{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T22:00:22Z","timestamp":1791928822959,"version":"4.3.4"},"reference-count":42,"publisher":"Association for Research in Vision and Ophthalmology (ARVO)","issue":"15","license":[{"start":{"date-parts":[[2023,12,22]],"date-time":"2023-12-22T00:00:00Z","timestamp":1703203200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Invest. Ophthalmol. Vis. Sci."],"published-print":{"date-parts":[[2023,12,22]]},"DOI":"10.1167\/iovs.64.15.32","type":"journal-article","created":{"date-parts":[[2023,12,22]],"date-time":"2023-12-22T09:31:04Z","timestamp":1703237464000},"page":"32","source":"Crossref","is-referenced-by-count":6,"title":["Retinal Ganglion Cell Fate Induction by Ngn-Family Transcription Factors"],"prefix":"10.1167","volume":"64","author":[{"given":"Ke","family":"Zhang","sequence":"first","affiliation":[{"name":"State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenwen","family":"Cai","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanling","family":"Xin","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qinghai","family":"He","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Canbin","family":"Chen","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingbing","family":"Zeng","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuyi","family":"Chen","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"27","reference":[{"key":"bib1","doi-asserted-by":"publisher","first-page":"1901","DOI":"10.1001\/jama.2014.3192","article-title":"The pathophysiology and treatment of glaucoma: a review","volume":"311","author":"Weinreb","year":"2014","journal-title":"JAMA"},{"key":"bib2","doi-asserted-by":"publisher","first-page":"2183","DOI":"10.1016\/S0140-6736(17)31469-1","article-title":"Glaucoma","volume":"390","author":"Jonas","year":"2017","journal-title":"Lancet"},{"key":"bib3","doi-asserted-by":"publisher","first-page":"2081","DOI":"10.1016\/j.ophtha.2014.05.013","article-title":"Global prevalence of glaucoma and projections of glaucoma burden through 2040: a systematic review and meta-analysis","volume":"121","author":"Tham","year":"2014","journal-title":"Ophthalmology"},{"key":"bib4","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1038\/cr.2013.1","article-title":"A blueprint for engineering cell fate: current technologies to reprogram cell identity","volume":"23","author":"Morris","year":"2013","journal-title":"Cell Res"},{"key":"bib5","doi-asserted-by":"publisher","first-page":"410","DOI":"10.1038\/s41580-021-00335-z","article-title":"Direct cell reprogramming: approaches, mechanisms and progress","volume":"22","author":"Wang","year":"2021","journal-title":"Nat Rev Mol Cell Biol"},{"key":"bib6","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1016\/j.stem.2015.01.013","article-title":"Direct lineage reprogramming: strategies, mechanisms, and applications","volume":"16","author":"Xu","year":"2015","journal-title":"Cell Stem Cell"},{"key":"bib7","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1038\/nature23283","article-title":"Stimulation of functional neuronal regeneration from Muller glia in adult mice","volume":"548","author":"Jorstad","year":"2017","journal-title":"Nature"},{"key":"bib8","doi-asserted-by":"publisher","first-page":"484","DOI":"10.1038\/s41586-018-0425-3","article-title":"Restoration of vision after de novo genesis of rod photoreceptors in mammalian retinas","volume":"560","author":"Yao","year":"2018","journal-title":"Nature"},{"key":"bib9","doi-asserted-by":"publisher","first-page":"eabb8598","DOI":"10.1126\/science.abb8598","article-title":"Gene regulatory networks controlling vertebrate retinal regeneration","volume":"370","author":"Hoang","year":"2020","journal-title":"Science"},{"key":"bib10","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.stemcr.2020.09.008","article-title":"Quick commitment and efficient reprogramming route of direct induction of retinal ganglion cell-like neurons","volume":"15","author":"Wang","year":"2020","journal-title":"Stem Cell Reports"},{"key":"bib11","doi-asserted-by":"publisher","first-page":"eabq7219","DOI":"10.1126\/sciadv.abq7219","article-title":"Reprogramming Muller glia to regenerate ganglion-like cells in adult mouse retina with developmental transcription factors","volume":"8","author":"Todd","year":"2022","journal-title":"Sci Adv"},{"key":"bib12","doi-asserted-by":"publisher","first-page":"621","DOI":"10.1016\/j.cell.2013.09.028","article-title":"Hierarchical mechanisms for direct reprogramming of fibroblasts to