{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T22:01:36Z","timestamp":1791928896193,"version":"4.3.4"},"reference-count":95,"publisher":"Association for Research in Vision and Ophthalmology (ARVO)","issue":"13","license":[{"start":{"date-parts":[[2024,11,21]],"date-time":"2024-11-21T00:00:00Z","timestamp":1732147200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Invest. Ophthalmol. Vis. Sci."],"published-print":{"date-parts":[[2024,11,21]]},"DOI":"10.1167\/iovs.65.13.46","type":"journal-article","created":{"date-parts":[[2024,11,21]],"date-time":"2024-11-21T11:30:53Z","timestamp":1732188653000},"page":"46","source":"Crossref","is-referenced-by-count":13,"title":["Diabetes Renders Photoreceptors Susceptible to Retinal Ischemia-Reperfusion Injury"],"prefix":"10.1167","volume":"65","author":[{"given":"David A.","family":"Antonetti","sequence":"first","affiliation":[{"name":"Department of Ophthalmology and Visual Sciences, University of Michigan, Michigan Medicine, Kellogg Eye Center, Ann Arbor, Michigan, United States"},{"name":"Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, Michigan, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng-Mao","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology and Visual Sciences, University of Michigan, Michigan Medicine, Kellogg Eye Center, Ann Arbor, Michigan, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sumathi","family":"Shanmugam","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology and Visual Sciences, University of Michigan, Michigan Medicine, Kellogg Eye Center, Ann Arbor, Michigan, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heather","family":"Hager","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology and Visual Sciences, University of Michigan, Michigan Medicine, Kellogg Eye Center, Ann Arbor, Michigan, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manjing","family":"Cao","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology and Visual Sciences, University of Michigan, Michigan Medicine, Kellogg Eye Center, Ann Arbor, Michigan, United States"},{"name":"Department of Ophthalmology, Shanghai General Hospital (Shanghai First People's Hospital), Shanghai Jiao Tong University School of Medicine, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuwen","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology and Visual Sciences, University of Michigan, Michigan Medicine, Kellogg Eye Center, Ann Arbor, Michigan, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alyssa","family":"Dreffs","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology and Visual Sciences, University of Michigan, Michigan Medicine, Kellogg Eye Center, Ann Arbor, Michigan, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam","family":"Habash","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology and Visual Sciences, University of Michigan, Michigan Medicine, Kellogg Eye Center, Ann Arbor, Michigan, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven F.","family":"Abcouwer","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology and Visual Sciences, University of Michigan, Michigan Medicine, Kellogg Eye Center, Ann Arbor, Michigan, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"27","reference":[{"key":"bib1","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1038\/s41574-020-00451-4","article-title":"Current understanding of the molecular and cellular pathology of diabetic retinopathy","volume":"17","author":"Antonetti","year":"2021","journal-title":"Nat Rev Endocrinol"},{"key":"bib2","first-page":"1098","article-title":"Update on the management of diabetic retinopathy: anti-VEGF agents for the prevention of complications and progression of nonproliferative and proliferative retinopathy","volume":"13","author":"Bahr","year":"2023","journal-title":"Life (Basel)"},{"key":"bib3","article-title":"Faricimab for neovascular age-related macular degeneration and diabetic macular edema: from preclinical studies to phase 3 outcomes [published online ahead of print June 7, 2024]","author":"Agostini","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"key":"bib4","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1016\/j.visres.2017.03.003","article-title":"Diabetic