{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T22:00:42Z","timestamp":1791928842770,"version":"4.3.4"},"reference-count":34,"publisher":"Association for Research in Vision and Ophthalmology (ARVO)","issue":"12","license":[{"start":{"date-parts":[[2024,10,4]],"date-time":"2024-10-04T00:00:00Z","timestamp":1728000000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Invest. Ophthalmol. Vis. Sci."],"published-print":{"date-parts":[[2024,10,4]]},"DOI":"10.1167\/iovs.65.12.3","type":"journal-article","created":{"date-parts":[[2024,10,4]],"date-time":"2024-10-04T10:31:01Z","timestamp":1728037861000},"page":"3","source":"Crossref","is-referenced-by-count":13,"title":["Predictors of Discordance Between Dry Eye Symptoms and Signs: Insights From the Sj\u00f6gren's International Collaborative Clinical Alliance"],"prefix":"10.1167","volume":"65","author":[{"given":"Fanxiu","family":"Xiong","sequence":"first","affiliation":[{"name":"Francis I. Proctor Foundation, University of California San Francisco, San Francisco, California, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin F.","family":"Arnold","sequence":"additional","affiliation":[{"name":"Francis I. Proctor Foundation, University of California San Francisco, San Francisco, California, United States"},{"name":"Department of Ophthalmology, University of California San Francisco, San Francisco, California, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas M.","family":"Lietman","sequence":"additional","affiliation":[{"name":"Francis I. Proctor Foundation, University of California San Francisco, San Francisco, California, United States"},{"name":"Department of Ophthalmology, University of California San Francisco, San Francisco, California, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John A.","family":"Gonzales","sequence":"additional","affiliation":[{"name":"Francis I. Proctor Foundation, University of California San Francisco, San Francisco, California, United States"},{"name":"Department of Ophthalmology, University of California San Francisco, San Francisco, California, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"27","reference":[{"issue":"23","key":"bib1","doi-asserted-by":"publisher","first-page":"2212","DOI":"10.1056\/NEJMra1407936","article-title":"Dry eye","volume":"378","author":"Clayton","year":"2018","journal-title":"N Engl J Med"},{"issue":"4","key":"bib2","doi-asserted-by":"publisher","first-page":"802","DOI":"10.1016\/j.jtos.2017.08.003","article-title":"TFOS DEWS II report executive summary","volume":"15","author":"Craig","year":"2017","journal-title":"Ocul Surf"},{"issue":"3","key":"bib3","doi-asserted-by":"publisher","first-page":"334","DOI":"10.1016\/j.jtos.2017.05.003","article-title":"TFOS DEWS II epidemiology report","volume":"15","author":"Stapleton","year":"2017","journal-title":"Ocul Surf"},{"issue":"4","key":"bib4","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1007\/s10384-010-0812-2","article-title":"Association between clinical diagnostic tests and health-related quality of life surveys in patients with dry eye syndrome","volume":"54","author":"Mizuno","year":"2010","journal-title":"Jpn J Ophthalmol"},{"key":"bib5","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1016\/j.ajo.2015.11.017","article-title":"Clinical characteristics of dry eye patients with chronic pain syndromes","volume":"162","author":"Vehof","year":"2016","journal-title":"Am J Ophthalmol"},{"issue":"3","key":"bib6","doi-asserted-by":"publisher","first-page":"280","DOI":"10.1016\/j.ophtha.2016.11.008","article-title":"Predictors of discordance between symptoms and signs in dry eye disease","volume":"124","author":"Vehof","year":"2017","journal-title":"Ophthalmology"},{"issue":"4","key":"bib7","doi-asserted-by":"publisher","first-page":"475","DOI":"10.1002\/acr.21591","article-title":"American college of rheumatology classification criteria for Sj\u00f6gren's syndrome: a data-driven, expert consensus approach in the SICCA cohort","volume":"64","author":"Shiboski","year":"2012","journal-title":"Arthritis Care Res (Hoboken)"},{"issue":"1","key":"bib8","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1002\/art.39859","article-title":"2016 American college of rheumatology\/European league against rheumatism classification criteria for primary Sj\u00f6gren's syndrome: a consensus and data-driven methodology involving three international patient cohorts","volume":"69","author":"Shiboski","year":"2017","journal-title":"Arthritis Rheumatol"},{"issue":"4","key":"bib9","doi-asserted-by":"publisher","first-page":"817","DOI":"10.1016\/j.jtos.2019.08.008","article-title":"The development and evaluation of the new Ocular Surface Disease Index-6","volume":"17","author":"Pult","year":"2019","journal-title":"Ocul Surf"},{"issue":"1","key":"bib11","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1186\/s41512-020-00074-3","article-title":"State of the art in selection of variables and functional forms in multivariable analysis\u2014outstanding issues","volume":"4","author":"Sauerbrei","year":"2020","journal-title":"Diagn Progn Res"},{"issue":"9","key":"bib13","doi-asserted-by":"publisher","first-page":"5722","DOI":"10.1167\/iovs.11-9094","article-title":"Assessment of vision-related quality of life in dry eye patients","volume":"53","author":"Li","year":"2012","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"2","key":"bib14","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1007\/s40135-013-0009-1","article-title":"Dry eye disease: impact on quality of life and vision","volume":"1","author":"Uchino","year":"2013","journal-title":"Curr Ophthalmol Rep"},{"issue":"7","key":"bib15","doi-asserted-by":"publisher","first-page":"869","DOI":"10.1097\/ICO.0000000000002580","article-title":"Ocular discomfort and quality of life among patients in the Dry Eye Assessment and Management (DREAM) study","volume":"40","author":"Sayegh","year":"2021","journal-title":"Cornea"},{"issue":"4","key":"bib16","doi-asserted-by":"publisher","first-page":"392","DOI":"10.1001\/jamaophthalmol.2022.0140","article-title":"Association between depression and severity of dry eye symptoms, signs, and inflammatory markers in the DREAM study","volume":"140","author":"Zhou","year":"2022","journal-title":"JAMA Ophthalmol"},{"issue":"6","key":"bib17","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1167\/tvst.7.6.35","article-title":"The relationship of dry eye disease with depression and anxiety: a naturalistic observational study","volume":"7","author":"Kitazawa","year":"2018","journal-title":"Transl Vis Sci Technol"},{"key":"bib18","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1016\/j.ajo.2018.04.004","article-title":"How are ocular signs and symptoms of dry eye associated with depression in women with and without Sj\u00f6gren syndrome?","volume":"191","author":"Gonzales","year":"2018","journal-title":"Am J Ophthalmol"},{"key":"bib19","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1016\/j.ajo.2022.09.016","article-title":"How are sicca signs and symptoms associated with depression among men classified with and without Sj\u00f6gren disease?","volume":"247","author":"Nortey","year":"2023","journal-title":"Am J Ophthalmol"},{"issue":"6","key":"bib21","doi-asserted-by":"publisher","first-page":"919","DOI":"10.1007\/s00192-015-2911-6","article-title":"Dry eye findings worsen with anticholinergic therapy in patients with urge incontinence","volume":"27","author":"Ozen Tunay","year":"2016","journal-title":"Int Urogynecology J"},{"issue":"2","key":"bib22","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1097\/ICU.0b013e32808738d5","article-title":"Drug-induced acute angle closure glaucoma","volume":"18","author":"Lachkar","year":"2007","journal-title":"Curr Opin Ophthalmol"},{"issue":"suppl 2","key":"bib25","first-page":"20","article-title":"Managing anticholinergic side effects","volume":"6","author":"Lieberman","year":"2004","journal-title":"Prim Care Companion J Clin Psychiatry"},{"issue":"1","key":"bib27","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1016\/j.jtos.2018.09.005","article-title":"Ethnic differences between the Asian and Caucasian ocular surface: a co-located adult migrant population cohort study","volume":"17","author":"Craig","year":"2019","journal-title":"Ocul Surf"},{"issue":"1","key":"bib28","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1167\/iovs.65.1.23","article-title":"Sj\u00f6gren's versus non-Sj\u00f6gren's ocular features: similar symptoms, but significantly worse signs","volume":"65","author":"Xiong","year":"2024","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib29","doi-asserted-by":"publisher","first-page":"702755","DOI":"10.3389\/fimmu.2021.702755","article-title":"Differentially expressed gene pathways in the conjunctiva of Sj\u00f6gren syndrome keratoconjunctivitis sicca","volume":"12","author":"de Paiva","year":"2021","journal-title":"Front Immunol"},{"issue":"6","key":"bib30","doi-asserted-by":"publisher","first-page":"2545","DOI":"10.1167\/iovs.02-1260","article-title":"Corneal innervation and morphology in primary Sj\u00f6gren's syndrome","volume":"44","author":"Tuominen","year":"2003","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"5","key":"bib31","doi-asserted-by":"publisher","first-page":"674","DOI":"10.1136\/bjophthalmol-2017-310633","article-title":"Epidemiology of discordance between symptoms and signs of dry eye","volume":"102","author":"Ong","year":"2018","journal-title":"Br J Ophthalmol"},{"issue":"8","key":"bib32","doi-asserted-by":"publisher","first-page":"1013","DOI":"10.1097\/ICO.0000000000002311","article-title":"Ocular clinical signs and diagnostic tests most compatible with keratoconjunctivitis sicca: a latent class approach","volume":"39","author":"Gonzales","year":"2020","journal-title":"Cornea"},{"issue":"5","key":"bib33","doi-asserted-by":"publisher","first-page":"292","DOI":"10.1002\/acr2.1033","article-title":"Reproducibility of ocular surface staining in the assessment of Sj\u00f6gren syndrome\u2013related keratoconjunctivitis sicca: implications on disease classification","volume":"1","author":"Rasmussen","year":"2019","journal-title":"ACR Open Rheumatol"},{"issue":"2, suppl","key":"bib34","doi-asserted-by":"publisher","first-page":"S1","DOI":"10.1016\/j.jtos.2014.02.002","article-title":"Rethinking dry eye disease: a perspective on clinical implications","volume":"12","author":"Bron","year":"2014","journal-title":"Ocul Surf"},{"key":"bib10","article-title":"Package \u2018missRanger\u2019","author":"Mayer"},{"key":"bib12","volume-title":"How to Score the SF-12 Physical and Mental Summary Scales","author":"Ware"},{"key":"bib20","article-title":"How systemic drugs trigger dry eye disease","author":"Gilberson Kuiken"},{"key":"bib23","article-title":"Stress","author":"Mind"},{"key":"bib24","doi-asserted-by":"crossref","article-title":"Migraine","author":"National Institute of Neurological Disorders and Stroke","DOI":"10.32388\/211831"},{"key":"bib26","article-title":"Dangers of second-hand smoke","author":"NHS Inform"}],"container-title":["Investigative Ophthalmology & Visual Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/iovs.arvojournals.org\/article.aspx?articleid=2802089","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:31:51Z","timestamp":1791927111000},"score":1,"resource":{"primary":{"URL":"https:\/\/iovs.arvojournals.org\/article.aspx?articleid=2802089"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,4]]},"references-count":34,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2024,10,1]]}},"URL":"https:\/\/doi.org\/10.1167\/iovs.65.12.3","relation":{},"ISSN":["1552-5783"],"issn-type":[{"value":"1552-5783","type":"print"}],"subject":[],"published":{"date-parts":[[2024,10,4]]}}}