{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T22:00:12Z","timestamp":1791928812794,"version":"4.3.4"},"reference-count":37,"publisher":"Association for Research in Vision and Ophthalmology (ARVO)","issue":"2","license":[{"start":{"date-parts":[[2023,2,2]],"date-time":"2023-02-02T00:00:00Z","timestamp":1675296000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Invest. Ophthalmol. Vis. Sci."],"published-print":{"date-parts":[[2023,2,2]]},"DOI":"10.1167\/iovs.64.2.3","type":"journal-article","created":{"date-parts":[[2023,2,2]],"date-time":"2023-02-02T11:31:48Z","timestamp":1675337508000},"page":"3","source":"Crossref","is-referenced-by-count":11,"title":["Pharmacokinetic and Target Engagement Measures of ANX007, an Anti-C1q Antibody Fragment, Following Intravitreal Administration in Nonhuman Primates"],"prefix":"10.1167","volume":"64","author":[{"given":"Anita","family":"Grover","sequence":"first","affiliation":[{"name":"Annexon Biosciences Inc., Brisbane, California, United States"},{"name":"ACELYRIN, Inc., Agoura Hills, California, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sethu","family":"Sankaranarayanan","sequence":"additional","affiliation":[{"name":"Annexon Biosciences Inc., Brisbane, California, United States"},{"name":"Escape Bio, South San Francisco, California, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vidhu","family":"Mathur","sequence":"additional","affiliation":[{"name":"Annexon Biosciences Inc., Brisbane, California, United States"},{"name":"Acelot Inc., Palo Alto, California, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Poojan","family":"Suri","sequence":"additional","affiliation":[{"name":"Annexon Biosciences Inc., Brisbane, California, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiyan","family":"Qiu","sequence":"additional","affiliation":[{"name":"Annexon Biosciences Inc., Brisbane, California, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaisa","family":"Andrews-Zwilling","sequence":"additional","affiliation":[{"name":"Annexon Biosciences Inc., Brisbane, California, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kirsten","family":"Mease","sequence":"additional","affiliation":[{"name":"ToxStrategies Inc., Durham, North Carolina, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lori K.","family":"Taylor","sequence":"additional","affiliation":[{"name":"Annexon Biosciences Inc., Brisbane, California, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ellen","family":"Cahir-McFarland","sequence":"additional","affiliation":[{"name":"Annexon Biosciences Inc., Brisbane, California, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanjay","family":"Keswani","sequence":"additional","affiliation":[{"name":"Annexon Biosciences Inc., Brisbane, California, United States"},{"name":"Phoenix R&D Solutions Ltd, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ted","family":"Yednock","sequence":"additional","affiliation":[{"name":"Annexon Biosciences Inc., Brisbane, California, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"27","reference":[{"key":"bib1","doi-asserted-by":"publisher","first-page":"1164","DOI":"10.1016\/j.cell.2007.10.036","article-title":"The classical complement cascade mediates CNS synapse elimination","volume":"131","author":"Stevens","year":"2007","journal-title":"Cell"},{"key":"bib2","doi-asserted-by":"publisher","first-page":"691","DOI":"10.1016\/j.neuron.2012.03.026","article-title":"Microglia sculpt postnatal neural circuits in an activity and complement-dependent manner","volume":"74","author":"Schafer","year":"2012","journal-title":"Neuron"},{"key":"bib3","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1146\/neuro.2012.35.issue-1","article-title":"The complement system: an unexpected role in synaptic pruning during development and disease","volume":"35","author":"Stephan","year":"2012","journal-title":"Annu Rev Neurosci"},{"issue":"3","key":"bib4","doi-asserted-by":"publisher","first-page":"1024","DOI":"10.1167\/iovs.05-0830","article-title":"Complement component 1Q (C1Q) upregulation in retina of murine, primate, and human glaucomatous eyes","volume":"47","author":"Stasi","year":"2006","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib5","doi-asserted-by":"publisher","first-page":"4675","DOI":"10.3390\/ijms22094675","article-title":"Aberrant complement system activation in neurological disorders","volume":"22","author":"Ziabska","year":"2021","journal-title":"Int J Mol Sci"},{"issue":"6286","key":"bib6","doi-asserted-by":"publisher","first-page":"712","DOI":"10.1126\/science.aad8373","article-title":"Complement