{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T22:00:52Z","timestamp":1791928852098,"version":"4.3.4"},"reference-count":37,"publisher":"Association for Research in Vision and Ophthalmology (ARVO)","issue":"11","license":[{"start":{"date-parts":[[2024,9,6]],"date-time":"2024-09-06T00:00:00Z","timestamp":1725580800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Invest. Ophthalmol. Vis. Sci."],"published-print":{"date-parts":[[2024,9,6]]},"DOI":"10.1167\/iovs.65.11.11","type":"journal-article","created":{"date-parts":[[2024,9,6]],"date-time":"2024-09-06T11:31:47Z","timestamp":1725622307000},"page":"11","source":"Crossref","is-referenced-by-count":3,"title":["Intraocular Concentration of Stem Cell Factor\/c-KIT and Galectin-1 in Retinal Diseases"],"prefix":"10.1167","volume":"65","author":[{"given":"Yong Je","family":"Choi","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seongnam, Republic of Korea"},{"name":"Department of Ophthalmology, Eunpyeong St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyeong Min","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seongnam, Republic of Korea"},{"name":"Department of Ophthalmology, Konkuk University School of Medicine, Seoul, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tae-Young","family":"Na","sequence":"additional","affiliation":[{"name":"Novelty Nobility, Seongnam, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyu Hyung","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Seoul National University College of Medicine, Seoul National University Hospital, Seoul, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sang Gyu","family":"Park","sequence":"additional","affiliation":[{"name":"Novelty Nobility, Seongnam, Republic of Korea"},{"name":"College of Pharmacy and Research Institute of Pharmaceutical Science and Technology, Ajou University, Suwon, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Se Joon","family":"Woo","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seongnam, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"27","reference":[{"key":"bib1","doi-asserted-by":"publisher","first-page":"e106","DOI":"10.1016\/S2214-109X(13)70145-1","article-title":"Global prevalence of age-related macular degeneration and disease burden projection for 2020 and 2040: a systematic review and meta-analysis","volume":"2","author":"Wong","year":"2014","journal-title":"Lancet Glob Health"},{"key":"bib3","doi-asserted-by":"publisher","first-page":"365","DOI":"10.3390\/pharmaceutics11080365","article-title":"Pharmacokinetics of intravitreal anti-VEGF drugs in age-related macular degeneration","volume":"11","author":"Garc\u00eda-Quintanilla","year":"2019","journal-title":"Pharmaceutics"},{"key":"bib4","doi-asserted-by":"publisher","first-page":"e1","DOI":"10.1111\/aos.14191","article-title":"Galectin-1 studies in proliferative diabetic retinopathy","volume":"98","author":"Abu El-Asrar","year":"2020","journal-title":"Acta Ophthalmol"},{"key":"bib5","doi-asserted-by":"publisher","first-page":"16168","DOI":"10.1038\/s41598-017-16499-8","article-title":"Advanced glycation endproducts link inflammatory cues to upregulation of galectin-1 in diabetic retinopathy","volume":"7","author":"Kanda","year":"2017","journal-title":"Sci Rep"},{"key":"bib6","doi-asserted-by":"publisher","first-page":"2120","DOI":"10.1161\/ATVBAHA.119.313179","article-title":"SCF (stem cell factor) and cKIT modulate pathological ocular neovascularization","volume":"39","author":"Kim","year":"2019","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"bib7","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1186\/s12886-019-1278-8","article-title":"Comparison of cytokine levels in the aqueous humor of polypoidal choroidal vasculopathy and neovascular age-related macular degeneration patients","volume":"20","author":"Zhou","year":"2020","journal-title":"BMC Ophthalmol"},{"key":"bib8","doi-asserted-by":"publisher","first-page":"161","DOI":"10.2147\/OPTH.S125676","article-title":"Switching to aflibercept among patients with treatment-resistant neovascular age-related macular degeneration: a systematic review with meta-analysis","volume":"11","author":"Spooner","year":"2017","journal-title":"Clin Ophthalmol"},{"key":"bib9","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1080\/13816810.2018.1484928","article-title":"The association of matrix metalloproteinases polymorphisms and interleukins in advanced age-related macular degeneration","volume":"39","author":"Budiene","year":"2018","journal-title":"Ophthalmic