{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T22:01:34Z","timestamp":1791928894505,"version":"4.3.4"},"reference-count":59,"publisher":"Association for Research in Vision and Ophthalmology (ARVO)","issue":"13","license":[{"start":{"date-parts":[[2024,11,20]],"date-time":"2024-11-20T00:00:00Z","timestamp":1732060800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Invest. Ophthalmol. Vis. Sci."],"published-print":{"date-parts":[[2024,11,20]]},"DOI":"10.1167\/iovs.65.13.44","type":"journal-article","created":{"date-parts":[[2024,11,20]],"date-time":"2024-11-20T10:30:55Z","timestamp":1732098655000},"page":"44","source":"Crossref","is-referenced-by-count":6,"title":["Metabolomic Profiling of Open-Angle Glaucoma Etiologic Endotypes: Tohoku Multi-Omics Glaucoma Study"],"prefix":"10.1167","volume":"65","author":[{"given":"Akiko","family":"Hanyuda","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Keio University School of Medicine, Shinjuku-ku, Tokyo, Japan"},{"name":"Division of Epidemiology, National Cancer Center Institute for Cancer Control, Chuo-ku, Tokyo, Japan"},{"name":"Department of Ophthalmology, Tohoku University Graduate School of Medicine, Aoba-ku, Sendai, Miyagi, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshihiko","family":"Raita","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Okinawa Prefectural Chubu Hospital, Uruma City, Naha, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takahiro","family":"Ninomiya","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Tohoku University Graduate School of Medicine, Aoba-ku, Sendai, Miyagi, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuki","family":"Hashimoto","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Tohoku University Graduate School of Medicine, Aoba-ku, Sendai, Miyagi, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoko","family":"Takada","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Tohoku University Graduate School of Medicine, Aoba-ku, Sendai, Miyagi, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kota","family":"Sato","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Tohoku University Graduate School of Medicine, Aoba-ku, Sendai, Miyagi, Japan"},{"name":"Department of Advanced Ophthalmic Medicine, Tohoku University Graduate School of Medicine, Aoba-ku, Sendai, Miyagi, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin","family":"Inoue","sequence":"additional","affiliation":[{"name":"Department of Integrative Genomics, Tohoku Medical Megabank Organization, Tohoku University, Aoba-ku, Sendai, Miyagi, Japan"},{"name":"The Advanced Research Center for Innovations in Next-Generation Medicine (INGEM), Tohoku University, Aoba-ku, Sendai, Miyagi, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seizo","family":"Koshiba","sequence":"additional","affiliation":[{"name":"Department of Integrative Genomics, Tohoku Medical Megabank Organization, Tohoku University, Aoba-ku, Sendai, Miyagi, Japan"},{"name":"The Advanced Research Center for Innovations in Next-Generation Medicine (INGEM), Tohoku University, Aoba-ku, Sendai, Miyagi, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gen","family":"Tamiya","sequence":"additional","affiliation":[{"name":"Department of Integrative Genomics, Tohoku Medical Megabank Organization, Tohoku University, Aoba-ku, Sendai, Miyagi, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akira","family":"Narita","sequence":"additional","affiliation":[{"name":"Department of Integrative Genomics, Tohoku Medical Megabank Organization, Tohoku University, Aoba-ku, Sendai, Miyagi, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masato","family":"Akiyama","sequence":"additional","affiliation":[{"name":"Department of Ocular Pathology and Imaging Science, Graduate School of Medical Sciences, Kyushu University, Higashi-ku, Fukuoka, Japan"},{"name":"Department of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, Higashi-ku, Fukuoka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuko","family":"Omodaka","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Tohoku University Graduate School of