{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T22:00:52Z","timestamp":1791928852118,"version":"4.3.4"},"reference-count":52,"publisher":"Association for Research in Vision and Ophthalmology (ARVO)","issue":"13","license":[{"start":{"date-parts":[[2024,11,6]],"date-time":"2024-11-06T00:00:00Z","timestamp":1730851200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Invest. Ophthalmol. Vis. Sci."],"published-print":{"date-parts":[[2024,11,6]]},"DOI":"10.1167\/iovs.65.13.10","type":"journal-article","created":{"date-parts":[[2024,11,6]],"date-time":"2024-11-06T11:30:48Z","timestamp":1730892648000},"page":"10","source":"Crossref","is-referenced-by-count":6,"title":["Mechanisms Regulating Mitochondrial Transfer in Human Corneal Epithelial Cells"],"prefix":"10.1167","volume":"65","author":[{"given":"Sonali","family":"Pal-Ghosh","sequence":"first","affiliation":[{"name":"Department of Anatomy and Cell Biology, GW School of Medicine and Health Sciences, Washington, District of Columbia, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beverly A.","family":"Karpinski","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Cell Biology, GW School of Medicine and Health Sciences, Washington, District of Columbia, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Himani","family":"Datta-Majumdar","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Cell Biology, GW School of Medicine and Health Sciences, Washington, District of Columbia, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soneha","family":"Datta","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Cell Biology, GW School of Medicine and Health Sciences, Washington, District of Columbia, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shelly","family":"Dimri","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Cell Biology, GW School of Medicine and Health Sciences, Washington, District of Columbia, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jordan","family":"Hally","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Cell Biology, GW School of Medicine and Health Sciences, Washington, District of Columbia, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hugo","family":"Wehmeyer","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Cell Biology, GW School of Medicine and Health Sciences, Washington, District of Columbia, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary Ann","family":"Stepp","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Cell Biology, GW School of Medicine and Health Sciences, Washington, District of Columbia, United States"},{"name":"Department of Ophthalmology, GW School of Medicine and Health Sciences, Washington, District of Columbia, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"27","reference":[{"key":"bib1","doi-asserted-by":"publisher","first-page":"851","DOI":"10.1002\/glia.23102","article-title":"Corneal epithelial cells function as surrogate Schwann cells for their sensory nerves","volume":"65","author":"Stepp","year":"2017","journal-title":"GLIA"},{"issue":"11","key":"bib2","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1167\/iovs.61.11.1","article-title":"Diurnal control of sensory axon growth and shedding in the mouse cornea","volume":"61","author":"Pal-Ghosh","year":"2020","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib3","doi-asserted-by":"publisher","first-page":"107998","DOI":"10.1016\/j.exer.2020.107998","article-title":"Axonal debris accumulates in corneal epithelial cells after intraepithelial corneal nerves are damaged: a focused ion beam scanning electron microscopy (FIB-SEM) study","volume":"194","author":"Parlanti","year":"2020","journal-title":"Exp Eye Res"},{"key":"bib4","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1038\/s41586-023-06537-z","article-title":"The power and potential of mitochondria transfer","volume":"623","author":"Borcherding","year":"2023","journal-title":"Nature"},{"key":"bib5","doi-asserted-by":"publisher","first-page":"755","DOI":"10.1016\/j.jconrel.2023.01.059","article-title":"Mechanisms behind therapeutic potentials of mesenchymal stem cell mitochondria transfer\/delivery","volume":"354","author":"Malekpour","year":"2023","journal-title":"J Control Rel"},{"key":"bib6","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1016\/j.mito.2022.05.002","article-title":"Mitochondria transfer and transplantation in human health and diseases","volume":"65","author":"Wang","year":"2022","journal-title":"Mitochondrion"},{"issue":"3","key":"bib7","doi-asserted-by":"publisher","first-page":"e202211044","DOI":"10.1083\/jcb.202211044","article-title":"Mitochondria on the move: horizontal mitochondrial transfer in