Genet"},{"key":"bib10","doi-asserted-by":"crossref","first-page":"e381","DOI":"10.1111\/j.1755-3768.2012.02414.x","article-title":"Cytokine concentration in aqueous humour of eyes with exudative age-related macular degeneration","volume":"90","author":"Jonas","year":"2012","journal-title":"Acta Ophthalmol"},{"key":"bib11","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1159\/000365487","article-title":"Aqueous humor cytokine levels in patients with polypoidal choroidal vasculopathy and neovascular age-related macular degeneration","volume":"53","author":"Sakurada","year":"2015","journal-title":"Ophthalmic Res"},{"key":"bib12","doi-asserted-by":"publisher","first-page":"202","DOI":"10.1167\/iovs.18-25878","article-title":"Systemic levels of interleukin-6 correlate with progression rate of geographic atrophy secondary to age-related macular degeneration","volume":"60","author":"Krogh Nielsen","year":"2019","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib13","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1159\/000490153","article-title":"Aqueous humor levels of cytokines in patients with age-related macular degeneration","volume":"241","author":"Mimura","year":"2019","journal-title":"Ophthalmologica"},{"key":"bib14","doi-asserted-by":"publisher","first-page":"286","DOI":"10.3389\/fnagi.2019.00286","article-title":"The interplay between systemic inflammatory factors and microRNAs in age-related macular degeneration","volume":"11","author":"Litwinska","year":"2019","journal-title":"Front Aging Neurosci"},{"key":"bib15","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1111\/aos.13886","article-title":"Plasma markers of chronic low-grade inflammation in polypoidal choroidal vasculopathy and neovascular age-related macular degeneration","volume":"97","author":"Subhi","year":"2019","journal-title":"Acta Ophthalmol"},{"key":"bib16","doi-asserted-by":"publisher","first-page":"45081","DOI":"10.1038\/srep45081","article-title":"Elevated angiopoietin 2 in aqueous of patients with neovascular age related macular degeneration correlates with disease severity at presentation","volume":"7","author":"Ng","year":"2017","journal-title":"Sci Rep"},{"key":"bib17","doi-asserted-by":"publisher","first-page":"242","DOI":"10.1111\/aos.12581","article-title":"Early and exudative age-related macular degeneration is associated with increased plasma levels of soluble TNF receptor II","volume":"93","author":"Faber","year":"2015","journal-title":"Acta Ophthalmol"},{"key":"bib18","first-page":"1258","article-title":"Semaphorin 3A blocks the formation of pathologic choroidal neovascularization induced by transforming growth factor beta","volume":"20","author":"Bai","year":"2014","journal-title":"Mol Vis"},{"key":"bib19","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1167\/iovs.16-20922","article-title":"HTRA1 and TGF-\u00df1 concentrations in the aqueous humor of patients with neovascular age-related macular degeneration","volume":"58","author":"Tosi","year":"2017","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib20","doi-asserted-by":"publisher","first-page":"8053","DOI":"10.1038\/s41598-018-26442-0","article-title":"TGF-\u00df concentrations and activity are down-regulated in the aqueous humor of patients with neovascular age-related macular degeneration","volume":"8","author":"Tosi","year":"2018","journal-title":"Sci Rep"},{"key":"bib21","doi-asserted-by":"publisher","first-page":"533","DOI":"10.1111\/aos.12670","article-title":"Impact of visceral fat and pro-inflammatory factors on the pathogenesis of age-related macular degeneration","volume":"93","author":"Haas","year":"2015","journal-title":"Acta Ophthalmol"},{"key":"bib22","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1167\/iovs.13-12978","article-title":"Systemic upregulation of PDGF-B in patients with neovascular AMD","volume":"55","author":"Zehetner","year":"2014","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib23","doi-asserted-by":"publisher","first-page":"1619","DOI":"10.1152\/physrev.00046.2011","article-title":"Stem cell factor receptor\/c-Kit: from basic science to clinical implications","volume":"92","author":"Lennartsson","year":"2012","journal-title":"Physiol Rev"},{"key":"bib24","doi-asserted-by":"publisher","first-page":"1459","DOI":"10.1161\/ATVBAHA.114.303575","article-title":"Stem cell factor is a potent endothelial permeability factor","volume":"34","author":"Kim","year":"2014","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"bib25","doi-asserted-by":"publisher","first-page":"1308","DOI":"10.3390\/pharmaceutics13081308","article-title":"A fully human monoclonal