and microglia mediate early synapse loss in Alzheimer mouse models","volume":"352","author":"Hong","year":"2016","journal-title":"Science"},{"issue":"4","key":"bib7","doi-asserted-by":"publisher","first-page":"921","DOI":"10.1016\/j.cell.2016.04.001","article-title":"Progranulin deficiency promotes circuit-specific synaptic pruning by microglia via complement activation","volume":"165","author":"Lui","year":"2016","journal-title":"Cell"},{"key":"bib8","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1038\/nature16549","article-title":"Schizophrenia risk from complex variation of complement component 4","volume":"530","author":"Sekar","year":"2016","journal-title":"Nature"},{"key":"bib9","doi-asserted-by":"publisher","first-page":"620","DOI":"10.1016\/j.exer.2006.03.002","article-title":"Retinal synthesis and deposition of complement components induced by ocular hypertension","volume":"83","author":"Kuehn","year":"2006","journal-title":"Exp Eye Res"},{"issue":"10","key":"bib10","doi-asserted-by":"publisher","first-page":"5071","DOI":"10.1167\/iovs.10-5289","article-title":"Oxidative stress and the regulation of the complement activation in human glaucoma","volume":"51","author":"Tezel","year":"2010","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib11","doi-asserted-by":"publisher","first-page":"1429","DOI":"10.1172\/JCI44646","article-title":"Molecular clustering identifies complement and endothelin induction as early events in a mouse model of glaucoma","volume":"121","author":"Howell","year":"2011","journal-title":"J Clin Invest"},{"key":"bib12","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1016\/j.molimm.2017.05.028","article-title":"The link between morphology and complement in ocular disease","volume":"89","author":"Mohlin","year":"2017","journal-title":"Mol Immunol"},{"issue":"11","key":"bib13","doi-asserted-by":"publisher","first-page":"2081","DOI":"10.1016\/j.ophtha.2014.05.013","article-title":"Global prevalence of glaucoma and projections of glaucoma burden through 2040: a systematic review and meta-analysis","volume":"121","author":"Tham","year":"2014","journal-title":"Ophthalmol"},{"issue":"539","key":"bib14","first-page":"1","article-title":"C-reactive protein as a mediator of complement activation and inflammatory activation and inflammatory signaling in age-related macular degeneration","volume":"9","author":"Chirco","year":"2018","journal-title":"Front Immunol"},{"issue":"1","key":"bib15","doi-asserted-by":"publisher","first-page":"7348","DOI":"10.1038\/s41598-018-25557-8","article-title":"Classical and alternative complement activation on photoreceptor outer segments drives monocyte-dependent retinal atrophy","volume":"8","author":"Katschke","year":"2018","journal-title":"Sci Rep"},{"key":"bib16","first-page":"1236","article-title":"Photoreceptor loss in age-related macular degeneration","volume":"37","author":"Curcio","year":"1996","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib17","doi-asserted-by":"publisher","first-page":"1124","DOI":"10.3390\/jcm10051124","article-title":"Age-related macular degeneration (AMD): a view to the future","volume":"10","author":"Miller","year":"2021","journal-title":"J Clin Med"},{"key":"bib18","doi-asserted-by":"publisher","first-page":"7451","DOI":"10.1016\/S0021-9258(18)47587-4","article-title":"Serum lectin with known structure activates complement through the classical pathway","volume":"262","author":"Ikeda","year":"1987","journal-title":"J. Biol. Chem."},{"key":"bib19","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1111\/tan.2006.68.issue-3","article-title":"Mannose-binding lectin in innate immunity: past, present and future","volume":"68","author":"Dommett","year":"2006","journal-title":"Tissue Antigens"},{"key":"bib20","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1038\/cr.2009.139","article-title":"Complement and its role in innate and adaptive immune responses","volume":"20","author":"Dunkelberger","year":"2010","journal-title":"Cell Res"},{"issue":"9","key":"bib21","doi-asserted-by":"publisher","first-page":"2835","DOI":"10.1016\/j.celrep.2019.10.084","article-title":"Cell-type-specific complement expression in the healthy and diseased retina","volume":"29","author":"Pauly","year":"2019","journal-title":"Cell Rep"},{"key":"bib22","doi-asserted-by":"publisher","first-page":"13460","DOI":"10.1523\/JNEUROSCI.1333-13.2013","article-title":"A dramatic increase of C1q protein in the CNS during normal