{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T22:00:33Z","timestamp":1791928833093,"version":"4.3.4"},"reference-count":47,"publisher":"Association for Research in Vision and Ophthalmology (ARVO)","issue":"15","license":[{"start":{"date-parts":[[2023,12,6]],"date-time":"2023-12-06T00:00:00Z","timestamp":1701820800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Invest. Ophthalmol. Vis. Sci."],"published-print":{"date-parts":[[2023,12,6]]},"DOI":"10.1167\/iovs.64.15.7","type":"journal-article","created":{"date-parts":[[2023,12,6]],"date-time":"2023-12-06T10:31:11Z","timestamp":1701858671000},"page":"7","source":"Crossref","is-referenced-by-count":1,"title":["Ontogenesis of the Mouse Ocular Surface Lymphatic Vascular Network"],"prefix":"10.1167","volume":"64","author":[{"given":"Mariela","family":"Subileau","sequence":"first","affiliation":[{"name":"University Grenoble Alpes, CEA, Inserm, IRIG, UA13 BGE, Grenoble, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Vittet","sequence":"additional","affiliation":[{"name":"University Grenoble Alpes, CEA, Inserm, IRIG, UA13 BGE, Grenoble, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"27","reference":[{"key":"bib1","doi-asserted-by":"publisher","first-page":"270","DOI":"10.1016\/j.cell.2020.06.039","article-title":"The lymphatic vasculature in the 21(st) century: novel functional roles in homeostasis and disease","volume":"182","author":"Oliver","year":"2020","journal-title":"Cell"},{"key":"bib2","doi-asserted-by":"publisher","first-page":"308","DOI":"10.3389\/fimmu.2019.00308","article-title":"Inflammation and lymphatic function","volume":"10","author":"Schwager","year":"2019","journal-title":"Front Immunol"},{"key":"bib3","doi-asserted-by":"publisher","first-page":"2750","DOI":"10.3390\/ijms22052750","article-title":"Specialized pro-resolving mediators and the lymphatic system","volume":"22","author":"Kraft","year":"2021","journal-title":"Int J Mol Sci"},{"issue":"7839","key":"bib4","doi-asserted-by":"publisher","first-page":"705","DOI":"10.1038\/s41586-020-2998-x","article-title":"Lymphoangiocrine signals promote cardiac growth and repair","volume":"588","author":"Liu","year":"2020","journal-title":"Nature"},{"key":"bib5","doi-asserted-by":"publisher","first-page":"1067","DOI":"10.1016\/j.stem.2022.05.007","article-title":"Lymphatics act as a signaling hub to regulate intestinal stem cell activity","volume":"29","author":"Niec","year":"2022","journal-title":"Cell Stem Cell"},{"key":"bib6","doi-asserted-by":"publisher","first-page":"1262","DOI":"10.1016\/j.stem.2022.07.007","article-title":"Lymphangiocrine signals are required for proper intestinal repair after cytotoxic injury","volume":"29","author":"Palikuqi","year":"2022","journal-title":"Cell Stem Cell"},{"key":"bib7","doi-asserted-by":"publisher","first-page":"382","DOI":"10.1016\/j.cell.2022.12.031","article-title":"Lymphatic vessels in bone support regeneration after injury","volume":"186","author":"Biswas","year":"2023","journal-title":"Cell"},{"key":"bib8","first-page":"582","article-title":"Lymphatics in eye fluid homeostasis: minor contributors or significant actors?","volume":"10","author":"Subileau","year":"2021","journal-title":"Biology (Basel)"},{"key":"bib9","doi-asserted-by":"publisher","first-page":"659","DOI":"10.1016\/j.survophthal.2021.10.004","article-title":"Aqueous outflow channels and its lymphatic association: a review","volume":"67","author":"Narayanaswamy","year":"2022","journal-title":"Surv Ophthalmol"},{"key":"bib10","doi-asserted-by":"publisher","first-page":"10139","DOI":"10.3390\/ijms231710139","article-title":"Ocular lymphatic and glymphatic systems: implications for retinal health and disease","volume":"23","author":"Uddin","year":"2022","journal-title":"Int J Mol Sci"},{"key":"bib11","doi-asserted-by":"crossref","first-page":"101157","DOI":"10.1016\/j.preteyeres.2022.101157","article-title":"The