{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T22:00:11Z","timestamp":1791928811248,"version":"4.3.4"},"reference-count":100,"publisher":"Association for Research in Vision and Ophthalmology (ARVO)","issue":"2","license":[{"start":{"date-parts":[[2023,2,22]],"date-time":"2023-02-22T00:00:00Z","timestamp":1677024000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Invest. Ophthalmol. Vis. Sci."],"published-print":{"date-parts":[[2023,2,22]]},"DOI":"10.1167\/iovs.64.2.22","type":"journal-article","created":{"date-parts":[[2023,2,22]],"date-time":"2023-02-22T11:31:07Z","timestamp":1677065467000},"page":"22","source":"Crossref","is-referenced-by-count":18,"title":["The Impaired Wound Healing Process Is a Major Factor in Remodeling of the Corneal Epithelium in Adult and Adolescent Patients With Keratoconus"],"prefix":"10.1167","volume":"64","author":[{"given":"Katarzyna","family":"Jaskiewicz","sequence":"first","affiliation":[{"name":"Institute of Human Genetics, Polish Academy of Sciences, Poznan, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magdalena","family":"Maleszka-Kurpiel","sequence":"additional","affiliation":[{"name":"Optegra Eye Health Care Clinic in Poznan, Poznan, Poland"},{"name":"Department of Optometry, Chair of Ophthalmology and Optometry, Poznan University of Medical Sciences, Poznan, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eliza","family":"Matuszewska","sequence":"additional","affiliation":[{"name":"Chair and Department of Inorganic and Analytical Chemistry, Poznan University of Medical Sciences, Poznan, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Micha\u0142","family":"Kabza","sequence":"additional","affiliation":[{"name":"Chair and Department of Genetics and Pharmaceutical Microbiology, Poznan University of Medical Sciences, Poznan, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Malgorzata","family":"Rydzanicz","sequence":"additional","affiliation":[{"name":"Department of Medical Genetics, Medical University of Warsaw, Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Malinowski","sequence":"additional","affiliation":[{"name":"Institute of Plant Genetics, Polish Academy of Sciences, Poznan, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafal","family":"Ploski","sequence":"additional","affiliation":[{"name":"Department of Medical Genetics, Medical University of Warsaw, Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Matysiak","sequence":"additional","affiliation":[{"name":"Chair and Department of Inorganic and Analytical Chemistry, Poznan University of Medical Sciences, Poznan, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marzena","family":"Gajecka","sequence":"additional","affiliation":[{"name":"Institute of Human Genetics, Polish Academy of Sciences, Poznan, Poland"},{"name":"Chair and Department of Genetics and Pharmaceutical Microbiology, Poznan University of Medical Sciences, Poznan, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"27","reference":[{"issue":"11","key":"bib1","doi-asserted-by":"publisher","first-page":"736","DOI":"10.3928\/1081597X-20151021-02","article-title":"Detection of keratoconus in clinically and algorithmically topographically normal fellow eyes using epithelial thickness analysis","volume":"31","author":"Reinstein","year":"2015","journal-title":"J Refract Surg"},{"issue":"3","key":"bib2","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1016\/j.jtos.2020.03.006","article-title":"The keratoconus enigma: a review with emphasis on pathogenesis","volume":"18","author":"Ferrari","year":"2020","journal-title":"Ocul Surf"},{"issue":"2","key":"bib3","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1097\/ICO.0000000000002150","article-title":"The prevalence and risk factors for keratoconus: a systematic review and meta-analysis","volume":"39","author":"Hashemi","year":"2020","journal-title":"Cornea"},{"issue":"7-9","key":"bib4","first-page":"208","article-title":"[Keratoconus. I. Various epidemiologic data]","volume":"91","author":"Iwaszkiewicz","year":"1989","journal-title":"Klin