{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T22:01:24Z","timestamp":1791928884544,"version":"4.3.4"},"reference-count":29,"publisher":"Association for Research in Vision and Ophthalmology (ARVO)","issue":"11","license":[{"start":{"date-parts":[[2024,9,4]],"date-time":"2024-09-04T00:00:00Z","timestamp":1725408000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Invest. Ophthalmol. Vis. Sci."],"published-print":{"date-parts":[[2024,9,4]]},"DOI":"10.1167\/iovs.65.11.4","type":"journal-article","created":{"date-parts":[[2024,9,4]],"date-time":"2024-09-04T12:33:47Z","timestamp":1725453227000},"page":"4","source":"Crossref","is-referenced-by-count":6,"title":["Prognostic Impact of Notch1 Intracellular Domain, P63, and c-MYC in Lacrimal Gland Adenoid Cystic Carcinoma"],"prefix":"10.1167","volume":"65","author":[{"given":"Jiawei","family":"Zhao","sequence":"first","affiliation":[{"name":"Orbital Oncology & Ophthalmic Plastic Surgery, Department of Plastic Surgery, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle D.","family":"Williams","sequence":"additional","affiliation":[{"name":"Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mike","family":"Hernandez","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grace","family":"Kuang","sequence":"additional","affiliation":[{"name":"Orbital Oncology & Ophthalmic Plastic Surgery, Department of Plastic Surgery, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hila","family":"Goldberg","sequence":"additional","affiliation":[{"name":"Orbital Oncology & Ophthalmic Plastic Surgery, Department of Plastic Surgery, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janet","family":"Fan","sequence":"additional","affiliation":[{"name":"Orbital Oncology & Ophthalmic Plastic Surgery, Department of Plastic Surgery, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Ning","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renata","family":"Ferrarotto","sequence":"additional","affiliation":[{"name":"Department of Thoracic\/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bita","family":"Esmaeli","sequence":"additional","affiliation":[{"name":"Orbital Oncology & Ophthalmic Plastic Surgery, Department of Plastic Surgery, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"27","reference":[{"key":"bib1","doi-asserted-by":"publisher","first-page":"431","DOI":"10.1016\/S0161-6420(89)32873-9","article-title":"Clinicopathologic review of 142 cases of lacrimal gland lesions","volume":"96","author":"Shields","year":"1989","journal-title":"Ophthalmology"},{"key":"bib2","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1097\/ICU.0b013e32830b13e1","article-title":"Epithelial tumors of the lacrimal gland: an update","volume":"19","author":"Bernardini","year":"2008","journal-title":"Curr Opin Ophthalmol"},{"key":"bib3","doi-asserted-by":"publisher","first-page":"815","DOI":"10.1016\/S1470-2045(10)70245-X","article-title":"Systemic therapy in the management of metastatic or locally recurrent adenoid cystic carcinoma of the salivary glands: a systematic review","volume":"12","author":"Laurie","year":"2011","journal-title":"Lancet Oncol"},{"key":"bib4","doi-asserted-by":"publisher","first-page":"2965","DOI":"10.1172\/JCI67201","article-title":"Whole exome sequencing of adenoid cystic carcinoma","volume":"123","author":"Stephens","year":"2013","journal-title":"J Clin Invest"},{"key":"bib5","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1097\/PAS.0000000000000102","article-title":"Comprehensive genomic profiling of relapsed and metastatic adenoid cystic carcinomas by next-generation sequencing reveals potential new routes to targeted therapies","volume":"38","author":"Ross","year":"2014","journal-title":"Am J Surg Pathol"},{"key":"bib6","doi-asserted-by":"publisher","first-page":"791","DOI":"10.1038\/ng.2643","article-title":"The mutational landscape of adenoid cystic