{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T07:33:38Z","timestamp":1792481618437,"version":"4.5.0"},"reference-count":31,"publisher":"Association for Research in Vision and Ophthalmology (ARVO)","issue":"13","license":[{"start":{"date-parts":[[2023,10,16]],"date-time":"2023-10-16T00:00:00Z","timestamp":1697414400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Invest. Ophthalmol. Vis. Sci."],"published-print":{"date-parts":[[2023,10,16]]},"DOI":"10.1167\/iovs.64.13.22","type":"journal-article","created":{"date-parts":[[2023,10,16]],"date-time":"2023-10-16T10:31:15Z","timestamp":1697452275000},"page":"22","source":"Crossref","is-referenced-by-count":20,"title":["Evaluation of Ocular and Systemic Oxidative Stress Markers in Ocular Rosacea Patients"],"prefix":"10.1167","volume":"64","author":[{"given":"Nilufer","family":"Yesilirmak","sequence":"first","affiliation":[{"name":"Centre de Recherche des Cordeliers, INSERM, Universit\u00e9 Paris Cit\u00e9, Sorbonne Universit\u00e9, Physiopathology of ocular diseases: Therapeutic innovations, Paris, France"},{"name":"Ophthalmopole Cochin University Hospital, Assistance Publique-H\u00f4pitaux de Paris, Paris, France"},{"name":"Department of Ophthalmology, Ankara Yildirim Beyazit University, Ankara City Hospital, Ankara, Turkey"},{"name":"Department of Medical Biochemistry, University of Gazi, Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neslihan","family":"Bukan","sequence":"additional","affiliation":[{"name":"Department of Medical Biochemistry, University of Gazi, Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Busra","family":"Kurt","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Ankara Yildirim Beyazit University, Ankara City Hospital, Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sema","family":"Yuzbasioglu","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Ankara Yildirim Beyazit University, Ankara City Hospital, Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Zhao","sequence":"additional","affiliation":[{"name":"Centre de Recherche des Cordeliers, INSERM, Universit\u00e9 Paris Cit\u00e9, Sorbonne Universit\u00e9, Physiopathology of ocular diseases: Therapeutic innovations, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"Rodrigues-Braz","sequence":"additional","affiliation":[{"name":"Centre de Recherche des Cordeliers, INSERM, Universit\u00e9 Paris Cit\u00e9, Sorbonne Universit\u00e9, Physiopathology of ocular diseases: Therapeutic innovations, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akin","family":"Aktas","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Ankara Yildirim Beyazit University, Ankara City Hospital, Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francine","family":"Behar-Cohen","sequence":"additional","affiliation":[{"name":"Centre de Recherche des Cordeliers, INSERM, Universit\u00e9 Paris Cit\u00e9, Sorbonne Universit\u00e9, Physiopathology of ocular diseases: Therapeutic innovations, Paris, France"},{"name":"Ophthalmopole Cochin University Hospital, Assistance Publique-H\u00f4pitaux de Paris, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Louis","family":"Bourges","sequence":"additional","affiliation":[{"name":"Centre de Recherche des Cordeliers, INSERM, Universit\u00e9 Paris Cit\u00e9, Sorbonne Universit\u00e9, Physiopathology of ocular diseases: Therapeutic innovations, Paris, France"},{"name":"Ophthalmopole Cochin University Hospital, Assistance Publique-H\u00f4pitaux de Paris, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"27","reference":[{"key":"bib1","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1007\/s40257-015-0156-2","article-title":"New and emerging treatments for rosacea","volume":"16","author":"Gold","year":"2015","journal-title":"Am J Clin Dermatol"},{"key":"bib2","doi-asserted-by":"publisher","first-page":"503","DOI":"10.1097\/ICU.0000000000000706","article-title":"Ocular rosacea","volume":"31","author":"Redd","year":"2020","journal-title":"Curr Opin Ophthalmol"},{"key":"bib3","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1111\/ceo.v49.2","article-title":"Ocular manifestations of rosacea: a clinical review","volume":"49","author":"Tavassoli","year":"2021","journal-title":"Clin Exp