{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T22:01:21Z","timestamp":1791928881257,"version":"4.3.4"},"reference-count":204,"publisher":"Association for Research in Vision and Ophthalmology (ARVO)","issue":"14","license":[{"start":{"date-parts":[[2024,12,27]],"date-time":"2024-12-27T00:00:00Z","timestamp":1735257600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Invest. Ophthalmol. Vis. Sci."],"published-print":{"date-parts":[[2024,12,27]]},"DOI":"10.1167\/iovs.65.14.41","type":"journal-article","created":{"date-parts":[[2024,12,27]],"date-time":"2024-12-27T09:30:52Z","timestamp":1735291852000},"page":"41","source":"Crossref","is-referenced-by-count":19,"title":["Functional Roles of Pigment Epithelium-Derived Factor in Retinal Degenerative and Vascular Disorders: A Scoping Review"],"prefix":"10.1167","volume":"65","author":[{"given":"Thomas Stax","family":"Jakobsen","sequence":"first","affiliation":[{"name":"Department of Biomedicine, Aarhus University, Aarhus C, Denmark"},{"name":"Department of Ophthalmology, Aarhus University Hospital, Aarhus N, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rikke L.","family":"Adsersen","sequence":"additional","affiliation":[{"name":"Department of Biomedicine, Aarhus University, Aarhus C, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne Louise","family":"Askou","sequence":"additional","affiliation":[{"name":"Department of Biomedicine, Aarhus University, Aarhus C, Denmark"},{"name":"Department of Ophthalmology, Aarhus University Hospital, Aarhus N, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas J.","family":"Corydon","sequence":"additional","affiliation":[{"name":"Department of Biomedicine, Aarhus University, Aarhus C, Denmark"},{"name":"Department of Ophthalmology, Aarhus University Hospital, Aarhus N, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"27","reference":[{"key":"bib1","doi-asserted-by":"publisher","first-page":"796","DOI":"10.1016\/j.oret.2022.03.021","article-title":"Longer-term anti-VEGF therapy outcomes in neovascular age-related macular degeneration, diabetic macular edema, and vein occlusion-related macular edema: clinical outcomes in 130 247 eyes","volume":"6","author":"Ciulla","year":"2022","journal-title":"Ophthalmol Retina"},{"key":"bib2","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1038\/s41434-020-0168-2","article-title":"Retinal gene therapy: an eye-opener of the 21st century","volume":"28","author":"Askou","year":"2021","journal-title":"Gene Ther"},{"key":"bib3","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1126\/science.285.5425.245","article-title":"Pigment epithelium-derived factor: a potent inhibitor of angiogenesis","volume":"285","author":"Dawson","year":"1999","journal-title":"Science"},{"key":"bib4","doi-asserted-by":"publisher","first-page":"1526","DOI":"10.1073\/pnas.90.4.1526","article-title":"Pigment epithelium-derived factor: neurotrophic activity and identification as a member of the serine protease inhibitor gene family","volume":"90","author":"Steele","year":"1993","journal-title":"Proc Natl Acad Sci USA"},{"key":"bib5","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1016\/0014-4835(91)90248-D","article-title":"PEDF: a pigment epithelium-derived factor with potent neuronal differentiative activity","volume":"53","author":"Tombran-Tink","year":"1991","journal-title":"Exp Eye Res"},{"key":"bib6","doi-asserted-by":"publisher","first-page":"739","DOI":"10.1016\/j.exer.2005.10.016","article-title":"Focus on molecules: pigment epithelium-derived factor (PEDF)","volume":"82","author":"Becerra","year":"2006","journal-title":"Exp Eye Res"},{"key":"bib7","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1186\/1471-2164-7-248","article-title":"Molecular phylogeny of the antiangiogenic and neurotrophic serpin, pigment epithelium derived factor in