Oczna"},{"issue":"11","key":"bib6","doi-asserted-by":"publisher","first-page":"1775","DOI":"10.18240\/ijo","article-title":"The correlation between keratoconus and eye rubbing: a review","volume":"12","author":"Najmi","year":"2019","journal-title":"Int J Ophthalmol"},{"issue":"2","key":"bib7","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1016\/j.drudis.2018.10.017","article-title":"Interplay between hereditary and environmental factors to establish an in vitro disease model of keratoconus","volume":"24","author":"Roy","year":"2019","journal-title":"Drug Discov Today"},{"key":"bib8","doi-asserted-by":"publisher","first-page":"108398","DOI":"10.1016\/j.exer.2020.108398","article-title":"Update on the genetics of keratoconus","volume":"202","author":"Bykhovskaya","year":"2021","journal-title":"Exp Eye Res"},{"issue":"2","key":"bib9","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1007\/s00438-016-1283-z","article-title":"Genomic strategies to understand causes of keratoconus","volume":"292","author":"Karolak","year":"2017","journal-title":"Mol Genet Genomics"},{"issue":"2","key":"bib10","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1007\/s40123-018-0144-8","article-title":"Genetic aspects of keratoconus: a literature review exploring potential genetic contributions and possible genetic relationships with comorbidities","volume":"7","author":"Loukovitis","year":"2018","journal-title":"Ophthalmol Ther"},{"key":"bib11","doi-asserted-by":"publisher","first-page":"201","DOI":"10.2174\/1874364101711010201","article-title":"Genetics in keratoconus\u2013- what is new?","volume":"11","author":"Moussa","year":"2017","journal-title":"Open Ophthalmol J"},{"issue":"2","key":"bib12","doi-asserted-by":"publisher","first-page":"129","DOI":"10.5301\/ejo.5000850","article-title":"Combined tomography and epithelial thickness mapping for diagnosis of keratoconus","volume":"27","author":"Silverman","year":"2017","journal-title":"Eur J Ophthalmol"},{"issue":"1","key":"bib13","doi-asserted-by":"publisher","first-page":"11971","DOI":"10.1038\/s41598-021-91263-7","article-title":"Corneal biomechanical parameters in keratoconus eyes with abnormal elevation on the back corneal surface only versus both back and front surfaces","volume":"11","author":"Sedaghat","year":"2021","journal-title":"Sci Rep"},{"issue":"2","key":"bib14","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1001\/jamaophthalmol.2015.4776","article-title":"Global survey of corneal transplantation and eye banking","volume":"134","author":"Gain","year":"2016","journal-title":"JAMA Ophthalmol"},{"issue":"12","key":"bib15","doi-asserted-by":"crossref","first-page":"1929","DOI":"10.18240\/ijo.2019.12.16","article-title":"Combined corneal CXL and photorefractive keratectomy for treatment of keratoconus: a review","volume":"12","author":"MM","year":"2019","journal-title":"Int J Ophthalmol"},{"issue":"2","key":"bib16","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1111\/opo.2013.33.issue-2","article-title":"Corneal cross-linking\u2013- a review","volume":"33","author":"Meek","year":"2013","journal-title":"Ophthalmic Physiol Opt"},{"issue":"5","key":"bib17","doi-asserted-by":"publisher","first-page":"796","DOI":"10.1016\/j.jcrs.2007.12.039","article-title":"Collagen crosslinking with riboflavin and ultraviolet-A light in keratoconus: long-term results","volume":"34","author":"Raiskup-Wolf","year":"2008","journal-title":"J Cataract Refract Surg"},{"issue":"4","key":"bib18","doi-asserted-by":"publisher","first-page":"356","DOI":"10.1097\/01.icu.0000233954.86723.25","article-title":"Crosslinking treatment of progressive keratoconus: new hope","volume":"17","author":"Wollensak","year":"2006","journal-title":"Curr Opin Ophthalmol"},{"issue":"11","key":"bib19","first-page":"1640","article-title":"Histopathologic findings of keratoconus corneas underwent penetrating keratoplasty according to topographic measurements and keratoconus severity","volume":"10","author":"Naderan","year":"2017","journal-title":"Int J Ophthalmol"},{"issue":"3","key":"bib20","first-page":"234","article-title":"An