retinopathy is a neurodegenerative disorder","volume":"139","author":"Lynch","year":"2017","journal-title":"Vision Res"},{"key":"bib5","doi-asserted-by":"publisher","first-page":"100420","DOI":"10.1016\/j.xops.2023.100420","article-title":"A new approach to staging diabetic eye disease: staging of diabetic retinal neurodegeneration and diabetic macular edema","volume":"4","author":"Channa","year":"2024","journal-title":"Ophthalmol Sci"},{"key":"bib6","doi-asserted-by":"publisher","first-page":"1342","DOI":"10.3390\/cells12091342","article-title":"Retinal cell damage in diabetic retinopathy","volume":"12","author":"Zhou","year":"2023","journal-title":"Cells"},{"key":"bib7","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1167\/iovs.62.10.20","article-title":"Correlation of retinal structure and visual function assessments in mouse diabetes models","volume":"62","author":"Sheskey","year":"2021","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib8","doi-asserted-by":"publisher","first-page":"1549","DOI":"10.2337\/db20-1220","article-title":"Vascular expression of permeability-resistant occludin mutant preserves visual function in diabetes","volume":"70","author":"Goncalves","year":"2021","journal-title":"Diabetes"},{"key":"bib9","doi-asserted-by":"publisher","first-page":"712","DOI":"10.1016\/j.survophthal.2021.08.011","article-title":"Clinical electroretinography in diabetic retinopathy: a review","volume":"67","author":"McAnany","year":"2022","journal-title":"Surv Ophthalmol"},{"key":"bib10","doi-asserted-by":"publisher","first-page":"100919","DOI":"10.1016\/j.preteyeres.2020.100919","article-title":"Photoreceptor cells and RPE contribute to the development of diabetic retinopathy","volume":"83","author":"Tonade","year":"2021","journal-title":"Prog Retin Eye Res"},{"key":"bib11","doi-asserted-by":"publisher","first-page":"100591","DOI":"10.1016\/j.xops.2024.100591","article-title":"Clinical evidence of a photoreceptor origin in diabetic retinal disease","volume":"5","author":"Rajagopal","year":"2025","journal-title":"Ophthalmol Sci"},{"key":"bib12","doi-asserted-by":"publisher","first-page":"788","DOI":"10.1016\/0002-9394(84)90518-X","article-title":"The negative coincidence of retinitis pigmentosa and proliferative diabetic retinopathy","volume":"97","author":"Sternberg","year":"1984","journal-title":"Am J Ophthalmol"},{"key":"bib13","doi-asserted-by":"publisher","first-page":"366","DOI":"10.1136\/bjo.85.3.366","article-title":"The absence of diabetic retinopathy in patients with retinitis pigmentosa: implications for pathophysiology and possible treatment","volume":"85","author":"Arden","year":"2001","journal-title":"Br J Ophthalmol"},{"key":"bib14","doi-asserted-by":"publisher","first-page":"1538","DOI":"10.1167\/iovs.18-26433","article-title":"Transducin1, phototransduction and the development of early diabetic retinopathy","volume":"60","author":"Liu","year":"2019","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib15","doi-asserted-by":"publisher","first-page":"16586","DOI":"10.1073\/pnas.1314575110","article-title":"Photoreceptor cells are major contributors to diabetes-induced oxidative stress and local inflammation in the retina","volume":"110","author":"Du","year":"2013","journal-title":"Proc Natl Acad Sci USA"},{"key":"bib16","doi-asserted-by":"publisher","first-page":"21568","DOI":"10.1074\/jbc.M115.655555","article-title":"Retinylamine benefits early diabetic retinopathy in mice","volume":"290","author":"Liu","year":"2015","journal-title":"J Biol Chem"},{"key":"bib17","doi-asserted-by":"publisher","first-page":"1125062","DOI":"10.3389\/fmed.2023.1125062","article-title":"Peripheral and central capillary non-perfusion in diabetic retinopathy: an updated overview","volume":"10","author":"Antropoli","year":"2023","journal-title":"Front Med (Lausanne)"},{"key":"bib18","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1167\/iovs.62.13.1","article-title":"Assessment of detailed photoreceptor structure and retinal sensitivity in diabetic macular ischemia using