{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T01:36:45Z","timestamp":1791941805130,"version":"4.3.4"},"reference-count":52,"publisher":"Association for Research in Vision and Ophthalmology (ARVO)","issue":"3","license":[{"start":{"date-parts":[[2023,3,6]],"date-time":"2023-03-06T00:00:00Z","timestamp":1678060800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Invest. Ophthalmol. Vis. Sci."],"published-print":{"date-parts":[[2023,3,6]]},"DOI":"10.1167\/iovs.64.3.14","type":"journal-article","created":{"date-parts":[[2023,3,6]],"date-time":"2023-03-06T11:30:52Z","timestamp":1678102252000},"page":"14","source":"Crossref","is-referenced-by-count":6,"title":["T-Cell Repertoire Analysis in the Conjunctiva of Murine Dry Eye Model"],"prefix":"10.1167","volume":"64","author":[{"given":"Xiaorui","family":"Bao","sequence":"first","affiliation":[{"name":"Fujian Provincial Key Laboratory of Ophthalmology and Visual Science, Eye Institute & Affiliated Xiamen Eye Center, School of Medicine, Xiamen University, Xiamen, Fujian, China"},{"name":"Department of Ophthalmology, Xiang'an Hospital of Xiamen University, Xiamen, Fujian, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanlin","family":"Zhong","sequence":"additional","affiliation":[{"name":"Fujian Provincial Key Laboratory of Ophthalmology and Visual Science, Eye Institute & Affiliated Xiamen Eye Center, School of Medicine, Xiamen University, Xiamen, Fujian, China"},{"name":"Department of Ophthalmology, Xiang'an Hospital of Xiamen University, Xiamen, Fujian, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunyan","family":"Yang","sequence":"additional","affiliation":[{"name":"School of Life Science, Xiamen University, Xiamen, Fujian, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yujie","family":"Chen","sequence":"additional","affiliation":[{"name":"Fujian Provincial Key Laboratory of Ophthalmology and Visual Science, Eye Institute & Affiliated Xiamen Eye Center, School of Medicine, Xiamen University, Xiamen, Fujian, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Han","sequence":"additional","affiliation":[{"name":"Fujian Provincial Key Laboratory of Ophthalmology and Visual Science, Eye Institute & Affiliated Xiamen Eye Center, School of Medicine, Xiamen University, Xiamen, Fujian, China"},{"name":"Department of Ophthalmology, Xiang'an Hospital of Xiamen University, Xiamen, Fujian, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Xiang'an Hospital of Xiamen University, Xiamen, Fujian, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caihong","family":"Huang","sequence":"additional","affiliation":[{"name":"Fujian Provincial Key Laboratory of Ophthalmology and Visual Science, Eye Institute & Affiliated Xiamen Eye Center, School of Medicine, Xiamen University, Xiamen, Fujian, China"},{"name":"Department of Ophthalmology, Xiang'an Hospital of Xiamen University, Xiamen, Fujian, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kejia","family":"Wang","sequence":"additional","affiliation":[{"name":"Fujian Provincial Key Laboratory of Ophthalmology and Visual Science, Eye Institute & Affiliated Xiamen Eye Center, School of Medicine, Xiamen University, Xiamen, Fujian, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zuguo","family":"Liu","sequence":"additional","affiliation":[{"name":"Fujian Provincial Key Laboratory of Ophthalmology and Visual Science, Eye Institute & Affiliated Xiamen Eye Center, School of Medicine, Xiamen University, Xiamen, Fujian, China"},{"name":"Department of Ophthalmology, Xiang'an Hospital of Xiamen University, Xiamen, Fujian, China"},{"name":"The First Affiliated Hospital of University of South China, Hengyang, Hunan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng","family":"Li","sequence":"additional","affiliation":[{"name":"Fujian Provincial Key Laboratory of Ophthalmology and Visual Science, Eye Institute & Affiliated Xiamen Eye Center, School of Medicine, Xiamen University, Xiamen, Fujian, China"},{"name":"Department of Ophthalmology, Xiang'an Hospital of Xiamen