in depth analysis of histopathological characteristics found in keratoconus","volume":"44","author":"Sykakis","year":"2012","journal-title":"Pathology (Phila)"},{"issue":"3","key":"bib21","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1159\/000500313","article-title":"Comparison of corneal epithelial and stromal thickness between keratoconic and normal eyes in an Asian population","volume":"62","author":"Wang","year":"2019","journal-title":"Ophthalmic Res"},{"key":"bib22","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1016\/j.jtos.2021.03.010","article-title":"A single cell atlas of human cornea that defines its development, limbal progenitor cells and their interactions with the immune cells","volume":"21","author":"Collin","year":"2021","journal-title":"Ocul Surf"},{"issue":"3","key":"bib23","doi-asserted-by":"publisher","first-page":"565","DOI":"10.1007\/s00417-019-04563-0","article-title":"HCE-T cell line lacks cornea-specific differentiation markers compared to primary limbal epithelial cells and differentiated corneal epithelium","volume":"258","author":"Rubelowski","year":"2020","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"issue":"11","key":"bib24","doi-asserted-by":"publisher","first-page":"583","DOI":"10.1089\/omi.2019.0143","article-title":"Mapping keratoconus molecular substrates by multiplexed high-resolution proteomics of unpooled corneas","volume":"23","author":"Shinde","year":"2019","journal-title":"OMICS J Integr Biol"},{"issue":"2","key":"bib25","doi-asserted-by":"publisher","first-page":"190","DOI":"10.4103\/ijo.IJO_646_17","article-title":"Anatomy of cornea and ocular surface","volume":"66","author":"Sridhar","year":"2018","journal-title":"Indian J Ophthalmol"},{"issue":"12","key":"bib27","doi-asserted-by":"publisher","first-page":"8371","DOI":"10.1167\/iovs.14-15444","article-title":"Corneal cross-linking in keratoconus using the standard and rapid treatment protocol: differences in demarcation line and 12-month outcomes","volume":"55","author":"Brittingham","year":"2014","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"2","key":"bib28","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1016\/j.jtos.2013.01.003","article-title":"Corneal crosslinking with riboflavin and ultraviolet A. Part II. Clinical indications and results","volume":"11","author":"Raiskup","year":"2013","journal-title":"Ocul Surf"},{"issue":"5","key":"bib29","doi-asserted-by":"publisher","first-page":"620","DOI":"10.1016\/S0002-9394(02)02220-1","article-title":"Riboflavin\/ultraviolet-a-induced collagen crosslinking for the treatment of keratoconus","volume":"135","author":"Wollensak","year":"2003","journal-title":"Am J Ophthalmol"},{"issue":"3","key":"bib30","doi-asserted-by":"publisher","first-page":"1147","DOI":"10.1007\/s10792-017-0575-6","article-title":"Comparison of ReLEx SMILE and PRK in terms of visual and refractive outcomes for the correction of low myopia","volume":"38","author":"Ganesh","year":"2018","journal-title":"Int Ophthalmol"},{"issue":"5","key":"bib31","doi-asserted-by":"publisher","first-page":"582","DOI":"10.1038\/ejhg.2017.4","article-title":"Collagen synthesis disruption and downregulation of core elements of TGF-\u00df, Hippo, and Wnt pathways in keratoconus corneas","volume":"25","author":"Kabza","year":"2017","journal-title":"Eur J Hum Genet EJHG"},{"issue":"5","key":"bib32","doi-asserted-by":"publisher","first-page":"1501","DOI":"10.1167\/iovs.18-25916","article-title":"Multiple differentially methylated regions specific to keratoconus explain known keratoconus linkage loci","volume":"60","author":"Kabza","year":"2019","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"1","key":"bib33","doi-asserted-by":"crossref","DOI":"10.1002\/0471250953.bi0807s7","article-title":"Using the Reactome database","volume":"7","author":"Stein","year":"2004","journal-title":"Curr Protoc Bioinforma"},{"issue":"17","key":"bib34","doi-asserted-by":"publisher","first-page":"e133","DOI":"10.1093\/nar\/gks461","article-title":"Camera: a competitive gene set