novel role of lymphatic vessels in the pathogenesis of ocular diseases","author":"Clahsen","year":"2023","journal-title":"Prog Retin Eye Res"},{"key":"bib12","doi-asserted-by":"publisher","first-page":"306","DOI":"10.1016\/j.jtos.2018.03.008","article-title":"Corneal lymphangiogenesis facilitates ocular surface inflammation and cell trafficking in dry eye disease","volume":"16","author":"Ji","year":"2018","journal-title":"Ocul Surf"},{"key":"bib13","doi-asserted-by":"publisher","first-page":"960","DOI":"10.1016\/j.survophthal.2021.03.007","article-title":"Corneal lymphangiogenesis as a potential target in dry eye disease\u2014a systematic review","volume":"66","author":"Chennakesavalu","year":"2021","journal-title":"Surv Ophthalmol"},{"key":"bib14","doi-asserted-by":"publisher","first-page":"11628","DOI":"10.3390\/ijms222111628","article-title":"Corneal lymphangiogenesis: current pathophysiological understandings and its functional role in ocular surface disease","volume":"22","author":"Lee","year":"2021","journal-title":"Int J Mol Sci"},{"key":"bib15","doi-asserted-by":"publisher","first-page":"7227","DOI":"10.1038\/s41598-017-07806-4","article-title":"Transient ingrowth of lymphatic vessels into the physiologically avascular cornea regulates corneal edema and transparency","volume":"7","author":"Hos","year":"2017","journal-title":"Sci Rep"},{"key":"bib16","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1016\/j.semcdb.2014.11.003","article-title":"Antilymphangiogenic therapy to promote transplant survival and to reduce cancer metastasis: what can we learn from the eye?","volume":"38","author":"Hos","year":"2015","journal-title":"Semin Cell Dev Biol"},{"issue":"1","key":"bib17","doi-asserted-by":"publisher","first-page":"16040","DOI":"10.1038\/s41598-020-71877-z","article-title":"Eye lymphatic defects induced by bone morphogenetic protein 9 deficiency have no functional consequences on intraocular pressure","volume":"10","author":"Subileau","year":"2020","journal-title":"Sci Rep"},{"key":"bib18","doi-asserted-by":"publisher","first-page":"272","DOI":"10.1016\/j.jtos.2023.05.009","article-title":"Novel discovery of a lymphatic bridge connecting Schlemm's canal to limbal and conjunctival lymphatic pathway","volume":"29","author":"Yang","year":"2023","journal-title":"Ocul Surf"},{"issue":"11","key":"bib19","doi-asserted-by":"publisher","first-page":"dev167098","DOI":"10.1242\/dev.167098","article-title":"When form meets function: the cells and signals that shape the lymphatic vasculature during development","volume":"148","author":"Francois","year":"2021","journal-title":"Development"},{"key":"bib20","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1007\/s10456-021-09784-8","article-title":"Mechanisms and cell lineages in lymphatic vascular development","volume":"24","author":"Jafree","year":"2021","journal-title":"Angiogenesis"},{"key":"bib21","doi-asserted-by":"publisher","first-page":"936","DOI":"10.1172\/JCI71607","article-title":"Inflammation-associated lymphangiogenesis: a double-edged sword?","volume":"124","author":"Kim","year":"2014","journal-title":"J Clin Invest"},{"key":"bib22","doi-asserted-by":"publisher","first-page":"2363","DOI":"10.1172\/JCI23874","article-title":"Inflammation-induced lymphangiogenesis in the cornea arises from CD11b-positive macrophages","volume":"115","author":"Maruyama","year":"2005","journal-title":"J Clin Invest"},{"key":"bib23","doi-asserted-by":"publisher","first-page":"3145","DOI":"10.1167\/iovs.11-8010","article-title":"The maintenance of lymphatic vessels in the cornea is dependent on the presence of macrophages","volume":"53","author":"Maruyama","year":"2012","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib24","doi-asserted-by":"publisher","first-page":"3899","DOI":"10.1242\/dev.050021","article-title":"Macrophages