{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T22:00:35Z","timestamp":1791928835361,"version":"4.3.4"},"reference-count":81,"publisher":"Association for Research in Vision and Ophthalmology (ARVO)","issue":"14","license":[{"start":{"date-parts":[[2024,12,5]],"date-time":"2024-12-05T00:00:00Z","timestamp":1733356800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Invest. Ophthalmol. Vis. Sci."],"published-print":{"date-parts":[[2024,12,5]]},"DOI":"10.1167\/iovs.65.14.14","type":"journal-article","created":{"date-parts":[[2024,12,5]],"date-time":"2024-12-05T12:30:56Z","timestamp":1733401856000},"page":"14","source":"Crossref","is-referenced-by-count":2,"title":["Mimicking Retinoblastoma Treatment With Repeated Topotecan or Melphalan Develops Cross-Resistance to Classic Agents But Not to Repurposed Drugs"],"prefix":"10.1167","volume":"65","author":[{"given":"Mar\u00eda Belen","family":"Cancela","sequence":"first","affiliation":[{"name":"Unit of Innovative Treatments, Hospital de Pediatr\u00eda JP Garrahan, Buenos Aires, Argentina"},{"name":"National Scientific and Technical Research Council, CONICET, Buenos Aires, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ursula","family":"Winter","sequence":"additional","affiliation":[{"name":"National Scientific and Technical Research Council, CONICET, Buenos Aires, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Santiago","family":"Zugbi","sequence":"additional","affiliation":[{"name":"Unit of Innovative Treatments, Hospital de Pediatr\u00eda JP Garrahan, Buenos Aires, Argentina"},{"name":"National Scientific and Technical Research Council, CONICET, Buenos Aires, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milagros","family":"Dinardi","sequence":"additional","affiliation":[{"name":"Unit of Innovative Treatments, Hospital de Pediatr\u00eda JP Garrahan, Buenos Aires, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"Alves da Quinta","sequence":"additional","affiliation":[{"name":"National Scientific and Technical Research Council, CONICET, Buenos Aires, Argentina"},{"name":"Laboratory of Molecular and Cellular Therapy, Instituto Leloir \u2013 Instituto de Investigaciones Bioqu\u00edmicas de Buenos Aires (IIBBA), Buenos Aires, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosario","family":"Aschero","sequence":"additional","affiliation":[{"name":"SJD Pediatric Cancer Center Barcelona, Hospital Sant Joan de Deu, Barcelona, Spain"},{"name":"Institut de Recerca Sant Joan de Deu, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daiana","family":"Ganiewich","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular and Cellular Therapy, Instituto Leloir \u2013 Instituto de Investigaciones Bioqu\u00edmicas de Buenos Aires (IIBBA), Buenos Aires, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Sampor","sequence":"additional","affiliation":[{"name":"Hematology-Oncology Service, Hospital de Pediatr\u00eda JP Garrahan, Buenos Aires, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariana","family":"Sgroi","sequence":"additional","affiliation":[{"name":"Ophthalmology Service, Hospital de Pediatr\u00eda JP Garrahan, Buenos Aires, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo","family":"Lagomarsino","sequence":"additional","affiliation":[{"name":"Pharmacy Service, Hospital de Pediatr\u00eda JP Garrahan, Buenos Aires, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriana","family":"Fandi\u00f1o","sequence":"additional","affiliation":[{"name":"Ophthalmology Service, Hospital de Pediatr\u00eda JP Garrahan, Buenos Aires, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea S.","family":"Llera","sequence":"additional","affiliation":[{"name":"National Scientific and Technical