{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T22:01:17Z","timestamp":1791928877532,"version":"4.3.4"},"reference-count":44,"publisher":"Association for Research in Vision and Ophthalmology (ARVO)","issue":"11","license":[{"start":{"date-parts":[[2024,9,27]],"date-time":"2024-09-27T00:00:00Z","timestamp":1727395200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Invest. Ophthalmol. Vis. Sci."],"published-print":{"date-parts":[[2024,9,27]]},"DOI":"10.1167\/iovs.65.11.41","type":"journal-article","created":{"date-parts":[[2024,9,27]],"date-time":"2024-09-27T10:31:00Z","timestamp":1727433060000},"page":"41","source":"Crossref","is-referenced-by-count":2,"title":["Effects of Short-Term Treatment of Rabbit Extraocular Muscle With Ciliary Neurotrophic Factor"],"prefix":"10.1167","volume":"65","author":[{"given":"Jolene C.","family":"Rudell","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, University of California San Diego, La Jolla, California, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda K.","family":"McLoon","sequence":"additional","affiliation":[{"name":"Departments of Ophthalmology and Visual Neurosciences, University of Minnesota, Minneapolis, Minnesota, United States"},{"name":"Stem Cell Institute, University of Minnesota, Minneapolis, Minnesota, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"27","reference":[{"key":"bib1","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1016\/j.neuroscience.2013.06.050","article-title":"Neuroprotective effects of NGF, BDNF, NT-3, and GDNF on axotomized extraocular motoneurons in neonatal rats","volume":"250","author":"Morcuende","year":"2013","journal-title":"Neuroscience"},{"issue":"12","key":"bib2","doi-asserted-by":"publisher","first-page":"2016","DOI":"10.3390\/ijms17122016","article-title":"Functional diversity of neurotrophin actions on the oculomotor system","volume":"17","author":"Ben\u00edtez-Termi\u00f1o","year":"2016","journal-title":"Int J Molec Sci"},{"key":"bib3","doi-asserted-by":"publisher","first-page":"399","DOI":"10.3389\/fnins.2017.00399","article-title":"Extraocular motor system exhibits a higher expression of neurotrophins when compared to other brainstem motor systems","volume":"11","author":"Hern\u00e1ndez","year":"2017","journal-title":"Front Neurosci"},{"issue":"3","key":"bib4","doi-asserted-by":"publisher","first-page":"747","DOI":"10.3390\/cells9030747","article-title":"Muscle progenitors derived from extraocular muscles express higher levels of neurotrophins and their receptors than other cranial and limb muscles","volume":"9","author":"Carrero-Rojas","year":"2020","journal-title":"Cells"},{"issue":"10","key":"bib5","doi-asserted-by":"publisher","first-page":"e109833","DOI":"10.1371\/journal.pone.0109833","article-title":"Analysis of neurotrophic factors in limb and extraocular muscles of mouse model of amyotrophic lateral sclerosis","volume":"9","author":"Harandi","year":"2014","journal-title":"PLoS One"},{"issue":"15","key":"bib6","doi-asserted-by":"publisher","first-page":"6831","DOI":"10.1167\/iovs.16-20074","article-title":"Unchanged neurotrophic factors and their receptors correlate with sparing in extraocular muscles in amyotrophic lateral sclerosis","volume":"57","author":"Harandi","year":"2016","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib7","doi-asserted-by":"publisher","first-page":"25960","DOI":"10.1038\/srep25960","article-title":"Differential neuronal vulnerability identifies IGF-2 as a protective factor in ALS","volume":"6","author":"Allodi","year":"2016","journal-title":"Sci Rep"},{"key":"bib8","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1080\/2576117X.2021.1893585","article-title":"Childhood onset strabismus: a neurotrophic factor hypothesis","volume":"71","author":"Rudell","year":"2021","journal-title":"J Binocul Vis Ocul Motil"},{"key":"bib9","doi-asserted-by":"publisher","first-page":"2461","DOI":"10.1167\/iovs.05-1416","article-title":"Increased extraocular muscle strength with direct injection of insulin-like growth factor-I","volume":"47","author":"Anderson","year":"2006","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"10","key":"bib10","doi-asserted-by":"publisher","first-page":"3538","DOI":"10.1167\/iovs.04-0393","article-title":"Role of exogenous and endogenous trophic factors in the regulation of extraocular muscle strength during development","volume":"45","author":"Chen","year":"2004","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"9","key":"bib11","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1167\/iovs.62.9.34","article-title":"Effect of fibroblast growth factor 2 on extraocular muscle structure and function","volume":"62","author":"Rudell","year":"2021","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib12","doi-asserted-by":"publisher","first-page":"6070","DOI":"10.1167\/iovs.16-19739","article-title":"Improvement of eye alignment in adult strabismic monkeys by sustained IGF-1 treatment","volume":"57","author":"McLoon","year":"2016","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"6","key":"bib13","doi-asserted-by":"publisher","first-page":"3484","DOI":"10.1167\/iovs.15-16761","article-title":"Adaptability