University, Xiamen, Fujian, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"27","reference":[{"issue":"3","key":"bib1","doi-asserted-by":"publisher","first-page":"276","DOI":"10.1016\/j.jtos.2017.05.008","article-title":"TFOS DEWS II definition and classification report","volume":"15","author":"Craig","year":"2017","journal-title":"Ocular Surface"},{"issue":"8","key":"bib2","first-page":"2609","article-title":"Conjunctival T-cell subpopulations in Sj\u00f6gren's and non-Sj\u00f6gren's patients with dry eye","volume":"43","author":"Stern","year":"2002","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"14","key":"bib3","doi-asserted-by":"publisher","first-page":"6056","DOI":"10.1167\/iovs.17-22852","article-title":"Topical application of mizoribine suppresses CD4+ T-cell-mediated pathogenesis in murine dry eye","volume":"58","author":"Zhang","year":"2017","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"8","key":"bib4","doi-asserted-by":"publisher","first-page":"3293","DOI":"10.1167\/iovs.05-1382","article-title":"Desiccating stress stimulates expression of matrix metalloproteinases by the corneal epithelium","volume":"47","author":"Corrales","year":"2006","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib5","doi-asserted-by":"publisher","first-page":"108294","DOI":"10.1016\/j.exer.2020.108294","article-title":"Inflammatory basis for dry eye disease flares","volume":"201","author":"Perez","year":"2020","journal-title":"Exp Eye Res"},{"key":"bib6","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1111\/joa.2005.206.issue-3","article-title":"The role of eye-associated lymphoid tissue in corneal immune protection","volume":"206","author":"Knop","year":"2005","journal-title":"J Anat"},{"issue":"4","key":"bib7","doi-asserted-by":"publisher","first-page":"620","DOI":"10.1038\/s41385-022-00507-w","article-title":"Single-cell transcriptional profiling of murine conjunctival immune cells reveals distinct populations expressing homeostatic and regulatory genes","volume":"15","author":"Alam","year":"2022","journal-title":"Mucosal Immunol"},{"issue":"4","key":"bib8","doi-asserted-by":"publisher","first-page":"897","DOI":"10.1038\/s41385-018-0127-z","article-title":"Age-associated antigen-presenting cell alterations promote dry-eye inducing Th1 cells","volume":"12","author":"Bian","year":"2019","journal-title":"Mucosal Immunol"},{"issue":"8","key":"bib9","doi-asserted-by":"publisher","first-page":"3802","DOI":"10.1167\/iovs.08-2417","article-title":"Characterization of effector T cells in dry eye disease","volume":"50","author":"El Annan","year":"2009","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib10","doi-asserted-by":"publisher","first-page":"102933","DOI":"10.1016\/j.autrev.2021.102933","article-title":"Autoimmunity in dry eye disease\u2014an updated review of evidence on effector and memory Th17 cells in disease pathogenicity","volume":"20","author":"Chen","year":"2021","journal-title":"Autoimmun Rev"},{"issue":"3","key":"bib11","doi-asserted-by":"publisher","first-page":"1247","DOI":"10.4049\/jimmunol.182.3.1247","article-title":"Autoimmunity in dry eye is due to resistance of Th17 to Treg suppression","volume":"182","author":"Chauhan","year":"2009","journal-title":"J Immunol"},{"key":"bib12","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1016\/j.jtos.2020.05.009","article-title":"The role of Th17 immunity in chronic ocular surface disorders","volume":"19","author":"Fan","year":"2021","journal-title":"Ocular Surface"},{"issue":"3","key":"bib13","doi-asserted-by":"publisher","first-page":"423","DOI":"10.1093\/intimm\/dxh046","article-title":"Development of TCRB CDR3 length repertoire of human T lymphocytes","volume":"16","author":"Nishio","year":"2004","journal-title":"Int Immunol"},{"issue":"19","key":"bib14","doi-asserted-by":"publisher","first-page":"4099","DOI":"10.1182\/blood-2009-04-217604","article-title":"Comprehensive assessment of T-cell receptor beta-chain diversity in alphabeta T