Research Council, CONICET, Buenos Aires, Argentina"},{"name":"Laboratory of Molecular and Cellular Therapy, Instituto Leloir \u2013 Instituto de Investigaciones Bioqu\u00edmicas de Buenos Aires (IIBBA), Buenos Aires, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guillermo","family":"Chantada","sequence":"additional","affiliation":[{"name":"SJD Pediatric Cancer Center Barcelona, Hospital Sant Joan de Deu, Barcelona, Spain"},{"name":"Institut de Recerca Sant Joan de Deu, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angel M.","family":"Carcaboso","sequence":"additional","affiliation":[{"name":"SJD Pediatric Cancer Center Barcelona, Hospital Sant Joan de Deu, Barcelona, Spain"},{"name":"Institut de Recerca Sant Joan de Deu, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paula","family":"Schaiquevich","sequence":"additional","affiliation":[{"name":"Unit of Innovative Treatments, Hospital de Pediatr\u00eda JP Garrahan, Buenos Aires, Argentina"},{"name":"National Scientific and Technical Research Council, CONICET, Buenos Aires, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"27","reference":[{"issue":"8","key":"bib2","doi-asserted-by":"publisher","first-page":"e1128","DOI":"10.1016\/S2214-109X(22)00250-9","article-title":"The Global Retinoblastoma Outcome Study: a prospective, cluster-based analysis of 4064 patients from 149 countries","volume":"10","author":"Fabian","year":"2022","journal-title":"Lancet Glob Heal"},{"issue":"12","key":"bib3","doi-asserted-by":"publisher","first-page":"1719","DOI":"10.1016\/j.ophtha.2020.05.050","article-title":"A multicenter, international collaborative study for American Joint Committee on Cancer Staging of Retinoblastoma: Part I: Metastasis-Associated Mortality","volume":"127","author":"Tomar","year":"2020","journal-title":"Ophthalmology"},{"issue":"15","key":"bib4","doi-asserted-by":"publisher","first-page":"3646","DOI":"10.3390\/cancers13153646","article-title":"Natural history of untreated retinoblastoma","volume":"13","author":"Zhao","year":"2021","journal-title":"Cancers (Basel)"},{"issue":"12","key":"bib5","doi-asserted-by":"publisher","first-page":"2276","DOI":"10.1016\/j.ophtha.2006.06.018","article-title":"The International Classification of Retinoblastoma predicts chemoreduction success","volume":"113","author":"Shields","year":"2006","journal-title":"Ophthalmology"},{"issue":"33","key":"bib6","doi-asserted-by":"publisher","first-page":"3839","DOI":"10.1200\/JCO.21.02337","article-title":"Intensive multimodality therapy for extraocular retinoblastoma: a children's oncology group trial (ARET0321)","volume":"40","author":"Dunkel","year":"2022","journal-title":"J Clin Oncol"},{"issue":"6","key":"bib7","doi-asserted-by":"publisher","first-page":"342","DOI":"10.1097\/00043426-200606000-00004","article-title":"Treatment of retinoblastoma patients with chemoreduction plus local therapy: experience of the AC Camargo Hospital, Brazil","volume":"28","author":"Antoneli","year":"2006","journal-title":"J Pediatr Hematol Oncol"},{"key":"bib8","doi-asserted-by":"publisher","first-page":"100764","DOI":"10.1016\/j.preteyeres.2019.05.005","article-title":"Conservative management of retinoblastoma: challenging orthodoxy without compromising the state of metastatic grace. \u201cAlive, with good vision and no comorbidity.