of the immature ocular motor control system: unilateral IGF-1 medial rectus treatment","volume":"56","author":"Willoughby","year":"2015","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"1","key":"bib14","doi-asserted-by":"publisher","first-page":"11927","DOI":"10.1038\/s41598-020-68743-3","article-title":"Eye alignment changes causes by sustained GDNF treatment of an extraocular muscle in infant non-human primates","volume":"10","author":"Fleuriet","year":"2020","journal-title":"Sci Rep"},{"issue":"14","key":"bib15","doi-asserted-by":"publisher","first-page":"6040","DOI":"10.1167\/iovs.16-20481","article-title":"Longitudinal evaluation of eye misalignment and eye movements following surgical correction of strabismus surgery in monkeys","volume":"57","author":"Pullela","year":"2016","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"12","key":"bib16","doi-asserted-by":"publisher","first-page":"5011","DOI":"10.1167\/iovs.18-25245","article-title":"Neural plasticity following surgical correction of strabismus in monkeys","volume":"59","author":"Pullela","year":"2018","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib17","doi-asserted-by":"publisher","first-page":"5168","DOI":"10.1167\/iovs.12-9785","article-title":"Differences in gene expression between strabismic and normal human extraocular muscles","volume":"53","author":"Altick","year":"2012","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib18","doi-asserted-by":"publisher","first-page":"5576","DOI":"10.1167\/iovs.16-20294","article-title":"Altered protein composition and gene expression in strabismic human extraocular muscles and tendons","volume":"57","author":"Agarwal","year":"2016","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"12","key":"bib19","doi-asserted-by":"publisher","first-page":"E2486","DOI":"10.1073\/pnas.1615372114","article-title":"Novel combinatorial screening identified neurotrophic factors for selective classes of motor neurons","volume":"114","author":"Schaller","year":"2017","journal-title":"Proc Natl Acad Sci USA"},{"key":"bib20","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1167\/iovs.07-0600","article-title":"Myogenic growth factors can decrease extraocular muscle force generation: a potential biological approach to the treatment of strabismus","volume":"49","author":"Anderson","year":"2008","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"8","key":"bib21","doi-asserted-by":"publisher","first-page":"e0202861","DOI":"10.1371\/journal.pone.0202861","article-title":"Changing muscle function with sustained glial derived neurotrophic factor treatment of rabbit extraocular muscle","volume":"13","author":"Fitzpatrick","year":"2018","journal-title":"PLoS One"},{"key":"bib22","doi-asserted-by":"publisher","first-page":"4021","DOI":"10.1167\/iovs.10-6878","article-title":"Sustained release of bone morphogenetic protein-4 in adult rabbit extraocular muscle results in decreased force and muscle size: potential for strabismus treatment","volume":"52","author":"Anderson","year":"2011","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib23","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1007\/s00424-011-0925-6","article-title":"How to make rapid eye movements \u201crapid\u201d: the role of growth factors for muscle contractile properties","volume":"461","author":"Li","year":"2011","journal-title":"Pflugers Arch \u2013 Eur J Physiol"},{"key":"bib24","doi-asserted-by":"publisher","first-page":"975","DOI":"10.1007\/s10792-019-01270-x","article-title":"NGF and CNTF expression and regulation mechanism by miRNA in acute paralytic strabismus","volume":"40","author":"Liu","year":"2020","journal-title":"Int Ophthalmol"},{"key":"bib25","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1126\/science.1648265","article-title":"The receptor for ciliary neurotrophic factor","volume":"253","author":"Davis","year":"1991","journal-title":"Science"},{"key":"bib26","doi-asserted-by":"publisher","first-page":"1736","DOI":"10.1126\/science.7681218","article-title":"Released form of CNTF receptor a component as a soluble mediator of CNTF responses","volume":"259","author":"Davis","year":"1993","journal-title":"Science"},{"key":"bib27","doi-asserted-by":"publisher","first-page":"493","DOI":"10.1016\/0092-8674(94)90113-9","article-title":"Trophic effect of ciliary neurotrophic factor on denervated skeletal muscle","volume":"76","author":"Helgren","year":"1994","journal-title":"Cell"},{"key":"bib28","doi-asserted-by":"publisher","first-page":"2393","DOI":"10.1046\/j.1471-4159.1995.65062393.x","article-title":"Cloning of the a component of the chick ciliary neurotrophic receptor: developmental expression and down-regulation in denervated skeletal muscle","volume":"65","author":"Ip","year":"1995","journal-title":"J Neurochem"},{"key":"bib29","doi-asserted-by":"publisher","first-page":"408","DOI":"10.1038\/nn1653","article-title":"Selective vulnerability and pruning of phasic motoneuron axons in motoneuron disease alleviated by