disease and health","volume":"222","author":"Dong","year":"2023","journal-title":"J Cell Biol"},{"key":"bib8","doi-asserted-by":"publisher","first-page":"107","DOI":"10.3389\/fcell.2016.00107","article-title":"Mitochondria know no boundaries: mechanisms and functions of intercellular mitochondrial transfer","volume":"4","author":"Torralba","year":"2016","journal-title":"Front Cell Dev Biol"},{"key":"bib9","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1016\/j.cmet.2020.12.006","article-title":"Platelets facilitate the wound-healing capability of mesenchymal stem cells by mitochondrial transfer and metabolic reprogramming","volume":"33","author":"Levoux","year":"2021","journal-title":"Cell Metab"},{"key":"bib10","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1016\/j.trsl.2021.03.017","article-title":"Mitochondria transplantation protects traumatic brain injury via promoting neuronal survival and astrocytic BDNF","volume":"235","author":"Zhao","year":"2021","journal-title":"Transl Res"},{"key":"bib11","doi-asserted-by":"publisher","first-page":"551","DOI":"10.1038\/nature18928","article-title":"Transfer of mitochondria from astrocytes to neurons after stroke","volume":"535","author":"Hayakawa","year":"2016","journal-title":"Nature"},{"issue":"12","key":"bib12","doi-asserted-by":"publisher","first-page":"10294","DOI":"10.3390\/ijms241210294","article-title":"Extracellular vesicles and Cx43-gap junction channels are the main routes for mitochondrial transfer from ultra-purified mesenchymal stem cells, RECs.","volume":"24","author":"Yang","year":"2023","journal-title":"Int J Mol Sci"},{"key":"bib13","doi-asserted-by":"publisher","first-page":"174","DOI":"10.1111\/tra.12786","article-title":"Transfer of mitochondria and endosomes between cells by gap junction internalization","volume":"22","author":"Norris","year":"2021","journal-title":"Traffic"},{"key":"bib14","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3390\/ijms21144995","article-title":"From cell entry to engraftment of exogenous mitochondria","volume":"21","author":"Kami","year":"2020","journal-title":"Int J Mol Sci"},{"key":"bib15","doi-asserted-by":"publisher","first-page":"109497","DOI":"10.1016\/j.exer.2023.109497","article-title":"Tunneling nanotubes-based intercellular mitochondrial trafficking as a novel therapeutic target in dry eye","volume":"232","author":"Jiang","year":"2023","journal-title":"Exp Eye Res"},{"key":"bib16","doi-asserted-by":"publisher","first-page":"472","DOI":"10.1111\/ceo.14224","article-title":"ROCK inhibitors in ophthalmology: a critical review of the existing clinical evidence","volume":"51","author":"Karri","year":"2023","journal-title":"Clin Exp Ophthalmol"},{"key":"bib17","doi-asserted-by":"publisher","first-page":"399","DOI":"10.31925\/farmacia.2021.3.2","article-title":"Rho-kinase inhibitors\u2014a new broad-spectrum treatment in ophthalmic diseases. A review","volume":"69","author":"Iancu","year":"2021","journal-title":"Farmacia"},{"key":"bib18","doi-asserted-by":"publisher","first-page":"1101","DOI":"10.1007\/s00417-019-04283-5","article-title":"Rho kinase inhibitors\u2014a review on the physiology and clinical use in ophthalmology","volume":"257","author":"Moura-Coelho","year":"2019","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"key":"bib19","doi-asserted-by":"publisher","first-page":"2439","DOI":"10.1167\/iovs.12-11320","article-title":"The ROCK inhibitor eye drop accelerates corneal endothelium wound healing","volume":"54","author":"Okumura","year":"2013","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib20","first-page":"652","article-title":"Rho\/ROCK pathway and neural regeneration: a potential therapeutic target for central nervous system and optic nerve damage","volume":"4","author":"Tan","year":"2011","journal-title":"Int J Ophthalmol"},{"key":"bib21","doi-asserted-by":"publisher","first-page":"94","DOI":"10.2174\/0113894501286195231220094646","article-title":"Rho Kinase (ROCK) Inhibitors for the Treatment of Glaucoma","volume":"25","author":"Wu","year":"2024","journal-title":"Curr Drug Targets"},{"key":"bib22","doi-asserted-by":"publisher","first-page":"5549","DOI":"10.1167\/iovs.07-0878","article-title":"Potential role of rho-associated protein kinase inhibitor Y-27632 in glaucoma filtration surgery","volume":"48","author":"Honjo","year":"2007","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib23","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1097\/FJC.0b013e318070d1bd","article-title":"Rho kinase (ROCK) inhibitors","volume":"50","author":"Liao","year":"2007","journal-title":"J Cardiovasc Pharmacol"},{"key":"bib24","doi-asserted-by":"publisher","first-page":"2496","DOI":"10.1167\/iovs.02-0851","article-title":"Mucin