10.1016\/j.ajo.2014.11.011","article-title":"Optical density ratio in the subretinal fluid: differentiating chronic central serous chorioretinopathy and polypodial choroidal vasculopathy","volume":"159","author":"Baek","year":"2015","journal-title":"Am J Ophthalmol"},{"issue":"4","key":"bib14","doi-asserted-by":"publisher","first-page":"805","DOI":"10.1364\/AO.41.000805","article-title":"High-resolution full-field optical coherence tomography with a Linnik microscope","volume":"41","author":"Dubois","year":"2002","journal-title":"Appl Opt"},{"issue":"12","key":"bib15","doi-asserted-by":"publisher","first-page":"1200","DOI":"10.3109\/02713683.2014.888454","article-title":"Blood components and OCT reflectivity evaluated in animal model","volume":"39","author":"Sonoda","year":"2014","journal-title":"Curr Eye Res"},{"issue":"11","key":"bib16","doi-asserted-by":"publisher","first-page":"874","DOI":"10.1136\/bjo.72.11.874","article-title":"Detection and quantification of S-100 protein in ocular tissues and fluids from patients with intraocular melanoma","volume":"72","author":"Cochran","year":"1988","journal-title":"Br J Ophthalmol"},{"issue":"3","key":"bib17","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1097\/IAE.0b013e31826710ea","article-title":"Intravitreal cellular infiltrate imaged as punctate spots by spectral-domain optical coherence tomography in eyes with posterior segment inflammatory disease","volume":"33","author":"Saito","year":"2013","journal-title":"Retina"},{"issue":"3","key":"bib18","doi-asserted-by":"publisher","first-page":"690","DOI":"10.1080\/09273948.2022.2075399","article-title":"The vitreous in uveitis: characterizing the invisible with optical coherence tomography","volume":"30","author":"Pichi","year":"2022","journal-title":"Ocul Immunol Inflamm"},{"key":"bib19","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1016\/j.ajo.2021.11.023","article-title":"Advanced OCT analysis of biopsy-proven vitreoretinal lymphoma","volume":"238","author":"Pichi","year":"2022","journal-title":"Am J Ophthalmol"},{"issue":"4","key":"bib20","doi-asserted-by":"publisher","first-page":"448","DOI":"10.1136\/bjo.86.4.448","article-title":"Vascular endothelial growth factor is elevated in ocular fluids of eyes harbouring uveal melanoma: identification of a potential therapeutic window","volume":"86","author":"Boyd","year":"2002","journal-title":"Br J Ophthalmol"},{"issue":"11","key":"bib21","doi-asserted-by":"publisher","first-page":"6748","DOI":"10.1167\/iovs.12-10123","article-title":"Cytokines and chemokines in the vitreous fluid of eyes with uveal melanoma","volume":"53","author":"Nagarkatti-Gude","year":"2012","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"7","key":"bib22","doi-asserted-by":"publisher","first-page":"7816","DOI":"10.18632\/oncotarget.v7i7","article-title":"Hypoxia-inducible factor 1 upregulation of both VEGF and ANGPTL4 is required to promote the angiogenic phenotype in uveal melanoma","volume":"7","author":"Hu","year":"2016","journal-title":"Oncotarget"},{"issue":"2","key":"bib23","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1016\/j.canlet.2013.03.005","article-title":"Vascular permeability changes involved in tumor metastasis","volume":"335","author":"Garc\u00eda-Rom\u00e1n","year":"2013","journal-title":"Cancer Lett"},{"issue":"7058","key":"bib24","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1038\/nature03987","article-title":"Pathophysiological consequences of VEGF-induced vascular permeability","volume":"437","author":"Weis","year":"2005","journal-title":"Nature"},{"issue":"5","key":"bib25","doi-asserted-by":"publisher","first-page":"593","DOI":"10.1016\/S0014-4835(03)00189-1","article-title":"Retinal pigment epithelium and endothelial cell interaction causes retinal pigment epithelial barrier dysfunction via a soluble VEGF-dependent mechanism","volume":"77","author":"Hartnett","year":"2003","journal-title":"Exp Eye Res"},{"issue":"6","key":"bib26","doi-asserted-by":"publisher","first-page":"762","DOI":"10.1016\/j.exer.2007.08.010","article-title":"VEGF modulation of retinal pigment epithelium resistance","volume":"85","author":"Ablonczy","year":"2007","journal-title":"Exp Eye Res"},{"issue":"5","key":"bib27","first-page":"1289","article-title":"Blood-ocular barrier breakdown in eyes with ocular melanoma. A potential role for vascular endothelial growth factor\/vascular permeability factor","volume":"147","author":"Vinores","year":"1995","journal-title":"Am J Pathol"},{"issue":"3","key":"bib28","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1136\/bjo.54.3.145","article-title":"Choroidal