CNTF","volume":"9","author":"Pun","year":"2006","journal-title":"Nature Neurosci"},{"key":"bib30","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1038\/365027a0","article-title":"Disruption of the CNTF gene results in motor neuron degeneration","volume":"365","author":"Masu","year":"1993","journal-title":"Nature"},{"issue":"3","key":"bib31","doi-asserted-by":"publisher","first-page":"312","DOI":"10.1111\/j.1529-8027.2012.00419.x","article-title":"Exogenous ciliary neurotrophic factor (CNTF) reduces synaptic depression during repetitive stimulation","volume":"17","author":"Garcia","year":"2021","journal-title":"J Peripher Nerv Syst"},{"key":"bib32","doi-asserted-by":"publisher","first-page":"5834","DOI":"10.1167\/iovs.16-19679","article-title":"Prolongation of relaxation time in extraocular muscles with brain derived neurotrophic factor in adult rabbit","volume":"57","author":"Nelson","year":"2016","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib33","doi-asserted-by":"publisher","first-page":"88","DOI":"10.3368\/aoj.61.1.88","article-title":"Incomitant strabismus: does extraocular muscle form denote function?","volume":"61","author":"Kushner","year":"2011","journal-title":"Amer Orthop J"},{"key":"bib34","doi-asserted-by":"crossref","first-page":"3866","DOI":"10.1167\/iovs.03-0223","article-title":"Increasing extraocular muscle strength with insulin-like growth factor II","volume":"443","author":"McLoon","year":"2003","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"5","key":"bib35","doi-asserted-by":"publisher","first-page":"424","DOI":"10.1016\/j.jaapos.2006.06.011","article-title":"Increasing muscle strength as a treatment for strabismus: sustained release of insulin-like growth factor-1 in rabbit extraocular muscle","volume":"10","author":"McLoon","year":"2006","journal-title":"J AAPOS"},{"key":"bib36","doi-asserted-by":"publisher","first-page":"627","DOI":"10.1113\/jphysiol.1989.sp017595","article-title":"The force-velocity relationship at high shortening velocities in the soleus muscle of the rat","volume":"411","author":"Claflin","year":"1989","journal-title":"J Physiol"},{"key":"bib37","doi-asserted-by":"publisher","first-page":"240","DOI":"10.1007\/BF01843577","article-title":"Correlation between shortening velocity, force-velocity relation and histochemical fibre-type composition in rat muscles","volume":"11","author":"Ranatunga","year":"1990","journal-title":"J Musc Res Cell Motil"},{"key":"bib38","doi-asserted-by":"publisher","first-page":"1178","DOI":"10.1152\/japplphysiol.00368.2011","article-title":"A continuum of myofibers in adult rabbit extraocular muscle: force, shortening velocity, and patterns of myosin heavy chain colocalization","volume":"111","author":"McLoon","year":"2011","journal-title":"J Appl Physiol"},{"key":"bib39","first-page":"652","article-title":"Extraocular muscle forces in normal human subjects","volume":"20","author":"Collins","year":"1981","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib40","first-page":"223","article-title":"Measurements of active and passive force of horizontal muscles in strabismus","volume":"32","author":"Iwashige","year":"1988","journal-title":"Jpn J Ophthalmol"},{"key":"bib41","doi-asserted-by":"publisher","first-page":"791","DOI":"10.1016\/S0002-9394(14)70324-1","article-title":"Length-tension properties of extraocular muscles in patients with esotropia and intermittent exotropia","volume":"117","author":"Rosenbaum","year":"1994","journal-title":"Am J Ophthalmol"},{"key":"bib42","doi-asserted-by":"publisher","first-page":"197","DOI":"10.3109\/09273979409035475","article-title":"Force-length recording of eye muscles during local-anesthesia surgery in 32 strabismus patients","volume":"2","author":"Simonsz","year":"1994","journal-title":"Strabismus"},{"key":"bib43","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1080\/09273970490522515","article-title":"Applied force and elongation in the medial rectus in esotropic patients with and without movement restriction","volume":"12","author":"Krieger","year":"2004","journal-title":"Strabismus"},{"key":"bib44","doi-asserted-by":"publisher","first-page":"539","DOI":"10.1007\/s00417-005-0183-4","article-title":"Isometric force measured in human horizontal eye muscles attached to or detached from the globe","volume":"244","author":"Lennerstrand","year":"2006","journal-title":"Graefes Arch Clin Exp Ophthalmol"}],"container-title":["Investigative Ophthalmology &amp; Visual Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/iovs.arvojournals.org\/article.aspx?articleid=2800847","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:31:54Z","timestamp":1791927114000},"score":1,"resource":{"primary":{"URL":"https:\/\/iovs.arvojournals.org\/article.aspx?articleid=2800847"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,27]]},"references-count":44,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2024,9,3]]}},"URL":"https:\/\/doi.org\/10.1167\/iovs.65.11.41","relation":{},"ISSN":["1552-5783"],"issn-type":[{"value":"1552-5783","type":"print"}],"subject":[],"published":{"date-parts":[[2024,9,27]]}}}