{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:59:49Z","timestamp":1791928789490,"version":"4.3.4"},"reference-count":30,"publisher":"Association for Research in Vision and Ophthalmology (ARVO)","issue":"5","license":[{"start":{"date-parts":[[2023,5,17]],"date-time":"2023-05-17T00:00:00Z","timestamp":1684281600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Invest. Ophthalmol. Vis. Sci."],"published-print":{"date-parts":[[2023,5,17]]},"DOI":"10.1167\/iovs.64.5.13","type":"journal-article","created":{"date-parts":[[2023,5,17]],"date-time":"2023-05-17T11:30:56Z","timestamp":1684323056000},"page":"13","source":"Crossref","is-referenced-by-count":9,"title":["The Presence of Guttae in Fuchs Endothelial Corneal Dystrophy Explants Correlates With Cellular Markers of Disease Progression"],"prefix":"10.1167","volume":"64","author":[{"given":"S\u00e9bastien","family":"M\u00e9thot","sequence":"first","affiliation":[{"name":"Centre de Recherche du CHU de Qu\u00e9bec \u2013 Universit\u00e9 Laval, Axe M\u00e9decine R\u00e9g\u00e9n\u00e9ratrice, H\u00f4pital du Saint-Sacrement, Qu\u00e9bec, Canada"},{"name":"Centre de Recherche en Organog\u00e9n\u00e8se Exp\u00e9rimentale de l'Universit\u00e9 Laval\/LOEX, Qu\u00e9bec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"St\u00e9phanie","family":"Proulx","sequence":"additional","affiliation":[{"name":"Centre de Recherche du CHU de Qu\u00e9bec \u2013 Universit\u00e9 Laval, Axe M\u00e9decine R\u00e9g\u00e9n\u00e9ratrice, H\u00f4pital du Saint-Sacrement, Qu\u00e9bec, Canada"},{"name":"Centre de Recherche en Organog\u00e9n\u00e8se Exp\u00e9rimentale de l'Universit\u00e9 Laval\/LOEX, Qu\u00e9bec, Canada"},{"name":"Universit\u00e9 Laval, Facult\u00e9 de M\u00e9decine, D\u00e9partement d'Ophtalmologie, Universit\u00e9 Laval, Qu\u00e9bec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabelle","family":"Brunette","sequence":"additional","affiliation":[{"name":"Maisonneuve-Rosemont Hospital Research Center, Montreal, Qu\u00e9bec, Canada"},{"name":"Universit\u00e9 de Montr\u00e9al, Ophthalmology Department, Montreal, Qu\u00e9bec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick J.","family":"Rochette","sequence":"additional","affiliation":[{"name":"Centre de Recherche du CHU de Qu\u00e9bec \u2013 Universit\u00e9 Laval, Axe M\u00e9decine R\u00e9g\u00e9n\u00e9ratrice, H\u00f4pital du Saint-Sacrement, Qu\u00e9bec, Canada"},{"name":"Centre de Recherche en Organog\u00e9n\u00e8se Exp\u00e9rimentale de l'Universit\u00e9 Laval\/LOEX, Qu\u00e9bec, Canada"},{"name":"Universit\u00e9 Laval, Facult\u00e9 de M\u00e9decine, D\u00e9partement d'Ophtalmologie, Universit\u00e9 Laval, Qu\u00e9bec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"27","reference":[{"key":"bib1","doi-asserted-by":"publisher","first-page":"588","DOI":"10.1016\/j.jcrs.2010.12.037","article-title":"Anatomy and physiology of the cornea","volume":"37","author":"DelMonte","year":"2011","journal-title":"J Cataract Refract Surg"},{"issue":"Pt 3","key":"bib2","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1038\/eye.1990.53","article-title":"The corneal endothelium","volume":"4","author":"Tuft","year":"1990","journal-title":"Eye (London, England)"},{"key":"bib3","doi-asserted-by":"publisher","first-page":"326","DOI":"10.1016\/j.exer.2010.06.021","article-title":"The molecular basis of corneal transparency","volume":"91","author":"Hassell","year":"2010","journal-title":"Exp Eye Res"},{"key":"bib4","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1016\/S1542-0124(12)70232-X","article-title":"Fuchs endothelial corneal dystrophy","volume":"8","author":"Elhalis","year":"2010","journal-title":"Ocul Surf"},{"key":"bib5","first-page":"295","article-title":"REVIEW: current understanding of the pathogenesis of Fuchs' endothelial corneal dystrophy","volume":"25","author":"Nanda","year":"2019","journal-title":"Molec Vis"},{"key":"bib6","doi-asserted-by":"publisher","first-page":"2036","DOI":"10.1001\/archopht.1978.03910060424004","article-title":"Corneal