\u201d","volume":"73","author":"Munier","year":"2019","journal-title":"Prog Retin Eye Res"},{"issue":"1","key":"bib9","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1200\/JCO.2000.18.1.12","article-title":"Chemoreduction and local ophthalmic therapy for intraocular retinoblastoma","volume":"18","author":"Friedman","year":"2000","journal-title":"J Clin Oncol"},{"issue":"2","key":"bib10","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1080\/10799893.2018.1436561","article-title":"JTC-801 exerts anti-proliferative effects in human osteosarcoma cells by inducing apoptosis","volume":"38","author":"Zheng","year":"2018","journal-title":"J Recept Signal Transduct"},{"key":"bib11","article-title":"What have we learnt about intraarterial chemotherapy (Ophthalmic Artery Chemosurgery) for retinoblastoma in the past 18 years? The third A. Linn Murphree Lecture [published online ahead of print September 4, 2024]","author":"Abramson","journal-title":"Ophthalmic Genet"},{"issue":"4","key":"bib12","doi-asserted-by":"publisher","first-page":"193","DOI":"10.3109\/13816810.2014.973045","article-title":"Classification and management of seeds in retinoblastoma. Ellsworth Lecture Ghent August 24th 2013","volume":"35","author":"Munier","year":"2014","journal-title":"Ophthalmic Genet"},{"key":"bib13","doi-asserted-by":"publisher","first-page":"696787","DOI":"10.3389\/fphar.2021.696787","article-title":"Safety and efficacy of intravitreal chemotherapy (melphalan) to treat vitreous seeds in retinoblastoma","volume":"12","author":"Yousef","year":"2021","journal-title":"Front Pharmacol"},{"issue":"4","key":"bib14","doi-asserted-by":"publisher","first-page":"490","DOI":"10.1136\/bjophthalmol-2017-310641","article-title":"Intravitreal topotecan in the management of refractory and recurrent vitreous seeds in retinoblastoma","volume":"102","author":"Rao","year":"2018","journal-title":"Br J Ophthalmol"},{"issue":"4","key":"bib15","doi-asserted-by":"publisher","first-page":"488","DOI":"10.1016\/j.ophtha.2016.12.015","article-title":"Efficacy and toxicity of intravitreous chemotherapy for retinoblastoma: four-year experience","volume":"124","author":"Francis","year":"2017","journal-title":"Ophthalmology"},{"issue":"9","key":"bib16","doi-asserted-by":"publisher","first-page":"1810","DOI":"10.1016\/j.ophtha.2014.03.028","article-title":"Local and systemic toxicity of intravitreal melphalan for vitreous seeding in retinoblastoma: a preclinical and clinical study","volume":"121","author":"Francis","year":"2014","journal-title":"Ophthalmology"},{"issue":"12","key":"bib17","doi-asserted-by":"publisher","first-page":"1459","DOI":"10.1001\/jamaophthalmol.2015.3119","article-title":"Anterior ocular toxicity of intravitreous melphalan for retinoblastoma","volume":"133","author":"Francis","year":"2015","journal-title":"JAMA Ophthalmol"},{"issue":"3","key":"bib18","doi-asserted-by":"publisher","first-page":"288","DOI":"10.1016\/j.oret.2018.09.020","article-title":"Changes in retinal thickness on OCT from intravitreal melphalan","volume":"3","author":"Narala","year":"2019","journal-title":"Ophthalmol Retin"},{"issue":"4","key":"bib19","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1007\/s10384-020-00743-2","article-title":"Comparison of intravitreal melphalan with and without topotecan in the management of vitreous disease in retinoblastoma","volume":"64","author":"Kiratli","year":"2020","journal-title":"Jpn J Ophthalmol"},{"key":"bib20","doi-asserted-by":"publisher","first-page":"891652","DOI":"10.3389\/fonc.2022.1059978","article-title":"Multidrug resistance in cancer: understanding molecular mechanisms, immunoprevention and therapeutic approaches","volume":"12","author":"Bin","year":"2022","journal-title":"Front Oncol"},{"key":"bib21","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1016\/j.jconrel.2017.08.018","article-title":"Increased delivery of chemotherapy to the vitreous by inhibition of the blood-retinal barrier","volume":"264","author":"Pascual-Pasto","year":"2017","journal-title":"J Control