test accounting for inter-gene correlation","volume":"40","author":"Wu","year":"2012","journal-title":"Nucleic Acids Res"},{"issue":"6","key":"bib35","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1016\/j.cels.2015.12.004","article-title":"The Molecular Signatures Database (mSigDB) hallmark gene set collection","volume":"1","author":"Liberzon","year":"2015","journal-title":"Cell Syst"},{"issue":"D1","key":"bib36","doi-asserted-by":"publisher","first-page":"D605","DOI":"10.1093\/nar\/gkaa1074","article-title":"The STRING database in 2021: customizable protein-protein networks, and functional characterization of user-uploaded gene\/measurement sets","volume":"49","author":"Szklarczyk","year":"2021","journal-title":"Nucleic Acids Res"},{"issue":"D1","key":"bib37","doi-asserted-by":"publisher","first-page":"D687","DOI":"10.1093\/nar\/gkab1028","article-title":"The reactome pathway knowledgebase 2022","volume":"50","author":"Gillespie","year":"2022","journal-title":"Nucleic Acids Res"},{"issue":"D1","key":"bib38","doi-asserted-by":"publisher","first-page":"D419","DOI":"10.1093\/nar\/gky1038","article-title":"PANTHER version 14: more genomes, a new PANTHER GO-slim and improvements in enrichment analysis tools","volume":"47","author":"Mi","year":"2019","journal-title":"Nucleic Acids Res"},{"issue":"D1","key":"bib39","first-page":"D489","article-title":"Pathway Commons 2019 Update: integration, analysis and exploration of pathway data","volume":"48","author":"Rodchenkov","year":"2020","journal-title":"Nucleic Acids Res"},{"issue":"D1","key":"bib40","doi-asserted-by":"publisher","first-page":"D701","DOI":"10.1093\/nar\/gkab909","article-title":"SignaLink3: a multi-layered resource to uncover tissue-specific signaling networks","volume":"50","author":"Csabai","year":"2022","journal-title":"Nucleic Acids Res"},{"issue":"D1","key":"bib41","first-page":"D504","article-title":"SIGNOR 2.0, the SIGnaling Network Open Resource 2.0: 2019 update","volume":"48","author":"Licata","year":"2020","journal-title":"Nucleic Acids Res"},{"key":"bib42","doi-asserted-by":"publisher","first-page":"e9793","DOI":"10.7717\/peerj.9793","article-title":"Further evaluation of differential expression of keratoconus candidate genes in human corneas","volume":"8","author":"Karolak","year":"2020","journal-title":"PeerJ"},{"key":"bib43","doi-asserted-by":"publisher","first-page":"e8982","DOI":"10.7717\/peerj.8982","article-title":"Accumulation of sequence variants in genes of Wnt signaling and focal adhesion pathways in human corneas further explains their involvement in keratoconus","volume":"8","author":"Karolak","year":"2020","journal-title":"PeerJ"},{"issue":"12","key":"bib45","doi-asserted-by":"publisher","first-page":"2032","DOI":"10.1093\/bioinformatics\/btv098","article-title":"Sambamba: fast processing of NGS alignment formats","volume":"31","author":"Tarasov","year":"2015","journal-title":"Bioinforma Oxf Engl"},{"issue":"8","key":"bib46","doi-asserted-by":"publisher","first-page":"912","DOI":"10.1038\/ng.3036","article-title":"Integrating mapping-, assembly- and haplotype-based approaches for calling variants in clinical sequencing applications","volume":"46","author":"Rimmer","year":"2014","journal-title":"Nat Genet"},{"issue":"1","key":"bib47","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1186\/s13059-016-0974-4","article-title":"The Ensembl variant effect predictor","volume":"17","author":"McLaren","year":"2016","journal-title":"Genome Biol"},{"issue":"6","key":"bib48","doi-asserted-by":"publisher","first-page":"845","DOI":"10.1136\/bjophthalmol-2016-309834","article-title":"Ultrastructural study of peripheral and central stroma of keratoconus cornea","volume":"101","author":"Alkanaan","year":"2017","journal-title":"Br J Ophthalmol"},{"issue":"1","key":"bib49","first-page":"121","article-title":"Collagen fibril orientation in the human corneal stroma and its implication in keratoconus","volume":"38","author":"Daxer","year":"1997","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib50","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1016\/j.exer.2017.03.002","article-title":"Elastic