endothelial dystrophy. A study of 64 families","volume":"96","author":"Krachmer","year":"1978","journal-title":"Arch Ophthalmol (Chicago, Ill: 1960)"},{"key":"bib7","doi-asserted-by":"publisher","first-page":"813","DOI":"10.1097\/00003226-200011000-00010","article-title":"Trends in the indications for penetrating keratoplasty in the midwestern United States","volume":"19","author":"Dobbins","year":"2000","journal-title":"Cornea"},{"key":"bib8","doi-asserted-by":"publisher","first-page":"2171","DOI":"10.1016\/j.ophtha.2006.06.034","article-title":"Trends of penetrating keratoplasty in the United States from 1980 to 2004","volume":"113","author":"Darlington","year":"2006","journal-title":"Ophthalmology"},{"key":"bib9","doi-asserted-by":"publisher","first-page":"e001103","DOI":"10.1136\/bmjophth-2022-001103","article-title":"Fuchs endothelial corneal dystrophy: current perspectives on diagnostic pathology and genetics - Bowman Club Lecture","volume":"7","author":"Thaung","year":"2022","journal-title":"BMJ Open Ophthalmol"},{"issue":"Suppl 1","key":"bib10","doi-asserted-by":"crossref","first-page":"S50","DOI":"10.1097\/ICO.0000000000001775","article-title":"Endothelial corneal dystrophy through the prism of oxidative stress","volume":"37","author":"Jurkunas","year":"2018","journal-title":"Cornea"},{"key":"bib11","doi-asserted-by":"publisher","first-page":"5926","DOI":"10.1167\/iovs.16-20551","article-title":"Restoration of mitochondrial integrity, telomere length, and sensitivity to oxidation by in vitro culture of Fuchs' endothelial corneal dystrophy cells","volume":"57","author":"Gendron","year":"2016","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib12","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1016\/j.mrfmmm.2013.12.001","article-title":"Mutagenesis of mitochondrial DNA in Fuchs endothelial corneal dystrophy","volume":"760","author":"Czarny","year":"2014","journal-title":"Mutat Res"},{"key":"bib13","doi-asserted-by":"publisher","first-page":"2278","DOI":"10.2353\/ajpath.2010.100279","article-title":"Evidence of oxidative stress in the pathogenesis of Fuchs endothelial corneal dystrophy","volume":"177","author":"Jurkunas","year":"2010","journal-title":"Am J Pathol"},{"key":"bib14","doi-asserted-by":"publisher","first-page":"5811","DOI":"10.1038\/s41598-020-62602-x","article-title":"Chronology of cellular events related to mitochondrial burnout leading to cell death in Fuchs endothelial corneal dystrophy","volume":"10","author":"Methot","year":"2020","journal-title":"Sci Rep"},{"key":"bib15","doi-asserted-by":"publisher","first-page":"5662","DOI":"10.1167\/iovs.09-3568","article-title":"Progression of Fuchs corneal dystrophy in a family linked to the FCD1 locus","volume":"50","author":"Meadows","year":"2009","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib16","doi-asserted-by":"publisher","first-page":"8193","DOI":"10.1167\/iovs.11-8047","article-title":"Histological and confocal microscopy changes in chronic corneal edema: implications for endothelial transplantation","volume":"52","author":"Alomar","year":"2011","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib17","doi-asserted-by":"publisher","first-page":"570","DOI":"10.1016\/j.jcjo.2018.12.009","article-title":"Regional variability in corneal endothelial cell density between guttae and non-guttae areas in Fuchs endothelial corneal dystrophy","volume":"54","author":"Ong Tone","year":"2019","journal-title":"Canadian J Ophthalmol. Journal canadien d'ophtalmologie"},{"key":"bib18","doi-asserted-by":"publisher","first-page":"1308","DOI":"10.1136\/bjophthalmol-2014-305069","article-title":"On the origin of \u2018guttae\u2019","volume":"98","author":"Son","year":"2014","journal-title":"Br J Ophthalmol"},{"key":"bib19","doi-asserted-by":"publisher","first-page":"886","DOI":"10.1001\/jamaophthalmol.2018.2031","article-title":"Association of the gutta-induced microenvironment with corneal endothelial cell behavior