antibody targeting cKIT is a potent inhibitor of pathological choroidal neovascularization in mice","volume":"13","author":"Seo","year":"2021","journal-title":"Pharmaceutics"},{"key":"bib26","doi-asserted-by":"publisher","first-page":"1386","DOI":"10.3390\/biom11091386","article-title":"Galectins in endothelial cell biology and angiogenesis: the basics","volume":"11","author":"Thijssen","year":"2021","journal-title":"Biomolecules"},{"key":"bib27","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1167\/iovs.62.2.22","article-title":"Hypoxia induces galectin-1 expression via autoinduction of placental growth factor in retinal pigment epithelium cells","volume":"62","author":"Yamamoto","year":"2021","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib28","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1007\/s00417-008-0926-0","article-title":"Resolving the clinical acuity categories \u201chand motion\u201d and \u201ccounting fingers\u201d using the Freiburg Visual Acuity Test (FrACT)","volume":"247","author":"Lange","year":"2009","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"key":"bib29","doi-asserted-by":"publisher","first-page":"2498","DOI":"10.1096\/fj.201801227R","article-title":"Galectin-1 promotes choroidal neovascularization and subretinal fibrosis mediated via epithelial-mesenchymal transition","volume":"33","author":"Wu","year":"2019","journal-title":"FASEB J"},{"key":"bib30","first-page":"5053035","article-title":"Suppression of retinal neovascularization by inhibition of galectin-1 in a murine model of oxygen-induced retinopathy","volume":"2017","author":"Yang","year":"2017","journal-title":"J Ophthalmol"},{"key":"bib31","doi-asserted-by":"crossref","first-page":"1497","DOI":"10.2147\/OPTH.S46817","article-title":"Correlation between vascular endothelial growth factor and nonperfused areas in macular edema secondary to branch retinal vein occlusion","volume":"7","author":"Fujikawa","year":"2013","journal-title":"Clin Ophthalmol"},{"key":"bib32","doi-asserted-by":"publisher","first-page":"330","DOI":"10.1186\/s12967-015-0683-x","article-title":"Wnt signaling in age-related macular degeneration: human macular tissue and mouse model","volume":"13","author":"Tuo","year":"2015","journal-title":"J Transl Med"},{"key":"bib33","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1016\/j.visres.2017.02.007","article-title":"Canonical Wnt signaling in diabetic retinopathy","volume":"139","author":"Chen","year":"2017","journal-title":"Vision Res"},{"key":"bib34","doi-asserted-by":"publisher","first-page":"744","DOI":"10.1016\/j.cell.2014.01.043","article-title":"Glycosylation-dependent lectin-receptor interactions preserve angiogenesis in anti-VEGF refractory tumors","volume":"156","author":"Croci","year":"2014","journal-title":"Cell"},{"key":"bib35","doi-asserted-by":"publisher","first-page":"1205","DOI":"10.1038\/s41467-019-08961-0","article-title":"Organoid-derived C-Kit+\/SSEA4\u2013 human retinal progenitor cells promote a protective retinal microenvironment during transplantation in rodents","volume":"10","author":"Zou","year":"2019","journal-title":"Nat Commun"},{"key":"bib36","doi-asserted-by":"publisher","first-page":"1283","DOI":"10.1093\/glycob\/cwu083","article-title":"Regulatory role of glycans in the control of hypoxia-driven angiogenesis and sensitivity to anti-angiogenic treatment","volume":"24","author":"Croci","year":"2014","journal-title":"Glycobiology"},{"key":"bib37","doi-asserted-by":"publisher","first-page":"65","DOI":"10.2174\/156800906775471725","article-title":"The stem cell factor receptor\/c-Kit as a drug target in cancer","volume":"6","author":"Lennartsson","year":"2006","journal-title":"Curr Cancer Drug Targets"},{"key":"bib2","first-page":"1426","article-title":"Pharmacotherapy of age-related macular degeneration","volume-title":"Ryan's Retina","author":"Greg Budoff","year":"2022"}],"container-title":["Investigative Ophthalmology & Visual Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/iovs.arvojournals.org\/article.aspx?articleid=2800780","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:31:46Z","timestamp":1791927106000},"score":1,"resource":{"primary":{"URL":"https:\/\/iovs.arvojournals.org\/article.aspx?articleid=2800780"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,6]]},"references-count":37,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2024,9,3]]}},"URL":"https:\/\/doi.org\/10.1167\/iovs.65.11.11","relation":{},"ISSN":["1552-5783"],"issn-type":[{"value":"1552-5783","type":"print"}],"subject":[],"published":{"date-parts":[[2024,9,6]]}}}