{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T22:00:21Z","timestamp":1791928821068,"version":"4.3.4"},"reference-count":74,"publisher":"Association for Research in Vision and Ophthalmology (ARVO)","issue":"13","license":[{"start":{"date-parts":[[2023,10,19]],"date-time":"2023-10-19T00:00:00Z","timestamp":1697673600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Invest. Ophthalmol. Vis. Sci."],"published-print":{"date-parts":[[2023,10,19]]},"DOI":"10.1167\/iovs.64.13.30","type":"journal-article","created":{"date-parts":[[2023,10,19]],"date-time":"2023-10-19T11:31:33Z","timestamp":1697715093000},"page":"30","source":"Crossref","is-referenced-by-count":3,"title":["Variability in Capillary Perfusion Is Increased in Regions of Retinal Ischemia Due to Branch Retinal Vein Occlusion"],"prefix":"10.1167","volume":"64","author":[{"given":"Martin","family":"Hein","sequence":"first","affiliation":[{"name":"Lions Eye Institute, Nedlands, Western Australia, Australia"},{"name":"Centre for Ophthalmology and Visual Science, University of Western Australia, Perth, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Mehnert","sequence":"additional","affiliation":[{"name":"Lions Eye Institute, Nedlands, Western Australia, Australia"},{"name":"Centre for Ophthalmology and Visual Science, University of Western Australia, Perth, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K. Bailey","family":"Freund","sequence":"additional","affiliation":[{"name":"Vitreous Retina Macula Consultants of New York, New York, New York, United States"},{"name":"Department of Ophthalmology, New York University Grossman School of Medicine, New York, New York, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dao-Yi","family":"Yu","sequence":"additional","affiliation":[{"name":"Lions Eye Institute, Nedlands, Western Australia, Australia"},{"name":"Centre for Ophthalmology and Visual Science, University of Western Australia, Perth, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chandrakumar","family":"Balaratnasingam","sequence":"additional","affiliation":[{"name":"Lions Eye Institute, Nedlands, Western Australia, Australia"},{"name":"Centre for Ophthalmology and Visual Science, University of Western Australia, Perth, Australia"},{"name":"Department of Ophthalmology, Sir Charles Gairdner Hospital, Western Australia, Perth, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"27","reference":[{"key":"bib1","doi-asserted-by":"publisher","first-page":"284","DOI":"10.1016\/j.preteyeres.2008.02.002","article-title":"Regulation of retinal blood flow in health and disease","volume":"27","author":"Pournaras","year":"2008","journal-title":"Prog Retin Eye Res"},{"key":"bib2","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1111\/ceo.1998.26.issue-2","article-title":"Overview of studies on metabolic and vascular regulatory changes in early diabetic retinopathy","volume":"26","author":"Alder","year":"1998","journal-title":"Aust N Z J Ophthalmol"},{"key":"bib3","first-page":"1716","article-title":"Retinal blood flow by hydrogen clearance polarography in the streptozotocin-induced diabetic rat","volume":"34","author":"Cringle","year":"1993","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib4","doi-asserted-by":"publisher","first-page":"E45077","DOI":"10.7554\/eLife.45077","article-title":"Imaging single-cell blood flow in the smallest to largest vessels in the living retina","volume":"8","author":"Joseph","year":"2019","journal-title":"Elife"},{"key":"bib5","doi-asserted-by":"publisher","first-page":"0005","DOI":"10.1523\/ENEURO.0005-15.2015","article-title":"Measurement of retinal blood flow using fluorescently labeled red blood cells","volume":"2","author":"Kornfield","year":"2015","journal-title":"Eneuro"},{"key":"bib6","doi-asserted-by":"publisher","first-page":"6729","DOI":"10.1167\/iovs.10-5364","article-title":"Impaired retinal circulation in patients with type 2 diabetes mellitus: retinal laser Doppler velocimetry study","volume":"51","author":"Nagaoka","year":"2010","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib7","doi-asserted-by":"publisher","first-page":"991","DOI":"10.1001\/archopht.1986.01050190049038","article-title":"Laser Doppler velocimetry study of retinal circulation in diabetes mellitus","volume":"104","author":"Grunwald","year":"1986","journal-title":"Arch Ophthalmol"},{"key":"bib8","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.preteyeres.2018.08.002","article-title":"Adaptive optics imaging of the human retina","volume":"68","author":"Burns","year":"2019","journal-title":"Prog Retin Eye