{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T12:54:48Z","timestamp":1793019288991,"version":"4.5.0"},"reference-count":53,"publisher":"Association for Research in Vision and Ophthalmology (ARVO)","issue":"11","license":[{"start":{"date-parts":[[2024,9,13]],"date-time":"2024-09-13T00:00:00Z","timestamp":1726185600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Invest. Ophthalmol. Vis. Sci."],"published-print":{"date-parts":[[2024,9,13]]},"DOI":"10.1167\/iovs.65.11.21","type":"journal-article","created":{"date-parts":[[2024,9,13]],"date-time":"2024-09-13T10:33:44Z","timestamp":1726223624000},"page":"21","source":"Crossref","is-referenced-by-count":3,"title":["The Effects of STRA6 Regulation of the Circadian Rhythm on Choroidal Neovascularization"],"prefix":"10.1167","volume":"65","author":[{"given":"Ying","family":"Yang","sequence":"first","affiliation":[{"name":"Eye Institute, Affiliated Hospital of Nantong University, Nantong, Jiangsu, China"},{"name":"Medical School of Nantong University, Nantong, Jiangsu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shenglai","family":"Zhang","sequence":"additional","affiliation":[{"name":"Eye Institute, Affiliated Hospital of Nantong University, Nantong, Jiangsu, China"},{"name":"Medical School of Nantong University, Nantong, Jiangsu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shu","family":"Su","sequence":"additional","affiliation":[{"name":"Eye Institute, Affiliated Hospital of Nantong University, Nantong, Jiangsu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaowei","family":"Yang","sequence":"additional","affiliation":[{"name":"Eye Institute, Affiliated Hospital of Nantong University, Nantong, Jiangsu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia","family":"Chen","sequence":"additional","affiliation":[{"name":"Eye Institute, Affiliated Hospital of Nantong University, Nantong, Jiangsu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aimin","family":"Sang","sequence":"additional","affiliation":[{"name":"Eye Institute, Affiliated Hospital of Nantong University, Nantong, Jiangsu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"27","reference":[{"issue":"5","key":"bib1","doi-asserted-by":"publisher","first-page":"921","DOI":"10.1016\/j.ophtha.2009.10.007","article-title":"The prevalence of age-related macular degeneration in Asians: a systematic review and meta-analysis","volume":"117","author":"Kawasaki","year":"2010","journal-title":"Ophthalmology"},{"issue":"3","key":"bib2","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1016\/S0008-4182(05)80070-5","article-title":"Age-related macular degeneration: economic burden and value-based medicine analysis","volume":"40","author":"Brown","year":"2005","journal-title":"Can J Ophthalmol"},{"issue":"3","key":"bib3","first-page":"353","article-title":"Age-related macular degeneration (AMD): pathogenesis and therapy","volume":"58","author":"Nowak","year":"2006","journal-title":"Pharmacol Rep"},{"issue":"6","key":"bib4","doi-asserted-by":"publisher","first-page":"502","DOI":"10.1097\/ICU.0b013e3282f0ca54","article-title":"Anti-vascular endothelial growth factor therapy for ocular neovascular disease","volume":"18","author":"Andreoli","year":"2007","journal-title":"Curr Opin Ophthalmol"},{"issue":"8","key":"bib5","first-page":"CD005139","article-title":"Anti-vascular endothelial growth factor for neovascular age-related macular degeneration","volume":"8","author":"Solomon","year":"2014","journal-title":"Cochrane Database Syst Rev"},{"issue":"6","key":"bib6","doi-asserted-by":"publisher","first-page":"1000","DOI":"10.1038\/s42255-024-01051-6","article-title":"Circadian-independent light regulation of mammalian