define dermal lymphatic vessel calibre during development by regulating lymphatic endothelial cell proliferation","volume":"137","author":"Gordon","year":"2010","journal-title":"Development"},{"issue":"9","key":"bib25","doi-asserted-by":"publisher","first-page":"e7067","DOI":"10.1371\/journal.pone.0007067","article-title":"Myeloid cells contribute to tumor lymphangiogenesis","volume":"4","author":"Zumsteg","year":"2009","journal-title":"PLoS One"},{"key":"bib26","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1189\/jlb.1MR1016-434RR","article-title":"Novel role of immature myeloid cells in formation of new lymphatic vessels associated with inflammation and tumors","volume":"102","author":"Ran","year":"2017","journal-title":"J Leukoc Biol"},{"issue":"13","key":"bib27","doi-asserted-by":"publisher","first-page":"e135121","DOI":"10.1172\/jci.insight.135121","article-title":"Organogenesis and distribution of the ocular lymphatic vessels in the anterior eye","volume":"5","author":"Wu","year":"2020","journal-title":"JCI Insight"},{"key":"bib28","doi-asserted-by":"publisher","first-page":"2162","DOI":"10.1167\/iovs.06-0783","article-title":"LYVE-1-positive macrophages are present in normal murine eyes","volume":"48","author":"Xu","year":"2007","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib29","doi-asserted-by":"publisher","first-page":"1511","DOI":"10.1038\/s41467-018-03959-6","article-title":"Matrix stiffness controls lymphatic vessel formation through regulation of a GATA2-dependent transcriptional program","volume":"9","author":"Frye","year":"2018","journal-title":"Nat Commun"},{"issue":"9","key":"bib30","doi-asserted-by":"publisher","first-page":"e0249256","DOI":"10.1371\/journal.pone.0249256","article-title":"Vegfr3-tdTomato, a reporter mouse for microscopic visualization of lymphatic vessel by multiple modalities","volume":"16","author":"Redder","year":"2021","journal-title":"PLoS One"},{"issue":"1","key":"bib31","doi-asserted-by":"publisher","first-page":"5878","DOI":"10.1038\/s41467-023-41456-7","article-title":"Self-organized and directed branching results in optimal coverage in developing dermal lymphatic networks","volume":"14","author":"Ucar","year":"2023","journal-title":"Nat Commun"},{"key":"bib32","doi-asserted-by":"publisher","first-page":"953187","DOI":"10.1155\/2012\/953187","article-title":"Conjunctival lymphatic response to corneal inflammation in mice","volume":"2012","author":"Ecoiffier","year":"2012","journal-title":"J Ophthalmol"},{"key":"bib33","doi-asserted-by":"publisher","first-page":"430","DOI":"10.1016\/j.devcel.2011.12.020","article-title":"Mechanotransduction, PROX1, and FOXC2 cooperate to control connexin37 and calcineurin during lymphatic-valve formation","volume":"22","author":"Sabine","year":"2012","journal-title":"Dev Cell"},{"key":"bib34","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1016\/j.addr.2020.12.005","article-title":"Development and aging of the lymphatic vascular system","volume":"169","author":"Gonzalez-Loyola","year":"2021","journal-title":"Adv Drug Deliv Rev"},{"issue":"6432","key":"bib35","doi-asserted-by":"publisher","first-page":"eaau0964","DOI":"10.1126\/science.aau0964","article-title":"Two distinct interstitial macrophage populations coexist across tissues in specific subtissular niches","volume":"363","author":"Chakarov","year":"2019","journal-title":"Science"},{"issue":"1","key":"bib36","doi-asserted-by":"publisher","first-page":"5176","DOI":"10.1038\/s41598-022-08987-3","article-title":"Kinetics of LYVE-1-positive M2-like macrophages in developing and repairing dental pulp in vivo and their pro-angiogenic activity in vitro","volume":"12","author":"Kieu","year":"2022","journal-title":"Sci Rep"},{"key":"bib37","first-page":"1902","article-title":"Diverse roles of macrophages in intraocular