Medicine, Aoba-ku, Sendai, Miyagi, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoru","family":"Tsuda","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Tohoku University Graduate School of Medicine, Aoba-ku, Sendai, Miyagi, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Yokoyama","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Tohoku University Graduate School of Medicine, Aoba-ku, Sendai, Miyagi, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noriko","family":"Himori","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Tohoku University Graduate School of Medicine, Aoba-ku, Sendai, Miyagi, Japan"},{"name":"Department of Aging Vision Healthcare, Tohoku University Graduate School of Biomedical Engineering, Aoba-ku, Sendai, Miyagi, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuko","family":"Yamamoto","sequence":"additional","affiliation":[{"name":"Ophthalmic Innovation Center, Santen Pharmaceutical Co., Ltd, Ikoma-shi, Nara, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takazumi","family":"Taniguchi","sequence":"additional","affiliation":[{"name":"Ophthalmic Innovation Center, Santen Pharmaceutical Co., Ltd, Ikoma-shi, Nara, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuno","family":"Negishi","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Keio University School of Medicine, Shinjuku-ku, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toru","family":"Nakazawa","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Tohoku University Graduate School of Medicine, Aoba-ku, Sendai, Miyagi, Japan"},{"name":"Department of Advanced Ophthalmic Medicine, Tohoku University Graduate School of Medicine, Aoba-ku, Sendai, Miyagi, Japan"},{"name":"Department of Retinal Disease Control, Ophthalmology, Tohoku University Graduate School of Medicine, Aoba-ku, Sendai, Miyagi, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"27","reference":[{"issue":"2","key":"bib1","doi-asserted-by":"publisher","first-page":"e144","DOI":"10.1016\/S2214-109X(20)30489-7","article-title":"Vision loss expert group of the global burden of disease study. Causes of blindness and vision impairment in 2020 and trends over 30 years, and prevalence of avoidable blindness in relation to VISION 2020: the Right to Sight: an analysis for the Global Burden of Disease Study","volume":"9","author":"GBD 2019 Blindness and Vision Impairment Collaborators","year":"2021","journal-title":"Lancet Glob Health"},{"issue":"1","key":"bib2","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1097\/APO.0000000000000183","article-title":"Ocular blood flow and influencing factors for glaucoma","volume":"5","author":"Nakazawa","year":"2016","journal-title":"Asia Pac J Ophthalmol (Phila)"},{"issue":"5","key":"bib3","doi-asserted-by":"publisher","first-page":"663","DOI":"10.1016\/j.ophtha.2020.10.010","article-title":"Time-course changes in optic nerve head blood flow and retinal nerve fiber layer thickness in eyes with open-angle glaucoma","volume":"128","author":"Kiyota","year":"2021","journal-title":"Ophthalmology"},{"issue":"1","key":"bib4","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1186\/s12886-022-02587-5","article-title":"Clinical characteristics of glaucoma patients with various risk factors","volume":"22","author":"Omodaka","year":"2022","journal-title":"BMC Ophthalmol"},{"issue":"1","key":"bib5","doi-asserted-by":"publisher","first-page":"1258","DOI":"10.1038\/s41467-020-20851-4","article-title":"Genome-wide meta-analysis identifies 127 open-angle glaucoma loci with consistent effect across ancestries","volume":"12","author":"Gharahkhani","year":"2021","journal-title":"Nat Commun"},{"issue":"16","key":"bib6","doi-asserted-by":"publisher","first-page":"2646","DOI":"10.1016\/j.neuron.2022.06.022","article-title":"Single-cell transcriptome analysis of regenerating RGCs reveals potent glaucoma neural repair genes","volume":"110","author":"Li","year":"2022","journal-title":"Neuron"},{"issue":"15","key":"bib7","doi-asserted-by":"publisher","first-page":"8136","DOI":"10.3390\/ijms23158136","article-title":"Clinical tear fluid proteomics-a novel tool in glaucoma research","volume":"23","author":"N\u00e4ttinen","year":"2022","journal-title":"Int J Mol