microfibril distribution in the cornea: differences between normal and keratoconic stroma","volume":"159","author":"White","year":"2017","journal-title":"Exp Eye Res"},{"key":"bib51","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1016\/j.ajo.2018.02.006","article-title":"Distinguishing keratoconic eyes and healthy eyes using ultrahigh-resolution optical coherence tomography\u2013based corneal epithelium thickness mapping","volume":"189","author":"Pircher","year":"2018","journal-title":"Am J Ophthalmol"},{"issue":"3","key":"bib52","first-page":"173","article-title":"SD-OCT analysis of regional epithelial thickness profiles in keratoconus, postoperative corneal ectasia, and normal eyes","volume":"29","author":"Rocha","year":"2013","journal-title":"J Refract Surg Thorofare NJ 1995"},{"issue":"4","key":"bib53","doi-asserted-by":"publisher","first-page":"259","DOI":"10.3928\/1081597X-20100218-01","article-title":"Epithelial, stromal, and total corneal thickness in keratoconus: three-dimensional display with artemis very-high frequency digital ultrasound","volume":"26","author":"Reinstein","year":"2010","journal-title":"J Refract Surg"},{"issue":"1","key":"bib54","doi-asserted-by":"publisher","first-page":"2965","DOI":"10.1038\/s41598-019-39182-6","article-title":"Differential epithelial and stromal protein profiles in cone and non-cone regions of keratoconus corneas","volume":"9","author":"Yam","year":"2019","journal-title":"Sci Rep"},{"issue":"1","key":"bib55","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1038\/s41598-017-18480-x","article-title":"RNA-Seq analysis and comparison of corneal epithelium in keratoconus and myopia patients","volume":"8","author":"You","year":"2018","journal-title":"Sci Rep"},{"issue":"13","key":"bib56","doi-asserted-by":"publisher","first-page":"5372","DOI":"10.1167\/iovs.16-19677","article-title":"Differential molecular expression of extracellular matrix and inflammatory genes at the corneal cone apex drives focal weakening in keratoconus","volume":"57","author":"Pahuja","year":"2016","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"1","key":"bib57","doi-asserted-by":"publisher","first-page":"20891","DOI":"10.1038\/s41598-021-99805-9","article-title":"Keratoconus patients exhibit a distinct ocular surface immune cell and inflammatory profile","volume":"11","author":"D'Souza","year":"2021","journal-title":"Sci Rep"},{"issue":"1","key":"bib58","doi-asserted-by":"publisher","first-page":"e16437","DOI":"10.1371\/journal.pone.0016437","article-title":"Subnormal cytokine profile in the tear fluid of keratoconus patients","volume":"6","author":"Jun","year":"2011","journal-title":"PLoS One"},{"issue":"3","key":"bib59","doi-asserted-by":"publisher","first-page":"e170","DOI":"10.1111\/aos.2014.92.issue-3","article-title":"Genomics of corneal wound healing: a review of the literature","volume":"92","author":"Maycock","year":"2014","journal-title":"Acta Ophthalmol (Copenh)"},{"issue":"22","key":"bib60","doi-asserted-by":"publisher","first-page":"12426","DOI":"10.3390\/ijms222212426","article-title":"Contribution of the transcription factors Sp1\/Sp3 and AP-1 to Clusterin gene expression during corneal wound healing of tissue-engineered human corneas","volume":"22","author":"Gross","year":"2021","journal-title":"Int J Mol Sci"},{"issue":"1","key":"bib61","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1038\/s41536-021-00126-2","article-title":"The common YAP activation mediates corneal epithelial regeneration and repair with different-sized wounds","volume":"6","author":"Li","year":"2021","journal-title":"NPJ Regen Med"},{"issue":"1","key":"bib62","first-page":"59","article-title":"Pathophysiology of corneal scarring in persistent epithelial defects after PRK and other corneal injuries","volume":"34","author":"Wilson","year":"2018","journal-title":"J Refract Surg Thorofare NJ 1995"},{"issue":"5","key":"bib63","first-page":"1422","article-title":"Delay of corneal epithelial wound healing and