neurons","volume":"155","author":"Wapinski","year":"2013","journal-title":"Cell"},{"key":"bib13","doi-asserted-by":"publisher","first-page":"3519","DOI":"10.1242\/dev.064006","article-title":"Ascl1 expression defines a subpopulation of lineage-restricted progenitors in the mammalian retina","volume":"138","author":"Brzezinski","year":"2011","journal-title":"Development"},{"key":"bib14","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1016\/j.mcn.2005.10.018","article-title":"The final fates of neurogenin2-expressing cells include all major neuron types in the mouse retina","volume":"31","author":"Ma","year":"2006","journal-title":"Mol Cell Neurosci"},{"key":"bib15","doi-asserted-by":"publisher","first-page":"517","DOI":"10.1038\/nrn874","article-title":"Proneural genes and the specification of neural cell types","volume":"3","author":"Bertrand","year":"2002","journal-title":"Nat Rev Neurosci"},{"key":"bib16","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1038\/s41586-018-0103-5","article-title":"Diverse reprogramming codes for neuronal identity","volume":"557","author":"Tsunemoto","year":"2018","journal-title":"Nature"},{"key":"bib17","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1038\/nn.3887","article-title":"Selective conversion of fibroblasts into peripheral sensory neurons","volume":"18","author":"Blanchard","year":"2015","journal-title":"Nat Neurosci"},{"key":"bib18","doi-asserted-by":"publisher","first-page":"1027","DOI":"10.1073\/pnas.0610155104","article-title":"Controlled expression of transgenes introduced by in vivo electroporation","volume":"104","author":"Matsuda","year":"2007","journal-title":"Proc Natl Acad Sci USA"},{"key":"bib19","doi-asserted-by":"publisher","first-page":"852","DOI":"10.1016\/j.neuron.2009.01.020","article-title":"Distinct roles of transcription factors brn3a and brn3b in controlling the development, morphology, and function of retinal ganglion cells","volume":"61","author":"Badea","year":"2009","journal-title":"Neuron"},{"key":"bib20","doi-asserted-by":"publisher","first-page":"1202","DOI":"10.1016\/j.cell.2015.05.002","article-title":"Highly parallel genome-wide expression profiling of individual cells using nanoliter droplets","volume":"161","author":"Macosko","year":"2015","journal-title":"Cell"},{"key":"bib21","doi-asserted-by":"publisher","first-page":"eaaz5858","DOI":"10.1126\/sciadv.aaz5858","article-title":"Generation of self-organized sensory ganglion organoids and retinal ganglion cells from fibroblasts","volume":"6","author":"Xiao","year":"2020","journal-title":"Sci Adv"},{"key":"bib22","doi-asserted-by":"publisher","first-page":"4821","DOI":"10.1242\/dev.125.23.4821","article-title":"Math5 encodes a murine basic helix-loop-helix transcription factor expressed during early stages of retinal neurogenesis","volume":"125","author":"Brown","year":"1998","journal-title":"Development"},{"key":"bib23","doi-asserted-by":"publisher","first-page":"541","DOI":"10.1242\/dev.085886","article-title":"Reprogramming amacrine and photoreceptor progenitors into retinal ganglion cells by replacing Neurod1 with Atoh7","volume":"140","author":"Mao","year":"2013","journal-title":"Development"},{"key":"bib24","doi-asserted-by":"publisher","first-page":"240","DOI":"10.1016\/j.ydbio.2003.08.005","article-title":"Math5 determines the competence state of retinal ganglion cell progenitors","volume":"264","author":"Yang","year":"2003","journal-title":"Dev Biol"},{"key":"bib25","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1101\/gad.855301","article-title":"Requirement for math5 in the development of retinal ganglion cells","volume":"15","author":"Wang","year":"2001","journal-title":"Genes Dev"},{"key":"bib26","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1038\/nrn2057","article-title":"Specification and connectivity of neuronal subtypes in the sensory lineage","volume":"8","author":"Marmigere","year":"2007","journal-title":"Nat Rev Neurosci"},{"key":"bib27","doi-asserted-by":"publisher","first-page":"589","DOI":"10.1073\/pnas.93.2.589","article-title":"Cell fate determination in the vertebrate retina","volume":"93","author":"Cepko","year":"1996","journal-title":"Proc Natl Acad Sci USA"},{"key":"bib28","doi-asserted-by":"publisher","first-page":"5970","DOI":"10.1167\/iovs.09-4504","article-title":"Generation of retinal ganglion-like cells from reprogrammed mouse fibroblasts","volume":"51","author":"Chen","year":"2010","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib29","doi-asserted-by":"publisher","first-page":"490","DOI":"10.1016\/j.ydbio.2010.02.002","article-title":"Neurog2 controls the leading edge of neurogenesis in