{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T04:32:45Z","timestamp":1792125165115,"version":"4.4.0"},"reference-count":50,"publisher":"Association for Research in Vision and Ophthalmology (ARVO)","issue":"14","license":[{"start":{"date-parts":[[2023,11,28]],"date-time":"2023-11-28T00:00:00Z","timestamp":1701129600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Invest. Ophthalmol. Vis. Sci."],"published-print":{"date-parts":[[2023,11,28]]},"DOI":"10.1167\/iovs.64.14.42","type":"journal-article","created":{"date-parts":[[2023,11,28]],"date-time":"2023-11-28T10:52:20Z","timestamp":1701168740000},"page":"42","source":"Crossref","is-referenced-by-count":24,"title":["GSK840 Alleviates Retinal Neuronal Injury by Inhibiting RIPK3\/MLKL-Mediated RGC Necroptosis After Ischemia\/Reperfusion"],"prefix":"10.1167","volume":"64","author":[{"given":"Yanlin","family":"Feng","sequence":"first","affiliation":[{"name":"State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenyang","family":"Hu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaixuan","family":"Cui","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew","family":"Fan","sequence":"additional","affiliation":[{"name":"Yale College, Yale University, New Haven, Connecticut, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wu","family":"Xiang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Ye","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuxun","family":"Shi","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huiwen","family":"Ye","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue","family":"Bai","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yantao","family":"Wei","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Xu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingjing","family":"Huang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"27","reference":[{"key":"bib1","first-page":"1374","article-title":"Ischemia-reperfusion injury of the retina is linked to necroptosis via the ERK1\/2-RIP3 pathway","volume":"20","author":"Gao","year":"2014","journal-title":"Mol Vis"},{"issue":"1","key":"bib2","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1016\/j.preteyeres.2003.12.001","article-title":"Retinal ischemia: mechanisms of damage and potential therapeutic strategies","volume":"23","author":"Osborne","year":"2004","journal-title":"Prog Retin Eye Res"},{"issue":"5","key":"bib3","doi-asserted-by":"publisher","first-page":"507","DOI":"10.1038\/s41419-022-04911-9","article-title":"Inhibiting multiple forms of cell death optimizes ganglion cells survival after retinal ischemia reperfusion injury","volume":"13","author":"Qin","year":"2022","journal-title":"Cell Death Dis"},{"key":"bib4","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.exer.2014.04.009","article-title":"Retinal ganglion cell (RGC) programmed necrosis contributes to ischemia-reperfusion-induced retinal damage","volume":"123","author":"Dvoriantchikova","year":"2014","journal-title":"Exp Eye Res"},{"issue":"5","key":"bib5","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1056\/NEJMra1310050","article-title":"Necroptosis","volume":"370","author":"Linkermann","year":"2014","journal-title":"N Engl J Med"},{"issue":"10","key":"bib6","doi-asserted-by":"publisher","first-page":"721","DOI":"10.1016\/j.tcb.2016.06.004","article-title":"An evolutionary perspective on the necroptotic pathway","volume":"26","author":"Dondelinger","year":"2016","journal-title":"Trends Cell Biol"},{"issue":"9","key":"bib7","doi-asserted-by":"publisher","first-page":"1236","DOI":"10.1038\/nn.4608","article-title":"Necroptosis activation in Alzheimer's disease","volume":"20","author":"Caccamo","year":"2017","journal-title":"Nat Neurosci"},{"issue":"8","key":"bib8","doi-asserted-by":"publisher","first-page":"2066","DOI":"10.1016\/j.celrep.2018.01.089","article-title":"Pharmacological inhibition of necroptosis protects from dopaminergic neuronal cell death in Parkinson's disease models","volume":"22","author":"Iannielli","year":"2018","journal-title":"Cell Rep"},{"issue":"11","key":"bib9","doi-asserted-by":"publisher","first-page":"1836","DOI":"10.1016\/j.celrep.2015.02.051","article-title":"Activation of necroptosis in multiple sclerosis","volume":"10","author":"Ofengeim","year":"2015","journal-title":"Cell