Ophthalmol"},{"key":"bib4","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1038\/jidsymp.2011.7","article-title":"Clinical, cellular, and molecular aspects in the pathophysiology of rosacea","volume":"15","author":"Steinhoff","year":"2011","journal-title":"J Investig Dermatol Symp Proc"},{"key":"bib5","doi-asserted-by":"publisher","first-page":"1562","DOI":"10.3390\/ijms17091562","article-title":"Rosacea: molecular mechanisms and management of chronic cutaneous inflammatory condition","volume":"17","author":"Woo","year":"2016","journal-title":"Int J Mol Sci"},{"issue":"1","key":"bib6","doi-asserted-by":"publisher","first-page":"e1361574","DOI":"10.1080\/19381980.2017.1361574","article-title":"Rosacea: epidemiology, pathogenesis, and treatment","volume":"9","author":"Rainer","year":"2017","journal-title":"Dermatoendocrinol"},{"key":"bib7","doi-asserted-by":"crossref","first-page":"8416763","DOI":"10.1155\/2017\/8416763","article-title":"Oxidative stress: harms and benefits for human health","volume":"2017","author":"Pizzino","year":"2017","journal-title":"Oxid Med Cell Longev"},{"key":"bib8","doi-asserted-by":"publisher","first-page":"4642","DOI":"10.3390\/ijms22094642","article-title":"The chemistry of reactive oxygen species (ROS) revisited: outlining their role in biological macromolecules (DNA, lipids and proteins) and induced pathologies","volume":"22","author":"Juan","year":"2021","journal-title":"Int J Mol Sci"},{"key":"bib9","doi-asserted-by":"publisher","first-page":"270","DOI":"10.1016\/j.jaad.2008.10.014","article-title":"Oxidative stress and ferritin expression in the skin of patients with rosacea","volume":"60","author":"Tisma","year":"2009","journal-title":"J Am Acad Dermatol"},{"key":"bib10","doi-asserted-by":"publisher","first-page":"494","DOI":"10.1111\/ijd.2004.43.issue-7","article-title":"Plasma reactive oxygen species activity and antioxidant potential levels in rosacea patients: correlation with seropositivity to Helicobacter pylori","volume":"43","author":"Baz","year":"2004","journal-title":"Int J Dermatol"},{"key":"bib11","doi-asserted-by":"publisher","first-page":"188","DOI":"10.1046\/j.1365-2230.2003.01179.x","article-title":"The role of free oxygen radicals in the aetiopathogenesis of rosacea","volume":"28","author":"Oztas","year":"2003","journal-title":"Clin Exp Dermatol"},{"key":"bib12","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1111\/jdv.2015.29.issue-2","article-title":"Decreased serum paraoxonase and arylesterase activities in patients with rosacea","volume":"29","author":"Takci","year":"2015","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"bib13","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1016\/j.clinbiochem.2003.11.015","article-title":"A novel automated direct measurement method for total antioxidant capacity using a new generation, more stable ABTS radical cation","volume":"37","author":"Erel","year":"2004","journal-title":"Clin Biochem"},{"key":"bib14","doi-asserted-by":"publisher","first-page":"1103","DOI":"10.1016\/j.clinbiochem.2005.08.008","article-title":"A new automated colorimetric method for measuring total oxidant status","volume":"38","author":"Erel","year":"2005","journal-title":"Clin Biochem"},{"key":"bib15","doi-asserted-by":"publisher","first-page":"120","DOI":"10.4103\/tjd.tjd_96_22","article-title":"Increased oxidative stress and imbalance dynamic thiol\u2013disulfide homeostasis in Rosacea","volume":"16","author":"Guler","year":"2022","journal-title":"Turk J Dermatol"},{"key":"bib16","doi-asserted-by":"publisher","first-page":"304","DOI":"10.5114\/ada.2018.76228","article-title":"Advanced oxidation protein products and serum total oxidant\/antioxidant status levels in rosacea","volume":"35","author":"Erdogan","year":"2018","journal-title":"Postepy Dermatol Alergol"},{"key":"bib17","doi-asserted-by":"publisher","first-page":"431","DOI":"10.1111\/bjd.2017.176.issue-2","article-title":"Updating the diagnosis, classification and assessment of rosacea: recommendations from the global ROSacea COnsensus (ROSCO) panel","volume":"176","author":"Tan","year":"2017","journal-title":"Br J Dermatol"},{"key":"bib18","doi-asserted-by":"publisher","first-page":"276","DOI":"10.1016\/j.jtos.2017.05.008","article-title":"TFOS