adaptive optics-OCT and microperimetry","volume":"62","author":"Datlinger","year":"2021","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib19","doi-asserted-by":"publisher","first-page":"e0169926","DOI":"10.1371\/journal.pone.0169926","article-title":"Adaptive optics reveals photoreceptor abnormalities in diabetic macular ischemia","volume":"12","author":"Nesper","year":"2017","journal-title":"PLoS One"},{"key":"bib20","doi-asserted-by":"publisher","first-page":"1036","DOI":"10.1001\/jamaophthalmol.2015.2183","article-title":"Association of diabetic macular nonperfusion with outer retinal disruption on optical coherence tomography","volume":"133","author":"Scarinci","year":"2015","journal-title":"JAMA Ophthalmol"},{"key":"bib21","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1016\/j.ajo.2016.05.002","article-title":"Deep retinal capillary nonperfusion is associated with photoreceptor disruption in diabetic macular ischemia","volume":"168","author":"Scarinci","year":"2016","journal-title":"Am J Ophthalmol"},{"key":"bib22","doi-asserted-by":"publisher","first-page":"7589841","DOI":"10.1155\/2019\/7589841","article-title":"Retinal sensitivity loss correlates with deep capillary plexus impairment in diabetic macular ischemia","volume":"2019","author":"Scarinci","year":"2019","journal-title":"J Ophthalmol"},{"key":"bib23","doi-asserted-by":"publisher","first-page":"10167","DOI":"10.3390\/ijms241210167","article-title":"The role of diabetic choroidopathy in the pathogenesis and progression of diabetic retinopathy","volume":"24","author":"Scuderi","year":"2023","journal-title":"Int J Mol Sci"},{"key":"bib24","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1167\/iovs.61.3.50","article-title":"Microvascular changes in the choriocapillaris of diabetic patients without retinopathy investigated by swept-source OCT angiography","volume":"61","author":"Dai","year":"2020","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib25","doi-asserted-by":"publisher","first-page":"1133","DOI":"10.1007\/s00417-019-04295-1","article-title":"Relationship between choroidal structure and duration of diabetes","volume":"257","author":"Endo","year":"2019","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"key":"bib26","first-page":"e10871","article-title":"Choroidal changes in diabetic patients with different stages of diabetic retinopathy","volume":"12","author":"Hamadneh","year":"2020","journal-title":"Cureus"},{"key":"bib27","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1159\/000504756","article-title":"Thinner average choroidal thickness is a risk factor for the onset of diabetic retinopathy","volume":"63","author":"Huang","year":"2020","journal-title":"Ophthalmic Res"},{"key":"bib28","doi-asserted-by":"publisher","first-page":"986209","DOI":"10.3389\/fmed.2022.986209","article-title":"Optical coherence tomography evaluation of choroidal structure changes in diabetic retinopathy patients: a systematic review and meta-analysis","volume":"9","author":"Jiang","year":"2022","journal-title":"Front Med (Lausanne)"},{"key":"bib29","doi-asserted-by":"publisher","first-page":"3537","DOI":"10.1007\/s00417-021-05292-z","article-title":"Choroidal vascular structures in diabetic patients: a meta-analysis","volume":"259","author":"Kase","year":"2021","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"key":"bib30","doi-asserted-by":"publisher","first-page":"3661","DOI":"10.1007\/s10792-022-02363-w","article-title":"Choroidal structural alterations in diabetic patients in association with disease duration, HbA1c level, and presence of retinopathy","volume":"42","author":"Temel","year":"2022","journal-title":"Int Ophthalmol"},{"key":"bib31","doi-asserted-by":"publisher","first-page":"2401","DOI":"10.1097\/IAE.0000000000003613","article-title":"Progressive peripapillary choroid thinning and retinal neurodegeneration in patients with diabetes: a 3-year cohort study","volume":"42","author":"Zhang","year":"2022","journal-title":"Retina"},{"key":"bib32","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1167\/iovs.63.4.9","article-title":"Macular choroidal thickness and the risk of