Res"},{"key":"bib9","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1016\/j.exer.2018.02.006","article-title":"Quantitative comparisons between optical coherence tomography angiography and matched histology in the human eye","volume":"170","author":"An","year":"2018","journal-title":"Exp Eye Res"},{"key":"bib10","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1167\/tvst.10.1.29","article-title":"Use of the retinal vascular histology to validate an optical coherence tomography angiography technique","volume":"10","author":"Yu","year":"2021","journal-title":"Transl Vis Sci Technol"},{"key":"bib11","doi-asserted-by":"publisher","first-page":"1588","DOI":"10.1016\/j.ophtha.2019.05.022","article-title":"Correlation between histologic and oct angiography analysis of macular circulation","volume":"126","author":"Balaratnasingam","year":"2019","journal-title":"Ophthalmology"},{"key":"bib12","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.preteyeres.2017.11.003","article-title":"Optical coherence tomography angiography","volume":"64","author":"Spaide","year":"2018","journal-title":"Prog Retin Eye Res"},{"key":"bib13","doi-asserted-by":"publisher","first-page":"875","DOI":"10.1080\/17434440.2018.1548932","article-title":"Optical coherence tomography angiography (OCTA) flow speed mapping technology for retinal diseases","volume":"15","author":"Arya","year":"2018","journal-title":"Expert Rev Med Devices"},{"key":"bib14","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1016\/j.preteyeres.2019.01.001","article-title":"Retinal capillary perfusion: spatial and temporal heterogeneity","volume":"70","author":"Yu","year":"2019","journal-title":"Prog Retin Eye Res"},{"key":"bib15","doi-asserted-by":"publisher","first-page":"7550","DOI":"10.1038\/s41598-023-33490-8","article-title":"An assessment of microvascular hemodynamics in human macula","volume":"13","author":"Yu","year":"2023","journal-title":"Sci Rep"},{"key":"bib16","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1016\/S1350-9462(02)00044-7","article-title":"Isolated preparations of ocular vasculature and their applications in ophthalmic research","volume":"22","author":"Yu","year":"2003","journal-title":"Prog Retin Eye Res"},{"key":"bib17","doi-asserted-by":"publisher","first-page":"101134","DOI":"10.1016\/j.preteyeres.2022.101134","article-title":"Studies of the retinal microcirculation using human donor eyes and high-resolution clinical imaging: insights gained to guide future research in diabetic retinopathy","volume":"94","author":"Balaratnasingam","year":"2022","journal-title":"Prog Retin Eye Res"},{"key":"bib18","doi-asserted-by":"publisher","first-page":"2353","DOI":"10.1167\/iovs.12-11103","article-title":"The effects of macular ischemia on visual acuity in diabetic retinopathy","volume":"54","author":"Sim","year":"2013","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib19","first-page":"112","article-title":"Outcomes of retinopathy of prematurity","volume":"5","author":"Heidary","year":"2016","journal-title":"Med Hypothesis Discov Innov Ophthalmol"},{"key":"bib20","doi-asserted-by":"crossref","first-page":"679","DOI":"10.2147\/OPTH.S20527","article-title":"Influence of ischemia on visual function in patients with branch retinal vein occlusion and macular edema","volume":"5","author":"Noma","year":"2011","journal-title":"Clin Ophthalmol"},{"key":"bib21","doi-asserted-by":"publisher","first-page":"284","DOI":"10.1016\/j.preteyeres.2008.02.002","article-title":"Regulation of retinal blood flow in health and disease","volume":"27","author":"Pournaras","year":"2008","journal-title":"Prog Retin Eye Res"},{"key":"bib22","doi-asserted-by":"publisher","first-page":"807","DOI":"10.1016\/S0161-6420(13)38013-0","article-title":"Classification of diabetic retinopathy from fluorescein angiograms. ETDRS Report Number 11","volume":"98","author":"Early Treatment Diabetic Retinopathy Study Research Group","year":"1991","journal-title":"Ophthalmology"},{"key":"bib23","doi-asserted-by":"publisher","first-page":"2163","DOI":"10.1097\/IAE.0000000000000765","article-title":"Image artifacts in optical coherence tomography angiography","volume":"35","author":"Spaide","year":"2015","journal-title":"Retina"},{"key":"bib24","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1167\/iovs.62.14.29","article-title":"Measuring temporal and spatial variability of red blood cell velocity in human retinal vessels","volume":"62","author":"Warner","year":"2021","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib26","doi-asserted-by":"publisher","first-page":"24699","DOI":"10.1364\/OE.23.024699","article-title":"Speckle