gene expression in immortalized human corneal-limbal and conjunctival epithelial cell lines","volume":"44","author":"Gipson","year":"2003","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib25","doi-asserted-by":"publisher","first-page":"2487","DOI":"10.1167\/iovs.02-0862","article-title":"MUC16 mucin is expressed by the human ocular surface epithelia and carries the H185 carbohydrate epitope","volume":"44","author":"Arg\u00fceso","year":"2003","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib26","doi-asserted-by":"publisher","first-page":"109353","DOI":"10.1016\/j.exer.2022.109353","article-title":"Molecular mechanisms regulating wound repair: evidence for paracrine signaling from corneal epithelial cells to fibroblasts and immune cells following transient epithelial cell treatment with mitomycin C","volume":"227","author":"Pal-Ghosh","year":"2023","journal-title":"Exp Eye Res"},{"issue":"1","key":"bib27","doi-asserted-by":"publisher","first-page":"13905","DOI":"10.1038\/s41598-019-50307-9","article-title":"Transient mitomycin C-treatment of human corneal epithelial cells and fibroblasts alters cell migration, cytokine secretion, and matrix accumulation","volume":"9","author":"Pal-Ghosh","year":"2019","journal-title":"Sci Rep"},{"key":"bib28","doi-asserted-by":"publisher","first-page":"2785","DOI":"10.1167\/iovs.17-21826","article-title":"KLF4 plays an essential role in corneal epithelial homeostasis by promoting epithelial cell fate and suppressing epithelial-mesenchymal transition","volume":"58","author":"Tiwari","year":"2017","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib29","doi-asserted-by":"publisher","first-page":"1425","DOI":"10.1167\/iovs.16-19957","article-title":"Silk-derived protein enhances corneal epithelial migration, adhesion, and proliferation","volume":"58","author":"Abdel-Naby","year":"2017","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"9","key":"bib30","doi-asserted-by":"publisher","first-page":"e44574","DOI":"10.1371\/journal.pone.0044574","article-title":"Communication between corneal epithelial cells and trigeminal neurons is facilitated by purinergic (P2) and glutamatergic receptors","volume":"7","author":"Oswald","year":"2012","journal-title":"PLoS ONE"},{"key":"bib31","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1167\/iovs.05-0735","article-title":"Mucin characteristics of human corneal-limbal epithelial cells that exclude the rose bengal anionic dye","volume":"47","author":"Arg\u00fceso","year":"2006","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib32","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1002\/cm.10161","article-title":"Myosin-mediated cytoskeleton contraction and Rho GTPases regulate laminin-5 matrix assembly","volume":"57","author":"DeHart","year":"2004","journal-title":"Cell Motil Cytoskeleton"},{"key":"bib33","doi-asserted-by":"publisher","first-page":"649","DOI":"10.1111\/j.1524-475X.2008.00423.x","article-title":"Primary dermal fibroblasts derived from sdc-1 deficient mice migrate faster and have altered av integrin function","volume":"16","author":"Jurjus","year":"2008","journal-title":"Wound Repair Regen"},{"issue":"4","key":"bib34","doi-asserted-by":"publisher","first-page":"e62095","DOI":"10.1371\/journal.pone.0062095","article-title":"ROCK inhibitor enhances adhesion and wound healing of human corneal endothelial cells","volume":"8","author":"Pipparelli","year":"2013","journal-title":"PLoS ONE"},{"key":"bib35","doi-asserted-by":"publisher","first-page":"268","DOI":"10.1016\/j.ajpath.2012.03.033","article-title":"ROCK inhibitor converts corneal endothelial cells into a phenotype capable of regenerating in vivo endothelial tissue","volume":"181","author":"Okumura","year":"2012","journal-title":"Am J Pathol"},{"key":"bib36","doi-asserted-by":"publisher","first-page":"9633","DOI":"10.1073\/pnas.1404651111","article-title":"Transcellular degradation of axonal mitochondria","volume":"111","author":"Davis","year":"2014","journal-title":"Proc Natl Acad Sci USA"},{"key":"bib37","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1186\/s12929-023-00979-3","article-title":"Extracellular release in the quality control of the mammalian mitochondria","volume":"30","author":"Pan","year":"2023","journal-title":"J Biomed Sci"},{"key":"bib38","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1186\/s13578-022-00805-7","article-title":"Mitochondrial transfer\/transplantation: an emerging therapeutic approach for multiple diseases","volume":"12","author":"Liu","year":"2022","journal-title":"Cell