the mammalian retina","volume":"340","author":"Hufnagel","year":"2010","journal-title":"Dev Biol"},{"key":"bib30","doi-asserted-by":"publisher","first-page":"2690","DOI":"10.1016\/j.stemcr.2022.10.011","article-title":"Directly induced human retinal ganglion cells mimic fetal RGCs and are neuroprotective after transplantation in vivo","volume":"17","author":"Luo","year":"2022","journal-title":"Stem Cell Reports"},{"key":"bib31","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1016\/j.neuroscience.2013.07.001","article-title":"Induction of retinal ganglion-like cells from fibroblasts by adenoviral gene delivery","volume":"250","author":"Meng","year":"2013","journal-title":"Neuroscience"},{"key":"bib32","doi-asserted-by":"publisher","first-page":"1717","DOI":"10.1101\/gad.13.13.1717","article-title":"Neurogenin1 and neurogenin2 control two distinct waves of neurogenesis in developing dorsal root ganglia","volume":"13","author":"Ma","year":"1999","journal-title":"Genes Dev"},{"key":"bib33","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1038\/nn.3886","article-title":"Modeling pain in vitro using nociceptor neurons reprogrammed from fibroblasts","volume":"18","author":"Wainger","year":"2015","journal-title":"Nat Neurosci"},{"key":"bib34","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1242\/dev.128.2.217","article-title":"Specification of neurotransmitter receptor identity in developing retina: the chick ATH5 promoter integrates the positive and negative effects of several bHLH proteins","volume":"128","author":"Matter-Sadzinski","year":"2001","journal-title":"Development"},{"key":"bib35","doi-asserted-by":"publisher","first-page":"913","DOI":"10.1242\/dev.02245","article-title":"Notch 1 inhibits photoreceptor production in the developing mammalian retina","volume":"133","author":"Jadhav","year":"2006","journal-title":"Development"},{"key":"bib36","doi-asserted-by":"publisher","first-page":"3188","DOI":"10.1242\/dev.090696","article-title":"Notch1 is required in newly postmitotic cells to inhibit the rod photoreceptor fate","volume":"140","author":"Mizeracka","year":"2013","journal-title":"Development"},{"key":"bib37","doi-asserted-by":"publisher","first-page":"109994","DOI":"10.1016\/j.celrep.2021.109994","article-title":"Gene regulatory networks controlling temporal patterning, neurogenesis, and cell-fate specification in mammalian retina","volume":"37","author":"Lyu","year":"2021","journal-title":"Cell Rep"},{"key":"bib38","doi-asserted-by":"publisher","first-page":"1111","DOI":"10.1016\/j.neuron.2019.04.010","article-title":"Single-cell RNA-seq analysis of retinal development identifies NFI factors as regulating mitotic exit and late-born cell specification","volume":"102","author":"Clark","year":"2019","journal-title":"Neuron"},{"key":"bib39","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1073\/pnas.2235688100","article-title":"Electroporation and RNA interference in the rodent retina in vivo and in vitro","volume":"101","author":"Matsuda","year":"2004","journal-title":"Proc Natl Acad Sci USA"},{"key":"bib40","doi-asserted-by":"publisher","first-page":"e22817","DOI":"10.1371\/journal.pone.0022817","article-title":"Genome-wide analysis of Muller glial differentiation reveals a requirement for Notch signaling in postmitotic cells to maintain the glial fate","volume":"6","author":"Nelson","year":"2011","journal-title":"PLoS One"},{"key":"bib41","doi-asserted-by":"publisher","first-page":"E247","DOI":"10.1371\/journal.pbio.0020247","article-title":"Genomic analysis of mouse retinal development","volume":"2","author":"Blackshaw","year":"2004","journal-title":"PLoS Biol"},{"key":"bib42","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1002\/cne.v509:2","article-title":"The transcriptome of retinal Muller glial cells","volume":"509","author":"Roesch","year":"2008","journal-title":"J Comp Neurol"}],"container-title":["Investigative Opthalmology &amp; Visual Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/iovs.arvojournals.org\/article.aspx?articleid=2793216","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:31:43Z","timestamp":1791927103000},"score":1,"resource":{"primary":{"URL":"https:\/\/iovs.arvojournals.org\/article.aspx?articleid=2793216"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12,22]]},"references-count":42,"journal-issue":{"issue":"15","published-print":{"date-parts":[[2023,12,1]]}},"URL":"https:\/\/doi.org\/10.1167\/iovs.64.15.32","relation":{},"ISSN":["1552-5783"],"issn-type":[{"value":"1552-5783","type":"print"}],"subject":[],"published":{"date-parts":[[2023,12,22]]}}}