and demise in Fuchs endothelial corneal dystrophy","volume":"136","author":"Kocaba","year":"2018","journal-title":"JAMA Ophthalmol"},{"key":"bib20","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1038\/s41467-017-02787-4","article-title":"Mitochondrial levels determine variability in cell death by modulating apoptotic gene expression","volume":"9","author":"M\u00e1rquez-Jurado","year":"2018","journal-title":"Nature Commun"},{"key":"bib21","doi-asserted-by":"publisher","first-page":"6656","DOI":"10.1038\/s41598-017-06523-2","article-title":"Activation of mitophagy leads to decline in Mfn2 and loss of mitochondrial mass in Fuchs endothelial corneal dystrophy","volume":"7","author":"Benischke","year":"2017","journal-title":"Sci Rep"},{"issue":"Suppl 1","key":"bib22","doi-asserted-by":"crossref","first-page":"S74","DOI":"10.1097\/ICO.0000000000001746","article-title":"Fuchs endothelial corneal dystrophy and mitochondria","volume":"37","author":"Miyai","year":"2018","journal-title":"Cornea"},{"key":"bib23","doi-asserted-by":"publisher","first-page":"1919","DOI":"10.1089\/ars.2010.3768","article-title":"Mitophagy selectively degrades individual damaged mitochondria after photoirradiation","volume":"14","author":"Kim","year":"2011","journal-title":"Antioxid Redox Signal"},{"key":"bib24","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1023\/A:1022945107762","article-title":"The mitochondrial membrane potential (deltapsi(m)) in apoptosis; an update","volume":"8","author":"Ly","year":"2003","journal-title":"Apoptosis: An Intl J Programmed Cell Death"},{"key":"bib25","doi-asserted-by":"publisher","first-page":"1068","DOI":"10.1016\/j.bbamcr.2018.10.016","article-title":"Calcium, mitochondria and cell metabolism: a functional triangle in bioenergetics","volume":"1866","author":"Rossi","year":"2019","journal-title":"Biochimica et biophysica acta. Molec Cell Res"},{"key":"bib26","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1111\/nyas.12885","article-title":"Calcium signaling as a mediator of cell energy demand and a trigger to cell death","volume":"1350","author":"Bhosale","year":"2015","journal-title":"Ann New York Acad Sci"},{"key":"bib27","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1016\/j.exer.2011.08.002","article-title":"Molecular bases of corneal endothelial dystrophies","volume":"95","author":"Schmedt","year":"2012","journal-title":"Exp Eye Res"},{"key":"bib28","doi-asserted-by":"publisher","first-page":"639","DOI":"10.1016\/j.tips.2006.10.005","article-title":"Bioenergetics and the formation of mitochondrial reactive oxygen species","volume":"27","author":"Adam-Vizi","year":"2006","journal-title":"Trends Pharmacol Sci"},{"key":"bib29","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1097\/ICO.0000000000002796","article-title":"Descemet stripping only for Fuchs endothelial corneal dystrophy: will it become the gold standard?","volume":"41","author":"Colby","year":"2022","journal-title":"Cornea"},{"key":"bib30","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1016\/j.jcjo.2021.06.010","article-title":"Descemet stripping only in Fuchs\u2019 endothelial dystrophy without use of topical Rho-kinase inhibitors: 5-year follow-up","volume":"57","author":"Iovieno","year":"2022","journal-title":"Can J Ophthalmol"}],"container-title":["Investigative Opthalmology & Visual Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/iovs.arvojournals.org\/article.aspx?articleid=2785624","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:31:38Z","timestamp":1791927098000},"score":1,"resource":{"primary":{"URL":"https:\/\/iovs.arvojournals.org\/article.aspx?articleid=2785624"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5,17]]},"references-count":30,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2023,5,1]]}},"URL":"https:\/\/doi.org\/10.1167\/iovs.64.5.13","relation":{},"ISSN":["1552-5783"],"issn-type":[{"value":"1552-5783","type":"print"}],"subject":[],"published":{"date-parts":[[2023,5,17]]}}}