metabolism","volume":"6","author":"Rao","year":"2024","journal-title":"Nat Metab"},{"key":"bib7","doi-asserted-by":"publisher","first-page":"517","DOI":"10.1146\/annurev-physiol-021909-135821","article-title":"The mammalian circadian timing system: organization and coordination of central and peripheral clocks","volume":"72","author":"Dibner","year":"2010","journal-title":"Annu Rev Physiol"},{"key":"bib8","doi-asserted-by":"publisher","first-page":"637","DOI":"10.3389\/fendo.2020.00637","article-title":"Editorial: Disorders of circadian rhythms","volume":"11","author":"Chi-Casta\u00f1eda","year":"2020","journal-title":"Front Endocrinol (Lausanne)"},{"issue":"2","key":"bib9","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1038\/s41580-019-0179-2","article-title":"Molecular mechanisms and physiological importance of circadian rhythms","volume":"21","author":"Patke","year":"2020","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"2","key":"bib10","doi-asserted-by":"publisher","first-page":"178","DOI":"10.1016\/j.immuni.2014.02.002","article-title":"Circadian clock proteins and immunity","volume":"40","author":"Curtis","year":"2014","journal-title":"Immunity"},{"key":"bib11","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1016\/j.preteyeres.2013.12.001","article-title":"Circadian organization of the mammalian retina: from gene regulation to physiology and diseases","volume":"39","author":"Mcmahon","year":"2014","journal-title":"Prog Retin Eye Res"},{"issue":"11","key":"bib12","doi-asserted-by":"publisher","first-page":"e50602","DOI":"10.1371\/journal.pone.0050602","article-title":"Heterogeneous expression of the core circadian clock proteins among neuronal cell types in mouse retina","volume":"7","author":"Liu","year":"2012","journal-title":"PLoS One"},{"issue":"1","key":"bib13","doi-asserted-by":"publisher","first-page":"4524","DOI":"10.1038\/s41467-019-12330-2","article-title":"Restoration of visual function by transplantation of optogenetically engineered photoreceptors","volume":"10","author":"Garita-Hernandez","year":"2019","journal-title":"Nat Commun"},{"issue":"3","key":"bib14","doi-asserted-by":"publisher","first-page":"820","DOI":"10.3390\/ijms21030820","article-title":"Circadian rhythms in exudative age-related macular degeneration: the key role of the canonical WNT\/\u00df-catenin pathway","volume":"21","author":"Vall\u00e9e","year":"2020","journal-title":"Int J Mol Sci"},{"issue":"2","key":"bib15","doi-asserted-by":"publisher","first-page":"392","DOI":"10.1083\/jcb.42.2.392","article-title":"Participation of the retinal pigment epithelium in the rod outer segment renewal process","volume":"42","author":"Young","year":"1969","journal-title":"J Cell Biol"},{"issue":"1","key":"bib16","doi-asserted-by":"publisher","first-page":"114","DOI":"10.3390\/biom11010114","article-title":"The influence of melatonin and light on VEGF secretion in primary RPE cells","volume":"11","author":"Klettner","year":"2021","journal-title":"Biomolecules"},{"issue":"5813","key":"bib17","doi-asserted-by":"publisher","first-page":"820","DOI":"10.1126\/science.1136244","article-title":"A membrane receptor for retinol binding protein mediates cellular uptake of vitamin A","volume":"315","author":"Kawaguchi","year":"2007","journal-title":"Science"},{"issue":"20","key":"bib18","doi-asserted-by":"publisher","first-page":"3649","DOI":"10.1007\/s00018-016-2318-7","article-title":"Metabolic and redox signaling in the retina","volume":"74","author":"L\u00e9veillard","year":"2017","journal-title":"Cell Mol Life Sci"},{"issue":"6","key":"bib19","doi-asserted-by":"publisher","first-page":"3027","DOI":"10.1167\/iovs.11-8476","article-title":"Retinoid content, visual responses, and ocular morphology