Release"},{"issue":"19","key":"bib22","doi-asserted-by":"publisher","first-page":"4966","DOI":"10.3390\/cancers14194966","article-title":"Early mechanisms of chemoresistance in retinoblastoma","volume":"14","author":"Zhang","year":"2022","journal-title":"Cancers (Basel)"},{"issue":"10","key":"bib23","doi-asserted-by":"publisher","first-page":"729","DOI":"10.14348\/molcells.2022.2014","article-title":"Establishment and characterization of carboplatin-resistant retinoblastoma cell lines","volume":"45","author":"Cho","year":"2022","journal-title":"Mol Cells"},{"key":"bib24","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1016\/j.preteyeres.2016.12.001","article-title":"Pharmacokinetic aspects of retinal drug delivery","volume":"57","author":"Del Amo","year":"2017","journal-title":"Prog Retin Eye Res"},{"issue":"4","key":"bib25","doi-asserted-by":"publisher","first-page":"1269","DOI":"10.1167\/iovs.05-1321","article-title":"Immunohistochemical detection of multidrug-resistant protein expression in retinoblastoma treated by primary enucleation","volume":"47","author":"Wilson","year":"2006","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"9","key":"bib26","doi-asserted-by":"publisher","first-page":"1425","DOI":"10.1016\/S0161-6420(91)32134-1","article-title":"Multidrug-resistant phenotype in retinoblastoma correlates with P-glycoprotein expression","volume":"98","author":"Chan","year":"1991","journal-title":"Ophthalmology"},{"issue":"6","key":"bib27","doi-asserted-by":"publisher","first-page":"784","DOI":"10.1136\/bjo.2005.068536","article-title":"P-glycoprotein expression in retinoblastoma","volume":"89","author":"Dunkel","year":"2005","journal-title":"Br J Ophthalmol"},{"issue":"1","key":"bib28","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1016\/j.bcp.2009.03.026","article-title":"Influx and efflux transport as determinants of melphalan cytotoxicity: resistance to melphalan in MDR1 overexpressing tumor cell lines","volume":"78","author":"K\u00fchne","year":"2009","journal-title":"Biochem Pharmacol"},{"issue":"1","key":"bib29","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1186\/s12886-020-01348-6","article-title":"Different transcriptome profiles between human retinoblastoma Y79 cells and an etoposide-resistant subline reveal a chemoresistance mechanism","volume":"20","author":"Song","year":"2020","journal-title":"BMC Ophthalmol"},{"issue":"1","key":"bib30","first-page":"160","article-title":"Characterization of etoposide- and cisplatin-chemoresistant retinoblastoma cell lines","volume":"39","author":"Busch","year":"2018","journal-title":"Oncol Rep"},{"issue":"5","key":"bib31","doi-asserted-by":"publisher","first-page":"569","DOI":"10.1001\/jamaophthalmol.2020.0427","article-title":"Genomic and transcriptomic tumor heterogeneity in bilateral retinoblastoma","volume":"138","author":"Winter","year":"2020","journal-title":"JAMA Ophthalmol"},{"issue":"16","key":"bib32","doi-asserted-by":"publisher","first-page":"3578","DOI":"10.1158\/1078-0432.CCR-24-0221","article-title":"Targeting GPC2 on intraocular and CNS metastatic retinoblastomas with local and systemic delivery of CAR T cells","volume":"30","author":"Pascual-Pasto","year":"2024","journal-title":"Clin Cancer Res"},{"issue":"1","key":"bib33","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1016\/j.canlet.2016.06.012","article-title":"Preclinical platform of retinoblastoma xenografts recapitulating human disease and molecular markers of dissemination","volume":"380","author":"Pascual-Pasto","year":"2016","journal-title":"Cancer Lett"},{"issue":"5","key":"bib34","doi-asserted-by":"publisher","first-page":"1077","DOI":"10.3390\/ijms20051077","article-title":"Tridimensional retinoblastoma cultures as vitreous seeds models for live-cell