aging","volume":"33","author":"Stephan","year":"2013","journal-title":"J Neurosci"},{"key":"bib23","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1186\/s13024-016-0091-6","article-title":"Inhibition of the classical pathway of the complement cascade prevents early dendritic and synaptic degeneration in glaucoma","volume":"11","author":"Williams","year":"2016","journal-title":"Mol Neurodegener"},{"key":"bib24","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1167\/iovs.09-4081","article-title":"Functional and structural changes in a canine model of hereditary primary angle-closure glaucoma","volume":"51","author":"Grozdanic","year":"2010","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib25","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1186\/1742-2094-10-76","article-title":"Deficiency of complement component 5 ameliorates glaucoma in DBA\/2J mice","volume":"10","author":"Howell","year":"2013","journal-title":"J Neuroinflammation"},{"issue":"1","key":"bib26","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1186\/s13024-018-0278-0","article-title":"Subretinal macrophages produce classical complement activator C1q leading to the progression of focal retinal degeneration","volume":"13","author":"Jiao","year":"2018","journal-title":"Mol Neurodegener"},{"key":"bib27","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1186\/s13024-016-0089-0","article-title":"C1q propagates microglial activation and neurodegeneration in the visual axis following retinal ischemia\/reperfusion injury","volume":"11","author":"Silverman","year":"2016","journal-title":"Mol Neurodegener"},{"issue":"1-3","key":"bib28","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1016\/j.molimm.2006.06.021","article-title":"Complement proteins C1q and MBL are pattern recognition molecules that signal immediate and long-term protective immune functions","volume":"44","author":"Bohlson","year":"2007","journal-title":"Mol Immunol"},{"key":"bib29","doi-asserted-by":"publisher","first-page":"108","DOI":"10.3390\/pharmaceutics13010108","article-title":"Ocular drug delivery to the retina: current innovations and future perspectives","volume":"13","author":"Kim","year":"2021","journal-title":"Pharmaceutics"},{"issue":"168","key":"bib32","first-page":"36112","article-title":"Final Rules: Animal welfare; 9 CFR Parts 1, 2, and 3","volume":"54","author":"U.S. Department of Agriculture","year":"1989","journal-title":"Federal Register"},{"key":"bib35","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1186\/s12974-017-0814-9","article-title":"Cell-specific deletion of C1qa identifies microglia as the dominant source of C1q in mouse brain","volume":"14","author":"Fonseca","year":"2017","journal-title":"J Neuroinflammation"},{"issue":"2","key":"bib36","doi-asserted-by":"publisher","first-page":"288","DOI":"10.1124\/jpet.115.227223","article-title":"A mechanistic pharmacokinetic\/pharmacodynamic model of factor D inhibition in cynomolgus monkeys by lampalizumab for the treatment of geographic atrophy","volume":"355","author":"Le","year":"2015","journal-title":"J Pharmacol Exp Ther"},{"issue":"2","key":"bib37","doi-asserted-by":"publisher","first-page":"726","DOI":"10.1167\/iovs.04-0601","article-title":"Preclinical pharmacokinetics of ranibizumab (rhuFabV2) after a single intravitreal administration","volume":"46","author":"Gaudreault","year":"2005","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib30","author":"ClinicalTrials.gov"},{"key":"bib31","author":"ClinicalTrials.gov"},{"key":"bib33","volume-title":"Public Health Service Policy on Humane Care and Use of Laboratory Animals from the Office of Laboratory Animal Welfare","author":"U.S. Department of Health and Human Services, NIH"},{"key":"bib34","volume-title":"Guide for the care and use of laboratory animals","author":"National Institutes of Health","edition":"8th ed."}],"container-title":["Investigative Opthalmology & Visual Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/iovs.arvojournals.org\/article.aspx?articleid=2785330","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:31:42Z","timestamp":1791927102000},"score":1,"resource":{"primary":{"URL":"https:\/\/iovs.arvojournals.org\/article.aspx?articleid=2785330"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2,2]]},"references-count":37,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2023,2,1]]}},"URL":"https:\/\/doi.org\/10.1167\/iovs.64.2.3","relation":{},"ISSN":["1552-5783"],"issn-type":[{"value":"1552-5783","type":"print"}],"subject":[],"published":{"date-parts":[[2023,2,2]]}}}