{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T22:01:24Z","timestamp":1791928884475,"version":"4.3.4"},"reference-count":45,"publisher":"Association for Research in Vision and Ophthalmology (ARVO)","issue":"1","license":[{"start":{"date-parts":[[2024,1,31]],"date-time":"2024-01-31T00:00:00Z","timestamp":1706659200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Invest. Ophthalmol. Vis. Sci."],"published-print":{"date-parts":[[2024,1,31]]},"DOI":"10.1167\/iovs.65.1.48","type":"journal-article","created":{"date-parts":[[2024,1,31]],"date-time":"2024-01-31T11:31:29Z","timestamp":1706700689000},"page":"48","source":"Crossref","is-referenced-by-count":6,"title":["Induced Attenuation of Scleral TGF-\u03b2 Signaling in Mutant Mice Increases Susceptibility to IOP-Induced Optic Nerve Damage"],"prefix":"10.1167","volume":"65","author":[{"given":"Magdalena","family":"Gebert","sequence":"first","affiliation":[{"name":"Institute of Human Anatomy and Embryology, University of Regensburg, Regensburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johanna","family":"Heimbucher","sequence":"additional","affiliation":[{"name":"Institute of Human Anatomy and Embryology, University of Regensburg, Regensburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentina K.","family":"Gsell","sequence":"additional","affiliation":[{"name":"Institute of Human Anatomy and Embryology, University of Regensburg, Regensburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristof","family":"Keimer","sequence":"additional","affiliation":[{"name":"Institute of Human Anatomy and Embryology, University of Regensburg, Regensburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea E.","family":"Dillinger","sequence":"additional","affiliation":[{"name":"Institute of Human Anatomy and Embryology, University of Regensburg, Regensburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ernst R.","family":"Tamm","sequence":"additional","affiliation":[{"name":"Institute of Human Anatomy and Embryology, University of Regensburg, Regensburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"27","reference":[{"issue":"1","key":"bib1","doi-asserted-by":"publisher","first-page":"5","DOI":"10.3109\/09286589509071448","article-title":"Available data on blindness (update 1994)","volume":"2","author":"Thylefors","year":"1995","journal-title":"Ophthalmic Epidemiol"},{"issue":"1","key":"bib2","first-page":"115","article-title":"Global data on blindness","volume":"73","author":"Thylefors","year":"1995","journal-title":"Bull World Health Organ"},{"issue":"9774","key":"bib3","doi-asserted-by":"publisher","first-page":"1367","DOI":"10.1016\/S0140-6736(10)61423-7","article-title":"Glaucoma","volume":"377","author":"Quigley","year":"2011","journal-title":"Lancet"},{"issue":"2","key":"bib4","doi-asserted-by":"publisher","first-page":"238","DOI":"10.1136\/bjo.86.2.238","article-title":"The definition and classification of glaucoma in prevalence surveys","volume":"86","author":"Foster","year":"2002","journal-title":"Br J Ophthalmol"},{"issue":"11","key":"bib5","doi-asserted-by":"publisher","first-page":"1113","DOI":"10.1056\/NEJMra0804630","article-title":"Primary open-angle glaucoma","volume":"360","author":"Kwon","year":"2009","journal-title":"N Engl J Med"},{"issue":"1","key":"bib6","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1001\/archopht.121.1.48","article-title":"Factors for glaucoma progression and the effect of treatment: the early manifest glaucoma trial","volume":"121","author":"Leske","year":"2003","journal-title":"Arch Ophthalmol"},{"issue":"2","key":"bib7","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1097\/00055735-200304000-00006","article-title":"Collaborative normal tension glaucoma study","volume":"14","author":"Anderson","year":"2003","journal-title":"Curr Opin Ophthalmol"},{"issue":"6","key":"bib8","doi-asserted-by":"publisher","first-page":"714","DOI":"10.1001\/archopht.120.6.714","article-title":"The