{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T22:00:18Z","timestamp":1791928818809,"version":"4.3.4"},"reference-count":50,"publisher":"Association for Research in Vision and Ophthalmology (ARVO)","issue":"4","license":[{"start":{"date-parts":[[2023,4,7]],"date-time":"2023-04-07T00:00:00Z","timestamp":1680825600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Invest. Ophthalmol. Vis. Sci."],"published-print":{"date-parts":[[2023,4,7]]},"DOI":"10.1167\/iovs.64.4.6","type":"journal-article","created":{"date-parts":[[2023,4,7]],"date-time":"2023-04-07T10:30:52Z","timestamp":1680863452000},"page":"6","source":"Crossref","is-referenced-by-count":8,"title":["The Relationship Between Retinal and Choroidal Thickness and Adiponectin Concentrations in Patients With Type 2 Diabetes Mellitus"],"prefix":"10.1167","volume":"64","author":[{"given":"Hyun Seung","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Applied Bioengineering, Graduate School of Convergence Science and Technology, Seoul National University, Seoul, South Korea"},{"name":"Department of Ophthalmology, Seoul Shinsegae Eye Center, Eui Jung Bu, Gyeonggi-do, South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young Je","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Veterans Health Service Medical Center, South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hee Yong","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Veterans Health Service Medical Center, South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hak Su","family":"Kim","sequence":"additional","affiliation":[{"name":"Veterans Medical Research Institute, Veterans Health Service Medical Center, South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"So Hyun","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Seoul Chuk Hospital, Eui Jung Bu, Gyeonggi-do, South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeongmin","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Applied Bioengineering, Graduate School of Convergence Science and Technology, Seoul National University, Seoul, South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sangkyung","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Veterans Health Service Medical Center, South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"27","reference":[{"key":"bib1","doi-asserted-by":"publisher","first-page":"517","DOI":"10.1016\/j.diabet.2019.04.002","article-title":"Diabetic retinopathy, a vascular and inflammatory disease: therapeutic implications","volume":"45","author":"Semeraro","year":"2019","journal-title":"Diabetes Metab"},{"issue":"6","key":"bib2","doi-asserted-by":"publisher","first-page":"E1321","DOI":"10.3390\/ijms18061321","article-title":"Adiponectin, a therapeutic target for obesity, diabetes, and endothelial dysfunction","volume":"18","author":"Achari","year":"2017","journal-title":"Int J Mol Sci"},{"key":"bib3","first-page":"718","article-title":"Inflammation and diabetic retinopathy","volume":"26","author":"Ucgun","year":"2020","journal-title":"Mol Vis"},{"key":"bib4","doi-asserted-by":"publisher","first-page":"5989","DOI":"10.1167\/iovs.14-14864","article-title":"Elevated plasma pentraxin 3 levels are associated with development and progression of diabetic retinopathy in Korean patients with type 2 diabetes mellitus","volume":"55","author":"Yang","year":"2014","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"11","key":"bib5","doi-asserted-by":"publisher","first-page":"e0259683","DOI":"10.1371\/journal.pone.0259683","article-title":"Serum and aqueous humor adiponectin levels correlate with diabetic retinopathy development and progression","volume":"16","author":"Yang","year":"2021","journal-title":"PLoS One"},{"key":"bib6","doi-asserted-by":"publisher","first-page":"442","DOI":"10.1002\/(ISSN)1520-7560","article-title":"Vascular endothelial growth factor and diabetic retinopathy: pathophysiological mechanisms and treatment perspectives","volume":"19","author":"Caldwell","year":"2003","journal-title":"Diabetes Metab Res Rev"},{"key":"bib7","doi-asserted-by":"publisher","first-page":"1473","DOI":"10.2337\/diab.46.9.1473","article-title":"Vascular endothelial growth factor-induced retinal permeability is mediated by protein kinase C in vivo and suppressed by an orally effective beta-isoform-selective inhibitor","volume":"46","author":"Aiello","year":"1997","journal-title":"Diabetes"},{"key":"bib8","doi-asserted-by":"publisher","first-page":"1953","DOI":"10.2337\/diabetes.47.12.1953","article-title":"Vascular