referable diabetic retinopathy in type 2 diabetes: a 2-year longitudinal study","volume":"63","author":"Wang","year":"2022","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib33","doi-asserted-by":"publisher","first-page":"1121","DOI":"10.1007\/s00417-023-06282-z","article-title":"Association between choroidopathy and photoreceptors during the early stage of diabetic retinopathy: a cross-sectional study","volume":"262","author":"Dou","year":"2023","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"key":"bib34","doi-asserted-by":"publisher","first-page":"15183","DOI":"10.1038\/s41598-021-94580-z","article-title":"Outer retina dysfunction and choriocapillaris impairment in type 1 diabetes","volume":"11","author":"Parravano","year":"2021","journal-title":"Sci Rep"},{"key":"bib35","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1167\/iovs.61.6.1","article-title":"Association between alterations of the choriocapillaris microcirculation and visual function and cone photoreceptors in patients with diabetes","volume":"61","author":"Ro-Mase","year":"2020","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib36","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1016\/j.preteyeres.2003.12.001","article-title":"Retinal ischemia: mechanisms of damage and potential therapeutic strategies","volume":"23","author":"Osborne","year":"2004","journal-title":"Prog Retin Eye Res"},{"key":"bib37","doi-asserted-by":"publisher","first-page":"186","DOI":"10.1186\/s12974-021-02237-5","article-title":"Inflammatory resolution and vascular barrier restoration after retinal ischemia reperfusion injury","volume":"18","author":"Abcouwer","year":"2021","journal-title":"J Neuroinflammation"},{"key":"bib38","doi-asserted-by":"publisher","first-page":"5920","DOI":"10.1167\/iovs.10-5264","article-title":"Effects of ischemic preconditioning and bevacizumab on apoptosis and vascular permeability following retinal ischemia-reperfusion injury","volume":"51","author":"Abcouwer","year":"2010","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib39","doi-asserted-by":"publisher","first-page":"522","DOI":"10.1038\/jcbfm.2013.230","article-title":"Ischemia-reperfusion injury induces occludin phosphorylation\/ubiquitination and retinal vascular permeability in a VEGFR-2-dependent manner","volume":"34","author":"Muthusamy","year":"2014","journal-title":"J Cereb Blood Flow Metab"},{"key":"bib40","doi-asserted-by":"publisher","first-page":"1192464","DOI":"10.3389\/fncel.2023.1192464","article-title":"Delineating effects of angiopoietin-2 inhibition on vascular permeability and inflammation in models of retinal neovascularization and ischemia\/reperfusion","volume":"17","author":"Canonica","year":"2023","journal-title":"Front Cell Neurosci"},{"key":"bib41","doi-asserted-by":"publisher","first-page":"2486","DOI":"10.1016\/j.ajpath.2016.04.018","article-title":"Occludin S490 phosphorylation regulates vascular endothelial growth factor-induced retinal neovascularization","volume":"186","author":"Liu","year":"2016","journal-title":"Am J Pathol"},{"key":"bib42","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1080\/07435800.2023.2278049","article-title":"Animal models of type 2 diabetes complications: a review","volume":"49","author":"Sun","year":"2024","journal-title":"Endocr Res"},{"issue":"Suppl 2","key":"bib43","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1111\/dom.13630","article-title":"What does sodium-glucose co-transporter 1 inhibition add: prospects for dual inhibition","volume":"21","author":"Dominguez Rieg","year":"2019","journal-title":"Diabetes Obes Metab"},{"key":"bib44","doi-asserted-by":"publisher","first-page":"2079","DOI":"10.1007\/s00125-018-4654-7","article-title":"Development of SGLT1 and SGLT2 inhibitors","volume":"61","author":"Rieg","year":"2018","journal-title":"Diabetologia"},{"key":"bib45","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1093\/cvr\/cvp190","article-title":"SGLT1 is a novel cardiac glucose transporter that is perturbed in disease states","volume":"84","author":"Banerjee","year":"2009","journal-title":"Cardiovasc