induction of keratocyte apoptosis by platelet-activating factor","volume":"43","author":"Chandrasekher","year":"2002","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"9","key":"bib64","doi-asserted-by":"publisher","first-page":"1595","DOI":"10.1002\/term.v13.9","article-title":"Contribution of the WNK1 kinase to corneal wound healing using the tissue-engineered human cornea as an in vitro model","volume":"13","author":"Desjardins","year":"2019","journal-title":"J Tissue Eng Regen Med"},{"key":"bib65","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1016\/j.cyto.2016.12.025","article-title":"Hepatocyte growth factor in physiology and infectious diseases","volume":"98","author":"Imamura","year":"2017","journal-title":"Cytokine"},{"key":"bib66","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1016\/j.exer.2018.09.001","article-title":"Modulation of human corneal stromal cell differentiation by hepatocyte growth factor and substratum compliance","volume":"176","author":"Miyagi","year":"2018","journal-title":"Exp Eye Res"},{"issue":"6","key":"bib67","doi-asserted-by":"publisher","first-page":"690","DOI":"10.1038\/s41374-021-00576-8","article-title":"Impairment of corneal epithelial wound healing is association with increased neutrophil infiltration and reactive oxygen species activation in tenascin X-deficient mice","volume":"101","author":"Sumioka","year":"2021","journal-title":"Lab Invest"},{"issue":"10","key":"bib68","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1167\/iovs.61.10.27","article-title":"Epithelial cell migration and proliferation patterns during initial wound closure in normal mice and an experimental model of limbal stem cell deficiency","volume":"61","author":"Puri","year":"2020","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"5","key":"bib69","doi-asserted-by":"publisher","first-page":"3889","DOI":"10.3892\/ol.2017.5896","article-title":"Fibronectin induces epithelial-mesenchymal transition in human breast cancer MCF-7 cells via activation of calpain","volume":"13","author":"Li","year":"2017","journal-title":"Oncol Lett"},{"key":"bib70","doi-asserted-by":"publisher","first-page":"e273","DOI":"10.1038\/cddis.2012.14","article-title":"Occludin is required for apoptosis when claudin-claudin interactions are disrupted","volume":"3","author":"Beeman","year":"2012","journal-title":"Cell Death Dis"},{"issue":"2","key":"bib71","doi-asserted-by":"publisher","first-page":"515","DOI":"10.1083\/jcb.141.2.515","article-title":"Integrin and cadherin synergy regulates contact inhibition of migration and motile activity","volume":"141","author":"Huttenlocher","year":"1998","journal-title":"J Cell Biol"},{"issue":"7","key":"bib72","doi-asserted-by":"publisher","first-page":"2977","DOI":"10.1167\/iovs.18-24367","article-title":"Integrated stress response and decreased ECM in cultured stromal cells from keratoconus corneas","volume":"59","author":"Foster","year":"2018","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"9","key":"bib73","doi-asserted-by":"publisher","first-page":"4492","DOI":"10.1167\/iovs.09-4380","article-title":"Quantitative analysis of the effects of extracellular matrix proteins on membrane dynamics associated with corneal epithelial cell motility","volume":"51","author":"Kimura","year":"2010","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"1","key":"bib74","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1016\/j.exer.2010.11.002","article-title":"Challenges to the study of asymmetric cell division in corneal and limbal epithelia","volume":"92","author":"Castro-Mu\u00f1ozledo","year":"2011","journal-title":"Exp Eye Res"},{"issue":"1","key":"bib75","doi-asserted-by":"publisher","first-page":"e29611","DOI":"10.1371\/journal.pone.0029611","article-title":"Inscuteable regulates the pins-mud spindle orientation pathway.","volume":"7","author":"Mauser","year":"2012","journal-title":"PLoS One"},{"issue":"3","key":"bib76","doi-asserted-by":"publisher","first-page":"769","DOI":"10.1096\/fsb2.v24.3","article-title":"Role of androgens and the androgen receptor