{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T22:00:53Z","timestamp":1791928853529,"version":"4.3.4"},"reference-count":49,"publisher":"Association for Research in Vision and Ophthalmology (ARVO)","issue":"10","license":[{"start":{"date-parts":[[2024,8,5]],"date-time":"2024-08-05T00:00:00Z","timestamp":1722816000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Invest. Ophthalmol. Vis. Sci."],"published-print":{"date-parts":[[2024,8,5]]},"DOI":"10.1167\/iovs.65.10.8","type":"journal-article","created":{"date-parts":[[2024,8,5]],"date-time":"2024-08-05T13:31:38Z","timestamp":1722864698000},"page":"8","source":"Crossref","is-referenced-by-count":10,"title":["IL-23 Priming Enhances the Neuroprotective Effects of MSC-Derived Exosomes in Treating Retinal Degeneration"],"prefix":"10.1167","volume":"65","author":[{"given":"Hong","family":"Zhou","sequence":"first","affiliation":[{"name":"State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Liu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tian","family":"Zhou","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziqi","family":"Yang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Biyan","family":"Ni","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Zhou","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huiyi","family":"Xu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaojing","family":"Lin","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiya","family":"Lin","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang","family":"He","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xialin","family":"Liu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"27","reference":[{"key":"bib1","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1016\/j.preteyeres.2018.11.003","article-title":"Stemming retinal regeneration with pluripotent stem cells","volume":"69","author":"Jin","year":"2019","journal-title":"Prog Retin Eye Res"},{"key":"bib2","doi-asserted-by":"publisher","first-page":"1149","DOI":"10.1038\/s41591-022-01862-8","article-title":"Regenerative and restorative medicine for eye disease","volume":"28","author":"Van Gelder","year":"2022","journal-title":"Nat Med"},{"key":"bib3","doi-asserted-by":"publisher","first-page":"673","DOI":"10.1007\/s00281-022-00939-3","article-title":"Glial-mediated neuroinflammatory mechanisms in age-related macular degeneration","volume":"44","author":"Dhodapkar","year":"2022","journal-title":"Semin Immunopathol"},{"key":"bib4","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1016\/j.preteyeres.2014.11.004","article-title":"Retinal microglia: just bystander or target for therapy?","volume":"45","author":"Karlstetter","year":"2015","journal-title":"Prog Retin Eye Res"},{"key":"bib5","doi-asserted-by":"publisher","first-page":"414","DOI":"10.1007\/s00417-006-0382-7","article-title":"Transplantation of bone marrow-derived mesenchymal stem cells rescue photoreceptor cells in the dystrophic retina of the rhodopsin knockout mouse","volume":"245","author":"Arnhold","year":"2007","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"key":"bib6","doi-asserted-by":"publisher","first-page":"423","DOI":"10.1186\/s13287-022-03122-5","article-title":"Emerging role of mesenchymal stromal cells (MSCs)-derived exosome in neurodegeneration-associated conditions: a groundbreaking cell-free approach","volume":"13","author":"Yari","year":"2022","journal-title":"Stem Cell Res Ther"},{"key":"bib7","doi-asserted-by":"publisher","first-page":"428","DOI":"10.1016\/j.cell.2019.02.029","article-title":"Reassessment of exosome composition","volume":"177","author":"Jeppesen","year":"2019","journal-title":"Cell"},{"key":"bib8","doi-asserted-by":"publisher","first-page":"146","DOI":"10.3389\/fbioe.2020.00146","article-title":"Extracellular vesicles derived from mesenchymal stem cells (MSC) in regenerative medicine: applications in skin wound healing","volume":"8","author":"Casado-D\u00edaz","year":"2020","journal-title":"Front Bioeng Biotechnol"},{"key":"bib9","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1186\/s13287-023-03287-7","article-title":"Mesenchymal stromal\/stem cell (MSC)-derived exosomes in clinical trials","volume":"14","author":"Lotfy","year":"2023","journal-title":"Stem Cell Res Ther"},{"key":"bib10","doi-asserted-by":"publisher","first-page":"294","DOI":"10.1167\/iovs.18-25617","article-title":"Exosomes