DEWS II definition and classification report","volume":"15","author":"Craig","year":"2017","journal-title":"Ocul Surf"},{"key":"bib19","doi-asserted-by":"publisher","first-page":"438","DOI":"10.1016\/j.jtos.2017.05.011","article-title":"TFOS DEWS II pathophysiology report","volume":"15","author":"Bron","year":"2017","journal-title":"Ocul Surf"},{"key":"bib20","doi-asserted-by":"crossref","first-page":"621","DOI":"10.17343\/sdutfd.962200","article-title":"Evaluation of meibomian glands in cutaneous rosacea","volume":"28","author":"Muhafiz","year":"2021","journal-title":"Med J SDU"},{"key":"bib21","doi-asserted-by":"publisher","first-page":"615","DOI":"10.1001\/archopht.118.5.615","article-title":"Reliability and validity of the ocular surface disease index","volume":"118","author":"Schiffman","year":"2000","journal-title":"Arch Ophthalmol"},{"key":"bib22","doi-asserted-by":"publisher","first-page":"107897","DOI":"10.1016\/j.exer.2019.107897","article-title":"Oxidative stress markers dynamics in keratoconus patients' tears before and after corneal collagen crosslinking procedure","volume":"190","author":"Balmus","year":"2020","journal-title":"Exp Eye Res"},{"key":"bib23","first-page":"391","article-title":"A new automated method for phenotyping arylesterase (EC 3.1.1.2) based upon inhibition of enzymatic hydrolysis of 4-nitrophenyl acetate by phenyl acetate","volume":"30","author":"Haagen","year":"1992","journal-title":"Eur J Clin Chem Clin Biochem"},{"issue":"3 suppl","key":"bib24","first-page":"17","article-title":"Reactive oxygen species and rosacea","volume":"74","author":"Jones","year":"2004","journal-title":"Cutis"},{"key":"bib25","first-page":"26","article-title":"Rosacea, reactive oxygen species, and azelaic acid","volume":"2","author":"Jones","year":"2009","journal-title":"J Clin Aesthet Dermatol"},{"key":"bib26","doi-asserted-by":"publisher","first-page":"526","DOI":"10.1007\/BF00371948","article-title":"The effect of UV radiation and sun blockers on free radical defence in human and guinea pig epidermis","volume":"282","author":"Sundaram","year":"1990","journal-title":"Arch Dermatol Res"},{"key":"bib27","doi-asserted-by":"publisher","first-page":"360438","DOI":"10.1155\/2014\/360438","article-title":"Lipid peroxidation: production, metabolism, and signaling mechanisms of malondialdehyde and 4-hydroxy-2-nonenal","volume":"2014","author":"Ayala","year":"2014","journal-title":"Oxid Med Cell Longev"},{"key":"bib28","first-page":"123","article-title":"Reliability of malondialdehyde as a biomarker of oxidative stress in psychological disorders","volume":"5","author":"Khoubnasabjafari","year":"2015","journal-title":"Bioimpacts"},{"key":"bib29","doi-asserted-by":"publisher","first-page":"208","DOI":"10.1111\/ppp.2006.22.issue-4","article-title":"GSTM1 and GSTT1 null genotypes as possible heritable factors of rosacea","volume":"22","author":"Yazici","year":"2006","journal-title":"Photodermatol Photoimmunol Photomed"},{"issue":"14","key":"bib30","doi-asserted-by":"publisher","first-page":"DES163","DOI":"10.1167\/iovs.17-23402","article-title":"Potential role of oxidative stress in ocular surface inflammation and dry eye disease","volume":"59","author":"Dogru","year":"2018","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"4","key":"bib31","doi-asserted-by":"publisher","first-page":"e412","DOI":"10.1111\/aos.2018.96.issue-4","article-title":"Dry eye disease and oxidative stress","volume":"96","author":"Seen","year":"2018","journal-title":"Acta Ophthalmol"}],"container-title":["Investigative Opthalmology & Visual Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/iovs.arvojournals.org\/article.aspx?articleid=2792925","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:31:40Z","timestamp":1791927100000},"score":1,"resource":{"primary":{"URL":"https:\/\/iovs.arvojournals.org\/article.aspx?articleid=2792925"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10,16]]},"references-count":31,"journal-issue":{"issue":"13","published-print":{"date-parts":[[2023,10,3]]}},"URL":"https:\/\/doi.org\/10.1167\/iovs.64.13.22","relation":{},"ISSN":["1552-5783"],"issn-type":[{"value":"1552-5783","type":"print"}],"subject":[],"published":{"date-parts":[[2023,10,16]]}}}