in epithelial-mesenchymal transition and invasion of prostate cancer cells","volume":"24","author":"Zhu","year":"2010","journal-title":"FASEB J"},{"issue":"2","key":"bib77","doi-asserted-by":"publisher","first-page":"e17218","DOI":"10.1371\/journal.pone.0017218","article-title":"Androgen-induced cell migration: role of androgen receptor\/filamin A association","volume":"6","author":"Castoria","year":"2011","journal-title":"PloS One"},{"issue":"7","key":"bib78","doi-asserted-by":"publisher","first-page":"2690","DOI":"10.1210\/en.2010-1257","article-title":"Visualization of estrogen receptor transcriptional activation in zebrafish","volume":"152","author":"Gorelick","year":"2011","journal-title":"Endocrinology"},{"issue":"1","key":"bib79","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1038\/aps.2014.123","article-title":"Identification of estrogen-responsive genes based on the DNA binding properties of estrogen receptors using high-throughput sequencing technology","volume":"36","author":"Ikeda","year":"2015","journal-title":"Acta Pharmacol Sin"},{"key":"bib80","first-page":"2554","article-title":"Influence of sex on gene expression in human corneal epithelial cells","volume":"15","author":"Suzuki","year":"2009","journal-title":"Mol Vis"},{"issue":"11","key":"bib81","first-page":"753","article-title":"Progression of keratoconus and efficacy of pediatric [corrected] corneal collagen cross-linking in children and adolescents","volume":"28","author":"Chatzis","year":"2012","journal-title":"J Refract Surg Thorofare NJ 1995"},{"issue":"4","key":"bib82","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1097\/ICO.0000000000000408","article-title":"Global consensus on keratoconus and ectatic diseases","volume":"34","author":"Gomes","year":"2015","journal-title":"Cornea"},{"issue":"7","key":"bib83","first-page":"454","article-title":"Corneal cross-linking for treatment of progressive keratoconus in various age groups","volume":"30","author":"Soeters","year":"2014","journal-title":"J Refract Surg Thorofare NJ 1995"},{"issue":"9","key":"bib84","doi-asserted-by":"publisher","first-page":"1534","DOI":"10.1016\/j.ophtha.2008.02.020","article-title":"Sensitivity and specificity of posterior corneal elevation measured by Pentacam in discriminating keratoconus\/subclinical keratoconus","volume":"115","author":"de Sanctis","year":"2008","journal-title":"Ophthalmology"},{"issue":"6","key":"bib85","doi-asserted-by":"publisher","first-page":"2703","DOI":"10.1002\/jcp.v237.6","article-title":"Cell cycle arrest induced by trichoplein depletion is independent of cilia assembly","volume":"237","author":"Huang","year":"2022","journal-title":"J Cell Physiol"},{"issue":"4","key":"bib86","doi-asserted-by":"publisher","first-page":"e1008721","DOI":"10.1371\/journal.pgen.1008721","article-title":"Mutations in SPATA13\/ASEF2 cause primary angle closure glaucoma","volume":"16","author":"Waseem","year":"2020","journal-title":"PLoS Genet"},{"issue":"4","key":"bib87","doi-asserted-by":"publisher","first-page":"315","DOI":"10.3109\/10409238.2012.667214","article-title":"Ccr4-Not complex: the control freak of eukaryotic cells","volume":"47","author":"Miller","year":"2012","journal-title":"Crit Rev Biochem Mol Biol"},{"key":"bib88","first-page":"577","article-title":"Keratoconus in vitro and the key players of the TGF-\u00df pathway","volume":"21","author":"Priyadarsini","year":"2015","journal-title":"Mol Vis"},{"issue":"2","key":"bib89","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1007\/s10616-020-00373-z","article-title":"Keratin 12 mRNA expression could serve as an early corneal marker for limbal explant cultures","volume":"72","author":"Shi","year":"2020","journal-title":"Cytotechnology"},{"issue":"6","key":"bib90","doi-asserted-by":"publisher","first-page":"291","DOI":"10.4110\/in.2015.15.6.291","article-title":"The anti-inflammatory effect of GV1001 mediated by the downregulation of ENO1-induced pro-inflammatory cytokine production","volume":"15","author":"Choi","year":"2015","journal-title":"Immune