vertebrates","volume":"7","author":"Xu","year":"2006","journal-title":"BMC Genomics"},{"key":"bib9","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1186\/s13046-015-0278-7","article-title":"Anti-tumor effects of pigment epithelium-derived factor (PEDF): implication for cancer therapy. A mini-review","volume":"35","author":"Belkacemi","year":"2016","journal-title":"J Exp Clin Cancer Res"},{"key":"bib10","doi-asserted-by":"publisher","first-page":"11131","DOI":"10.1073\/pnas.211268598","article-title":"Crystal structure of human PEDF, a potent anti-angiogenic and neurite growth-promoting factor","volume":"98","author":"Simonovic","year":"2001","journal-title":"Proc Natl Acad Sci USA"},{"key":"bib11","doi-asserted-by":"publisher","first-page":"1677","DOI":"10.1515\/BC.2002.188","article-title":"Pigment epithelium-derived factor (PEDF), a serpin with potent anti-angiogenic and neurite outgrowth-promoting properties","volume":"383","author":"Gettins","year":"2002","journal-title":"Biol Chem"},{"key":"bib12","doi-asserted-by":"publisher","first-page":"25992","DOI":"10.1074\/jbc.270.43.25992","article-title":"Pigment epithelium-derived factor behaves like a noninhibitory serpin","volume":"270","author":"Becerra","year":"1995","journal-title":"J Biol Chem"},{"key":"bib13","doi-asserted-by":"publisher","first-page":"5144","DOI":"10.1158\/0008-5472.CAN-04-3744","article-title":"Two functional epitopes of pigment epithelial-derived factor block angiogenesis and induce differentiation in prostate cancer","volume":"65","author":"Filleur","year":"2005","journal-title":"Cancer Res"},{"key":"bib14","doi-asserted-by":"publisher","first-page":"107798","DOI":"10.1016\/j.exer.2019.107798","article-title":"Novel anti-angiogenic PEDF-derived small peptides mitigate choroidal neovascularization","volume":"188","author":"Sheibani","year":"2019","journal-title":"Exp Eye Res"},{"key":"bib15","doi-asserted-by":"publisher","first-page":"822","DOI":"10.1046\/j.1432-1033.2003.03374.x","article-title":"Secretion of pigment epithelium-derived factor","volume":"270","author":"Shao","year":"2003","journal-title":"Eur J Biochem"},{"key":"bib16","doi-asserted-by":"publisher","first-page":"e26234","DOI":"10.1371\/journal.pone.0026234","article-title":"Pigment epithelium-derived factor (PEDF) interacts with transportin SR2, and active nuclear import is facilitated by a novel nuclear localization motif","volume":"6","author":"Anguissola","year":"2011","journal-title":"PLoS One"},{"key":"bib17","doi-asserted-by":"publisher","first-page":"670","DOI":"10.1182\/blood-2004-04-1569","article-title":"Extracellular phosphorylation converts pigment epithelium\u2013derived factor from a neurotrophic to an antiangiogenic factor","volume":"105","author":"Maik-Rachline","year":"2005","journal-title":"Blood"},{"key":"bib18","doi-asserted-by":"publisher","first-page":"45400","DOI":"10.1074\/jbc.M208339200","article-title":"Mapping the type I collagen-binding site on pigment epithelium-derived factor","volume":"277","author":"Meyer","year":"2002","journal-title":"J Biol Chem"},{"key":"bib19","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1186\/s12886-022-02295-0","article-title":"A short peptide derived from pigment epithelial-derived factor exhibits an angioinhibitory effect","volume":"22","author":"Ho","year":"2022","journal-title":"BMC Ophthalmol"},{"key":"bib20","doi-asserted-by":"publisher","first-page":"25241","DOI":"10.1074\/jbc.M115.645846","article-title":"Small retinoprotective peptides reveal a receptor-binding region on pigment epithelium-derived factor","volume":"290","author":"Kenealey","year":"2015","journal-title":"J Biol Chem"},{"key":"bib21","doi-asserted-by":"publisher","first-page":"10480","DOI":"10.1074\/jbc.M809259200","article-title":"Laminin receptor involvement in the anti-angiogenic activity