Res"},{"key":"bib46","doi-asserted-by":"publisher","first-page":"739","DOI":"10.2147\/DMSO.S242282","article-title":"Dual SGLT1\/SGLT2 inhibitor phlorizin ameliorates non-alcoholic fatty liver disease and hepatic glucose production in type 2 diabetic mice","volume":"13","author":"David-Silva","year":"2020","journal-title":"Diabetes Metab Syndr Obes"},{"key":"bib47","doi-asserted-by":"publisher","first-page":"12372","DOI":"10.1038\/s41598-020-69256-9","article-title":"Sodium-glucose co-transporter (SGLT) inhibitor restores lost axonal varicosities of the myenteric plexus in a mouse model of high-fat diet-induced obesity","volume":"10","author":"Shimo","year":"2020","journal-title":"Sci Rep"},{"key":"bib48","doi-asserted-by":"publisher","first-page":"2777","DOI":"10.1167\/iovs.13-13372","article-title":"Loss of inner retinal neurons after retinal ischemia in rats","volume":"55","author":"Schmid","year":"2014","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib49","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1097\/00041327-200103000-00015","article-title":"Functional and morphologic comparison of two methods to produce transient retinal ischemia in the rat","volume":"21","author":"Rosenbaum","year":"2001","journal-title":"J Neuroophthalmol"},{"key":"bib50","doi-asserted-by":"publisher","first-page":"931","DOI":"10.1016\/j.molcel.2015.07.027","article-title":"P16INK4a upregulation mediated by SIX6 defines retinal ganglion cell pathogenesis in glaucoma","volume":"59","author":"Skowronska-Krawczyk","year":"2015","journal-title":"Mol Cell"},{"key":"bib51","doi-asserted-by":"publisher","first-page":"642176","DOI":"10.3389\/fnins.2021.642176","article-title":"Knock-out of tenascin-C ameliorates ischemia-induced rod-photoreceptor degeneration and retinal dysfunction","volume":"15","author":"Wiemann","year":"2021","journal-title":"Front Neurosci"},{"key":"bib52","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1002\/cne.21470","article-title":"Alterations in photoreceptor-bipolar cell signaling following ischemia\/reperfusion in the rat retina","volume":"505","author":"Sun","year":"2007","journal-title":"J Comp Neurol"},{"key":"bib53","first-page":"1903","article-title":"Mouse models of retinal ischemic tolerance","volume":"43","author":"Zhu","year":"2002","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib54","doi-asserted-by":"crossref","first-page":"2629150","DOI":"10.1155\/2021\/2629150","article-title":"Transneuronal degeneration in the visual pathway of rats following acute retinal ischemia\/reperfusion","volume":"2021","author":"Fu","year":"2021","journal-title":"Dis Markers"},{"key":"bib55","doi-asserted-by":"publisher","first-page":"174","DOI":"10.3389\/fncel.2019.00174","article-title":"From ganglion cell to photoreceptor layer: timeline of deterioration in a rat ischemia\/reperfusion model","volume":"13","author":"Palmhof","year":"2019","journal-title":"Front Cell Neurosci"},{"key":"bib56","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1167\/iovs.61.6.8","article-title":"All-trans-retinaldehyde contributes to retinal vascular permeability in ischemia reperfusion","volume":"61","author":"Dreffs","year":"2020","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib57","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1016\/j.ophtha.2009.06.051","article-title":"The 25-year incidence of visual impairment in type 1 diabetes mellitus the Wisconsin epidemiologic study of diabetic retinopathy","volume":"117","author":"Klein","year":"2010","journal-title":"Ophthalmology"},{"key":"bib58","doi-asserted-by":"publisher","first-page":"166995","DOI":"10.1016\/j.bbadis.2023.166995","article-title":"Glucose transport, transporters and metabolism in diabetic retinopathy","volume":"1870","author":"Zhang","year":"2024","journal-title":"Biochim Biophys Acta Mol Basis Dis"},{"issue":"499","key":"bib59","doi-asserted-by":"publisher","first-page":"eaau6627","DOI":"10.1126\/scitranslmed.aau6627","article-title":"Retinol binding protein 3 is increased in the retina of patients with diabetes resistant to diabetic retinopathy","volume":"11","author":"Yokomizo","year":"2019","journal-title":"Sci Transl