derived from mesenchymal stem cells modulate miR-126 to ameliorate hyperglycemia-induced retinal inflammation via targeting HMGB1","volume":"60","author":"Zhang","year":"2019","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib11","doi-asserted-by":"publisher","first-page":"5473","DOI":"10.1167\/iovs.18-25310","article-title":"Mesenchymal stem cell-derived small extracellular vesicles promote neuroprotection in a genetic DBA\/2J mouse model of glaucoma","volume":"59","author":"Mead","year":"2018","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib12","doi-asserted-by":"publisher","first-page":"702","DOI":"10.1167\/iovs.17-22855","article-title":"Mesenchymal stem cell-derived small extracellular vesicles promote neuroprotection in rodent models of glaucoma","volume":"59","author":"Mead","year":"2018","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib13","doi-asserted-by":"publisher","first-page":"1041","DOI":"10.1038\/s41418-020-00636-4","article-title":"Photoreceptor protection by mesenchymal stem cell transplantation identifies exosomal MiR-21 as a therapeutic for retinal degeneration","volume":"28","author":"Deng","year":"2021","journal-title":"Cell Death Differ"},{"key":"bib14","doi-asserted-by":"publisher","first-page":"1748931","DOI":"10.1080\/20013078.2020.1748931","article-title":"Exosomes derived from neural progenitor cells preserve photoreceptors during retinal degeneration by inactivating microglia","volume":"9","author":"Bian","year":"2020","journal-title":"J Extracell Vesicles"},{"key":"bib15","doi-asserted-by":"publisher","first-page":"493","DOI":"10.1038\/s41581-018-0023-5","article-title":"Immunoregulatory mechanisms of mesenchymal stem and stromal cells in inflammatory diseases","volume":"14","author":"Shi","year":"2018","journal-title":"Nat Rev Nephrol"},{"key":"bib16","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1186\/s13287-019-1224-y","article-title":"Priming approaches to improve the efficacy of mesenchymal stromal cell-based therapies","volume":"10","author":"Noronha","year":"2019","journal-title":"Stem Cell Res Ther"},{"key":"bib17","doi-asserted-by":"publisher","first-page":"803","DOI":"10.1111\/imm.v164.4","article-title":"The IL-23\/IL-17 axis promotes the formation of retinal neovascularization by activating the NLRP3 inflammasome in macrophages in an experimental retinopathy mouse model","volume":"164","author":"Sui","year":"2021","journal-title":"Immunology"},{"key":"bib18","doi-asserted-by":"publisher","first-page":"100866","DOI":"10.1016\/j.preteyeres.2020.100866","article-title":"Activation of the interleukin-23\/interleukin-17 signalling pathway in autoinflammatory and autoimmune uveitis","volume":"80","author":"Zhong","year":"2021","journal-title":"Prog Retin Eye Res"},{"key":"bib19","doi-asserted-by":"publisher","first-page":"eabj9617","DOI":"10.1126\/sciadv.abj9617","article-title":"miR-204-containing exosomes ameliorate GVHD-associated dry eye disease","volume":"8","author":"Zhou","year":"2022","journal-title":"Sci Adv"},{"key":"bib20","doi-asserted-by":"publisher","first-page":"e2305947121","DOI":"10.1073\/pnas.2305947121","article-title":"Effective treatment of optic neuropathies by intraocular delivery of MSC-sEVs through augmenting the G-CSF-macrophage pathway","volume":"121","author":"Yi","year":"2024","journal-title":"Proc Natl Acad Sci USA"},{"key":"bib21","first-page":"1820","article-title":"Paraoxonase 2 deficiency causes mitochondrial dysfunction in retinal pigment epithelial cells and retinal degeneration in mice","volume":"12","author":"Sreekumar","year":"2023","journal-title":"Antioxidants (Basel, Switzerland)"},{"key":"bib22","doi-asserted-by":"publisher","first-page":"1056","DOI":"10.1038\/s41419-022-05433-0","article-title":"IL-4 induces reparative phenotype of RPE cells and protects against retinal neurodegeneration via Nrf2 activation","volume":"13","author":"Zhou","year":"2022","journal-title":"Cell Death Dis"},{"key":"bib23","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1038\/cdd.2017.141","article-title":"Necroptosis in microglia contributes to neuroinflammation and retinal degeneration through TLR4 activation","volume":"25","author":"Huang","year":"2018","journal-title":"Cell Death Differ"},{"key":"bib24","doi-asserted-by":"publisher","first-page":"e2023290118","DOI":"10.1073\/pnas.2023290118","article-title":"A