Sci"},{"key":"bib8","article-title":"Differential protein expression and metabolite profiling in glaucoma: insights from a multi-omics analysis [published online ahead of print May 31, 2024]","author":"Mok","journal-title":"Biofactors"},{"issue":"10","key":"bib9","doi-asserted-by":"publisher","first-page":"3559","DOI":"10.1007\/s10792-023-02763-6","article-title":"Comparative analysis of tear cytokines in patients with glaucoma, ocular hypertension, and healthy controls","volume":"43","author":"Mravec Bencurova","year":"2023","journal-title":"Int Ophthalmol"},{"issue":"6","key":"bib10","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1167\/iovs.62.6.9","article-title":"Metabolomics in glaucoma: a systematic review","volume":"62","author":"Wang","year":"2021","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"4","key":"bib11","doi-asserted-by":"publisher","first-page":"2439","DOI":"10.1167\/iovs.14-16088","article-title":"Comparison of risk factor profiles for primary open-angle glaucoma subtypes defined by pattern of visual field loss: a prospective study","volume":"56","author":"Kang","year":"2015","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"4","key":"bib12","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1007\/s10384-024-01071-5","article-title":"Comparative features of superior versus inferior hemisphere microvasculature dropout in open-angle glaucoma","volume":"68","author":"Takahashi","year":"2024","journal-title":"Jpn J Ophthalmol"},{"issue":"7","key":"bib13","doi-asserted-by":"publisher","first-page":"847","DOI":"10.1080\/02713683.2019.1703006","article-title":"Evaluation of papillomacular nerve fiber bundle thickness in glaucoma patients with visual acuity disturbance","volume":"45","author":"Takahashi","year":"2020","journal-title":"Curr Eye Res"},{"issue":"7","key":"bib14","doi-asserted-by":"publisher","first-page":"2650","DOI":"10.1167\/iovs.19-27230","article-title":"Sectoral differences in the association of optic nerve head blood flow and glaucomatous visual field defect severity and progression","volume":"60","author":"Kiyota","year":"2019","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"1","key":"bib15","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1016\/j.preteyeres.2003.10.003","article-title":"Mitochondrial dysfunction as a cause of optic neuropathies","volume":"23","author":"Carelli","year":"2004","journal-title":"Prog Retin Eye Res"},{"issue":"1","key":"bib16","doi-asserted-by":"publisher","first-page":"2860","DOI":"10.1038\/s41467-023-38466-w","article-title":"Plasma metabolite profile for primary open-angle glaucoma in three US cohorts and the UK Biobank","volume":"14","author":"Zeleznik","year":"2023","journal-title":"Nat Commun"},{"key":"bib17","doi-asserted-by":"publisher","first-page":"31463","DOI":"10.1038\/srep31463","article-title":"The structural origin of metabolic quantitative diversity","volume":"6","author":"Koshiba","year":"2016","journal-title":"Sci Rep"},{"issue":"11","key":"bib18","doi-asserted-by":"publisher","first-page":"2692","DOI":"10.1038\/nprot.2007.376","article-title":"Metabolic profiling, metabolomic and metabonomic procedures for NMR spectroscopy of urine, plasma, serum and tissue extracts","volume":"2","author":"Beckonert","year":"2007","journal-title":"Nat Protoc"},{"issue":"3","key":"bib19","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1093\/jb\/mvab060","article-title":"Japonica Array NEO with increased genome-wide coverage and abundant disease risk SNPs","volume":"170","author":"Sakurai-Yageta","year":"2021","journal-title":"J Biochem"},{"issue":"3S","key":"bib20","doi-asserted-by":"crossref","first-page":"S2","DOI":"10.1016\/j.je.2016.12.005","article-title":"Overview of the biobank Japan Project: study design and profile","volume":"27","author":"Nagai","year":"2017","journal-title":"J Epidemiol"},{"issue":"10","key":"bib21","doi-asserted-by":"publisher","first-page":"1809","DOI":"10.1016\/S0161-6420(00)00284-0","article-title":"Mapping the visual field to the optic disc in normal tension glaucoma eyes","volume":"107","author":"Garway-Heath","year":"2000","journal-title":"Ophthalmology"},{"issue":"1","key":"bib22","first-page":"92","article-title":"Multivariate