Rep"},{"issue":"4","key":"bib10","doi-asserted-by":"publisher","first-page":"e12828","DOI":"10.1111\/jpi.v73.4","article-title":"Anti-PANoptosis is involved in neuroprotective effects of melatonin in acute ocular hypertension model","volume":"73","author":"Ye","year":"2022","journal-title":"J Pineal Res"},{"issue":"1","key":"bib11","doi-asserted-by":"publisher","first-page":"3947","DOI":"10.1080\/21655979.2021.1944456","article-title":"Investigation on the expression regulation of RIPK1\/RIPK3 in the retinal ganglion cells (RGCs) cultured in high glucose","volume":"12","author":"Gao","year":"2021","journal-title":"Bioengineered"},{"issue":"1","key":"bib12","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1016\/j.yexcr.2017.08.012","article-title":"A novel RIPK1 inhibitor that prevents retinal degeneration in a rat glaucoma model","volume":"359","author":"Do","year":"2017","journal-title":"Exp Cell Res"},{"issue":"1","key":"bib13","doi-asserted-by":"publisher","first-page":"262","DOI":"10.1186\/s12974-022-02626-4","article-title":"GSK872 and necrostatin-1 protect retinal ganglion cells against necroptosis through inhibition of RIP1\/RIP3\/MLKL pathway in glutamate-induced retinal excitotoxic model of glaucoma","volume":"19","author":"Liu","year":"2022","journal-title":"J Neuroinflammation"},{"key":"bib14","doi-asserted-by":"publisher","first-page":"109019","DOI":"10.1016\/j.biopha.2019.109019","article-title":"RIP3 inhibition protects locomotion function through ameliorating mitochondrial antioxidative capacity after spinal cord injury","volume":"116","author":"Wang","year":"2019","journal-title":"Biomed Pharmacother"},{"key":"bib15","doi-asserted-by":"publisher","first-page":"2622","DOI":"10.1093\/cercor\/bhy089","article-title":"RIPK3\/MLKL-mediated neuronal necroptosis modulates the M1\/m2 polarization of microglia\/macrophages in the ischemic cortex","volume":"28","author":"Yang","year":"2018","journal-title":"Cereb Cortex"},{"key":"bib17","doi-asserted-by":"publisher","first-page":"481","DOI":"10.1016\/j.molcel.2014.10.021","article-title":"RIP3 induces apoptosis independent of pronecrotic kinase activity","volume":"56","author":"Mandal","year":"2014","journal-title":"Mol Cell"},{"key":"bib18","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1038\/cdd.2015.70","article-title":"Characterization of RIPK3-mediated phosphorylation of the activation loop of MLKL during necroptosis","volume":"23","author":"Rodriguez","year":"2016","journal-title":"Cell Death Differ"},{"issue":"1","key":"bib19","doi-asserted-by":"publisher","first-page":"1931","DOI":"10.1038\/s41467-017-02035-9","article-title":"Pandemic H1N1 influenza A viruses suppress immunogenic RIPK3-driven dendritic cell death","volume":"8","author":"Hartmann","year":"2017","journal-title":"Nat Commun"},{"issue":"2","key":"bib20","doi-asserted-by":"publisher","first-page":"e1636","DOI":"10.1038\/cddis.2015.16","article-title":"Differential roles of RIPK1 and RIPK3 in TNF-induced necroptosis and chemotherapeutic agent-induced cell death","volume":"6","author":"Moriwaki","year":"2015","journal-title":"Cell Death Dis"},{"issue":"11","key":"bib21","doi-asserted-by":"publisher","first-page":"e2023290118","DOI":"10.1073\/pnas.2023290118","article-title":"A specific RIP3(+) subpopulation of microglia promotes retinopathy through a hypoxia-triggered necroptotic mechanism","volume":"118","author":"He","year":"2021","journal-title":"Proc Natl Acad Sci USA"},{"issue":"1","key":"bib22","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1038\/s41420-022-00891-z","article-title":"Loss of Ripk3 attenuated neutrophil accumulation in a lipopolysaccharide-induced zebrafish inflammatory model","volume":"8","author":"Wen","year":"2022","journal-title":"Cell Death Discov"},{"issue":"3","key":"bib23","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1167\/iovs.63.3.18","article-title":"Intravitreal injection of PACAP attenuates acute ocular hypertension-induced retinal injury via anti-apoptosis and anti-inflammation in mice","volume":"63","author":"Lu","year":"2022","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"4","key":"bib24","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1167\/iovs.64.4.31","article-title":"Neuroprotection of SRT2104 in murine