Med"},{"key":"bib60","doi-asserted-by":"publisher","first-page":"3275","DOI":"10.1523\/JNEUROSCI.2010-20.2021","article-title":"Reduction of Glut1 in the neural retina but not the RPE alleviates polyol accumulation and normalizes early characteristics of diabetic retinopathy","volume":"41","author":"Holoman","year":"2021","journal-title":"J Neurosci"},{"key":"bib61","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1186\/s12964-020-00698-4","article-title":"mTOR-dependent dysregulation of autophagy contributes to the retinal ganglion cell loss in streptozotocin-induced diabetic retinopathy","volume":"19","author":"Madrakhimov","year":"2021","journal-title":"Cell Commun Signal"},{"key":"bib62","doi-asserted-by":"publisher","first-page":"7437","DOI":"10.1038\/s41598-017-07942-x","article-title":"Suppression of diabetic retinopathy with GLUT1 siRNA","volume":"7","author":"You","year":"2017","journal-title":"Sci Rep"},{"key":"bib63","doi-asserted-by":"publisher","first-page":"927","DOI":"10.1016\/j.ajpath.2023.04.003","article-title":"Systemic reduction of Glut1 normalizes retinal dysfunction, inflammation, and oxidative stress in the retina of spontaneous type 2 diabetic mice","volume":"193","author":"Aiello","year":"2023","journal-title":"Am J Pathol"},{"key":"bib64","doi-asserted-by":"publisher","first-page":"254","DOI":"10.1016\/j.cmet.2015.12.009","article-title":"A unifying mechanism for mitochondrial superoxide production during ischemia-reperfusion injury","volume":"23","author":"Chouchani","year":"2016","journal-title":"Cell Metab"},{"key":"bib65","doi-asserted-by":"publisher","first-page":"615","DOI":"10.1017\/S0952523805225105","article-title":"Anesthesia can cause sustained hyperglycemia in C57\/BL6J mice","volume":"22","author":"Brown","year":"2005","journal-title":"Vis Neurosci"},{"key":"bib66","doi-asserted-by":"publisher","first-page":"3275","DOI":"10.1523\/JNEUROSCI.2010-20.2021","article-title":"Reduction of Glut1 in the neural retina but not the RPE alleviates polyol accumulation and normalizes early characteristics of diabetic retinopathy","volume":"41","author":"Holoman","year":"2021","journal-title":"J Neurosci"},{"key":"bib67","doi-asserted-by":"publisher","first-page":"360438","DOI":"10.1155\/2014\/360438","article-title":"Lipid peroxidation: production, metabolism, and signaling mechanisms of malondialdehyde and 4-hydroxy-2-nonenal","volume":"2014","author":"Ayala","year":"2014","journal-title":"Oxid Med Cell Longev"},{"key":"bib68","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1038\/s41418-022-01046-4","article-title":"Pathologically high intraocular pressure disturbs normal iron homeostasis and leads to retinal ganglion cell ferroptosis in glaucoma","volume":"30","author":"Yao","year":"2023","journal-title":"Cell Death Differ"},{"key":"bib69","doi-asserted-by":"publisher","first-page":"3","DOI":"10.21037\/atm-22-3298","article-title":"Lipocalin 2 induces visual impairment by promoting ferroptosis in retinal ischemia-reperfusion injury","volume":"11","author":"Mei","year":"2023","journal-title":"Ann Transl Med"},{"key":"bib70","doi-asserted-by":"crossref","first-page":"970156","DOI":"10.1155\/2015\/970156","article-title":"Octreotide protects the mouse retina against ischemic reperfusion injury through regulation of antioxidation and activation of NF-?B","volume":"2015","author":"Wang","year":"2015","journal-title":"Oxid Med Cell Longev"},{"key":"bib71","doi-asserted-by":"publisher","first-page":"9210","DOI":"10.3892\/mmr.2017.7739","article-title":"Edaravone protects the retina against ischemia\/reperfusion induced oxidative injury through the PI3K\/Akt\/Nrf2 pathway","volume":"16","author":"Xu","year":"2017","journal-title":"Mol Med Rep"},{"key":"bib72","doi-asserted-by":"publisher","first-page":"296","DOI":"10.1186\/s12974-023-02982-9","article-title":"Empagliflozin targets Mfn1 and Opa1 to attenuate microglia-mediated neuroinflammation in retinal ischemia and reperfusion injury","volume":"20","author":"Yang","year":"2023","journal-title":"J Neuroinflammation"},{"key":"bib73","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1016\/j.jacc.2019.11.036","article-title":"Clinical