carcinoma","volume":"45","author":"Ho","year":"2013","journal-title":"Nat Genet"},{"key":"bib7","doi-asserted-by":"publisher","first-page":"718","DOI":"10.4161\/cc.3.6.949","article-title":"Notch and epithelial-mesenchyme transition in development and tumor progression: another turn of the screw","volume":"3","author":"Grego-Bessa","year":"2004","journal-title":"Cell Cycle"},{"key":"bib8","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1016\/j.gde.2003.11.004","article-title":"Multiple niches for Notch in cancer: context is everything","volume":"14","author":"Weng","year":"2004","journal-title":"Curr Opin Genet Dev"},{"issue":"5694","key":"bib9","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1126\/science.1102160","article-title":"Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia","volume":"306","author":"Weng","year":"2004","journal-title":"Science"},{"key":"bib10","doi-asserted-by":"publisher","first-page":"770","DOI":"10.1158\/2159-8290.CD-12-0537","article-title":"Integrative genomic characterization of oral squamous cell carcinoma identifies frequent somatic drivers","volume":"3","author":"Pickering","year":"2013","journal-title":"Cancer Discov"},{"issue":"6046","key":"bib11","doi-asserted-by":"publisher","first-page":"1154","DOI":"10.1126\/science.1206923","article-title":"Exome sequencing of head and neck squamous cell carcinoma reveals inactivating mutations in NOTCH1","volume":"333","author":"Agrawal","year":"2011","journal-title":"Science"},{"key":"bib12","doi-asserted-by":"publisher","first-page":"352","DOI":"10.1200\/JCO.2016.67.5264","article-title":"Activating NOTCH1 mutations define a distinct subgroup of patients with adenoid cystic carcinoma who have poor prognosis, propensity to bone and liver metastasis, and potential responsiveness to Notch1 inhibitors","volume":"35","author":"Ferrarotto","year":"2017","journal-title":"J Clin Oncol"},{"key":"bib13","doi-asserted-by":"publisher","first-page":"852","DOI":"10.1158\/1078-0432.CCR-20-1192","article-title":"Proteogenomic analysis of salivary adenoid cystic carcinomas defines molecular subtypes and identifies therapeutic targets","volume":"27","author":"Ferrarotto","year":"2021","journal-title":"Clin Cancer Res"},{"key":"bib14","doi-asserted-by":"publisher","first-page":"2737","DOI":"10.1158\/1078-0432.CCR-23-1697","article-title":"Correction: proteogenomic analysis of salivary adenoid cystic carcinomas defines molecular subtypes and identifies therapeutic targets","volume":"29","author":"Ferrarotto","year":"2023","journal-title":"Clin Cancer Res"},{"key":"bib15","doi-asserted-by":"publisher","first-page":"1473","DOI":"10.1097\/PAS.0000000000000945","article-title":"Diffuse staining for activated NOTCH1 correlates with NOTCH1 mutation status and is associated with worse outcome in adenoid cystic carcinoma","volume":"41","author":"Sajed","year":"2017","journal-title":"Am J Surg Pathol"},{"key":"bib16","doi-asserted-by":"publisher","first-page":"106028","DOI":"10.1016\/j.oraloncology.2022.106028","article-title":"Clinical disease course and survival outcomes following disease recurrence in adenoid cystic carcinoma with and without NOTCH signaling pathway activation","volume":"133","author":"Feeney","year":"2022","journal-title":"Oral Oncol"},{"issue":"6","key":"bib17","doi-asserted-by":"publisher","first-page":"BIO240","DOI":"10.1167\/iovs.16-21097","article-title":"Whole exome sequencing of lacrimal gland adenoid cystic carcinoma","volume":"58","author":"Sant","year":"2017","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"8","key":"bib18","doi-asserted-by":"publisher","first-page":"e1467","DOI":"10.1111\/aos.14812","article-title":"Prognostic impact of Notch1 receptor and clinicopathological high-risk predictors in lacrimal gland adenoid cystic carcinoma","volume":"99","author":"Anjum","year":"2021","journal-title":"Acta