{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:59:44Z","timestamp":1791928784152,"version":"4.3.4"},"reference-count":40,"publisher":"Association for Research in Vision and Ophthalmology (ARVO)","issue":"7","license":[{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Invest. Ophthalmol. Vis. Sci."],"DOI":"10.1167\/iovs.64.7.1","type":"journal-article","created":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T10:31:21Z","timestamp":1685615481000},"page":"1","source":"Crossref","is-referenced-by-count":20,"title":["The Mechanosensitive Piezo1 Channel Mediates Mechanochemical Transmission in Myopic Eyes"],"prefix":"10.1167","volume":"64","author":[{"given":"Weiqi","family":"Zhong","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan, China"},{"name":"Medical School of Ophthalmology & Optometry, North Sichuan Medical College, Nanchong, Sichuan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changjun","family":"Lan","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan, China"},{"name":"Medical School of Ophthalmology & Optometry, North Sichuan Medical College, Nanchong, Sichuan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiming","family":"Gu","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan, China"},{"name":"Medical School of Ophthalmology & Optometry, North Sichuan Medical College, Nanchong, Sichuan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingqing","family":"Tan","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan, China"},{"name":"Medical School of Ophthalmology & Optometry, North Sichuan Medical College, Nanchong, Sichuan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoling","family":"Xiang","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan, China"},{"name":"Medical School of Ophthalmology & Optometry, North Sichuan Medical College, Nanchong, Sichuan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan, China"},{"name":"Medical School of Ophthalmology & Optometry, North Sichuan Medical College, Nanchong, Sichuan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuan","family":"Liao","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan, China"},{"name":"Medical School of Ophthalmology & Optometry, North Sichuan Medical College, Nanchong, Sichuan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"27","published-online":{"date-parts":[[2023,6,1]]},"reference":[{"issue":"5","key":"bib1","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1167\/iovs.62.5.6","article-title":"IMI prevention of myopia and its progression","volume":"62","author":"Jonas","year":"2021","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"1","key":"bib2","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1038\/s41572-020-00231-4","article-title":"Myopia","volume":"6","author":"Baird","year":"2020","journal-title":"Nat Rev Dis Primers"},{"issue":"3","key":"bib3","doi-asserted-by":"publisher","first-page":"338","DOI":"10.1016\/j.ophtha.2018.10.029","article-title":"Potential lost productivity resulting from the global burden of myopia: systematic review, meta-analysis, and modeling","volume":"126","author":"Naidoo","year":"2019","journal-title":"Ophthalmology"},{"key":"bib4","doi-asserted-by":"publisher","first-page":"100773","DOI":"10.1016\/j.preteyeres.2019.100773","article-title":"Scleral structure and biomechanics","volume":"74","author":"Boote","year":"2020","journal-title":"Prog Retin Eye Res"},{"issue":"4","key":"bib5","doi-asserted-by":"publisher","first-page":"2720","DOI":"10.1167\/iovs.14-15631","article-title":"Scleral thickness in Chinese eyes","volume":"56","author":"Shen","year":"2015","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"5","key":"bib6","doi-asserted-by":"publisher","first-page":"224","DOI":"10.1097\/WNR.0b013e32835eb9d1","article-title":"Mechanical stretching induces matrix metalloproteinase-2 expression in rat retinal glial (Muller) cells","volume":"24","author":"Wang","year":"2013","journal-title":"Neuroreport"},{"issue":"11","key":"bib7","doi-asserted-by":"publisher","first-page":"a022038","DOI":"10.1101\/cshperspect.a022038","article-title":"Mechanical properties of the cytoskeleton and cells","volume":"9","author":"Pegoraro","year":"2017","journal-title":"Cold Spring Harb Perspect Biol"},{"issue":"19","key":"bib8","doi-asserted-by":"publisher","first-page":"7089","DOI":"10.1523\/JNEUROSCI.0359-11.2011","article-title":"The polymodal ion channel transient receptor potential vanilloid 4 modulates calcium flux, spiking rate, and apoptosis of mouse retinal ganglion cells","volume":"31","author":"Ryskamp","year":"2011","journal-title":"J Neurosci"},{"key":"bib9","doi-asserted-by":"publisher","first-page":"102588","DOI":"10.1016\/j.ceca.2022.102588","article-title":"TRPV4 and TRPC1 channels mediate the response to tensile strain in mouse Muller