specific RIP3(+) subpopulation of microglia promotes retinopathy through a hypoxia-triggered necroptotic mechanism","volume":"118","author":"He","year":"2021","journal-title":"Proc Natl Acad Sci USA"},{"key":"bib25","doi-asserted-by":"publisher","first-page":"290","DOI":"10.1038\/s41419-020-2490-4","article-title":"Mesenchymal stem cell-derived exosomal miR-223 regulates neuronal cell apoptosis","volume":"11","author":"Wei","year":"2020","journal-title":"Cell Death Dis"},{"key":"bib26","doi-asserted-by":"publisher","first-page":"346","DOI":"10.1186\/s12951-023-02085-w","article-title":"Dominoes with interlocking consequences triggered by zinc: involvement of microelement-stimulated MSC-derived exosomes in senile osteogenesis and osteoclast dialogue","volume":"21","author":"Yin","year":"2023","journal-title":"J Nanobiotechnology"},{"key":"bib27","doi-asserted-by":"publisher","first-page":"2349","DOI":"10.1681\/ASN.2014070710","article-title":"AKI recovery induced by mesenchymal stromal cell-derived extracellular vesicles carrying microRNAs","volume":"26","author":"Collino","year":"2015","journal-title":"J Am Soc Nephrol"},{"key":"bib28","doi-asserted-by":"publisher","first-page":"388","DOI":"10.1016\/S1474-4422(15)70016-5","article-title":"Neuroinflammation in Alzheimer's disease","volume":"14","author":"Heneka","year":"2015","journal-title":"Lancet Neurol"},{"key":"bib29","doi-asserted-by":"publisher","first-page":"869","DOI":"10.1021\/acsnano.1c08473","article-title":"Intranasal administration of self-oriented nanocarriers based on therapeutic exosomes for synergistic treatment of Parkinson's disease","volume":"16","author":"Peng","year":"2022","journal-title":"ACS Nano"},{"key":"bib30","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1186\/s13287-023-03295-7","article-title":"Research progress of engineered mesenchymal stem cells and their derived exosomes and their application in autoimmune\/inflammatory diseases","volume":"14","author":"Zhu","year":"2023","journal-title":"Stem Cell Res Ther"},{"key":"bib31","doi-asserted-by":"publisher","first-page":"eabe0083","DOI":"10.1126\/sciadv.abe0083","article-title":"Metabolically engineered stem cell-derived exosomes to regulate macrophage heterogeneity in rheumatoid arthritis","volume":"7","author":"You","year":"2021","journal-title":"Sci Adv"},{"key":"bib32","doi-asserted-by":"publisher","first-page":"e2302962","DOI":"10.1002\/smll.v19.46","article-title":"Engineered extracellular vesicles for delivery of an IL-1 receptor antagonist promote targeted repair of retinal degeneration","volume":"19","author":"Liu","year":"2023","journal-title":"Small (Weinheim an der Bergstrasse, Germany)"},{"key":"bib33","doi-asserted-by":"publisher","first-page":"4774","DOI":"10.3390\/ijms21134774","article-title":"Reproducible large-scale isolation of exosomes from adipose tissue-derived mesenchymal stem\/stromal cells and their application in acute kidney injury","volume":"21","author":"Lee","year":"2020","journal-title":"Int J Mol Sci"},{"key":"bib34","doi-asserted-by":"publisher","first-page":"763","DOI":"10.3390\/ijms22020763","article-title":"Therapeutic properties of mesenchymal stromal\/stem cells: the need of cell priming for cell-free therapies in regenerative medicine","volume":"22","author":"Miceli","year":"2021","journal-title":"Int J Mol Sci"},{"key":"bib35","doi-asserted-by":"publisher","first-page":"818","DOI":"10.3389\/fphys.2017.00818","article-title":"Low-intensity ultrasound-induced anti-inflammatory effects are mediated by several new mechanisms including gene induction, immunosuppressor cell promotion, and enhancement of exosome biogenesis and docking","volume":"8","author":"Yang","year":"2017","journal-title":"Front Physiol"},{"key":"bib36","doi-asserted-by":"publisher","first-page":"945234","DOI":"10.3389\/fimmu.2022.945234","article-title":"Tumor necrosis factor-a-primed mesenchymal stem cell-derived exosomes promote M2 macrophage polarization via Galectin-1 and modify intrauterine adhesion on a novel murine model","volume":"13","author":"Li","year":"2022","journal-title":"Front Immunol"},{"key":"bib37","doi-asserted-by":"publisher","first-page":"118658","DOI":"10.1016\/j.lfs.2020.118658","article-title":"Exosomal miR-21 secreted by IL-1\u00df-primed-mesenchymal stem cells induces macrophage M2 polarization