ischemia\/reperfusion injury through the enhancement of sirt1-mediated deacetylation","volume":"64","author":"Bai","year":"2023","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib25","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1159\/issn.0250-3751","article-title":"Retinal anatomy and pathology","volume":"55","author":"Gupta","year":"2016","journal-title":"Dev Ophthalmol"},{"issue":"5","key":"bib26","doi-asserted-by":"publisher","first-page":"483","DOI":"10.1007\/s10735-011-9346-2","article-title":"Unusual retinal layer organization in HPC-1\/syntaxin 1A knockout mice","volume":"42","author":"Kaneko","year":"2011","journal-title":"J Mol Histol"},{"issue":"3","key":"bib27","doi-asserted-by":"publisher","first-page":"400","DOI":"10.1007\/s11596-011-0389-0","article-title":"Culture of rat retinal ganglion cells","volume":"31","author":"Xu","year":"2011","journal-title":"J Huazhong Univ Sci Technolog Med Sci"},{"issue":"4","key":"bib28","doi-asserted-by":"crossref","DOI":"10.1084\/jem.20190930","article-title":"Neuronal Epac1 mediates retinal neurodegeneration in mouse models of ocular hypertension","volume":"217","author":"Liu","year":"2020","journal-title":"J Exp Med"},{"issue":"1","key":"bib29","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1186\/s10020-018-0054-1","article-title":"Propofol inhibited autophagy through Ca(2+)\/CaMKK\u00df\/AMPK\/mTOR pathway in OGD\/R-induced neuron injury","volume":"24","author":"Sun","year":"2018","journal-title":"Mol Med"},{"key":"bib30","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1007\/978-1-4939-2152-2","article-title":"In vitro oxygen-glucose deprivation to study ischemic cell death","volume":"1254","author":"Tasca","year":"2015","journal-title":"Methods Mol Biol"},{"issue":"30","key":"bib31","doi-asserted-by":"publisher","first-page":"11181","DOI":"10.1073\/pnas.1402819111","article-title":"Caspase-8 promotes NLRP1\/NLRP3 inflammasome activation and IL-1\u00df production in acute glaucoma","volume":"111","author":"Chi","year":"2014","journal-title":"Proc Natl Acad Sci USA"},{"issue":"1","key":"bib32","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1186\/s13024-020-00372-w","article-title":"NLRP12 collaborates with NLRP3 and NLRC4 to promote pyroptosis inducing ganglion cell death of acute glaucoma","volume":"15","author":"Chen","year":"2020","journal-title":"Mol Neurodegener"},{"issue":"1","key":"bib33","doi-asserted-by":"publisher","first-page":"176","DOI":"10.1038\/s41418-019-0351-4","article-title":"LncRNA H19 initiates microglial pyroptosis and neuronal death in retinal ischemia\/reperfusion injury","volume":"27","author":"Wan","year":"2020","journal-title":"Cell Death Differ"},{"key":"bib34","doi-asserted-by":"publisher","first-page":"101199","DOI":"10.1016\/j.redox.2019.101199","article-title":"Hyperhomocysteinemia-induced death of retinal ganglion cells: the role of M\u00fcller glial cells and NRF2","volume":"24","author":"Navneet","year":"2019","journal-title":"Redox Biol"},{"issue":"6","key":"bib35","doi-asserted-by":"publisher","first-page":"1411","DOI":"10.1002\/cne.v522.6","article-title":"The RNA binding protein RBPMS is a selective marker of ganglion cells in the mammalian retina","volume":"522","author":"Rodriguez","year":"2014","journal-title":"J Comp Neurol"},{"issue":"1","key":"bib36","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s10633-017-9621-y","article-title":"ISCEV guide to visual electrodiagnostic procedures","volume":"136","author":"Robson","year":"2018","journal-title":"Doc Ophthalmol"},{"issue":"7","key":"bib37","doi-asserted-by":"publisher","first-page":"4691","DOI":"10.1167\/iovs.13-12415","article-title":"The photopic negative response of the mouse electroretinogram: reduction by acute elevation of intraocular pressure","volume":"54","author":"Chrysostomou","year":"2013","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"8","key":"bib38","doi-asserted-by":"publisher","first-page":"928","DOI":"10.1038\/sj.cdd.4401250","article-title":"Intravenously administered propidium iodide labels necrotic cells in the intact mouse brain after injury","volume":"10","author":"Unal Cevik","year":"2003","journal-title":"Cell Death Differ"},{"issue":"2","key":"bib39","doi-asserted-by":"publisher","first-page":"813","DOI":"10.1152\/physrev.00011.2017","article-title":"Neuronal