cells","volume":"104","author":"Jo","year":"2022","journal-title":"Cell Calcium"},{"issue":"3","key":"bib10","doi-asserted-by":"publisher","first-page":"893","DOI":"10.1016\/S0306-4522(99)00484-4","article-title":"Immunolocalization of the arachidonic acid and mechanosensitive baseline TRAAK potassium channel in the nervous system","volume":"95","author":"Reyes","year":"2000","journal-title":"Neuroscience"},{"key":"bib11","first-page":"749","article-title":"Astrocytes in the optic nerve head express putative mechanosensitive channels","volume":"21","author":"Choi","year":"2015","journal-title":"Mol Vis"},{"issue":"6000","key":"bib12","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1126\/science.1193270","article-title":"Piezo1 and Piezo2 are essential components of distinct mechanically activated cation channels","volume":"330","author":"Coste","year":"2010","journal-title":"Science"},{"key":"bib13","doi-asserted-by":"publisher","first-page":"693","DOI":"10.1007\/978-3-319-17121-0","article-title":"Polymodal sensory integration in retinal ganglion cells","volume":"854","author":"Krizaj","year":"2016","journal-title":"Adv Exp Med Biol"},{"key":"bib14","doi-asserted-by":"publisher","first-page":"1160897","DOI":"10.3389\/fcell.2023.1160897","article-title":"Effects of exogenous retinoic acid on ocular parameters in Guinea pigs with form deprivation myopia","volume":"11","author":"Wu","year":"2023","journal-title":"Front Cell Dev Biol"},{"issue":"3","key":"bib15","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1136\/bjophthalmol-2017-311831","article-title":"Intraocular pressure and myopia progression in Chinese children: the Anyang Childhood Eye Study","volume":"103","author":"Li","year":"2019","journal-title":"Br J Ophthalmol"},{"key":"bib16","doi-asserted-by":"publisher","first-page":"310","DOI":"10.1016\/j.freeradbiomed.2013.04.027","article-title":"Cyclic stretch stimulates nitric oxide synthase-1-dependent peroxynitrite formation by neonatal rat pulmonary artery smooth muscle","volume":"61","author":"Dick","year":"2013","journal-title":"Free Radic Biol Med"},{"issue":"8","key":"bib17","doi-asserted-by":"publisher","first-page":"753","DOI":"10.1016\/j.injury.2010.11.015","article-title":"Effects of mechanical strain on oxygen free radical system in bone marrow mesenchymal stem cells from children","volume":"42","author":"Li","year":"2011","journal-title":"Injury"},{"issue":"11","key":"bib18","doi-asserted-by":"crossref","first-page":"15","DOI":"10.3390\/ijms22116044","article-title":"Sodium glucose co-transporter 2 inhibitors ameliorate endothelium barrier dysfunction induced by cyclic stretch through inhibition of reactive oxygen species","volume":"22","author":"Li","year":"2021","journal-title":"Int J Mol Sci"},{"issue":"1","key":"bib19","doi-asserted-by":"publisher","first-page":"869","DOI":"10.1038\/s41467-021-21178-4","article-title":"The mechanosensitive Piezo1 channel mediates heart mechano-chemo transduction","volume":"12","author":"Jiang","year":"2021","journal-title":"Nat Commun"},{"key":"bib20","doi-asserted-by":"publisher","first-page":"103684","DOI":"10.1016\/j.jprot.2020.103684","article-title":"Alteration of retinal metabolism and oxidative stress may implicate myopic eye growth: Evidence from discovery and targeted proteomics in an animal model","volume":"221","author":"Yu","year":"2020","journal-title":"J Proteomics"},{"key":"bib21","doi-asserted-by":"publisher","first-page":"108255","DOI":"10.1016\/j.exer.2020.108255","article-title":"The role of reactive oxygen species in the pathogenesis and treatment of retinal diseases","volume":"201","author":"Chan","year":"2020","journal-title":"Exp Eye Res"},{"key":"bib22","doi-asserted-by":"crossref","first-page":"426769","DOI":"10.1155\/2012\/426769","article-title":"Hypoxia-induced oxidative stress in ischemic retinopathy","volume":"2012","author":"Li","year":"2012","journal-title":"Oxid Med Cell Longev"},{"key":"bib23","doi-asserted-by":"publisher","first-page":"750637","DOI":"10.1155\/2015\/750637","article-title":"Oxidative stress in myopia","volume":"2015","author":"Francisco","year":"2015","journal-title":"Oxid Med Cell Longev"},{"issue":"10","key":"bib24","doi-asserted-by":"publisher","first-page":"1692","DOI":"10.4161\/auto.36076","article-title":"Oxidative stress induces autophagy in response to multiple noxious stimuli in retinal ganglion cells","volume":"10","author":"Lin","year":"2014","journal-title":"Autophagy"},{"issue":"23","key":"bib25","doi-asserted-by":"publisher","first-page":"eabm9027","DOI":"10.1126\/sciadv.abm9027","article-title":"The role of ipRGCs in ocular growth and myopia development","volume":"8","author":"Liu","year":"2022","journal-title":"Sci Adv"},{"issue":"7","key":"bib26","doi-asserted-by":"publisher","first-page":"e152330","DOI":"10.1172\/jci.insight.152330","article-title":"Mechanosensitive