permeability in experimental diabetes is associated with reduced endothelial occludin content: vascular endothelial growth factor decreases occludin in retinal endothelial cells. Penn State Retina Research Group","volume":"47","author":"Antonetti","year":"1998","journal-title":"Diabetes"},{"issue":"2-3","key":"bib9","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1016\/j.mvr.2007.03.004","article-title":"Roles for VEGF in the adult","volume":"74","author":"Maharaj","year":"2007","journal-title":"Microvasc Res"},{"key":"bib10","doi-asserted-by":"publisher","first-page":"3378","DOI":"10.1167\/iovs.12-11503","article-title":"Changes in choroidal thickness in relation to the severity of retinopathy and macular edema in type 2 diabetic patients","volume":"54","author":"Kim","year":"2013","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"11","key":"bib11","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1167\/iovs.61.11.12","article-title":"Effects of systemic profiles on choroidal thickness in treatment-na\u00efve eyes with diabetic retinopathy","volume":"61","author":"Choi","year":"2020","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib12","doi-asserted-by":"publisher","first-page":"736","DOI":"10.3109\/02713683.2013.867064","article-title":"Changes of choroidal thickness after treatment for diabetic retinopathy","volume":"39","author":"Lee","year":"2014","journal-title":"Curr Eye Res"},{"key":"bib13","doi-asserted-by":"publisher","first-page":"718","DOI":"10.1038\/eye.2016.23","article-title":"Effect of intravitreal dexamethasone implant on retinal and choroidal thickness in refractory diabetic macular oedema after multiple anti-VEGF injections","volume":"30","author":"Kim","year":"2016","journal-title":"Eye (Lond)"},{"issue":"4","key":"bib14","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1167\/iovs.61.4.29","article-title":"Choroidal thickness in diabetes and diabetic retinopathy: a swept source OCT study","volume":"61","author":"Wang","year":"2020","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib15","doi-asserted-by":"publisher","first-page":"307","DOI":"10.3109\/02713683.2014.973043","article-title":"Correlation of macular choroidal thickness with concentrations of aqueous vascular endothelial growth factor in high myopia","volume":"40","author":"Chen","year":"2015","journal-title":"Curr Eye Res"},{"key":"bib16","doi-asserted-by":"publisher","first-page":"1320","DOI":"10.2337\/diacare.25.8.1320","article-title":"Blood pressure, lipids, and obesity are associated with retinopathy: the Hoorn study","volume":"25","author":"van Leiden","year":"2002","journal-title":"Diabetes Care"},{"key":"bib17","doi-asserted-by":"publisher","first-page":"624903","DOI":"10.3389\/fphys.2020.624903","article-title":"Angiogenesis in adipose tissue: the interplay between adipose and endothelial cells","volume":"11","author":"Herold","year":"2020","journal-title":"Front Physiol"},{"key":"bib18","doi-asserted-by":"publisher","first-page":"29359","DOI":"10.1074\/jbc.C200312200","article-title":"Oligomerization state-dependent activation of NF-kappa B signaling pathway by adipocyte complement-related protein of 30 kDa (Acrp30)","volume":"277","author":"Tsao","year":"2002","journal-title":"J Biol Chem"},{"key":"bib19","doi-asserted-by":"publisher","first-page":"95","DOI":"10.2174\/1568011033353452","article-title":"Vascular endothelial cell growth factor (VEGF), an emerging target for cancer chemotherapy","volume":"3","author":"Shinkaruk","year":"2003","journal-title":"Curr Med Chem Anticancer Agents"},{"key":"bib20","doi-asserted-by":"publisher","first-page":"4143","DOI":"10.1167\/iovs.15-16447","article-title":"Relationship between retinal blood flow and serum adiponectin concentrations in patients with type 2 diabetes mellitus","volume":"56","author":"Omae","year":"2015","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib21","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1097\/IAE.0000000000000276","article-title":"Postoperative restoration of foveal inner retinal configuration in patients with epiretinal membrane and abnormally thick inner retina","volume":"35","author":"Yang","year":"2015","journal-title":"Retina"},{"key":"bib22","doi-asserted-by":"publisher","first-page":"3029","DOI":"10.1167\/iovs.14-13955","article-title":"Correlation