imaging of chemotherapy penetration","volume":"20","author":"Winter","year":"2019","journal-title":"Int J Mol Sci"},{"issue":"7","key":"bib35","doi-asserted-by":"publisher","first-page":"e0160094","DOI":"10.1371\/journal.pone.0160094","article-title":"Schedule-dependent antiangiogenic and cytotoxic effects of chemotherapy on vascular endothelial and retinoblastoma cells","volume":"11","author":"Winter","year":"2016","journal-title":"PLoS One"},{"issue":"6","key":"bib36","doi-asserted-by":"publisher","first-page":"1173","DOI":"10.1016\/j.ophtha.2015.01.017","article-title":"The classification of vitreous seeds in retinoblastoma and response","volume":"122","author":"Francis","year":"2015","journal-title":"Ophthalmology"},{"issue":"1","key":"bib37","doi-asserted-by":"publisher","first-page":"10","DOI":"10.14806\/ej.17.1.200","article-title":"Cutadapt removes adapter sequences from high-throughput sequencing reads","volume":"17","author":"Martin","year":"2011","journal-title":"EMBnet.journal"},{"issue":"14","key":"bib38","doi-asserted-by":"publisher","first-page":"1754","DOI":"10.1093\/bioinformatics\/btp324","article-title":"Fast and accurate short read alignment with Burrows-Wheeler transform","volume":"25","author":"Li","year":"2009","journal-title":"Bioinformatics"},{"issue":"1110","key":"bib39","first-page":"11.10.1","article-title":"From FastQ data to high confidence variant calls: the Genome Analysis Toolkit best practices pipeline","volume":"11","author":"Van der Auwera","year":"2013","journal-title":"Curr Protoc Bioinformatics"},{"issue":"1","key":"bib41","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1038\/nbt.1754","article-title":"Integrative genomics viewer","volume":"29","author":"Robinson","year":"2011","journal-title":"Nat Biotechnol"},{"issue":"11","key":"bib42","doi-asserted-by":"publisher","first-page":"1978","DOI":"10.1093\/bioinformatics\/bty897","article-title":"VarSome: the human genomic variant search engine","volume":"35","author":"Kopanos","year":"2019","journal-title":"Bioinformatics"},{"issue":"16","key":"bib43","doi-asserted-by":"publisher","first-page":"e131","DOI":"10.1093\/nar\/gkw520","article-title":"FACETS: allele-specific copy number and clonal heterogeneity analysis tool for high-throughput DNA sequencing","volume":"44","author":"Shen","year":"2016","journal-title":"Nucleic Acids Res"},{"issue":"8","key":"bib44","doi-asserted-by":"publisher","first-page":"e1003118","DOI":"10.1371\/journal.pcbi.1003118","article-title":"Software for computing and annotating genomic ranges","volume":"9","author":"Lawrence","year":"2013","journal-title":"PLoS Comput Biol"},{"key":"bib45","doi-asserted-by":"publisher","first-page":"440","DOI":"10.1016\/j.jconrel.2020.05.032","article-title":"Treatment-driven selection of chemoresistant Ewing sarcoma tumors with limited drug distribution","volume":"324","author":"Castillo-Ecija","year":"2020","journal-title":"J Control Release"},{"issue":"1","key":"bib47","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1186\/s13046-019-1251-7","article-title":"Ivermectin reverses the drug resistance in cancer cells through EGFR\/ERK\/Akt\/NF-?B pathway","volume":"38","author":"Jiang","year":"2019","journal-title":"J Exp Clin Cancer Res"},{"issue":"15","key":"bib48","doi-asserted-by":"publisher","first-page":"2142","DOI":"10.1111\/1759-7714.14527","article-title":"Inhibitors of ABCB1 and ABCG2 overcame resistance to topoisomerase inhibitors in small cell lung cancer","volume":"13","author":"Omori","year":"2022","journal-title":"Thorac Cancer"},{"issue":"2","key":"bib49","doi-asserted-by":"publisher","first-page":"426","DOI":"10.1007\/s10637-020-01030-0","article-title":"A decision process for drug