benefit of cardiorenal effects of sodium-glucose cotransporter 2 inhibitors: JACC State-of-the-Art Review","volume":"75","author":"Zelniker","year":"2020","journal-title":"J Am Coll Cardiol"},{"key":"bib74","doi-asserted-by":"publisher","first-page":"2188","DOI":"10.1038\/s41598-024-52331-w","article-title":"Effect of pharmacological selectivity of SGLT2 inhibitors on cardiovascular outcomes in patients with type 2 diabetes: a meta-analysis","volume":"14","author":"Sayour","year":"2024","journal-title":"Sci Rep"},{"key":"bib75","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/j.yjmcc.2022.03.005","article-title":"Cardiac mechanisms of the beneficial effects of SGLT2 inhibitors in heart failure: evidence for potential off-target effects","volume":"167","author":"Dyck","year":"2022","journal-title":"J Mol Cell Cardiol"},{"key":"bib76","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1186\/s12933-023-01816-5","article-title":"Insights into SGLT2 inhibitor treatment of diabetic cardiomyopathy: focus on the mechanisms","volume":"22","author":"Huang","year":"2023","journal-title":"Cardiovasc Diabetol"},{"key":"bib77","doi-asserted-by":"publisher","first-page":"9852","DOI":"10.3390\/ijms22189852","article-title":"Effects of SGLT2 inhibitors beyond glycemic control-focus on myocardial SGLT1","volume":"22","author":"Sayour","year":"2021","journal-title":"Int J Mol Sci"},{"key":"bib78","doi-asserted-by":"publisher","first-page":"e26498","DOI":"10.1371\/journal.pone.0026498","article-title":"Differential roles of hyperglycemia and hypoinsulinemia in diabetes induced retinal cell death: evidence for retinal insulin resistance","volume":"6","author":"Fort","year":"2011","journal-title":"PLoS One"},{"key":"bib79","doi-asserted-by":"publisher","first-page":"827896","DOI":"10.3389\/fphar.2022.827896","article-title":"Dapagliflozin reduces apoptosis of diabetic retina and human retinal microvascular endothelial cells through ERK1\/2\/cPLA2\/AA\/ROS pathway independent of hypoglycemic","volume":"13","author":"Hu","year":"2022","journal-title":"Front Pharmacol"},{"key":"bib80","first-page":"347","article-title":"Differential effects of empagliflozin on microvascular complications in murine models of type 1 and type 2 diabetes","volume":"9","author":"Eid","year":"2020","journal-title":"Biology (Basel)"},{"key":"bib81","doi-asserted-by":"publisher","first-page":"1153","DOI":"10.2337\/db22-0970","article-title":"The early pathogenesis of diabetic retinopathy and its attenuation by sodium-glucose transporter 2 inhibitors","volume":"73","author":"Yamato","year":"2024","journal-title":"Diabetes"},{"key":"bib82","doi-asserted-by":"publisher","first-page":"4281","DOI":"10.1167\/iovs.04-1361","article-title":"Vascular damage in a mouse model of diabetic retinopathy: relation to neuronal and glial changes","volume":"46","author":"Feit-Leichman","year":"2005","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib83","doi-asserted-by":"publisher","first-page":"1303238","DOI":"10.3389\/fendo.2023.1303238","article-title":"Associations of antidiabetic drugs with diabetic retinopathy in people with type 2 diabetes: an umbrella review and meta-analysis","volume":"14","author":"Tan","year":"2023","journal-title":"Front Endocrinol (Lausanne)"},{"key":"bib84","doi-asserted-by":"publisher","first-page":"1797","DOI":"10.3390\/jcm13061797","article-title":"Novel antidiabetic drugs and the risk of diabetic retinopathy: a systematic review and meta-analysis of randomized controlled trials","volume":"13","author":"Malyszczak","year":"2024","journal-title":"J Clin Med"},{"key":"bib85","doi-asserted-by":"publisher","first-page":"252","DOI":"10.1111\/dom.14197","article-title":"Sodium-glucose co-transporter-2 inhibition and ocular outcomes in patients with type 2 diabetes: a systematic review and meta-analysis","volume":"23","author":"Li","year":"2021","journal-title":"Diabetes Obes Metab"},{"key":"bib86","doi-asserted-by":"publisher","first-page":"e2348431","DOI":"10.1001\/jamanetworkopen.2023.48431","article-title":"Sodium-glucose cotransporter 2 inhibitors and risk of retinopathy