between spectral-domain OCT findings and visual acuity in X-linked retinoschisis","volume":"55","author":"Yang","year":"2014","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib23","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1007\/978-3-319-48382-5","article-title":"Adiponectin-resistance in obesity","volume":"960","author":"Engin","year":"2017","journal-title":"Adv Exp Med Biol"},{"key":"bib24","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1007\/s10238-009-0084-7","article-title":"Antioxidant potential, paraoxonase 1, ceruloplasmin activity and C-reactive protein concentration in diabetic retinopathy","volume":"10","author":"Nowak","year":"2010","journal-title":"Clin Exp Med"},{"key":"bib25","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1002\/cphy.c170046","article-title":"Adiponectin regulation and function","volume":"8","author":"Fang","year":"2018","journal-title":"Compr Physiol"},{"key":"bib26","doi-asserted-by":"publisher","first-page":"582060","DOI":"10.1155\/2015\/582060","article-title":"Diabetic retinopathy: vascular and inflammatory disease","volume":"2015","author":"Semeraro","year":"2015","journal-title":"J Diabetes Res"},{"key":"bib27","doi-asserted-by":"publisher","first-page":"3348","DOI":"10.1210\/jc.2015-1221","article-title":"Adiponectin, insulin sensitivity and diabetic retinopathy in Latinos with type 2 diabetes","volume":"100","author":"Kuo","year":"2015","journal-title":"J Clin Endocrinol Metab"},{"issue":"1","key":"bib28","doi-asserted-by":"publisher","first-page":"E17","DOI":"10.3390\/genes12010017","article-title":"Causal relationship between adiponectin and diabetic retinopathy: a mendelian randomization study in an Asian population","volume":"12","author":"Huang","year":"2020","journal-title":"Genes (Basel)"},{"key":"bib29","doi-asserted-by":"publisher","first-page":"532","DOI":"10.1055\/s-2008-1058086","article-title":"Serum levels of adiponectin are associated with diabetic retinopathy and with adiponectin gene mutations in Caucasian patients with diabetes mellitus type 2","volume":"116","author":"Zietz","year":"2008","journal-title":"Exp Clin Endocrinol Diabetes"},{"key":"bib30","doi-asserted-by":"publisher","first-page":"803","DOI":"10.3109\/02713683.2012.676700","article-title":"Aqueous humor and plasma adiponectin levels in proliferative diabetic retinopathy patients","volume":"37","author":"Mao","year":"2012","journal-title":"Curr Eye Res"},{"key":"bib31","doi-asserted-by":"publisher","first-page":"540326","DOI":"10.1155\/2014\/540326","article-title":"Effects of fenofibrate on adiponectin expression in retinas of streptozotocin-induced diabetic rats","volume":"2014","author":"Hsu","year":"2014","journal-title":"J Diabetes Res"},{"key":"bib32","doi-asserted-by":"publisher","first-page":"417","DOI":"10.4183\/aeb.2020.417","article-title":"Central macular thickness in diabetic macular edema","volume":"16","author":"Gungel","year":"2020","journal-title":"Acta Endocrinol (Buchar)"},{"key":"bib33","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1007\/s13312-012-0041-5","article-title":"Adiponectin as a marker of complications in type I diabetes","volume":"49","author":"Habeeb","year":"2012","journal-title":"Indian Pediatr"},{"key":"bib34","first-page":"1769","article-title":"Expression of adiponectin and its receptors in type 1 diabetes mellitus in human and mouse retinas","volume":"19","author":"Lin","year":"2013","journal-title":"Mol Vis"},{"issue":"2","key":"bib35","doi-asserted-by":"publisher","first-page":"e21313","DOI":"10.1096\/fsb2.v35.2","article-title":"Excess adiponectin in eyes with progressive ocular vascular diseases","volume":"35","author":"Nishinaka","year":"2021","journal-title":"FASEB J"},{"issue":"1","key":"bib36","doi-asserted-by":"publisher","first-page":"4159","DOI":"10.1038\/s41598-022-08041-2","article-title":"Adiponectin accumulation in the retinal vascular endothelium and its possible role in preventing early diabetic microvascular damage","volume":"12","author":"Sakaue","year":"2022","journal-title":"Sci Rep"},{"key":"bib37","doi-asserted-by":"publisher","first-page":"652","DOI":"10.1182\/blood.V97.3.652","article-title":"CD13\/APN is activated by angiogenic signals and is essential for capillary tube formation.","volume":"97","author":"Bhagwat","year":"2001","journal-title":"Blood."