Piezo1 channels mediate renal fibrosis","volume":"7","author":"Zhao","year":"2022","journal-title":"JCI Insight"},{"key":"bib27","doi-asserted-by":"publisher","first-page":"107900","DOI":"10.1016\/j.exer.2019.107900","article-title":"Piezo channel plays a part in retinal ganglion cell damage","volume":"191","author":"Morozumi","year":"2020","journal-title":"Exp Eye Res"},{"issue":"2","key":"bib28","doi-asserted-by":"publisher","first-page":"102042","DOI":"10.1016\/j.isci.2021.102042","article-title":"The role of Piezo1 in conventional aqueous humor outflow dynamics","volume":"24","author":"Zhu","year":"2021","journal-title":"iScience"},{"issue":"6","key":"bib29","doi-asserted-by":"publisher","first-page":"3623","DOI":"10.1167\/iovs.15-16597","article-title":"Real-time monitoring of suprachoroidal space (SCS) following SCS injection using ultra-high resolution optical coherence tomography in guinea pig eyes","volume":"56","author":"Gu","year":"2015","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"3","key":"bib30","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1136\/bjo.2005.079905","article-title":"Mechanosensitivity and the eye: cells coping with the pressure","volume":"90","author":"Tan","year":"2006","journal-title":"Br J Ophthalmol"},{"issue":"7693","key":"bib31","doi-asserted-by":"publisher","first-page":"481","DOI":"10.1038\/nature25453","article-title":"Structure of the mechanically activated ion channel Piezo1","volume":"554","author":"Saotome","year":"2018","journal-title":"Nature"},{"issue":"5","key":"bib32","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1097\/01.APO.0000578944.25956.8b","article-title":"Myopia: anatomic changes and consequences for its etiology","volume":"8","author":"Jonas","year":"2019","journal-title":"Asia Pac J Ophthalmol (Phila)"},{"issue":"5","key":"bib33","first-page":"16","article-title":"Hemispherical microelectrode array for ex vivo retinal neural recording","volume":"11","author":"Ha","year":"2020","journal-title":"Micromachines (Basel)"},{"key":"bib34","doi-asserted-by":"crossref","first-page":"270","DOI":"10.3389\/fncel.2016.00270","article-title":"Neuronal release of cytokine IL-3 triggered by mechanosensitive autostimulation of the P2 \u00d7 7 receptor is neuroprotective","volume":"10","author":"Lim","year":"2016","journal-title":"Front Cell Neurosci"},{"issue":"11","key":"bib35","doi-asserted-by":"crossref","DOI":"10.3390\/ijms23116202","article-title":"Myopia alters the structural organization of the retinal vasculature, GFAP-positive glia, and ganglion cell layer thickness","volume":"23","author":"Lin","year":"2022","journal-title":"Int J Mol Sci"},{"issue":"1","key":"bib36","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1002\/glia.23709","article-title":"Piezo1 regulates calcium oscillations and cytokine release from astrocytes","volume":"68","author":"Velasco-Estevez","year":"2020","journal-title":"Glia"},{"issue":"12","key":"bib37","doi-asserted-by":"publisher","first-page":"1592","DOI":"10.1038\/nn.4394","article-title":"Mechanosensing is critical for axon growth in the developing brain","volume":"19","author":"Koser","year":"2016","journal-title":"Nat Neurosci"},{"issue":"11","key":"bib38","doi-asserted-by":"publisher","first-page":"5161","DOI":"10.1167\/iovs.08-2201","article-title":"Regulation of pigment epithelium-derived factor production and release by retinal glial (Muller) cells under hypoxia","volume":"49","author":"Lange","year":"2008","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib39","doi-asserted-by":"publisher","first-page":"463","DOI":"10.3389\/fphys.2020.00463","article-title":"Imbalance between oxidative stress and growth factors in human high myopia","volume":"11","author":"Merida","year":"2020","journal-title":"Front Physiol"},{"issue":"6048","key":"bib40","doi-asserted-by":"publisher","first-page":"1440","DOI":"10.1126\/science.1202768","article-title":"X-ROS signaling: rapid mechano-chemo transduction in heart","volume":"333","author":"Prosser","year":"2011","journal-title":"Science"}],"container-title":["Investigative Ophthalmology &amp; Visual Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/iovs.arvojournals.org\/article.aspx?articleid=2785666","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:31:37Z","timestamp":1791927097000},"score":1,"resource":{"primary":{"URL":"https:\/\/iovs.arvojournals.org\/article.aspx?articleid=2785666"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6,1]]},"references-count":40,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2023,6,1]]}},"URL":"https:\/\/doi.org\/10.1167\/iovs.64.7.1","relation":{},"ISSN":["1552-5783"],"issn-type":[{"value":"1552-5783","type":"print"}],"subject":[],"published":{"date-parts":[[2023,6,1]]}}}