in patients with type 2 diabetes","volume":"6","author":"Yen","year":"2023","journal-title":"JAMA Netw Open"},{"key":"bib87","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1002\/cpt.3074","article-title":"Risk of diabetic retinopathy in patients with type 2 diabetes after SGLT-2 inhibitors: a nationwide population cohort study","volume":"115","author":"Huang","year":"2024","journal-title":"Clin Pharmacol Ther"},{"key":"bib88","doi-asserted-by":"publisher","first-page":"1271","DOI":"10.1007\/s00125-024-06132-5","article-title":"Risk of diabetic retinopathy and diabetic macular oedema with sodium-glucose cotransporter 2 inhibitors and glucagon-like peptide 1 receptor agonists in type 2 diabetes: a real-world data study from a global federated database","volume":"67","author":"Eleftheriadou","year":"2024","journal-title":"Diabetologia"},{"key":"bib89","doi-asserted-by":"publisher","first-page":"236","DOI":"10.2174\/1574886318666230420084701","article-title":"Association between glucose-lowering treatments and risk of diabetic retinopathy in people with type 2 diabetes: a nationwide cohort study","volume":"19","author":"Hasselstr\u00f8m Jensen","year":"2024","journal-title":"Curr Drug Saf"},{"key":"bib90","doi-asserted-by":"publisher","first-page":"e0224549","DOI":"10.1371\/journal.pone.0224549","article-title":"Effects of sodium-glucose cotransporter-2 inhibitors and dipeptidyl peptidase-4 inhibitors on diabetic retinopathy and its progression: a real-world Korean study","volume":"14","author":"Chung","year":"2019","journal-title":"PLoS One"},{"key":"bib91","doi-asserted-by":"publisher","first-page":"17049","DOI":"10.1038\/s41598-023-43893-2","article-title":"Sodium-glucose co-transporter 2 inhibitor add-on therapy for metformin delays diabetic retinopathy progression in diabetes patients: a population-based cohort study","volume":"13","author":"Li","year":"2023","journal-title":"Sci Rep"},{"key":"bib92","doi-asserted-by":"publisher","first-page":"877","DOI":"10.1080\/17512433.2022.2102973","article-title":"The association between the use of sodium glucose cotransporter 2 inhibitor and the risk of diabetic retinopathy and other eye disorders: a systematic review and meta-analysis","volume":"15","author":"Ma","year":"2022","journal-title":"Expert Rev Clin Pharmacol"},{"key":"bib93","doi-asserted-by":"publisher","first-page":"394","DOI":"10.4093\/dmj.2022.0221","article-title":"Risk of diabetic retinopathy between sodium-glucose cotransporter-2 inhibitors and glucagon-like peptide-1 receptor agonists","volume":"47","author":"Lin","year":"2023","journal-title":"Diabetes Metab J"},{"key":"bib94","doi-asserted-by":"publisher","first-page":"1510","DOI":"10.1111\/dom.15454","article-title":"Sodium-glucose co-transporter 2 inhibitor therapy reduces the administration frequency of anti-vascular endothelial growth factor agents in patients with diabetic macular oedema with a history of anti-vascular endothelial growth factor agent use: a cohort study using the Japanese health insurance claims database","volume":"26","author":"Ishibashi","year":"2024","journal-title":"Diabetes Obes Metab"},{"key":"bib95","doi-asserted-by":"publisher","first-page":"111","DOI":"10.3390\/ph17010111","article-title":"Ocular and plasma pharmacokinetics of enavogliflozin ophthalmic solution in preclinical species","volume":"17","author":"Jang","year":"2024","journal-title":"Pharmaceuticals (Basel)"}],"container-title":["Investigative Ophthalmology &amp; Visual Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/iovs.arvojournals.org\/article.aspx?articleid=2802270","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:31:55Z","timestamp":1791927115000},"score":1,"resource":{"primary":{"URL":"https:\/\/iovs.arvojournals.org\/article.aspx?articleid=2802270"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,21]]},"references-count":95,"journal-issue":{"issue":"13","published-print":{"date-parts":[[2024,11,4]]}},"URL":"https:\/\/doi.org\/10.1167\/iovs.65.13.46","relation":{},"ISSN":["1552-5783"],"issn-type":[{"value":"1552-5783","type":"print"}],"subject":[],"published":{"date-parts":[[2024,11,21]]}}}