cells","volume":"114","author":"Robins","year":"2009","journal-title":"Blood"},{"issue":"7661","key":"bib15","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1038\/nature22976","article-title":"Identifying specificity groups in the T cell receptor repertoire","volume":"547","author":"Glanville","year":"2017","journal-title":"Nature"},{"key":"bib16","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1007\/s00281-016-0614-9","article-title":"T cell receptor repertoire usage in cancer as a surrogate marker for immune responses","volume":"39","author":"Schrama","year":"2017","journal-title":"Semin Immunopathol"},{"key":"bib17","doi-asserted-by":"publisher","first-page":"414","DOI":"10.1016\/j.ebiom.2019.07.032","article-title":"TCR repertoire and CDR3 motif analyses depict the role of a\u00df T cells in ankylosing spondylitis","volume":"47","author":"Zheng","year":"2019","journal-title":"EBioMedicine"},{"issue":"19","key":"bib18","doi-asserted-by":"publisher","first-page":"2585","DOI":"10.1182\/blood.2020009471","article-title":"Clinical effects of administering leukemia-specific donor T cells to patients with AML\/MDS after allogeneic transplant","volume":"137","author":"Lulla","year":"2021","journal-title":"Blood"},{"issue":"9","key":"bib19","doi-asserted-by":"publisher","first-page":"1220","DOI":"10.1038\/s41590-019-0429-7","article-title":"Connecting blood and intratumoral T(reg) cell activity in predicting future relapse in breast cancer","volume":"20","author":"Wang","year":"2019","journal-title":"Nat Immunol"},{"key":"bib20","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1038\/s41571-020-00460-2","article-title":"Advances in the development of personalized neoantigen-based therapeutic cancer vaccines","volume":"18","author":"Blass","year":"2021","journal-title":"Nat Rev Clin Oncol"},{"key":"bib21","doi-asserted-by":"publisher","first-page":"582010","DOI":"10.3389\/fimmu.2020.582010","article-title":"Longitudinal analysis of T and B cell receptor repertoire transcripts reveal dynamic immune response in COVID-19 patients","volume":"11","author":"Niu","year":"2020","journal-title":"Front Immunol"},{"issue":"20","key":"bib22","doi-asserted-by":"publisher","first-page":"e00935","DOI":"10.1128\/JVI.00935-20","article-title":"T cell receptor diversity and lineage relationship between virus-specific CD8 T cell subsets during chronic lymphocytic choriomeningitis virus infection","volume":"94","author":"Chang","year":"2020","journal-title":"J Virol"},{"key":"bib23","doi-asserted-by":"publisher","first-page":"1792","DOI":"10.1038\/s41467-017-01925-2","article-title":"T cell receptor \u00df-chains display abnormal shortening and repertoire sharing in type 1 diabetes","volume":"8","author":"Gomez-Tourino","year":"2017","journal-title":"Nat Commun"},{"key":"bib24","doi-asserted-by":"publisher","first-page":"2549","DOI":"10.3389\/fimmu.2019.02549","article-title":"Heterologous cytomegalovirus and allo-reactivity by shared T cell receptor repertoire in kidney transplantation","volume":"10","author":"Stranavova","year":"2019","journal-title":"Front Immunol"},{"key":"bib25","doi-asserted-by":"publisher","first-page":"12","DOI":"10.3389\/fimmu.2020.00012","article-title":"Dissection of the human T-cell receptor ? gene repertoire in the brain and peripheral blood identifies age- and Alzheimer's disease-associated clonotype profiles","volume":"11","author":"Aliseychik","year":"2020","journal-title":"Front Immunol"},{"key":"bib26","doi-asserted-by":"publisher","first-page":"643","DOI":"10.1158\/0008-5472.CAN-19-1457","article-title":"The diagnostic, prognostic, and therapeutic potential of adaptive immune receptor repertoire profiling in cancer","volume":"80","author":"Cowell","year":"2020","journal-title":"Cancer Res"},{"issue":"1","key":"bib27","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1038\/s41591-018-0266-5","article-title":"Low and variable tumor reactivity of the intratumoral TCR repertoire in human cancers","volume":"25","author":"Scheper","year":"2019","journal-title":"Nat