are compromised in the retinas of mice lacking the retinol-binding protein receptor, STRA6","volume":"53","author":"Ruiz","year":"2012","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"21","key":"bib20","doi-asserted-by":"publisher","first-page":"6341","DOI":"10.1158\/0008-5472.CAN-14-1052","article-title":"Holo-retinol-binding protein and its receptor STRA6 drive oncogenic transformation","volume":"74","author":"Berry","year":"2014","journal-title":"Cancer Res"},{"issue":"22","key":"bib21","doi-asserted-by":"publisher","first-page":"15160","DOI":"10.1074\/jbc.M801060200","article-title":"An essential ligand-binding domain in the membrane receptor for retinol-binding protein revealed by large-scale mutagenesis and a human polymorphism","volume":"283","author":"Kawaguchi","year":"2008","journal-title":"J Biol Chem"},{"issue":"3","key":"bib22","doi-asserted-by":"publisher","first-page":"366","DOI":"10.1111\/jnc.12620","article-title":"The rhythm of retinoids in the brain","volume":"129","author":"Ransom","year":"2014","journal-title":"J Neurochem"},{"issue":"36","key":"bib23","doi-asserted-by":"publisher","first-page":"15080","DOI":"10.1074\/jbc.M117.782334","article-title":"The retinol-binding protein receptor STRA6 regulates diurnal insulin responses","volume":"292","author":"Gliniak","year":"2017","journal-title":"J Biol Chem"},{"key":"bib24","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1016\/j.exer.2015.01.005","article-title":"Excessive retinol intake exacerbates choroidal neovascularization through upregulated vascular endothelial growth factor in retinal pigment epithelium in mice","volume":"131","author":"Tan","year":"2015","journal-title":"Exp Eye Res"},{"issue":"5","key":"bib25","doi-asserted-by":"publisher","first-page":"1011","DOI":"10.1200\/JCO.2005.06.081","article-title":"Role of the vascular endothelial growth factor pathway in tumor growth and angiogenesis","volume":"23","author":"Hicklin","year":"2005","journal-title":"J Clin Oncol"},{"issue":"4","key":"bib26","doi-asserted-by":"publisher","first-page":"e2750","DOI":"10.1038\/cddis.2016.421","article-title":"WISP-1 positively regulates angiogenesis by controlling VEGF-A expression in human osteosarcoma","volume":"8","author":"Tsai","year":"2017","journal-title":"Cell Death Dis"},{"issue":"6","key":"bib27","doi-asserted-by":"publisher","first-page":"1248","DOI":"10.1016\/j.cell.2019.01.021","article-title":"VEGF in signaling and disease: beyond discovery and development","volume":"176","author":"Apte","year":"2019","journal-title":"Cell"},{"issue":"15","key":"bib28","doi-asserted-by":"publisher","first-page":"3164","DOI":"10.1128\/MCB.00505-12","article-title":"Cross talk between signaling and vitamin A transport by the retinol-binding protein receptor STRA6","volume":"32","author":"Berry","year":"2012","journal-title":"Mol Cell Biol"},{"issue":"2","key":"bib29","first-page":"95","article-title":"Caprylic acid improves lipid metabolism, suppresses the inflammatory response and activates the ABCA1\/p-JAK2\/p-STAT3 signaling pathway in C57BL\/6J mice and RAW264.7 cells","volume":"35","author":"Zhang","year":"2022","journal-title":"Biomed Environ Sci"},{"issue":"7","key":"bib30","doi-asserted-by":"publisher","first-page":"1655","DOI":"10.1038\/s12276-024-01269-0","article-title":"Circadian disruption reduces MUC4 expression via the clock molecule BMAL1 during dry eye development","volume":"56","author":"Zeng","year":"2024","journal-title":"Exp Mol Med"},{"issue":"6","key":"bib31","doi-asserted-by":"publisher","first-page":"e15","DOI":"10.1161\/CIRCRESAHA.119.315502","article-title":"BMAL1-downregulation aggravates porphyromonas gingivalis-induced atherosclerosis by encouraging