of pigment epithelium-derived factor","volume":"284","author":"Bernard","year":"2009","journal-title":"J Biol Chem"},{"key":"bib22","doi-asserted-by":"publisher","first-page":"38022","DOI":"10.1074\/jbc.M600353200","article-title":"Identification of a lipase-linked cell membrane receptor for pigment epithelium-derived factor","volume":"281","author":"Notari","year":"2006","journal-title":"J Biol Chem"},{"key":"bib23","doi-asserted-by":"publisher","first-page":"3038","DOI":"10.1128\/MCB.01211-10","article-title":"Identification of a novel inhibitor of the canonical Wnt pathway","volume":"31","author":"Park","year":"2011","journal-title":"Mol Cell Biol"},{"key":"bib24","doi-asserted-by":"publisher","first-page":"730","DOI":"10.1007\/s11626-015-9884-0","article-title":"Recombinant pigment epithelium-derived factor PEDF binds vascular endothelial growth factor receptors 1 and 2","volume":"51","author":"Johnston","year":"2015","journal-title":"In Vitro Cell Dev Biol Anim"},{"key":"bib25","doi-asserted-by":"publisher","first-page":"2192","DOI":"10.1111\/j.1742-4658.2010.07641.x","article-title":"Pigment epithelium-derived factor binds to cell-surface F1-ATP synthase","volume":"277","author":"Notari","year":"2010","journal-title":"FEBS J"},{"key":"bib26","doi-asserted-by":"publisher","first-page":"e05401","DOI":"10.7554\/eLife.05401","article-title":"Identification of PLXDC1 and PLXDC2 as the transmembrane receptors for the multifunctional factor PEDF","volume":"3","author":"Cheng","year":"2014","journal-title":"Elife"},{"key":"bib27","doi-asserted-by":"publisher","first-page":"3160","DOI":"10.1021\/bi0206558","article-title":"Dual-site recognition of different extracellular matrix components by anti-angiogenic\/neurotrophic serpin, PEDF","volume":"42","author":"Yasui","year":"2003","journal-title":"Biochemistry"},{"key":"bib28","doi-asserted-by":"publisher","first-page":"33310","DOI":"10.1074\/jbc.M801287200","article-title":"Pigment epithelium-derived factor binds to hyaluronan. Mapping of a hyaluronan binding site","volume":"283","author":"Becerra","year":"2008","journal-title":"J Biol Chem"},{"key":"bib29","doi-asserted-by":"publisher","first-page":"10643","DOI":"10.1021\/bi9802317","article-title":"Pigment epithelium-derived factor (PEDF) binds to glycosaminoglycans: analysis of the binding site","volume":"37","author":"Alberdi","year":"1998","journal-title":"Biochemistry"},{"key":"bib30","doi-asserted-by":"publisher","first-page":"26364","DOI":"10.1074\/jbc.M111.252684","article-title":"Pigment epithelium-derived factor (PEDF) shares binding sites in collagen with heparin\/heparan sulfate proteoglycans","volume":"286","author":"Sekiya","year":"2011","journal-title":"J Biol Chem"},{"key":"bib31","doi-asserted-by":"publisher","first-page":"756","DOI":"10.1016\/j.bbrc.2005.07.140","article-title":"Involvement of the collagen I-binding motif in the anti-angiogenic activity of pigment epithelium-derived factor","volume":"335","author":"Hosomichi","year":"2005","journal-title":"Biochem Biophys Res Commun"},{"key":"bib32","doi-asserted-by":"publisher","first-page":"1709","DOI":"10.1007\/s00417-019-04394-z","article-title":"Type I pig collagen enhances the efficacy of PEDF 34-mer peptide in a mouse model of laser-induced choroidal neovascularization","volume":"257","author":"Kim","year":"2019","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"key":"bib33","doi-asserted-by":"publisher","first-page":"11450","DOI":"10.1073\/pnas.2004034117","article-title":"Spatiotemporal regulation of PEDF signaling by type I collagen remodeling","volume":"117","author":"Kawahara","year":"2020","journal-title":"Proc Natl Acad Sci USA"},{"key":"bib34","doi-asserted-by":"publisher","first-page":"561","DOI":"10.1016\/j.preteyeres.2004.05.002","article-title":"Neuroprotective and antiangiogenic actions