Med"},{"issue":"7","key":"bib28","doi-asserted-by":"publisher","first-page":"3950","DOI":"10.4049\/jimmunol.176.7.3950","article-title":"Desiccating stress induces T cell-mediated Sj\u00f6gren's Syndrome-like lacrimal keratoconjunctivitis","volume":"176","author":"Niederkorn","year":"2006","journal-title":"J Immunol"},{"issue":"11","key":"bib29","doi-asserted-by":"publisher","first-page":"4898","DOI":"10.1167\/iovs.17-22240","article-title":"Therapeutic effect of MK2 inhibitor on experimental murine dry eye","volume":"58","author":"Wu","year":"2017","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib30","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1097\/IIO.0000000000000169","article-title":"What we have learned from animal models of dry eye","volume":"57","author":"Stern","year":"2017","journal-title":"Int Ophthalmol Clin"},{"issue":"6","key":"bib31","doi-asserted-by":"publisher","first-page":"2553","DOI":"10.1167\/iovs.07-0069","article-title":"Dry eye-induced conjunctival epithelial squamous metaplasia is modulated by interferon-gamma","volume":"48","author":"De Paiva","year":"2007","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"5","key":"bib32","doi-asserted-by":"publisher","first-page":"1977","DOI":"10.1002\/hep.30067","article-title":"Intrahepatic T-cell receptor \u00df immune repertoire is essential for liver regeneration","volume":"68","author":"Liang","year":"2018","journal-title":"Hepatology"},{"issue":"10","key":"bib33","doi-asserted-by":"publisher","first-page":"e1219010","DOI":"10.1080\/2162402X.2016.1219010","article-title":"High-throughput T cell receptor sequencing reveals distinct repertoires between tumor and adjacent non-tumor tissues in HBV-associated HCC","volume":"5","author":"Chen","year":"2016","journal-title":"Oncoimmunology"},{"key":"bib34","doi-asserted-by":"publisher","first-page":"1188","DOI":"10.1101\/gr.849004","article-title":"WebLogo: a sequence logo generator","volume":"14","author":"Crooks","year":"2004","journal-title":"Genome Res"},{"key":"bib35","doi-asserted-by":"publisher","first-page":"6097","DOI":"10.1093\/nar\/18.20.6097","article-title":"Sequence logos: a new way to display consensus sequences","volume":"18","author":"Schneider","year":"1990","journal-title":"Nucleic Acids Res"},{"issue":"3","key":"bib36","doi-asserted-by":"publisher","first-page":"438","DOI":"10.1016\/j.jtos.2017.05.011","article-title":"TFOS DEWS II pathophysiology report","volume":"15","author":"Bron","year":"2017","journal-title":"Ocular Surface"},{"issue":"7","key":"bib37","doi-asserted-by":"publisher","first-page":"3086","DOI":"10.4049\/jimmunol.1500610","article-title":"Female-specific downregulation of tissue polymorphonuclear neutrophils drives impaired regulatory T cell and amplified effector T cell responses in autoimmune dry eye disease","volume":"195","author":"Gao","year":"2015","journal-title":"J Immunol"},{"issue":"10","key":"bib38","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1186\/gm502","article-title":"Sequence analysis of T-cell repertoires in health and disease","volume":"5","author":"Woodsworth","year":"2013","journal-title":"Genome Med"},{"issue":"3","key":"bib39","doi-asserted-by":"publisher","first-page":"423","DOI":"10.1093\/intimm\/dxh046","article-title":"Development of TCRB CDR3 length repertoire of human T lymphocytes","volume":"16","author":"Nishio","year":"2004","journal-title":"Int Immunol"},{"issue":"8","key":"bib40","doi-asserted-by":"publisher","first-page":"3259","DOI":"10.1167\/iovs.18-23965","article-title":"Hyperosmotic stress-induced TRPM2 channel activation stimulates NLRP3 inflammasome activity in primary human corneal epithelial cells","volume":"59","author":"Zheng","year":"2018","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"8","key":"bib41","doi-asserted-by":"publisher","first-page":"e85609","DOI":"10.1172\/jci.insight.85609","article-title":"Single-cell analysis of glandular T cell receptors in Sj\u00f6gren's syndrome","volume":"1","author":"Joachims","year":"2016","journal-title":"JCI