},{"key":"bib38","first-page":"722","article-title":"Aminopeptidase N is a receptor for tumor-homing peptides and a target for inhibiting angiogenesis.","volume":"60","author":"Pasqualini","year":"2000","journal-title":"Cancer Res."},{"key":"bib39","doi-asserted-by":"publisher","first-page":"4143","DOI":"10.1167\/iovs.15-16447","article-title":"Relationship between retinal blood flow and serum adiponectin concentrations in patients with type 2 diabetes mellitus","volume":"56","author":"Omae","year":"2015","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib40","doi-asserted-by":"publisher","first-page":"3190","DOI":"10.1177\/1120672120982899","article-title":"Subfoveal choroidal thickness and peripapillary retinal nerve fiber layer thickness in young obese males","volume":"31","author":"Uslu Dogan","year":"2021","journal-title":"Eur J Ophthalmol"},{"key":"bib41","doi-asserted-by":"publisher","first-page":"301","DOI":"10.4103\/ijo.IJO_295_20","article-title":"Evaluation of the choroidal thickness and retinal nerve fiber layer and visual fields in morbid obesity: Does bariatric surgery affect retinal structure and function","volume":"69","author":"Gonul","year":"2021","journal-title":"Indian J Ophthalmol"},{"key":"bib42","doi-asserted-by":"publisher","first-page":"461","DOI":"10.5935\/0004-2749.20180088","article-title":"Evaluation of choroidal perfusion changes in obese patients: ocular effects of insulin resistance","volume":"81","author":"\u00d6ner","year":"2018","journal-title":"Arq Bras Oftalmol"},{"key":"bib43","doi-asserted-by":"publisher","first-page":"1568","DOI":"10.1038\/eye.2016.187","article-title":"Subfoveal choroidal thickness in patients with diabetic retinopathy and diabetic macular oedema","volume":"30","author":"Rewbury","year":"2016","journal-title":"Eye (Lond)"},{"issue":"15","key":"bib44","first-page":"190","article-title":"Choroidal thickness in diabetic retinopathy: the role of anti-VEGF therapy","volume":"54","author":"Lains","year":"2013","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib45","doi-asserted-by":"publisher","first-page":"3248","DOI":"10.1007\/s12325-022-02129-x","article-title":"Choroidal thickness changes after intravitreal aflibercept injections in treatment-na\u00efve neovascular AMD","volume":"39","author":"Minnella","year":"2022","journal-title":"Adv Ther"},{"issue":"13","key":"bib46","first-page":"1749","article-title":"Choroidal thickness before and after intravitreal anti-VEGF therapy in patients with diabetic macular edema","volume":"55","author":"Saini","year":"2014","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib47","doi-asserted-by":"publisher","first-page":"288","DOI":"10.1046\/j.1464-5491.2001.00441.x","article-title":"Circulating plasma vascular endothelial growth factor and microvascular complications of type 1 diabetes mellitus: the influence of ACE inhibition","volume":"18","author":"Chaturvedi","year":"2001","journal-title":"Diabet Med"},{"key":"bib48","doi-asserted-by":"publisher","first-page":"1845","DOI":"10.2174\/092986706777585059","article-title":"Vascular endothelial growth factor (VEGF) as a target of bevacizumab in cancer: from the biology to the clinic","volume":"13","author":"Ranieri","year":"2006","journal-title":"Curr Med Chem"},{"key":"bib49","doi-asserted-by":"publisher","first-page":"26746","DOI":"10.1074\/jbc.270.45.26746","article-title":"A novel serum protein similar to C1q, produced exclusively in adipocytes","volume":"270","author":"Scherer","year":"1995","journal-title":"J Biol Chem"},{"key":"bib50","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1016\/bs.acc.2018.02.007","article-title":"Adiponectin and its isoforms in pathophysiology","volume":"85","author":"van Andel","year":"2018","journal-title":"Adv Clin Chem"}],"container-title":["Investigative Opthalmology &amp; Visual Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/iovs.arvojournals.org\/article.aspx?articleid=2785511","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:31:45Z","timestamp":1791927105000},"score":1,"resource":{"primary":{"URL":"https:\/\/iovs.arvojournals.org\/article.aspx?articleid=2785511"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,4,7]]},"references-count":50,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2023,4,3]]}},"URL":"https:\/\/doi.org\/10.1167\/iovs.64.4.6","relation":{},"ISSN":["1552-5783"],"issn-type":[{"value":"1552-5783","type":"print"}],"subject":[],"published":{"date-parts":[[2023,4,7]]}}}