of PEDF in the eye: molecular targets and therapeutic potential","volume":"23","author":"Barnstable","year":"2004","journal-title":"Prog Retin Eye Res"},{"key":"bib35","doi-asserted-by":"publisher","first-page":"4992","DOI":"10.1523\/JNEUROSCI.15-07-04992.1995","article-title":"Expression, secretion, and age-related downregulation of pigment epithelium-derived factor, a serpin with neurotrophic activity","volume":"15","author":"Tombran-Tink","year":"1995","journal-title":"J Neurosci"},{"key":"bib36","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1016\/j.exer.2003.10.013","article-title":"Pigment epithelium-derived factor in the monkey retinal pigment epithelium and interphotoreceptor matrix: apical secretion and distribution","volume":"78","author":"Becerra","year":"2004","journal-title":"Exp Eye Res"},{"key":"bib37","first-page":"1984","article-title":"Proteolytic activity directed toward pigment epithelium-derived factor in vitreous of bovine eyes. Implications of proteolytic processing","volume":"37","author":"Wu","year":"1996","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib39","first-page":"154","article-title":"Localization of pigment epithelium derived factor (PEDF) in developing and adult human ocular tissues","volume":"7","author":"Karakousis","year":"2001","journal-title":"Mol Vis"},{"key":"bib40","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1016\/S0014-4835(03)00174-X","article-title":"Expression of pigment epithelium-derived factor (PEDF) and vascular endothelial growth factor (VEGF) in sickle cell retina and choroid","volume":"77","author":"Kim","year":"2003","journal-title":"Exp Eye Res"},{"key":"bib41","doi-asserted-by":"publisher","first-page":"2641","DOI":"10.2337\/diabetes.50.12.2641","article-title":"Loss of the antiangiogenic pigment epithelium-derived factor in patients with angiogenic eye disease","volume":"50","author":"Spranger","year":"2001","journal-title":"Diabetes"},{"key":"bib42","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1016\/j.yexcr.2004.05.020","article-title":"PEDF derived from glial M\u00fcller cells: a possible regulator of retinal angiogenesis","volume":"299","author":"Eichler","year":"2004","journal-title":"Exp Cell Res"},{"key":"bib43","first-page":"1168","article-title":"Expression of pigment epithelium-derived factor in normal adult rat eye and experimental choroidal neovascularization","volume":"43","author":"Ogata","year":"2002","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib44","first-page":"1574","article-title":"Expression of pigment epithelium-derived factor in experimental choroidal neovascularization","volume":"43","author":"Renno","year":"2002","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib45","first-page":"449","article-title":"Pigment epithelium-derived factor expression in the developing mouse eye","volume":"8","author":"Behling","year":"2002","journal-title":"Mol Vis"},{"key":"bib46","doi-asserted-by":"publisher","first-page":"7745","DOI":"10.3390\/ijms23147745","article-title":"PEDF deletion induces senescence and defects in phagocytosis in the RPE","volume":"23","author":"Rebustini","year":"2022","journal-title":"Int J Mol Sci"},{"key":"bib47","doi-asserted-by":"publisher","first-page":"935","DOI":"10.1016\/j.ajo.2003.08.058","article-title":"Decrease of pigment epithelium-derived factor in aqueous humor with increasing age","volume":"137","author":"Ogata","year":"2004","journal-title":"Am J Ophthalmol"},{"key":"bib48","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1186\/s40942-024-00556-2","article-title":"Vitreous levels of pigment epithelium-derived factor and vascular endothelial growth factor in diabetic and non-diabetic retinopathy: associated factors and anatomical correlation","volume":"10","author":"Al-Dwairi","year":"2024","journal-title":"Int J Retina