discovery in retinoblastoma","volume":"39","author":"Cancela","year":"2020","journal-title":"Investig New Drugs"},{"issue":"2","key":"bib51","doi-asserted-by":"crossref","first-page":"E16","DOI":"10.3928\/01913913-20230110-01","article-title":"Intravitreal topotecan 90 \u00b5g for recurrent solid retinoblastoma tumors is effective and not toxic","volume":"60","author":"Abramson","year":"2023","journal-title":"J Pediatr Ophthalmol Strabismus"},{"issue":"12","key":"bib52","doi-asserted-by":"publisher","first-page":"3881","DOI":"10.1182\/blood-2005-10-009084","article-title":"ABCG2 expression, function, and promoter methylation in human multiple myeloma","volume":"108","author":"Turner","year":"2006","journal-title":"Blood"},{"key":"bib53","doi-asserted-by":"publisher","first-page":"607275","DOI":"10.3389\/fcell.2020.607275","article-title":"Establishment and characterization of a topotecan resistant non-small cell lung cancer NCI-H460\/TPT10 cell line.","volume":"8","author":"Lei","year":"2020","journal-title":"Front Cell Dev Biol."},{"issue":"5","key":"bib54","doi-asserted-by":"publisher","first-page":"e0197081","DOI":"10.1371\/journal.pone.0197081","article-title":"Ten-year experience with ophthalmic artery chemosurgery: ocular and recurrence-free survival","volume":"13","author":"Francis","year":"2018","journal-title":"PLoS One"},{"issue":"10","key":"bib55","doi-asserted-by":"publisher","first-page":"1215","DOI":"10.1016\/j.ophtha.2024.04.022","article-title":"Intravitreal topotecan for vitreous seeds in retinoblastoma: a long-term review of 91 eyes","volume":"131","author":"Sen","year":"2024","journal-title":"Ophthalmology"},{"key":"bib56","doi-asserted-by":"publisher","first-page":"1789","DOI":"10.2147\/OPTH.S417370","article-title":"Ocular survival following intravitreal melphalan as adjuvant treatment for vitreous retinoblastoma seeding","volume":"17","author":"Alahmadi","year":"2023","journal-title":"Clin Ophthalmol"},{"issue":"9","key":"bib57","doi-asserted-by":"publisher","first-page":"4802","DOI":"10.1158\/0008-5472.CAN-05-2915","article-title":"Gefitinib modulates the function of multiple ATP-binding cassette transporters in vivo","volume":"66","author":"Leggas","year":"2006","journal-title":"Cancer Res"},{"issue":"7","key":"bib58","doi-asserted-by":"publisher","first-page":"1343","DOI":"10.1158\/1535-7163.MCT-13-0100","article-title":"Overlapping functions of ABC transporters in topotecan disposition as determined in gene knockout mouse models","volume":"12","author":"Tiwari","year":"2013","journal-title":"Mol Cancer Ther"},{"issue":"1\u20132","key":"bib59","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1007\/s11010-009-0077-6","article-title":"Characterization of the ATP-binding cassette transporter gene expression profile in Y79: a retinoblastoma cell line","volume":"328","author":"Hendig","year":"2009","journal-title":"Mol Cell Biochem"},{"issue":"5","key":"bib60","doi-asserted-by":"publisher","first-page":"386","DOI":"10.1080\/02713680902859621","article-title":"Expression of the multi-drug resistance proteins and the pregnane X receptor in treated and untreated retinoblastoma","volume":"34","author":"Wilson","year":"2009","journal-title":"Curr Eye Res"},{"issue":"9","key":"bib61","first-page":"1499","article-title":"Combining cyclosporin with chemotherapy controls intraocular retinoblastoma without requiring radiation","volume":"2","author":"Chan","year":"1996","journal-title":"Clin Cancer Res"},{"issue":"1","key":"bib62","doi-asserted-by":"publisher","first-page":"67","DOI":"10.21873\/anticanres.13080","article-title":"A single nucleotide polymorphism in SLC7A5 was associated with clinical response in multiple myeloma