noise reduction algorithm with total variation regularization in optical coherence tomography","volume":"23","author":"Gong","year":"2015","journal-title":"Opt Express"},{"key":"bib27","doi-asserted-by":"publisher","first-page":"2823","DOI":"10.1364\/BOE.7.002823","article-title":"Automated motion correction using parallel-strip registration for wide-field en face OCT angiogram","volume":"7","author":"Zang","year":"2016","journal-title":"Biomed Opt Express"},{"key":"bib28","doi-asserted-by":"publisher","first-page":"676","DOI":"10.1038\/nmeth.2019","article-title":"Fiji: an open-source platform for biological-image analysis","volume":"9","author":"Schindelin","year":"2012","journal-title":"Nat Methods"},{"key":"bib30","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1023\/B:VISI.0000029664.99615.94","article-title":"Distinctive image features from scale-invariant keypoints","volume":"60","author":"Lowe","year":"2004","journal-title":"Int J Comput Vis"},{"key":"bib33","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1109\/34.659930","article-title":"An unbiased detector of curvilinear structures","volume":"20","author":"Steger","year":"1998","journal-title":"IEEE Trans Pattern Anal Machine Intell"},{"key":"bib34","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1016\/j.exer.2018.02.006","article-title":"Quantitative comparisons between optical coherence tomography angiography and matched histology in the human eye","volume":"170","author":"An","year":"2018","journal-title":"Exp Eye Res"},{"key":"bib38","doi-asserted-by":"publisher","first-page":"1841","DOI":"10.3389\/fpsyg.2017.01841","article-title":"Violation of the sphericity assumption and its effect on type-I error rates in repeated measures ANOVA and multi-level linear models (MLM)","volume":"8","author":"Haverkamp","year":"2017","journal-title":"Front Psychol"},{"key":"bib39","doi-asserted-by":"publisher","first-page":"269","DOI":"10.3102\/10769986005003269","article-title":"Pairwise multiple comparisons in repeated measures designs","volume":"5","author":"Maxwell","year":"1980","journal-title":"J Educ Stat"},{"key":"bib40","doi-asserted-by":"publisher","first-page":"1491","DOI":"10.1001\/archopht.116.11.1491","article-title":"Regulation of retinal and optic nerve blood flow","volume":"116","author":"Harris","year":"1998","journal-title":"Arch Ophthalmol"},{"key":"bib41","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1186\/s13613-020-00768-3","article-title":"Retinal blood flow in critical illness and systemic disease: a review","volume":"10","author":"Courtie","year":"2020","journal-title":"Ann Intens Care"},{"key":"bib42","doi-asserted-by":"publisher","first-page":"5584","DOI":"10.1167\/iovs.12-11543","article-title":"Theoretical analysis of vascular regulatory mechanisms contributing to retinal blood flow autoregulation","volume":"54","author":"Arciero","year":"2013","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib43","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/j.neuron.2017.07.030","article-title":"The neurovascular unit coming of age: a journey through neurovascular coupling in health and disease","volume":"96","author":"Iadecola","year":"2017","journal-title":"Neuron"},{"key":"bib44","first-page":"1706","article-title":"Autoregulation of human retinal blood flow","volume":"27","author":"Riva","year":"1986","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib45","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1097\/00004770-200403000-00006","article-title":"Vasoactive response of isolated pulpal arterioles to endothelin-1","volume":"30","author":"Yu","year":"2004","journal-title":"J Endod"},{"key":"bib46","doi-asserted-by":"publisher","first-page":"412","DOI":"10.1167\/iovs.15-18358","article-title":"Local modulation of retinal vein tone","volume":"57","author":"Yu","year":"2016","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib47","doi-asserted-by":"publisher","first-page":"27022","DOI":"10.1073\/pnas.1922755117","article-title":"Contractile pericytes determine the direction of blood flow at capillary junctions","volume":"117","author":"Gonzales","year":"2020","journal-title":"Proc Natl Acad Sci USA"},{"key":"bib48","doi-asserted-by":"publisher","first-page":"5","DOI":"10.3389\/fnene.2010.00005","article-title":"Pericyte-mediated regulation of capillary diameter: a component of neurovascular coupling in health and disease","volume":"2","author":"Hamilton","year":"2010","journal-title":"Front