Vitreous"},{"key":"bib49","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1016\/j.exer.2005.05.007","article-title":"Pigment epithelium-derived factor (PEDF) and vascular endothelial growth factor (VEGF) in aged human choroid and eyes with age-related macular degeneration","volume":"82","author":"Bhutto","year":"2006","journal-title":"Exp Eye Res"},{"key":"bib50","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1016\/j.clinbiochem.2005.11.013","article-title":"Contribution of VEGF and PEDF to choroidal angiogenesis: a need for balanced expressions","volume":"39","author":"Tong","year":"2006","journal-title":"Clin Biochem"},{"key":"bib51","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1167\/tvst.12.11.9","article-title":"Correlation of aqueous, vitreous, and serum protein levels in patients with retinal diseases","volume":"12","author":"Wilson","year":"2023","journal-title":"Transl Vis Sci Technol"},{"key":"bib52","doi-asserted-by":"publisher","first-page":"394","DOI":"10.1007\/s00125-003-1040-9","article-title":"Low content of the natural ocular anti-angiogenic agent pigment epithelium-derived factor (PEDF) in aqueous humor predicts progression of diabetic retinopathy","volume":"46","author":"Boehm","year":"2003","journal-title":"Diabetologia"},{"key":"bib53","doi-asserted-by":"publisher","first-page":"e799","DOI":"10.1210\/clinem\/dgad112","article-title":"Circulating AFABP, FGF21, and PEDF levels as prognostic biomarkers of sight-threatening diabetic retinopathy","volume":"108","author":"Lee","year":"2023","journal-title":"J Clin Endocrinol Metab"},{"key":"bib54","doi-asserted-by":"publisher","first-page":"1559","DOI":"10.1007\/s00417-010-1486-7","article-title":"Pigment epithelium-derived factor and vascular endothelial growth factor in branch retinal vein occlusion with macular edema","volume":"248","author":"Noma","year":"2010","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"key":"bib55","doi-asserted-by":"publisher","first-page":"220","DOI":"10.1016\/S0002-9394(02)01549-0","article-title":"Pigment epithelium-derived factor is deficient in the vitreous of patients with choroidal neovascularization due to age-related macular degeneration","volume":"134","author":"Holekamp","year":"2002","journal-title":"Am J Ophthalmol"},{"key":"bib56","doi-asserted-by":"publisher","first-page":"188","DOI":"10.1159\/000339952","article-title":"Vitreous levels of proteins implicated in angiogenesis are modulated in patients with retinal or choroidal neovascularization","volume":"228","author":"Huber","year":"2012","journal-title":"Ophthalmologica"},{"key":"bib57","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1016\/j.exer.2016.01.001","article-title":"Proteomics of vitreous in neovascular age-related macular degeneration","volume":"146","author":"Nobl","year":"2016","journal-title":"Exp Eye Res"},{"key":"bib58","doi-asserted-by":"publisher","first-page":"670","DOI":"10.1001\/archopht.126.5.670","article-title":"Reduction of endogenous angiogenesis inhibitors in Bruch's membrane of the submacular region in eyes with age-related macular degeneration","volume":"126","author":"Bhutto","year":"2008","journal-title":"Arch Ophthalmol"},{"key":"bib59","doi-asserted-by":"publisher","first-page":"809","DOI":"10.1136\/bjo.2003.032466","article-title":"Expression of pigment epithelium derived factor and vascular endothelial growth factor in choroidal neovascular membranes and polypoidal choroidal vasculopathy","volume":"88","author":"Matsuoka","year":"2004","journal-title":"Br J Ophthalmol"},{"key":"bib60","doi-asserted-by":"publisher","first-page":"2599","DOI":"10.1021\/pr060121j","article-title":"Secreted proteome profiling in human RPE cell cultures derived from donors with age related macular degeneration and age matched healthy donors","volume":"5","author":"An","year":"2006","journal-title":"J