patients","volume":"39","author":"Poi","year":"2019","journal-title":"Anticancer Res"},{"issue":"11","key":"bib63","doi-asserted-by":"publisher","first-page":"1496","DOI":"10.1111\/cas.12529","article-title":"Expression of L-type amino acid transporter 1 (LAT1) as a prognostic and therapeutic indicator in multiple myeloma","volume":"105","author":"Isoda","year":"2014","journal-title":"Cancer Sci"},{"issue":"16","key":"bib64","doi-asserted-by":"publisher","first-page":"4155","DOI":"10.3390\/cancers15164155","article-title":"Understanding DNA damage response and DNA repair in multiple myeloma","volume":"15","author":"Petrilla","year":"2023","journal-title":"Cancers (Basel)"},{"issue":"1","key":"bib65","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1038\/s41374-018-0114-8","article-title":"Overexpression of HIF-1a contributes to melphalan resistance in multiple myeloma cells by activation of ERK1\/2, Akt, and NF-?B","volume":"99","author":"Tsubaki","year":"2019","journal-title":"Lab Invest"},{"issue":"3","key":"bib66","doi-asserted-by":"publisher","first-page":"e24670","DOI":"10.1016\/j.heliyon.2024.e24670","article-title":"Metronomic chemotherapy and drug repurposing: a paradigm shift in oncology","volume":"10","author":"Jan","year":"2024","journal-title":"Heliyon"},{"issue":"8","key":"bib67","doi-asserted-by":"publisher","first-page":"4382","DOI":"10.1167\/iovs.14-16239","article-title":"Pharmacokinetics, safety, and efficacy of intravitreal digoxin in preclinical models for retinoblastoma","volume":"56","author":"Winter","year":"2015","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"1","key":"bib68","first-page":"107","article-title":"Impact of ABCB1 (MDR1) gene polymorphism and P-glycoprotein inhibitors on digoxin serum concentration in congestive heart failure patients","volume":"59","author":"Kurzawski","year":"2007","journal-title":"Pharmacol Rep"},{"issue":"24","key":"bib69","doi-asserted-by":"publisher","first-page":"1973","DOI":"10.1136\/heartjnl-2014-307419","article-title":"ABCB1 gene variants, digoxin and risk of sudden cardiac death in a general population","volume":"101","author":"Niemeijer","year":"2015","journal-title":"Heart"},{"issue":"9","key":"bib70","doi-asserted-by":"publisher","first-page":"e27246","DOI":"10.1002\/pbc.27246","article-title":"Gemcitabine\/nab-paclitaxel for pediatric relapsed\/refractory sarcomas","volume":"65","author":"Metts","year":"2018","journal-title":"Pediatr Blood Cancer"},{"issue":"12","key":"bib71","doi-asserted-by":"publisher","first-page":"2445","DOI":"10.1200\/JCO.2004.10.142","article-title":"Phase I trial and pharmacokinetics of gemcitabine in children with advanced solid tumors","volume":"22","author":"Reid","year":"2004","journal-title":"J Clin Oncol"},{"key":"bib72","doi-asserted-by":"publisher","first-page":"112260","DOI":"10.1016\/j.jphotobiol.2021.112260","article-title":"Methylene blue-mediated photodynamic therapy in human retinoblastoma cell lines","volume":"222","author":"Turchiello","year":"2021","journal-title":"J Photochem Photobiol B"},{"issue":"4","key":"bib73","doi-asserted-by":"publisher","first-page":"517","DOI":"10.4103\/0970-9185.74599","article-title":"Methylene blue: revisited","volume":"26","author":"Ginimuge","year":"2010","journal-title":"J Anaesthesiol Clin Pharmacol"},{"issue":"1","key":"bib74","doi-asserted-by":"publisher","first-page":"224","DOI":"10.1182\/blood.V100.1.224","article-title":"Repair of DNA interstrand crosslinks as a mechanism of clinical resistance to melphalan in multiple myeloma","volume":"100","author":"Spanswick","year":"2002","journal-title":"Blood"},{"key":"bib75","doi-asserted-by":"publisher","first-page":"436","DOI":"10.1186\/1471-2407-12-436","article-title":"Evidence