analysis in metabolomics","volume":"1","author":"Worley","year":"2013","journal-title":"Curr Metabolomics"},{"issue":"2","key":"bib24","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1111\/1467-9868.00293","article-title":"Estimating the number of clusters in a data set via the gap statistic","volume":"63","author":"Tibshirani","year":"2001","journal-title":"J R Stat Soc B"},{"issue":"6","key":"bib25","doi-asserted-by":"publisher","first-page":"1174","DOI":"10.1093\/aje\/kwz063","article-title":"Applying the E value to assess the robustness of epidemiologic fields of inquiry to unmeasured confounding","volume":"188","author":"Trinquart","year":"2019","journal-title":"Am J Epidemiol"},{"issue":"11","key":"bib26","doi-asserted-by":"publisher","first-page":"871","DOI":"10.1001\/jama.1995.03520350053028","article-title":"Placing trials in context using Bayesian analysis. GUSTO revisited by Reverend Bayes","volume":"273","author":"Brophy","year":"1995","journal-title":"JAMA"},{"issue":"7208","key":"bib27","doi-asserted-by":"publisher","first-page":"508","DOI":"10.1136\/bmj.319.7208.508","article-title":"Methods in health service research. An introduction to Bayesian methods in health technology assessment","volume":"319","author":"Spiegelhalter","year":"1999","journal-title":"BMJ"},{"issue":"1","key":"bib28","doi-asserted-by":"publisher","first-page":"3601","DOI":"10.1038\/s41467-021-23859-6","article-title":"Integrated omics endotyping of infants with respiratory syncytial virus bronchiolitis and risk of childhood asthma","volume":"12","author":"Raita","year":"2021","journal-title":"Nat Commun"},{"key":"bib29","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1016\/j.maturitas.2021.10.004","article-title":"Metabolic profiling of charged metabolites in association with menopausal status in Japanese community-dwelling midlife women: tsuruoka metabolomic cohort study","volume":"155","author":"Watanabe","year":"2022","journal-title":"Maturitas"},{"issue":"6","key":"bib30","doi-asserted-by":"publisher","first-page":"983","DOI":"10.1002\/ejhf.2144","article-title":"Machine learning based on biomarker profiles identifies distinct subgroups of heart failure with preserved ejection fraction","volume":"23","author":"Woolley","year":"2021","journal-title":"Eur J Heart Fail"},{"issue":"5","key":"bib31","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1016\/S2213-8587(18)30051-2","article-title":"Novel subgroups of adult-onset diabetes and their association with outcomes: a data-driven cluster analysis of six variables","volume":"6","author":"Ahlqvist","year":"2018","journal-title":"Lancet Diabetes Endocrinol"},{"issue":"1","key":"bib32","doi-asserted-by":"publisher","first-page":"4970","DOI":"10.1038\/s41467-022-32323-y","article-title":"Integrated relationship of nasopharyngeal airway host response and microbiome associates with bronchiolitis severity","volume":"13","author":"Fujiogi","year":"2022","journal-title":"Nat Commun"},{"issue":"17","key":"bib33","doi-asserted-by":"publisher","first-page":"10080","DOI":"10.3390\/ijms231710080","article-title":"A narrative review of the association between obstructive sleep apnea and glaucoma in adults","volume":"23","author":"Leggewie","year":"2022","journal-title":"Int J Mol Sci"},{"issue":"6","key":"bib34","doi-asserted-by":"publisher","first-page":"481","DOI":"10.1016\/j.smrv.2007.11.003","article-title":"Gender differences in obstructive sleep apnea and treatment implications","volume":"12","author":"Lin","year":"2008","journal-title":"Sleep Med Rev"},{"issue":"12","key":"bib35","doi-asserted-by":"publisher","first-page":"7021","DOI":"10.1167\/iovs.15-17860","article-title":"Nailfold capillary abnormalities in primary open-angle glaucoma: a multisite study","volume":"56","author":"Pasquale","year":"2015","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"11","key":"bib36","doi-asserted-by":"publisher","first-page":"1006","DOI":"10.1080\/02713683.2023.2234105","article-title":"The relationship between Kiritsu-Meijin-derived autonomic function parameters and visual-field defects in eyes with open-angle