Ocular Hypertension Treatment Study: baseline factors that predict the onset of primary open-angle glaucoma","volume":"120","author":"Gordon","year":"2002","journal-title":"Arch Ophthalmol"},{"issue":"6","key":"bib9","doi-asserted-by":"publisher","first-page":"701","DOI":"10.1001\/archopht.120.6.701","article-title":"The Ocular Hypertension Treatment Study: a randomized trial determines that topical ocular hypotensive medication delays or prevents the onset of primary open-angle glaucoma","volume":"120","author":"Kass","year":"2002","journal-title":"Arch Ophthalmol"},{"issue":"4","key":"bib10","doi-asserted-by":"publisher","first-page":"487","DOI":"10.1016\/S0002-9394(98)00223-2","article-title":"Comparison of glaucomatous progression between untreated patients with normal-tension glaucoma and patients with therapeutically reduced intraocular pressures","volume":"126","author":"Collaborative Normal-Tension Glaucoma Study Group","year":"1998","journal-title":"Am J Ophthalmol"},{"issue":"4","key":"bib11","doi-asserted-by":"publisher","first-page":"498","DOI":"10.1016\/S0002-9394(98)00272-4","article-title":"The effectiveness of intraocular pressure reduction in the treatment of normal-tension glaucoma","volume":"126","author":"Collaborative Normal-Tension Glaucoma Study Group","year":"1998","journal-title":"Am J Ophthalmol"},{"issue":"1","key":"bib12","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1001\/archopht.1989.01070010125040","article-title":"Ultrastructural location of extracellular matrix components in the optic nerve head","volume":"107","author":"Morrison","year":"1989","journal-title":"Arch Ophthalmol"},{"issue":"1","key":"bib13","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1001\/archopht.1990.01070030057028","article-title":"The size and shape of the optic disc in normal human eyes","volume":"108","author":"Quigley","year":"1990","journal-title":"Arch Ophthalmol"},{"issue":"6","key":"bib14","doi-asserted-by":"publisher","first-page":"800","DOI":"10.1001\/archopht.1969.00990020792015","article-title":"Ultrastructure of human and monkey lamina cribrosa and optic nerve head","volume":"82","author":"Anderson","year":"1969","journal-title":"Arch Ophthalmol"},{"issue":"4","key":"bib15","doi-asserted-by":"publisher","first-page":"1714","DOI":"10.1167\/iovs.11-8009","article-title":"Biomechanics of the human posterior sclera: age- and glaucoma-related changes measured using inflation testing","volume":"53","author":"Coudrillier","year":"2012","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"9","key":"bib16","doi-asserted-by":"publisher","first-page":"4046","DOI":"10.1167\/iovs.07-1342","article-title":"Estimation of ocular rigidity based on measurement of pulse amplitude using pneumotonometry and fundus pulse using laser interferometry in glaucoma","volume":"49","author":"Hommer","year":"2008","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib17","first-page":"1745","article-title":"Transforming growth factor-\u00df2 increases extracellular matrix proteins in optic nerve head cells via activation of the Smad signaling pathway","volume":"17","author":"Zode","year":"2011","journal-title":"Mol Vis"},{"issue":"2","key":"bib18","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1136\/bjo.83.2.209","article-title":"Transforming growth factor \u00df isoforms in human optic nerve heads","volume":"83","author":"Pena","year":"1999","journal-title":"Br J Ophthalmol"},{"key":"bib19","first-page":"612","article-title":"Aqueous humor TGF-\u00df2 levels in patients with open-angle glaucoma: a meta-analysis","volume":"21","author":"Agarwal","year":"2015","journal-title":"Mol Vis"},{"issue":"24","key":"bib20","doi-asserted-by":"publisher","first-page":"2046","DOI":"10.1016\/j.cub.2011.11.037","article-title":"The single-molecule mechanics of the latent TGF-\u00df1 complex","volume":"21","author":"Buscemi","year":"2011","journal-title":"Curr