Netw"},{"issue":"35","key":"bib91","doi-asserted-by":"publisher","first-page":"9816","DOI":"10.1073\/pnas.1611189113","article-title":"Clathrin light chains\u2019 role in selective endocytosis influences antibody isotype switching","volume":"113","author":"Wu","year":"2016","journal-title":"Proc Natl Acad Sci U S A"},{"key":"bib92","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1016\/j.exer.2015.02.009","article-title":"Stromal-epithelial interaction study: the effect of corneal epithelial cells on growth factor expression in stromal cells using organotypic culture model","volume":"135","author":"Kobayashi","year":"2015","journal-title":"Exp Eye Res"},{"issue":"2","key":"bib93","doi-asserted-by":"publisher","first-page":"178","DOI":"10.1159\/000509030","article-title":"A systematic review on cornea epithelial-stromal homeostasis","volume":"64","author":"Wong","year":"2021","journal-title":"Ophthalmic Res"},{"issue":"4","key":"bib94","doi-asserted-by":"publisher","first-page":"480","DOI":"10.1001\/jamaophthalmol.2014.5641","article-title":"In vivo biomechanical mapping of normal and keratoconus corneas","volume":"133","author":"Scarcelli","year":"2015","journal-title":"JAMA Ophthalmol"},{"issue":"8","key":"bib95","doi-asserted-by":"publisher","first-page":"946","DOI":"10.1097\/ICO.0000000000002344","article-title":"Measurement of in vivo biomechanical changes attributable to epithelial removal in keratoconus using a noncontact tonometer","volume":"39","author":"Ziaei","year":"2020","journal-title":"Cornea"},{"issue":"1","key":"bib96","first-page":"1","article-title":"Mechanisms of optical regression following corneal laser refractive surgery: epithelial and stromal responses","volume":"7","author":"Moshirfar","year":"2018","journal-title":"Med Hypothesis Discov Innov Ophthalmol J"},{"issue":"10","key":"bib97","doi-asserted-by":"publisher","first-page":"4237","DOI":"10.1167\/iovs.02-1188","article-title":"Molecular mechanisms controlling the fibrotic repair phenotype in cornea: implications for surgical outcomes","volume":"44","author":"Stramer","year":"2003","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib98","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1016\/j.ajo.2016.12.015","article-title":"Age-specific incidence and prevalence of keratoconus: a nationwide registration study","volume":"175","author":"Godefrooij","year":"2017","journal-title":"Am J Ophthalmol"},{"issue":"6","key":"bib99","doi-asserted-by":"publisher","first-page":"770","DOI":"10.1016\/j.survophthal.2017.06.009","article-title":"A review of keratoconus: diagnosis, pathophysiology, and genetics","volume":"62","author":"Mas Tur","year":"2017","journal-title":"Surv Ophthalmol"},{"issue":"4","key":"bib100","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1016\/j.clae.2007.03.001","article-title":"Collaborative Longitudinal Evaluation of Keratoconus (CLEK) study: methods and findings to date","volume":"30","author":"Wagner","year":"2007","journal-title":"Contact Lens Anterior Eye J Br Contact Lens Assoc"},{"key":"bib5","author":"Agency for Health Technology Assessment and Tariffs","year":"2015"},{"key":"bib26","article-title":"JASP (Version 0.16.3) [Computer software]","author":"JASP Team 2022. JASP Team","year":"2022"},{"key":"bib44","article-title":"Aligning sequence reads, clone sequences and assembly contigs with BWA-MEM","author":"Li"}],"container-title":["Investigative Opthalmology &amp; Visual Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/iovs.arvojournals.org\/article.aspx?articleid=2785390","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:31:40Z","timestamp":1791927100000},"score":1,"resource":{"primary":{"URL":"https:\/\/iovs.arvojournals.org\/article.aspx?articleid=2785390"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2,22]]},"references-count":100,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2023,2,1]]}},"URL":"https:\/\/doi.org\/10.1167\/iovs.64.2.22","relation":{},"ISSN":["1552-5783"],"issn-type":[{"value":"1552-5783","type":"print"}],"subject":[],"published":{"date-parts":[[2023,2,22]]}}}