glaucoma","volume":"48","author":"Yamada","year":"2023","journal-title":"Curr Eye Res"},{"issue":"6","key":"bib37","doi-asserted-by":"publisher","first-page":"e747","DOI":"10.1111\/aos.14361","article-title":"The optic nerve head vasoreactive response to systemic hyperoxia and visual field defect progression in open-angle glaucoma, a pilot study","volume":"98","author":"Kiyota","year":"2020","journal-title":"Acta Ophthalmol"},{"issue":"1","key":"bib38","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1186\/1878-5085-4-14","article-title":"The primary vascular dysregulation syndrome: implications for eye diseases","volume":"4","author":"Flammer","year":"2013","journal-title":"EPMA J"},{"issue":"12","key":"bib39","doi-asserted-by":"publisher","first-page":"8067","DOI":"10.1167\/iovs.14-14722","article-title":"Shear stress-triggered nitric oxide release from Schlemm's canal cells","volume":"55","author":"Ashpole","year":"2014","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"23","key":"bib40","doi-asserted-by":"publisher","first-page":"4707","DOI":"10.1093\/hmg\/ddr382","article-title":"Common variants near CAV1 and CAV2 are associated with primary open-angle glaucoma in Caucasians from the USA","volume":"20","author":"Wiggs","year":"2011","journal-title":"Hum Mol Genet"},{"issue":"10","key":"bib41","doi-asserted-by":"publisher","first-page":"1126","DOI":"10.1038\/ng.3087","article-title":"Genome-wide analysis of multi-ancestry cohorts identifies new loci influencing intraocular pressure and susceptibility to glaucoma","volume":"46","author":"Hysi","year":"2014","journal-title":"Nat Genet"},{"issue":"5","key":"bib42","doi-asserted-by":"publisher","first-page":"462","DOI":"10.1186\/s13075-014-0462-8","article-title":"Nailfold videocapillaroscopy micro-haemorrhage and giant capillary counting as an accurate approach for a steady state definition of disease activity in systemic sclerosis","volume":"16","author":"Sambataro","year":"2014","journal-title":"Arthritis Res Ther"},{"issue":"4","key":"bib43","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1016\/S0002-9394(00)00538-9","article-title":"The advanced glaucoma intervention study (AGIS): 7. The relationship between control of intraocular pressure and visual field deterioration","volume":"130","author":"The AGIS investigators","year":"2000","journal-title":"Am J Ophthalmol"},{"issue":"7","key":"bib44","doi-asserted-by":"publisher","first-page":"1318","DOI":"10.1016\/j.ophtha.2010.11.022","article-title":"The relationship between components of metabolic syndrome and open-angle glaucoma","volume":"118","author":"Newman-Casey","year":"2011","journal-title":"Ophthalmology"},{"issue":"9","key":"bib45","doi-asserted-by":"publisher","first-page":"e0163210","DOI":"10.1371\/journal.pone.0163210","article-title":"Patients with primary open-angle glaucoma may develop ischemic heart disease more often than those without glaucoma: an 11-year population-based cohort study","volume":"11","author":"Chen","year":"2016","journal-title":"PLoS One"},{"issue":"1","key":"bib46","doi-asserted-by":"publisher","first-page":"390","DOI":"10.1186\/s12886-020-01661-0","article-title":"Plasma lipid levels and risk of primary open angle glaucoma: a genetic study using Mendelian randomization","volume":"20","author":"Xu","year":"2020","journal-title":"BMC Ophthalmol"},{"issue":"4","key":"bib47","doi-asserted-by":"publisher","first-page":"1028","DOI":"10.1167\/iovs.18-25845","article-title":"Hyperlipidemia, blood lipid level, and the risk of glaucoma: a meta-analysis","volume":"60","author":"Wang","year":"2019","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"1","key":"bib48","doi-asserted-by":"publisher","first-page":"7829","DOI":"10.1038\/s41598-017-08295-1","article-title":"Triglycerides and open angle glaucoma \u2013 a meta-analysis with meta-regression","volume":"7","author":"Pertl","year":"2017","journal-title":"Sci Rep"},{"issue":"7","key":"bib49","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.1016\/j.ophtha.2009.12.001","article-title":"Genome-wide association study of normal tension glaucoma: common variants in SRBD1 and ELOVL5 contribute to disease susceptibility","volume":"117","author":"Writing