Proteome Res"},{"key":"bib61","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1159\/000111151","article-title":"Vitreous fluid of db\/db mice exhibits alterations in angiogenic and metabolic factors consistent with early diabetic retinopathy","volume":"40","author":"Cohen","year":"2008","journal-title":"Ophthalmic Res"},{"key":"bib62","doi-asserted-by":"publisher","first-page":"656","DOI":"10.18240\/ijo.2021.05.04","article-title":"Protective effects of piperine on the retina of mice with streptozotocin-induced diabetes by suppressing HIF-1\/VEGFA pathway and promoting PEDF expression","volume":"14","author":"Zhang","year":"2021","journal-title":"Int J Ophthalmol"},{"key":"bib63","doi-asserted-by":"publisher","first-page":"108027","DOI":"10.1016\/j.exer.2020.108027","article-title":"Dysregulation of trophic factors contributes to diabetic retinopathy in the Ins2(Akita) mouse","volume":"194","author":"Ara\u00fajo","year":"2020","journal-title":"Exp Eye Res"},{"key":"bib64","doi-asserted-by":"publisher","first-page":"5089","DOI":"10.1167\/iovs.08-1993","article-title":"Amelioration of diabetes-associated abnormalities in the vitreous fluid by an inhibitor of albumin glycation","volume":"49","author":"Cohen","year":"2008","journal-title":"Invest Opthalmol Vis Sci"},{"key":"bib65","doi-asserted-by":"publisher","first-page":"678","DOI":"10.1002\/dmrr.1007","article-title":"Protective role of pigment epithelium-derived factor (PEDF) in early phase of experimental diabetic retinopathy","volume":"25","author":"Yoshida","year":"2009","journal-title":"Diabetes Metab Res Rev"},{"key":"bib66","doi-asserted-by":"publisher","first-page":"954","DOI":"10.2337\/db07-1524","article-title":"Protective effect of perindopril on diabetic retinopathy is associated with decreased vascular endothelial growth factor\u2013to\u2013pigment epithelium\u2013derived factor ratio","volume":"58","author":"Zheng","year":"2009","journal-title":"Diabetes"},{"key":"bib67","doi-asserted-by":"publisher","first-page":"172","DOI":"10.1016\/j.exer.2005.05.011","article-title":"High levels of pigment epithelium-derived factor in the retina of a rat model of type 2 diabetes","volume":"82","author":"Matsuoka","year":"2006","journal-title":"Exp Eye Res"},{"key":"bib68","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1159\/000354116","article-title":"Beneficial effects of vildagliptin on retinal injury in obese type 2 diabetic rats","volume":"50","author":"Maeda","year":"2013","journal-title":"Ophthalmic Res"},{"key":"bib69","doi-asserted-by":"publisher","first-page":"1318","DOI":"10.1167\/iovs.09-4455","article-title":"Effects of human recombinant PEDF protein and PEDF-derived peptide 34-mer on choroidal neovascularization","volume":"51","author":"Amaral","year":"2010","journal-title":"Invest Opthalmol Vis Sci"},{"key":"bib70","doi-asserted-by":"publisher","first-page":"795","DOI":"10.1001\/archopht.125.6.795","article-title":"Biochemical alterations in the retinas of very low-density lipoprotein receptor knockout mice","volume":"125","author":"Li","year":"2007","journal-title":"Arch Ophthalmol"},{"key":"bib71","doi-asserted-by":"publisher","first-page":"109171","DOI":"10.1016\/j.exer.2022.109171","article-title":"Deletion of the Pedf gene leads to inflammation, photoreceptor loss and vascular disturbances in the retina","volume":"222","author":"Chen","year":"2022","journal-title":"Exp Eye Res"},{"key":"bib72","doi-asserted-by":"publisher","first-page":"226","DOI":"10.1016\/j.exer.2008.06.003","article-title":"PEDF-deficient mice exhibit an enhanced rate of retinal vascular expansion and are more sensitive to hyperoxia-mediated vessel obliteration","volume":"87","author":"Huang","year":"2008","journal-title":"Exp Eye Res"},{"issue":"Suppl 12","key":"bib73","article-title":"Thrombospondin-1 