Biol"},{"key":"bib21","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1016\/j.matbio.2015.05.006","article-title":"The extracellular matrix and transforming growth factor-\u00df1: tale of a strained relationship","volume":"47","author":"Hinz","year":"2015","journal-title":"Matrix Biol"},{"issue":"2","key":"bib22","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1083\/jcb.201402006","article-title":"Prestress in the extracellular matrix sensitizes latent TGF-\u00df1 for activation","volume":"207","author":"Klingberg","year":"2014","journal-title":"J Cell Biol"},{"issue":"3","key":"bib23","doi-asserted-by":"publisher","first-page":"503","DOI":"10.1038\/ki.2015.51","article-title":"Renal fibrosis is not reduced by blocking transforming growth factor-\u00df signaling in matrix-producing interstitial cells","volume":"88","author":"Neelisetty","year":"2015","journal-title":"Kidney Int"},{"issue":"5","key":"bib24","doi-asserted-by":"publisher","first-page":"1609","DOI":"10.1016\/S0002-9440(10)61108-X","article-title":"Ligand-dependent genetic recombination in fibroblasts: a potentially powerful technique for investigating gene function in fibrosis","volume":"160","author":"Zheng","year":"2002","journal-title":"Am J Pathol"},{"key":"bib25","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1007\/978-3-319-17121-0","article-title":"Tamoxifen-containing eye drops successfully trigger Cre-mediated recombination in the entire eye","volume":"854","author":"Schlecht","year":"2016","journal-title":"Adv Exp Med Biol"},{"issue":"109","key":"bib26","first-page":"e53731","article-title":"A magnetic microbead occlusion model to induce ocular hypertension-dependent glaucoma in mice","author":"Ito","year":"2016","journal-title":"J Vis Exp"},{"issue":"2","key":"bib28","doi-asserted-by":"publisher","first-page":"715","DOI":"10.1167\/iovs.06-0226","article-title":"Bone morphogenetic protein-7 is an antagonist of transforming growth factor-\u00df2 in human trabecular meshwork cells","volume":"48","author":"Fuchshofer","year":"2007","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib29","doi-asserted-by":"publisher","first-page":"107710","DOI":"10.1016\/j.exer.2019.107710","article-title":"Efficient determination of axon number in the optic nerve: a stereological approach","volume":"186","author":"Koschade","year":"2019","journal-title":"Exp Eye Res"},{"issue":"4","key":"bib30","doi-asserted-by":"publisher","first-page":"2072","DOI":"10.1074\/jbc.M807521200","article-title":"Regulation of scleral cell contraction by transforming growth factor-\u00df and stress: competing roles in myopic eye growth","volume":"284","author":"Jobling","year":"2009","journal-title":"J Biol Chem"},{"issue":"18","key":"bib31","doi-asserted-by":"publisher","first-page":"18121","DOI":"10.1074\/jbc.M400381200","article-title":"Isoform-specific changes in scleral transforming growth factor-\u00df expression and the regulation of collagen synthesis during myopia progression","volume":"279","author":"Jobling","year":"2004","journal-title":"J Biol Chem"},{"issue":"19","key":"bib32","doi-asserted-by":"publisher","first-page":"16587","DOI":"10.1074\/jbc.M300970200","article-title":"Collagen gene expression and the altered accumulation of scleral collagen during the development of high myopia","volume":"278","author":"Gentle","year":"2003","journal-title":"J Biol Chem"},{"issue":"10","key":"bib33","doi-asserted-by":"publisher","first-page":"1989","DOI":"10.1016\/j.ophtha.2011.03.012","article-title":"Myopia as a risk factor for open-angle glaucoma: a systematic review and meta-analysis","volume":"118","author":"Marcus","year":"2011","journal-title":"Ophthalmology"},{"key":"bib34","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/bs.pbr.2020.06.014","article-title":"Glaucoma neurodegeneration and myopia","volume":"257","author":"Jonas","year":"2020","journal-title":"Prog Brain Res"},{"issue":"10","key":"bib35","doi-asserted-by":"publisher","first-page":"1347","DOI":"10.1136\/bjophthalmol-2018-313530","article-title":"Glaucoma