melanomata. Fluorescence angiographic and histopathological study","volume":"54","author":"Hayreh","year":"1970","journal-title":"Br J Ophthalmol"},{"issue":"4","key":"bib29","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1016\/S0002-9394(14)76123-9","article-title":"Retinal vascular changes in malignant melanoma of the choroid","volume":"97","author":"Cantrill","year":"1984","journal-title":"Am J Ophthalmol"},{"issue":"2","key":"bib30","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1097\/00006982-200602000-00001","article-title":"Imaging the retina by en face optical coherence tomography","volume":"26","author":"van Velthoven","year":"2006","journal-title":"Retina"},{"issue":"4 Suppl.","key":"bib31","first-page":"S95","article-title":"Imaging serpiginous choroidopathy with spectral domain optical coherence tomography","volume":"39","author":"Punjabi","year":"2008","journal-title":"Ophthalmic Surg Lasers Imaging"},{"issue":"6","key":"bib32","doi-asserted-by":"publisher","first-page":"1200","DOI":"10.1016\/j.ajo.2015.09.010","article-title":"Volume-rendered optical coherence tomography of diabetic retinopathy pilot study","volume":"160","author":"Spaide","year":"2015","journal-title":"Am J Ophthalmol"},{"issue":"5","key":"bib33","doi-asserted-by":"publisher","first-page":"1373","DOI":"10.1016\/j.survophthal.2022.02.004","article-title":"Advanced retinal imaging and applications for clinical practice: a consensus review","volume":"67","author":"Fogel-Levin","year":"2022","journal-title":"Surv Ophthalmol"},{"key":"bib34","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.preteyeres.2017.11.003","article-title":"Optical coherence tomography angiography","volume":"64","author":"Spaide","year":"2018","journal-title":"Prog Retin Eye Res"},{"issue":"9","key":"bib35","doi-asserted-by":"publisher","first-page":"5432","DOI":"10.1167\/iovs.15-16952","article-title":"Optical density of subretinal fluid in retinal detachment","volume":"56","author":"Leshno","year":"2015","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"8","key":"bib36","doi-asserted-by":"publisher","first-page":"981","DOI":"10.1001\/archophthalmol.2009.151","article-title":"Choroidal nevus transformation into melanoma: analysis of 2514 consecutive cases","volume":"127","author":"Shields","year":"2009","journal-title":"Arch Ophthalmol"},{"issue":"2","key":"bib37","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1167\/tvst.10.2.24","article-title":"White paper on ophthalmic imaging for choroidal nevus identification and transformation into melanoma","volume":"10","author":"Shields","year":"2021","journal-title":"Transl Vis Sci Technol"},{"issue":"3","key":"bib38","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1097\/IAE.0000000000003741","article-title":"Role of optical coherence tomography in management of acute posterior vitreous detachment and its complications","volume":"43","author":"Wang","year":"2023","journal-title":"Retina"},{"issue":"7","key":"bib39","doi-asserted-by":"publisher","first-page":"1396","DOI":"10.1097\/IAE.0000000000003039","article-title":"Progression of partial posterior vitreous detachment over time","volume":"41","author":"Koller","year":"2021","journal-title":"Retina"},{"issue":"8","key":"bib40","doi-asserted-by":"publisher","first-page":"1425","DOI":"10.1097\/IAE.0000000000003500","article-title":"Imaging the vitreous with a novel boosted optical coherence tomography technique: posterior vitreous detachment","volume":"42","author":"Spaide","year":"2022","journal-title":"Retina"},{"issue":"4","key":"bib41","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1167\/iovs.62.4.31","article-title":"Volumetric optical imaging and quantitative analysis of age-related changes in anterior human vitreous","volume":"62","author":"Ruminski","year":"2021","journal-title":"Invest Ophthalmol Vis Sci"}],"container-title":["Investigative Opthalmology & Visual Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/iovs.arvojournals.org\/article.aspx?articleid=2792892","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:31:37Z","timestamp":1791927097000},"score":1,"resource":{"primary":{"URL":"https:\/\/iovs.arvojournals.org\/article.aspx?articleid=2792892"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10,3]]},"references-count":41,"journal-issue":{"issue":"13","published-print":{"date-parts":[[2023,10,3]]}},"URL":"https:\/\/doi.org\/10.1167\/iovs.64.13.1","relation":{},"ISSN":["1552-5783"],"issn-type":[{"value":"1552-5783","type":"print"}],"subject":[],"published":{"date-parts":[[2023,10,3]]}}}