deficiency exacerbates the pathogenesis of diabetic retinopathy","author":"Sorenson","year":"2013","journal-title":"J Diabetes Metab"},{"key":"bib74","doi-asserted-by":"publisher","first-page":"108121","DOI":"10.1016\/j.exer.2020.108121","article-title":"PEDF deficiency increases the susceptibility of rd10 mice to retinal degeneration","volume":"198","author":"Dixit","year":"2020","journal-title":"Exp Eye Res"},{"key":"bib75","doi-asserted-by":"publisher","first-page":"2697","DOI":"10.1007\/s11357-023-01038-3","article-title":"PEDF protects retinal pigment epithelium from ferroptosis and ameliorates dry AMD-like pathology in a murine model","volume":"46","author":"Xiang","year":"2023","journal-title":"GeroScience"},{"key":"bib76","doi-asserted-by":"publisher","first-page":"723","DOI":"10.1002\/jbmr.1480","article-title":"Lack of expression of SERPINF1, the gene coding for pigment epithelium-derived factor, causes progressively deforming osteogenesis imperfecta with normal type I collagen","volume":"27","author":"Venturi","year":"2012","journal-title":"J Bone Miner Res"},{"key":"bib77","doi-asserted-by":"publisher","first-page":"716","DOI":"10.1016\/j.ajo.2007.11.006","article-title":"Pigment epithelium-derived factor gene Met72Thr polymorphism is associated with increased risk of wet age-related macular degeneration","volume":"145","author":"Lin","year":"2008","journal-title":"Am J Ophthalmol"},{"key":"bib78","doi-asserted-by":"publisher","first-page":"e201","DOI":"10.1111\/aos.13519","article-title":"Association between CFH, CFB, ARMS2, SERPINF1, VEGFR1 and VEGF polymorphisms and anatomical and functional response to ranibizumab treatment in neovascular age-related macular degeneration","volume":"96","author":"Cobos","year":"2018","journal-title":"Acta Ophthalmol"},{"key":"bib79","doi-asserted-by":"publisher","first-page":"9497","DOI":"10.1038\/srep09497","article-title":"Association of PEDF polymorphisms with age-related macular degeneration and polypoidal choroidal vasculopathy: a systematic review and meta-analysis","volume":"5","author":"Ma","year":"2015","journal-title":"Sci Rep"},{"key":"bib80","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1016\/j.bbrc.2007.07.025","article-title":"Promoter polymorphisms of the pigment epithelium-derived factor gene are associated with diabetic retinopathy","volume":"361","author":"Iizuka","year":"2007","journal-title":"Biochem Biophys Res Commun"},{"key":"bib81","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1186\/1471-2350-11-158","article-title":"Association analysis of nine candidate gene polymorphisms in Indian patients with type 2 diabetic retinopathy","volume":"11","author":"Balasubbu","year":"2010","journal-title":"BMC Med Genet"},{"key":"bib82","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1258\/la.2010.009117","article-title":"Enhancing search efficiency by means of a search filter for finding all studies on animal experimentation in PubMed","volume":"44","author":"Hooijmans","year":"2010","journal-title":"Lab Anim"},{"key":"bib83","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1167\/iovs.63.9.11","article-title":"Animal models of choroidal neovascularization: a systematic review","volume":"63","author":"Fabian-Jessing","year":"2022","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib84","doi-asserted-by":"publisher","first-page":"4491","DOI":"10.1167\/iovs.04-0172","article-title":"Stimulation of neovascularization by the anti-angiogenic factor PEDF","volume":"45","author":"Apte","year":"2004","journal-title":"Invest Opthalmol Vis Sci"},{"key":"bib85","first-page":"2428","article-title":"Regression of ocular neovascularization in response to increased expression of pigment epithelium-derived