Neuroenergetics"},{"key":"bib49","doi-asserted-by":"publisher","first-page":"2862","DOI":"10.1523\/JNEUROSCI.4048-05.2006","article-title":"Glial cells dilate and constrict blood vessels: a mechanism of neurovascular coupling","volume":"26","author":"Metea","year":"2006","journal-title":"J Neurosci"},{"key":"bib50","doi-asserted-by":"publisher","first-page":"E0251607","DOI":"10.1371\/journal.pone.0251607","article-title":"Retinal oxygen saturation changes progressively over time in diabetic retinopathy","volume":"16","author":"Hardarson","year":"2021","journal-title":"PLoS One"},{"key":"bib52","doi-asserted-by":"publisher","first-page":"11658","DOI":"10.1073\/pnas.1918546117","article-title":"Retinal capillary oximetry with visible light optical coherence tomography","volume":"117","author":"Pi","year":"2020","journal-title":"Proc Natl Acad Sci USA"},{"key":"bib53","doi-asserted-by":"publisher","first-page":"6710","DOI":"10.1364\/BOE.408481","article-title":"Relative retinal flow velocity detection using optical coherence tomography angiography imaging","volume":"11","author":"Richter","year":"2020","journal-title":"Biomed Opt Express"},{"key":"bib54","doi-asserted-by":"publisher","first-page":"2371","DOI":"10.1097\/IAE.0000000000000716","article-title":"Optical coherence tomography angiography features of diabetic retinopathy","volume":"35","author":"Hwang","year":"2015","journal-title":"Retina (Philadelphia, Pa)"},{"key":"bib55","doi-asserted-by":"publisher","first-page":"2212","DOI":"10.1097\/IAE.0000000000000773","article-title":"Type 2 neovascularization secondary to age-related macular degeneration imaged by optical coherence tomography angiography","volume":"35","author":"El Ameen","year":"2015","journal-title":"Retina"},{"key":"bib56","doi-asserted-by":"publisher","first-page":"2219","DOI":"10.1097\/IAE.0000000000000766","article-title":"Optical coherence tomography angiography versus traditional multimodal imaging in assessing the activity of exudative age-related macular degeneration: a new diagnostic challenge","volume":"35","author":"Coscas","year":"2015","journal-title":"Retina"},{"key":"bib57","doi-asserted-by":"publisher","first-page":"2323","DOI":"10.1097\/IAE.0000000000000811","article-title":"Optical coherence tomography angiography of retinal venous occlusion","volume":"35","author":"Kashani","year":"2015","journal-title":"Retina"},{"issue":"suppl 1","key":"bib58","doi-asserted-by":"crossref","first-page":"S118","DOI":"10.1097\/IAE.0000000000001328","article-title":"Toward quantitative optical coherence tomography angiography: visualizing blood flow speeds in ocular pathology using variable interscan time analysis","volume":"36","author":"Ploner","year":"2016","journal-title":"Retina"},{"key":"bib59","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1016\/j.oret.2020.06.024","article-title":"Analyzing relative flow speeds in diabetic retinopathy using variable interscan time analysis OCT angiography","volume":"5","author":"Arya","year":"2021","journal-title":"Ophthalmol Retina"},{"key":"bib60","doi-asserted-by":"publisher","first-page":"785","DOI":"10.1111\/cep.1997.24.issue-9-10","article-title":"Diabetic retinopathy: early functional changes","volume":"24","author":"Alder","year":"1997","journal-title":"Clin Exp Pharmacol Physiol"},{"key":"bib61","doi-asserted-by":"publisher","first-page":"1909","DOI":"10.1364\/BOE.4.001909","article-title":"Blood flow velocity quantification using split-spectrum amplitude-decorrelation angiography with optical coherence tomography","volume":"4","author":"Tokayer","year":"2013","journal-title":"Biomed Opt Express"},{"key":"bib62","first-page":"1124","article-title":"Blood velocity and volumetric flow rate in human retinal vessels","volume":"26","author":"Riva","year":"1985","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib63","doi-asserted-by":"publisher","first-page":"E0218918","DOI":"10.1371\/journal.pone.0218918","article-title":"Mapping flow velocity in the human retinal capillary network with pixel intensity cross correlation","volume":"14","author":"Bedggood","year":"2019","journal-title":"PLoS One"},{"key":"bib64","doi-asserted-by":"publisher","first-page":"542","DOI":"10.1001\/archopht.1964.00970010558021","article-title":"Occlusive disease of retinal vasculature: a clinicopathological study","volume":"71","author":"Kornzweig","year":"1964","journal-title":"Arch Ophthalmol"},{"key":"bib65","doi-asserted-by":"publisher","first-page":"1132","DOI":"10.1001\/archopht.1982.01030040110020","article-title":"Histopathologic study of nine branch retinal vein