Ophthalmol"},{"issue":"6729","key":"bib19","doi-asserted-by":"publisher","first-page":"714","DOI":"10.1038\/19539","article-title":"p63 is essential for regenerative proliferation in limb, craniofacial and epithelial development","volume":"398","author":"Yang","year":"1999","journal-title":"Nature"},{"issue":"6880","key":"bib20","doi-asserted-by":"publisher","first-page":"560","DOI":"10.1038\/416560a","article-title":"p63 and p73 are required for p53-dependent apoptosis in response to DNA damage","volume":"416","author":"Flores","year":"2002","journal-title":"Nature"},{"key":"bib21","doi-asserted-by":"publisher","first-page":"280","DOI":"10.1097\/00125480-200209000-00002","article-title":"Taking advantage of basic research: p63 is a reliable myoepithelial and stem cell marker","volume":"9","author":"Reis-Filho","year":"2002","journal-title":"Adv Anat Pathol"},{"issue":"10","key":"bib22","doi-asserted-by":"publisher","first-page":"1600","DOI":"10.1038\/cdd.2010.37","article-title":"Antagonistic roles of Notch and p63 in controlling mammary epithelial cell fates","volume":"17","author":"Yalcin-Ozuysal","year":"2010","journal-title":"Cell Death Differ"},{"key":"bib23","doi-asserted-by":"publisher","first-page":"1028","DOI":"10.1101\/gad.1406006","article-title":"Cross-regulation between Notch and p63 in keratinocyte commitment to differentiation","volume":"20","author":"Nguyen","year":"2006","journal-title":"Genes Dev"},{"key":"bib24","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1038\/ng.3502","article-title":"An oncogenic MYB feedback loop drives alternate cell fates in adenoid cystic carcinoma","volume":"48","author":"Drier","year":"2016","journal-title":"Nat Genet"},{"key":"bib25","doi-asserted-by":"publisher","first-page":"9031","DOI":"10.18632\/oncotarget.3320","article-title":"WIP1 stimulates migration and invasion of salivary adenoid cystic carcinoma by inducing MMP-9 and VEGF-C","volume":"6","author":"Tang","year":"2015","journal-title":"Oncotarget"},{"key":"bib26","doi-asserted-by":"publisher","first-page":"278","DOI":"10.1016\/j.bcmd.2007.05.007","article-title":"Revisiting a selection of target genes for the hematopoietic transcription factor c-Myb using chromatin immunoprecipitation and c-Myb knockdown","volume":"39","author":"Berge","year":"2007","journal-title":"Blood Cells Mol Dis"},{"key":"bib27","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1146\/annurev-pathol-052016-100127","article-title":"The varied roles of Notch in cancer","volume":"12","author":"Aster","year":"2017","journal-title":"Annu Rev Pathol"},{"key":"bib28","doi-asserted-by":"publisher","first-page":"2130","DOI":"10.1016\/j.ophtha.2013.03.030","article-title":"Adenoid cystic carcinoma of the lacrimal gland: MYB gene activation, genomic imbalances, and clinical characteristics","volume":"120","author":"von Holstein","year":"2013","journal-title":"Ophthalmology"},{"key":"bib29","doi-asserted-by":"publisher","first-page":"1135","DOI":"10.1007\/s11864-022-01001-y","article-title":"Metastatic adenoid cystic carcinoma: genomic landscape and emerging treatments","volume":"23","author":"de Sousa","year":"2022","journal-title":"Curr Treat Options Oncol"}],"container-title":["Investigative Ophthalmology & Visual Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/iovs.arvojournals.org\/article.aspx?articleid=2800757","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:31:54Z","timestamp":1791927114000},"score":1,"resource":{"primary":{"URL":"https:\/\/iovs.arvojournals.org\/article.aspx?articleid=2800757"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,4]]},"references-count":29,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2024,9,3]]}},"URL":"https:\/\/doi.org\/10.1167\/iovs.65.11.4","relation":{},"ISSN":["1552-5783"],"issn-type":[{"value":"1552-5783","type":"print"}],"subject":[],"published":{"date-parts":[[2024,9,4]]}}}