Committee for the Normal Tension Glaucoma Genetic Study Group of Japan Glaucoma Society","year":"2010","journal-title":"Ophthalmology"},{"issue":"2","key":"bib50","doi-asserted-by":"publisher","first-page":"276","DOI":"10.1016\/j.neuron.2019.10.009","article-title":"Rewiring neuronal glycerolipid metabolism determines the extent of axon regeneration","volume":"105","author":"Yang","year":"2020","journal-title":"Neuron"},{"issue":"1","key":"bib51","doi-asserted-by":"publisher","first-page":"11930","DOI":"10.1038\/s41598-018-30464-z","article-title":"Metabolomic changes in the mouse retina after optic nerve injury","volume":"8","author":"Sato","year":"2018","journal-title":"Sci Rep"},{"issue":"11","key":"bib52","doi-asserted-by":"publisher","first-page":"4355","DOI":"10.1167\/iovs.18-24938","article-title":"A metabolomics profiling of glaucoma points to mitochondrial dysfunction, senescence, and polyamines deficiency","volume":"59","author":"Leruez","year":"2018","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib53","first-page":"1286","article-title":"Decreased carbohydrate metabolism enzyme activities in the glaucomatous trabecular meshwork","volume":"16","author":"Junk","year":"2010","journal-title":"Mol Vis"},{"issue":"11","key":"bib54","doi-asserted-by":"publisher","first-page":"5046","DOI":"10.1167\/iovs.16-20017","article-title":"Assessing the association of mitochondrial genetic variation with primary open-angle glaucoma using gene-set analyses","volume":"57","author":"Khawaja","year":"2016","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"3","key":"bib55","first-page":"45","article-title":"A ketogenic diet may offer neuroprotection in glaucoma and mitochondrial diseases of the optic nerve","volume":"1","author":"Zarnowski","year":"2012","journal-title":"Med Hypothesis Discov Innov Ophthalmol"},{"issue":"8","key":"bib56","doi-asserted-by":"publisher","first-page":"1465","DOI":"10.1038\/s41433-020-0820-5","article-title":"Low-carbohydrate-diet scores and the risk of primary open-angle glaucoma: data from three US cohorts","volume":"34","author":"Hanyuda","year":"2020","journal-title":"Eye (Lond)"},{"issue":"10","key":"bib57","doi-asserted-by":"publisher","first-page":"1319","DOI":"10.1007\/s00439-014-1468-7","article-title":"Hypothesis-independent pathway analysis implicates GABA and acetyl-CoA metabolism in primary open-angle glaucoma and normal-pressure glaucoma","volume":"133","author":"Bailey","year":"2014","journal-title":"Hum Genet"},{"issue":"2","key":"bib58","doi-asserted-by":"publisher","first-page":"e00544","DOI":"10.1016\/j.heliyon.2018.e00544","article-title":"Branched chain amino acids attenuate major pathologies in mouse models of retinal degeneration and glaucoma","volume":"4","author":"Hasegawa","year":"2018","journal-title":"Heliyon"},{"issue":"3","key":"bib59","doi-asserted-by":"publisher","first-page":"e760","DOI":"10.1111\/aos.14971","article-title":"Prospective study of dietary intake of branched-chain amino acids and the risk of primary open-angle glaucoma","volume":"100","author":"Hanyuda","year":"2022","journal-title":"Acta Ophthalmol"},{"key":"bib23","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/978-3-030-22475-2_1","article-title":"A systematic review on supervised and unsupervised machine learning algorithms for data science","volume-title":"Supervised and Unsupervised Learning for Data Science","author":"Alloghani","year":"2020"}],"container-title":["Investigative Ophthalmology &amp; Visual Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/iovs.arvojournals.org\/article.aspx?articleid=2802264","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:31:55Z","timestamp":1791927115000},"score":1,"resource":{"primary":{"URL":"https:\/\/iovs.arvojournals.org\/article.aspx?articleid=2802264"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,20]]},"references-count":59,"journal-issue":{"issue":"13","published-print":{"date-parts":[[2024,11,4]]}},"URL":"https:\/\/doi.org\/10.1167\/iovs.65.13.44","relation":{},"ISSN":["1552-5783"],"issn-type":[{"value":"1552-5783","type":"print"}],"subject":[],"published":{"date-parts":[[2024,11,20]]}}}