oxidative stress","volume":"126","author":"Xie","year":"2020","journal-title":"Circ Res"},{"issue":"16","key":"bib32","doi-asserted-by":"publisher","first-page":"e020896","DOI":"10.1161\/JAHA.121.020896","article-title":"Adverse effect of circadian rhythm disorder on reparative angiogenesis in hind limb ischemia","volume":"10","author":"Tsuzuki","year":"2021","journal-title":"J Am Heart Assoc"},{"issue":"6479","key":"bib33","doi-asserted-by":"publisher","first-page":"800","DOI":"10.1126\/science.aaw7365","article-title":"Circadian rhythms in the absence of the clock gene Bmal1","volume":"367","author":"Ray","year":"2020","journal-title":"Science"},{"issue":"5488","key":"bib34","doi-asserted-by":"publisher","first-page":"2344","DOI":"10.1126\/science.289.5488.2344","article-title":"Resetting of circadian time in peripheral tissues by glucocorticoid signaling","volume":"289","author":"Balsalobre","year":"2000","journal-title":"Science"},{"issue":"7","key":"bib35","doi-asserted-by":"publisher","first-page":"662","DOI":"10.1038\/s41419-022-05121-z","article-title":"Hypoxia aggravates ferroptosis in RPE cells by promoting the Fenton reaction","volume":"13","author":"Henning","year":"2022","journal-title":"Cell Death Dis"},{"issue":"6","key":"bib36","doi-asserted-by":"publisher","first-page":"929","DOI":"10.1016\/S0092-8674(00)81199-X","article-title":"A serum shock induces circadian gene expression in mammalian tissue culture cells","volume":"93","author":"Balsalobre","year":"1998","journal-title":"Cell"},{"issue":"24","key":"bib37","doi-asserted-by":"publisher","first-page":"9465","DOI":"10.1158\/0008-5472.CAN-09-2805","article-title":"Inositol hexaphosphate suppresses growth and induces apoptosis in prostate carcinoma cells in culture and nude mouse xenograft: PI3K-Akt pathway as potential target","volume":"69","author":"Gu","year":"2009","journal-title":"Cancer Res"},{"issue":"5","key":"bib38","first-page":"4739","article-title":"Silencing of pantothenate kinase 2 reduces endothelial cell angiogenesis","volume":"18","author":"Pagani","year":"2018","journal-title":"Mol Med Rep"},{"issue":"5","key":"bib39","doi-asserted-by":"publisher","first-page":"395","DOI":"10.1016\/0014-4835(76)90177-9","article-title":"Transport of retinol from the blood to the retina: an autoradiographic study of the pigment epithelial cell surface receptor for plasma retinol-binding protein","volume":"22","author":"Bok","year":"1976","journal-title":"Exp Eye Res"},{"issue":"3","key":"bib40","doi-asserted-by":"publisher","first-page":"340","DOI":"10.3390\/biom11030340","article-title":"Influence of circadian rhythm in the eye: significance of melatonin in glaucoma","volume":"11","author":"Mart\u00ednez-\u00c1guila","year":"2021","journal-title":"Biomolecules"},{"issue":"2","key":"bib41","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1016\/j.preteyeres.2007.10.001","article-title":"Circadian rhythms in the eye: the physiological significance of melatonin receptors in ocular tissues","volume":"27","author":"Wiechmann","year":"2008","journal-title":"Prog Retin Eye Res"},{"issue":"12","key":"bib42","doi-asserted-by":"publisher","first-page":"1431","DOI":"10.1080\/13543784.2020.1842872","article-title":"Circadian rhythms in diabetic retinopathy: an overview of pathogenesis and investigational drugs","volume":"29","author":"Bhatwadekar","year":"2020","journal-title":"Expert Opin Investig Drugs"},{"issue":"11","key":"bib43","doi-asserted-by":"publisher","first-page":"1640","DOI":"10.1001\/archopht.1984.01040031330019","article-title":"Age-related macular degeneration and blindness due to neovascular maculopathy","volume":"102","author":"Ferris","year":"1984","journal-title":"Arch