for different mechanisms of \u201cunhooking\u201d for melphalan and cisplatin-induced DNA interstrand cross-links in vitro and in clinical acquired resistant tumour samples","volume":"12","author":"Spanswick","year":"2012","journal-title":"BMC Cancer"},{"issue":"17","key":"bib76","doi-asserted-by":"publisher","first-page":"2760","DOI":"10.4161\/cc.25951","article-title":"DNA repair pathways in human multiple myeloma: role in oncogenesis and potential targets for treatment","volume":"12","author":"Gourzones-Dmitriev","year":"2013","journal-title":"Cell Cycle"},{"issue":"22","key":"bib77","first-page":"7900","article-title":"Genotypic and phenotypic comparisons of de novo and acquired melphalan resistance in an isogenic multiple myeloma cell line model","volume":"63","author":"Hazlehurst","year":"2003","journal-title":"Cancer Res"},{"issue":"2","key":"bib78","doi-asserted-by":"publisher","first-page":"e55493","DOI":"10.1371\/journal.pone.0055493","article-title":"An inverse switch in DNA base excision and strand break repair contributes to melphalan resistance in multiple myeloma cells","volume":"8","author":"Sousa","year":"2013","journal-title":"PLoS One"},{"issue":"4","key":"bib79","doi-asserted-by":"publisher","first-page":"680","DOI":"10.3390\/cancers16040680","article-title":"Understanding cancer's defense against topoisomerase-active drugs: a comprehensive review","volume":"16","author":"Sharma","year":"2024","journal-title":"Cancers (Basel)"},{"issue":"1","key":"bib80","doi-asserted-by":"publisher","first-page":"15664","DOI":"10.1038\/s41598-018-34037-y","article-title":"A three-dimensional organoid model recapitulates tumorigenic aspects and drug responses of advanced human retinoblastoma","volume":"8","author":"Saengwimol","year":"2018","journal-title":"Sci Rep"},{"key":"bib81","doi-asserted-by":"publisher","first-page":"109447","DOI":"10.1016\/j.exer.2023.109447","article-title":"The predictive capacity of in vitro preclinical models to evaluate drugs for the treatment of retinoblastoma","volume":"230","author":"Sinenko","year":"2023","journal-title":"Exp Eye Res"},{"key":"bib1","volume-title":"CureAll Framework: WHO Global Initiative for Childhood Cancer: Increasing Access, Advancing Quality, Saving Lives","author":"World Health Organization (WHO)","year":"2021"},{"key":"bib40","author":"Picard Tools - By Broad Institute"},{"key":"bib46","first-page":"212","article-title":"Addition of \u00df-blocker propranolol or antiparasitic drug ivermectin enhances methotrexate anticancer activity in human osteosarcoma cells","volume-title":"Reuni\u00f3n de Sociedades de Biociencia 2021","author":"Solern\u00f3","year":"2021"},{"key":"bib50","first-page":"134","article-title":"Ocular and systemic safety of repeated intravitreal high doses of topotecan in rabbits: implications in retinoblastoma treatment","volume-title":"International Society for Genetic Eye Diseases & Retinoblastoma 2021 Meeting","author":"Del Sole","year":"2021"}],"container-title":["Investigative Ophthalmology &amp; Visual Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/iovs.arvojournals.org\/article.aspx?articleid=2802325","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:31:47Z","timestamp":1791927107000},"score":1,"resource":{"primary":{"URL":"https:\/\/iovs.arvojournals.org\/article.aspx?articleid=2802325"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,5]]},"references-count":81,"journal-issue":{"issue":"14","published-print":{"date-parts":[[2024,12,2]]}},"URL":"https:\/\/doi.org\/10.1167\/iovs.65.14.14","relation":{},"ISSN":["1552-5783"],"issn-type":[{"value":"1552-5783","type":"print"}],"subject":[],"published":{"date-parts":[[2024,12,5]]}}}