in myopia: diagnostic dilemmas","volume":"103","author":"Tan","year":"2019","journal-title":"Br J Ophthalmol"},{"issue":"4","key":"bib36","first-page":"A628","article-title":"Transforming growth-factor-beta (TGF-beta) is an immunosuppressive molecule in aqueous humor","volume":"5","author":"Cousins","year":"1991","journal-title":"FASEB J"},{"issue":"1","key":"bib37","first-page":"23","article-title":"Immunolocalization of TGF-beta-1, TGF-beta-2, and TGF-beta-3 in the anterior segment of the human eye","volume":"34","author":"Pasquale","year":"1993","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"10","key":"bib38","doi-asserted-by":"publisher","first-page":"963","DOI":"10.3109\/02713689009069932","article-title":"Transforming growth factor-\u00df in human aqueous humor","volume":"9","author":"Jampel","year":"1990","journal-title":"Curr Eye Res"},{"issue":"6","key":"bib39","doi-asserted-by":"publisher","first-page":"1749","DOI":"10.1016\/j.ajpath.2015.02.007","article-title":"Deletion of ocular transforming growth factor \u00df signaling mimics essential characteristics of diabetic retinopathy","volume":"185","author":"Braunger","year":"2015","journal-title":"Am J Pathol"},{"issue":"35","key":"bib40","doi-asserted-by":"publisher","first-page":"14246","DOI":"10.1523\/JNEUROSCI.0991-13.2013","article-title":"TGF-\u00df signaling protects retinal neurons from programmed cell death during the development of the mammalian eye","volume":"33","author":"Braunger","year":"2013","journal-title":"J Neurosci"},{"issue":"11","key":"bib41","doi-asserted-by":"publisher","first-page":"2570","DOI":"10.1016\/j.ajpath.2017.06.018","article-title":"Deletion of endothelial transforming growth factor-\u00df signaling leads to choroidal neovascularization","volume":"187","author":"Schlecht","year":"2017","journal-title":"Am J Pathol"},{"issue":"10","key":"bib42","doi-asserted-by":"publisher","first-page":"e0141137","DOI":"10.1371\/journal.pone.0141137","article-title":"Losartan treatment protects retinal ganglion cells and alters scleral remodeling in experimental glaucoma","volume":"10","author":"Quigley","year":"2015","journal-title":"PLoS One"},{"issue":"6","key":"bib43","doi-asserted-by":"publisher","first-page":"864","DOI":"10.1002\/ana.v75.6","article-title":"Losartan prevents acquired epilepsy via TGF-\u00df signaling suppression","volume":"75","author":"Bar-Klein","year":"2014","journal-title":"Ann Neurol"},{"issue":"5","key":"bib44","doi-asserted-by":"publisher","first-page":"e0155730","DOI":"10.1371\/journal.pone.0155730","article-title":"Losartan attenuates myocardial endothelial-to-mesenchymal transition in spontaneous hypertensive rats via inhibiting TGF-\u00df\/Smad signaling","volume":"11","author":"Wu","year":"2016","journal-title":"PLoS One"},{"issue":"12","key":"bib45","doi-asserted-by":"publisher","first-page":"5800","DOI":"10.1167\/iovs.09-3678","article-title":"Neuroprotective effects of angiotensin II type 1 receptor blocker in a rat model of chronic glaucoma","volume":"50","author":"Yang","year":"2009","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib27","article-title":"Icare TONOLAB user's and maintenance manual","author":"Icare Finland Oy"}],"container-title":["Investigative Opthalmology &amp; Visual Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/iovs.arvojournals.org\/article.aspx?articleid=2793330","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:31:55Z","timestamp":1791927115000},"score":1,"resource":{"primary":{"URL":"https:\/\/iovs.arvojournals.org\/article.aspx?articleid=2793330"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1,31]]},"references-count":45,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,1,2]]}},"URL":"https:\/\/doi.org\/10.1167\/iovs.65.1.48","relation":{},"ISSN":["1552-5783"],"issn-type":[{"value":"1552-5783","type":"print"}],"subject":[],"published":{"date-parts":[[2024,1,31]]}}}