Insight"},{"issue":"8","key":"bib42","doi-asserted-by":"publisher","first-page":"4084","DOI":"10.4049\/jimmunol.155.8.4084","article-title":"Limited TCR repertoire of infiltrating T cells in the kidneys of Sj\u00f6gren's syndrome patients with interstitial nephritis","volume":"155","author":"Murata","year":"1995","journal-title":"J Immunol"},{"key":"bib43","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1016\/j.clim.2018.04.009","article-title":"Unique glandular ex-vivo Th1 and Th17 receptor motifs in Sj\u00f6gren's syndrome patients using single-cell analysis","volume":"192","author":"Voigt","year":"2018","journal-title":"Clin Immunol"},{"key":"bib44","first-page":"497","article-title":"Oligoclonality of T cells in salivary glands of autoimmune MRL\/lpr mice","volume":"81","author":"Skarstein","year":"1994","journal-title":"Immunology"},{"key":"bib45","doi-asserted-by":"publisher","first-page":"102432","DOI":"10.1016\/j.jaut.2020.102432","article-title":"Comprehensive TCR repertoire analysis of CD4(+) T-cell subsets in rheumatoid arthritis","volume":"109","author":"Jiang","year":"2020","journal-title":"J Autoimmun"},{"issue":"24","key":"bib46","doi-asserted-by":"publisher","first-page":"14447","DOI":"10.1073\/pnas.95.24.14447","article-title":"Perturbation of the T cell repertoire in rheumatoid arthritis","volume":"95","author":"Wagner","year":"1998","journal-title":"Proc Natl Acad Sci USA"},{"issue":"1","key":"bib47","doi-asserted-by":"publisher","first-page":"1058","DOI":"10.1038\/s41598-018-19548-y","article-title":"Increased diversity with reduced \u201cdiversity evenness\u201d of tumor infiltrating T-cells for the successful cancer immunotherapy","volume":"8","author":"Hosoi","year":"2018","journal-title":"Sci Rep"},{"issue":"1","key":"bib48","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1016\/j.ajo.2012.01.034","article-title":"Efficacy of topical blockade of interleukin-1 in experimental dry eye disease","volume":"154","author":"Okanobo","year":"2012","journal-title":"Am J Ophthalmol"},{"issue":"7","key":"bib49","doi-asserted-by":"publisher","first-page":"2847","DOI":"10.1167\/iovs.05-1281","article-title":"Apical corneal barrier disruption in experimental murine dry eye is abrogated by methylprednisolone and doxycycline","volume":"47","author":"De Paiva","year":"2006","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"1","key":"bib50","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1186\/s40425-018-0371-5","article-title":"Dexamethasone-induced immunosuppression: mechanisms and implications for immunotherapy","volume":"6","author":"Giles","year":"2018","journal-title":"J Immunother Cancer"},{"key":"bib51","doi-asserted-by":"publisher","first-page":"4037","DOI":"10.4049\/jimmunol.145.12.4037","article-title":"Programmed T lymphocyte death. Cell activation- and steroid-induced pathways are mutually antagonistic","volume":"145","author":"Zacharchuk","year":"1990","journal-title":"J Immunol"},{"key":"bib52","doi-asserted-by":"publisher","first-page":"643","DOI":"10.1002\/(ISSN)1521-4141","article-title":"Rescue of thymocytes and T cell hybridomas from glucocorticoid-induced apoptosis by stimulation via the T cell receptor\/CD3 complex: a possible in vitro model for positive selection of the T cell repertoire","volume":"21","author":"Iwata","year":"1991","journal-title":"Eur J Immunol"}],"container-title":["Investigative Opthalmology & Visual Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/iovs.arvojournals.org\/article.aspx?articleid=2785421","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:31:38Z","timestamp":1791927098000},"score":1,"resource":{"primary":{"URL":"https:\/\/iovs.arvojournals.org\/article.aspx?articleid=2785421"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3,6]]},"references-count":52,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2023,3,1]]}},"URL":"https:\/\/doi.org\/10.1167\/iovs.64.3.14","relation":{},"ISSN":["1552-5783"],"issn-type":[{"value":"1552-5783","type":"print"}],"subject":[],"published":{"date-parts":[[2023,3,6]]}}}