and ameliorates sepsis","volume":"264","author":"Yao","year":"2021","journal-title":"Life Sci"},{"key":"bib38","doi-asserted-by":"publisher","first-page":"719","DOI":"10.1038\/nm.3895","article-title":"IL-12 and IL-23 cytokines: from discovery to targeted therapies for immune-mediated inflammatory diseases","volume":"21","author":"Teng","year":"2015","journal-title":"Nat Med"},{"key":"bib39","doi-asserted-by":"publisher","first-page":"270","DOI":"10.1038\/s42003-023-04649-w","article-title":"Acetate attenuates hyperoxaluria-induced kidney injury by inhibiting macrophage infiltration via the miR-493-3p\/MIF axis","volume":"6","author":"Zhu","year":"2023","journal-title":"Commun Biol"},{"key":"bib40","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1016\/j.canlet.2020.01.005","article-title":"Exosome-encapsulated miRNAs contribute to CXCL12\/CXCR4-induced liver metastasis of colorectal cancer by enhancing M2 polarization of macrophages","volume":"474","author":"Wang","year":"2020","journal-title":"Cancer Lett"},{"key":"bib41","first-page":"98","article-title":"An SPM-enriched marine oil supplement shifted microglia polarization toward M2, ameliorating retinal degeneration in rd10 mice","volume":"12","author":"Olivares-Gonz\u00e1lez","year":"2022","journal-title":"Antioxidants (Basel, Switzerland)"},{"key":"bib42","doi-asserted-by":"publisher","first-page":"77","DOI":"10.3389\/fnana.2017.00077","article-title":"Microglia polarization with M1\/M2 phenotype changes in rd1 mouse model of retinal degeneration","volume":"11","author":"Zhou","year":"2017","journal-title":"Front Neuroanat"},{"key":"bib43","doi-asserted-by":"publisher","first-page":"741368","DOI":"10.3389\/fcell.2021.741368","article-title":"Shaping the microglia in retinal degenerative diseases using stem cell therapy: practice and prospects","volume":"9","author":"Jin","year":"2021","journal-title":"Front Cell Dev Biol"},{"key":"bib44","doi-asserted-by":"publisher","first-page":"987","DOI":"10.1038\/nn.4338","article-title":"A polarizing question: do M1 and M2 microglia exist?","volume":"19","author":"Ransohoff","year":"2016","journal-title":"Nat Neurosci"},{"key":"bib45","doi-asserted-by":"publisher","first-page":"107773","DOI":"10.1016\/j.exer.2019.107773","article-title":"Sex-related differences in the progressive retinal degeneration of the rd10 mouse","volume":"187","author":"Li","year":"2019","journal-title":"Exp Eye Res"},{"key":"bib46","doi-asserted-by":"publisher","first-page":"1644","DOI":"10.3390\/ijms16011644","article-title":"Protection of retina by mini-aA in NaIO3-induced retinal pigment epithelium degeneration mice","volume":"16","author":"Zhang","year":"2015","journal-title":"Int J Mol Sci"},{"key":"bib47","doi-asserted-by":"publisher","first-page":"222","DOI":"10.1002\/cne.v500:2","article-title":"Retinal organization in the retinal degeneration 10 (rd10) mutant mouse: a morphological and ERG study","volume":"500","author":"Gargini","year":"2007","journal-title":"J Comp Neurol"},{"key":"bib48","doi-asserted-by":"publisher","first-page":"101971","DOI":"10.1016\/j.redox.2021.101971","article-title":"HO-1-mediated ferroptosis as a target for protection against retinal pigment epithelium degeneration","volume":"43","author":"Tang","year":"2021","journal-title":"Redox Biol"},{"key":"bib49","doi-asserted-by":"publisher","first-page":"394","DOI":"10.1186\/s13287-022-03100-x","article-title":"Mesenchymal stem cell-derived extracellular vesicles protect retina in a mouse model of retinitis pigmentosa by anti-inflammation through miR-146a-Nr4a3 axis","volume":"13","author":"Zhang","year":"2022","journal-title":"Stem Cell Res Ther"}],"container-title":["Investigative Ophthalmology &amp; Visual Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/iovs.arvojournals.org\/article.aspx?articleid=2800645","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:31:56Z","timestamp":1791927116000},"score":1,"resource":{"primary":{"URL":"https:\/\/iovs.arvojournals.org\/article.aspx?articleid=2800645"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8,5]]},"references-count":49,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2024,8,1]]}},"URL":"https:\/\/doi.org\/10.1167\/iovs.65.10.8","relation":{},"ISSN":["1552-5783"],"issn-type":[{"value":"1552-5783","type":"print"}],"subject":[],"published":{"date-parts":[[2024,8,5]]}}}