neovascular diseases: a review","volume":"10","author":"Zhou","year":"2017","journal-title":"Int J Ophthalmol"},{"key":"bib38","doi-asserted-by":"publisher","first-page":"2316","DOI":"10.1172\/JCI26354","article-title":"The crucial role of macrophages in lymphangiogenesis","volume":"115","author":"Kerjaschki","year":"2005","journal-title":"J Clin Invest"},{"key":"bib39","doi-asserted-by":"publisher","first-page":"5650","DOI":"10.1182\/blood-2008-09-176776","article-title":"Critical role of CD11b+ macrophages and VEGF in inflammatory lymphangiogenesis, antigen clearance, and inflammation resolution","volume":"113","author":"Kataru","year":"2009","journal-title":"Blood"},{"issue":"9","key":"bib40","doi-asserted-by":"publisher","first-page":"e140685","DOI":"10.1172\/JCI140685","article-title":"Macrophage-produced VEGFC is induced by efferocytosis to ameliorate cardiac injury and inflammation","volume":"132","author":"Glinton","year":"2022","journal-title":"J Clin Invest"},{"issue":"7","key":"bib41","doi-asserted-by":"publisher","first-page":"e68811","DOI":"10.1371\/journal.pone.0068811","article-title":"Local delivery of polarized macrophages improves reperfusion recovery in a mouse hind limb ischemia model","volume":"8","author":"Jetten","year":"2013","journal-title":"PLoS One"},{"key":"bib42","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1007\/s10456-013-9381-6","article-title":"Anti-inflammatory M2, but not pro-inflammatory M1 macrophages promote angiogenesis in vivo","volume":"17","author":"Jetten","year":"2014","journal-title":"Angiogenesis"},{"key":"bib43","doi-asserted-by":"publisher","first-page":"535","DOI":"10.1146\/physiol.2019.81.issue-1","article-title":"Regulation of blood and lymphatic vessels by immune cells in tumors and metastasis","volume":"81","author":"Mazzone","year":"2019","journal-title":"Annu Rev Physiol"},{"issue":"10","key":"bib44","doi-asserted-by":"publisher","first-page":"e0162532","DOI":"10.1371\/journal.pone.0162532","article-title":"Signaling of prostaglandin E receptors, EP3 and EP4 facilitates wound healing and lymphangiogenesis with enhanced recruitment of M2 macrophages in mice","volume":"11","author":"Hosono","year":"2016","journal-title":"PLoS One"},{"key":"bib45","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1007\/s10456-016-9523-8","article-title":"Regulation of lymphangiogenesis in the diaphragm by macrophages and VEGFR-3 signaling","volume":"19","author":"Ochsenbein","year":"2016","journal-title":"Angiogenesis"},{"key":"bib46","doi-asserted-by":"publisher","first-page":"667830","DOI":"10.3389\/fimmu.2021.667830","article-title":"Macrophage-mediated tissue vascularization: similarities and differences between cornea and skin","volume":"12","author":"Hadrian","year":"2021","journal-title":"Front Immunol"},{"issue":"11-12","key":"bib47","doi-asserted-by":"publisher","first-page":"322","DOI":"10.1089\/scd.2022.0004","article-title":"Th2 cytokines IL-4, IL-13, and IL-10 promote differentiation of pro-lymphatic progenitors derived from bone marrow myeloid precursors","volume":"31","author":"Espinosa Gonzalez","year":"2022","journal-title":"Stem Cells Dev"}],"container-title":["Investigative Opthalmology & Visual Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/iovs.arvojournals.org\/article.aspx?articleid=2793083","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:31:45Z","timestamp":1791927105000},"score":1,"resource":{"primary":{"URL":"https:\/\/iovs.arvojournals.org\/article.aspx?articleid=2793083"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12,6]]},"references-count":47,"journal-issue":{"issue":"15","published-print":{"date-parts":[[2023,12,1]]}},"URL":"https:\/\/doi.org\/10.1167\/iovs.64.15.7","relation":{},"ISSN":["1552-5783"],"issn-type":[{"value":"1552-5783","type":"print"}],"subject":[],"published":{"date-parts":[[2023,12,6]]}}}