Cell Death","volume":"98","author":"Fricker","year":"2018","journal-title":"Physiol Rev"},{"issue":"2","key":"bib40","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1016\/j.preteyeres.2011.11.002","article-title":"The molecular basis of retinal ganglion cell death in glaucoma","volume":"31","author":"Almasieh","year":"2012","journal-title":"Prog Retin Eye Res"},{"issue":"5","key":"bib41","doi-asserted-by":"publisher","first-page":"1001","DOI":"10.1016\/j.neuron.2014.01.011","article-title":"Necroptosis drives motor neuron death in models of both sporadic and familial ALS","volume":"81","author":"Re","year":"2014","journal-title":"Neuron"},{"issue":"5","key":"bib42","doi-asserted-by":"publisher","first-page":"771","DOI":"10.1080\/02713683.2016.1227449","article-title":"Ischemia reperfusion injury triggers TNFa induced-necroptosis in rat retina","volume":"42","author":"Kim","year":"2017","journal-title":"Curr Eye Res"},{"key":"bib43","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1186\/1471-2202-14-16","article-title":"Differential neuronal expression of receptor interacting protein 3 in rat retina: involvement in ischemic stress response","volume":"14","author":"Huang","year":"2013","journal-title":"BMC Neurosci"},{"issue":"21","key":"bib44","doi-asserted-by":"publisher","first-page":"7753","DOI":"10.1073\/pnas.1401857111","article-title":"RIP1 suppresses innate immune necrotic as well as apoptotic cell death during mammalian parturition","volume":"111","author":"Kaiser","year":"2014","journal-title":"Proc Natl Acad Sci USA"},{"issue":"43","key":"bib45","doi-asserted-by":"publisher","first-page":"31268","DOI":"10.1074\/jbc.M113.462341","article-title":"Toll-like receptor 3-mediated necrosis via TRIF, RIP3, and MLKL","volume":"288","author":"Kaiser","year":"2013","journal-title":"J Biol Chem"},{"issue":"7","key":"bib46","doi-asserted-by":"publisher","first-page":"1569","DOI":"10.1002\/jnr.v88:7","article-title":"Necroptosis, a novel form of caspase-independent cell death, contributes to neuronal damage in a retinal ischemia-reperfusion injury model","volume":"88","author":"Rosenbaum","year":"2010","journal-title":"J Neurosci Res"},{"issue":"4","key":"bib47","doi-asserted-by":"publisher","first-page":"627","DOI":"10.1016\/j.jhep.2019.11.008","article-title":"Inhibition of receptor-interacting protein kinase 1 improves experimental non-alcoholic fatty liver disease","volume":"72","author":"Majdi","year":"2020","journal-title":"J Hepatol"},{"key":"bib48","doi-asserted-by":"publisher","first-page":"174","DOI":"10.3389\/fncel.2019.00174","article-title":"From ganglion cell to photoreceptor layer: timeline of deterioration in a rat ischemia\/reperfusion model","volume":"13","author":"Palmhof","year":"2019","journal-title":"Front Cell Neurosci"},{"issue":"1","key":"bib49","first-page":"1","article-title":"Functional and morphological alterations in a glaucoma model of acute ocular hypertension","volume":"256","author":"Gallego-Ortega","year":"2020","journal-title":"Prog Brain Res"},{"issue":"18","key":"bib50","doi-asserted-by":"publisher","first-page":"2928","DOI":"10.1016\/j.neuron.2021.07.008","article-title":"Direction selectivity in retinal bipolar cell axon terminals","volume":"109","author":"Matsumoto","year":"2021","journal-title":"Neuron"},{"key":"bib16","first-page":"357566","article-title":"Combined inhibition of apoptosis and necrosis promotes transient neuroprotection of retinal ganglion cells and partial-axon regeneration after optic nerve damage","author":"Kayama","year":"2018"}],"container-title":["Investigative Opthalmology & Visual Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/iovs.arvojournals.org\/article.aspx?articleid=2793053","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:31:44Z","timestamp":1791927104000},"score":1,"resource":{"primary":{"URL":"https:\/\/iovs.arvojournals.org\/article.aspx?articleid=2793053"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11,28]]},"references-count":50,"journal-issue":{"issue":"14","published-print":{"date-parts":[[2023,11,1]]}},"URL":"https:\/\/doi.org\/10.1167\/iovs.64.14.42","relation":{},"ISSN":["1552-5783"],"issn-type":[{"value":"1552-5783","type":"print"}],"subject":[],"published":{"date-parts":[[2023,11,28]]}}}