Ophthalmol"},{"issue":"6901","key":"bib44","doi-asserted-by":"publisher","first-page":"935","DOI":"10.1038\/nature00965","article-title":"Coordination of circadian timing in mammals","volume":"418","author":"Reppert","year":"2002","journal-title":"Nature"},{"issue":"10","key":"bib45","doi-asserted-by":"publisher","first-page":"939","DOI":"10.1007\/BF01953051","article-title":"Mammalian pineal melatonin: a clock for all seasons","volume":"45","author":"Bartness","year":"1989","journal-title":"Experientia"},{"issue":"1","key":"bib46","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1530\/ror.0.0030013","article-title":"Melatonin and the pineal gland: influence on mammalian seasonal and circadian physiology","volume":"3","author":"Arendt","year":"1998","journal-title":"Rev Reprod"},{"issue":"1","key":"bib47","doi-asserted-by":"publisher","first-page":"e12660","DOI":"10.1111\/jpi.12660","article-title":"Melatonin attenuates choroidal neovascularization by regulating macrophage\/microglia polarization via inhibition of RhoA\/ROCK signaling pathway","volume":"69","author":"Xu","year":"2020","journal-title":"J Pineal Res"},{"issue":"1","key":"bib48","doi-asserted-by":"publisher","first-page":"792","DOI":"10.1038\/s42003-022-03774-2","article-title":"Neuronal Bmal1 regulates retinal angiogenesis and neovascularization in mice","volume":"5","author":"Jidigam","year":"2022","journal-title":"Commun Biol"},{"issue":"3","key":"bib49","doi-asserted-by":"publisher","first-page":"405","DOI":"10.4161\/cc.23596","article-title":"Clock controls angiogenesis","volume":"12","author":"Jensen","year":"2013","journal-title":"Cell Cycle"},{"issue":"4","key":"bib50","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1016\/j.mam.2012.04.005","article-title":"Understanding age-related macular degeneration (AMD): relationships between the photoreceptor\/retinal pigment epithelium\/Bruch's membrane\/choriocapillaris complex","volume":"33","author":"Bhutto","year":"2012","journal-title":"Mol Aspects Med"},{"issue":"11","key":"bib51","doi-asserted-by":"publisher","first-page":"3987","DOI":"10.3390\/nu13113987","article-title":"Vitamin A transporters in visual function: a mini review on membrane receptors for dietary vitamin A uptake, storage, and transport to the eye","volume":"13","author":"Martin","year":"2021","journal-title":"Nutrients"},{"issue":"6","key":"bib52","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1016\/S0955-2863(99)00013-3","article-title":"Uptake of vitamin A in macrophages from physiologic transport proteins: role of retinol-binding protein and chylomicron remnants","volume":"10","author":"Hagen","year":"1999","journal-title":"J Nutr Biochem"},{"issue":"3","key":"bib53","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1016\/j.ophtha.2020.08.018","article-title":"Dietary nutrient intake and progression to late age-related macular degeneration in the age-related eye disease studies 1 and 2","volume":"128","author":"Agr\u00f3n","year":"2021","journal-title":"Ophthalmology"}],"container-title":["Investigative Ophthalmology &amp; Visual Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/iovs.arvojournals.org\/article.aspx?articleid=2800798","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:31:49Z","timestamp":1791927109000},"score":1,"resource":{"primary":{"URL":"https:\/\/iovs.arvojournals.org\/article.aspx?articleid=2800798"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,13]]},"references-count":53,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2024,9,3]]}},"URL":"https:\/\/doi.org\/10.1167\/iovs.65.11.21","relation":{},"ISSN":["1552-5783"],"issn-type":[{"value":"1552-5783","type":"print"}],"subject":[],"published":{"date-parts":[[2024,9,13]]}}}