occlusions","volume":"100","author":"Frangieh","year":"1982","journal-title":"Arch Ophthalmol"},{"key":"bib66","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1136\/bjo.63.6.377","article-title":"Experimental retinal branch vein occlusion in rhesus monkeys. I. Clinical appearances","volume":"63","author":"Hamilton","year":"1979","journal-title":"Br J Ophthalmol"},{"key":"bib67","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1167\/iovs.63.5.8","article-title":"Alpha-smooth muscle actin expression and parafoveal blood flow pathways are altered in preclinical diabetic retinopathy","volume":"63","author":"An","year":"2022","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"4","key":"bib68","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1167\/iovs.61.4.39","article-title":"Non-proliferative diabetic retinopathy is characterized by nonuniform alterations of peripapillary capillary networks","volume":"61","author":"An","year":"2020","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib69","doi-asserted-by":"publisher","first-page":"4574","DOI":"10.1167\/iovs.19-26986","article-title":"Topographic distribution of contractile protein in the human macular microvasculature","volume":"60","author":"Yu","year":"2019","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"6","key":"bib70","doi-asserted-by":"publisher","first-page":"2158","DOI":"10.3390\/ijms21062158","article-title":"Alpha-smooth muscle actin-positive perivascular cells in diabetic retina and choroid","volume":"21","author":"Kim","year":"2020","journal-title":"Int J Mol Sci"},{"key":"bib71","doi-asserted-by":"publisher","first-page":"2693","DOI":"10.1167\/iovs.05-1297","article-title":"Deletion of smooth muscle alpha-actin alters blood-retina barrier permeability and retinal function","volume":"47","author":"Tomasek","year":"2006","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib72","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1001\/archopht.1967.00980020407021","article-title":"Central retinal artery innervation. Absence of adrenergic innervation to the intraocular branches","volume":"77","author":"Laties","year":"1967","journal-title":"Arch Ophthalmol"},{"key":"bib73","doi-asserted-by":"publisher","first-page":"3937","DOI":"10.1161\/CIRCULATIONAHA.105.543124","article-title":"Blood flow remodels growing vasculature during vascular endothelial growth factor gene therapy and determines between capillary arterialization and sprouting angiogenesis","volume":"112","author":"Rissanen","year":"2005","journal-title":"Circulation"},{"key":"bib74","doi-asserted-by":"publisher","first-page":"26331055221109254","DOI":"10.1177\/26331055221109254","article-title":"VEGF paradoxically reduces cerebral blood flow in Alzheimer's disease mice","volume":"17","author":"Ali","year":"2022","journal-title":"Neurosci Insights"},{"key":"bib25","volume-title":"Biometry: The Principles and Practice of Statistics in Biological Research","author":"Gillbricht","year":"1969"},{"key":"bib29","volume-title":"R: A Language and Environment for Statistical Computing","author":"R-Development-Core-Team","year":"2011"},{"key":"bib31","volume-title":"Rniftyreg: Image Registration Using the \u2018Niftyreg\u2019 Library","author":"Clayden","year":"2020"},{"key":"bib32","volume-title":"Thorstenwager\/Ij-Ridgedetection: Ridge Detection 1.4.0 (Version V1.4.0)","author":"Wagner","year":"2017"},{"key":"bib35","volume-title":"Rstatix: Pipe-Friendly Framework for Basic Statistical Tests","author":"Kassambara","year":"2021"},{"key":"bib36","volume-title":"Afex: Analysis of Factorial Experiments","author":"Singmann","year":"2021"},{"key":"bib37","volume-title":"Emmeans: Estimated Marginal Means, aka Least-Squares Means","author":"Lenth","year":"2022"},{"key":"bib51","volume-title":"Handbook of Physiology: Microcirculation","author":"Tuma","year":"2008","edition":"2nd ed"}],"container-title":["Investigative Opthalmology & Visual Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/iovs.arvojournals.org\/article.aspx?articleid=2792939","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:31:42Z","timestamp":1791927102000},"score":1,"resource":{"primary":{"URL":"https:\/\/iovs.arvojournals.org\/article.aspx?articleid=2792939"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10,19]]},"references-count":74,"journal-issue":{"issue":"13","published-print":{"date-parts":[[2023,10,3]]}},"URL":"https:\/\/doi.org\/10.1167\/iovs.64.13.30","relation":{},"ISSN":["1552-5783"],"issn-type":[{"value":"1552-5783","type":"print"}],"subject":[],"published":{"date-parts":[[2023,10,19]]}}}