Biosci"},{"key":"bib39","doi-asserted-by":"publisher","first-page":"761","DOI":"10.1177\/0271678X20928147","article-title":"Mitochondrial transfer from mesenchymal stem cells improves neuronal metabolism after oxidant injury in vitro: the role of Miro1","volume":"41","author":"Tseng","year":"2021","journal-title":"J Cereb Blood Flow Metabol"},{"key":"bib40","doi-asserted-by":"publisher","first-page":"785761","DOI":"10.3389\/fnagi.2022.785761","article-title":"Neurons release injured mitochondria as \u201chelp-me\u201d signaling after ischemic stroke","volume":"14","author":"Gao","year":"2022","journal-title":"Front Aging Neurosci"},{"key":"bib41","doi-asserted-by":"publisher","first-page":"471","DOI":"10.1165\/rcmb.2017-0075OC","article-title":"The rho kinase isoforms ROCK1 and ROCK2 each contribute to the development of experimental pulmonary fibrosis","volume":"58","author":"Knipe","year":"2018","journal-title":"Am J Respir Cell Mol Biol"},{"key":"bib42","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1124\/pr.114.009381","article-title":"The rho kinases: critical mediators of multiple profibrotic processes and rational targets for new therapies for pulmonary fibrosis","volume":"67","author":"Knipe","year":"2015","journal-title":"Pharmacological Reviews"},{"key":"bib43","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/membranes10080177","article-title":"Macropinocytosis in different cell types: similarities and differences","volume":"10","author":"Lin","year":"2020","journal-title":"Membranes"},{"issue":"9","key":"bib44","doi-asserted-by":"publisher","first-page":"a029348","DOI":"10.1101\/cshperspect.a029348","article-title":"Connexins and disease","volume":"10","author":"Delmar","year":"2018","journal-title":"Cold Spring Harb Perspect Biol"},{"key":"bib45","doi-asserted-by":"publisher","first-page":"477","DOI":"10.1007\/s00232-012-9466-y","article-title":"The noncanonical functions of Cx43 in the heart","volume":"245","author":"Agullo-Pascual","year":"2012","journal-title":"J Membr Biol"},{"issue":"12","key":"bib46","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1167\/iovs.65.12.31","article-title":"ROCK inhibitor enhances neurite outgrowth in vitro and corneal sensory nerve reinnervation in vivo.","volume":"65","author":"Karpinski","year":"2024","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib47","doi-asserted-by":"publisher","first-page":"R619","DOI":"10.1016\/j.cub.2021.01.036","article-title":"The cytoskeleton in phagocytosis and macropinocytosis","volume":"31","author":"Mylvaganam","year":"2021","journal-title":"Curr Biol"},{"key":"bib48","doi-asserted-by":"publisher","first-page":"416","DOI":"10.1167\/iovs.16-21111","article-title":"Autophagy and macropinocytosis: keeping an eye on the corneal\/limbal epithelia","volume":"58","author":"Peng","year":"2017","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib49","doi-asserted-by":"publisher","first-page":"1694","DOI":"10.1111\/jcmm.12316","article-title":"Internalization of isolated functional mitochondria: involvement of macropinocytosis","volume":"18","author":"Kitani","year":"2014","journal-title":"J Cell Mol Med"},{"key":"bib50","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1111\/j.1365-2567.2006.02335.x","article-title":"Drinking a lot is good for dendritic cells","volume":"117","author":"Norbury","year":"2006","journal-title":"Immunology"},{"key":"bib51","doi-asserted-by":"publisher","first-page":"819","DOI":"10.1083\/jcb.200112107","article-title":"ROCK and mDia1 antagonize in Rho-dependent Rac activation in Swiss 3T3 fibroblasts","volume":"157","author":"Tsuji","year":"2002","journal-title":"J Cell Biol"},{"key":"bib52","doi-asserted-by":"publisher","first-page":"30564","DOI":"10.1074\/jbc.M501754200","article-title":"Tumor cell pseudopodial protrusions: localized signaling domains coordinating cytoskeleton remodeling, cell adhesion, glycolysis, RNA translocation, and protein translation","volume":"280","author":"Jia","year":"2005","journal-title":"J Biol Chem"}],"container-title":["Investigative Ophthalmology &amp; Visual Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/iovs.arvojournals.org\/article.aspx?articleid=2802211","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:31:46Z","timestamp":1791927106000},"score":1,"resource":{"primary":{"URL":"https:\/\/iovs.arvojournals.org\/article.aspx?articleid=2802211"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,6]]},"references-count":52,"journal-issue":{"issue":"13","published-print":{"date-parts":[[2024,11,4]]}},"URL":"https:\/\/doi.org\/10.1167\/iovs.65.13.10","relation":{},"ISSN":["1552-5783"],"issn-type":[{"value":"1552-5783","type":"print"}],"subject":[],"published":{"date-parts":[[2024,11,6]]}}}