factor","volume":"43","author":"Mori","year":"2002","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib86","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1089\/hum.2009.102","article-title":"Inhibition of choroidal neovascularization via brief subretinal exposure to a newly developed lentiviral vector pseudotyped with Sendai viral envelope proteins","volume":"21","author":"Murakami","year":"2010","journal-title":"Hum Gene Ther"},{"key":"bib87","doi-asserted-by":"publisher","first-page":"196","DOI":"10.1159\/000500026","article-title":"Pathophysiology of diabetic retinopathy: contribution and limitations of laboratory research","volume":"62","author":"Kern","year":"2019","journal-title":"Ophthalmic Res"},{"key":"bib88","doi-asserted-by":"publisher","first-page":"807","DOI":"10.1167\/iovs.18-25372","article-title":"Longitudinal in vivo characterization of the streptozotocin-induced diabetic mouse model: focus on early inner retinal responses","volume":"60","author":"Sergeys","year":"2019","journal-title":"Invest Opthalmol Vis Sci"},{"key":"bib89","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1186\/s12886-023-03155-1","article-title":"Diabetic retinopathy: a comprehensive update on in vivo, in vitro and ex vivo experimental models","volume":"23","author":"Sadikan","year":"2023","journal-title":"BMC Ophthalmol"},{"key":"bib90","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1096\/fj.05-4313fje","article-title":"Pigment epithelium-derived factor (PEDF) is an endogenous antiinflammatory factor","volume":"20","author":"Zhang","year":"2006","journal-title":"FASEB J"},{"key":"bib91","doi-asserted-by":"publisher","first-page":"1049678","DOI":"10.3389\/fcell.2022.1049678","article-title":"Sustained therapeutic effect of an anti-inflammatory peptide encapsulated in nanoparticles on ocular vascular leakage in diabetic retinopathy","volume":"10","author":"Qu","year":"2022","journal-title":"Front Cell Dev Biol"},{"key":"bib92","doi-asserted-by":"publisher","first-page":"1387","DOI":"10.2119\/molmed.2012.00008","article-title":"Pigment epithelium-derived factor (PEDF) peptide eye drops reduce inflammation, cell death and vascular leakage in diabetic retinopathy in Ins2(Akita) mice","volume":"18","author":"Liu","year":"2012","journal-title":"Mol Med"},{"key":"bib93","first-page":"2384","article-title":"Administration of pigment epithelium-derived factor delivered by adeno-associated virus inhibits blood-retinal barrier breakdown in diabetic rats","volume":"16","author":"Yu","year":"2010","journal-title":"Mol Vis"},{"key":"bib94","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1016\/j.mvr.2006.04.002","article-title":"Pigment epithelium-derived factor (PEDF) prevents diabetes- or advanced glycation end products (AGE)-elicited retinal leukostasis","volume":"72","author":"Yamagishi","year":"2006","journal-title":"Microvasc Res"},{"key":"bib95","doi-asserted-by":"publisher","first-page":"108030","DOI":"10.1016\/j.exer.2020.108030","article-title":"Inhibition of retinal neovascularization by a PEDF-derived nonapeptide in newborn mice subjected to oxygen-induced ischemic retinopathy","volume":"195","author":"Sheibani","year":"2020","journal-title":"Exp Eye Res"},{"key":"bib96","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1186\/s12951-023-02066-z","article-title":"Enhanced therapeutic effect of PEDF-loaded mesenchymal stem cell-derived small extracellular vesicles against oxygen-induced retinopathy through increased stability and penetrability of PEDF","volume":"21","author":"Fan","year":"2023","journal-title":"J Nanobiotechnology"},{"key":"bib97","doi-asserted-by":"publisher","first-page":"109743","DOI":"10.1016\/j.exer.2023.109743","article-title":"Short peptides derived from pigment epithelium-derived factor attenuate retinal ischemia reperfusion injury through inhibition of apoptosis and inflammatory response in rats","volume":"238","author":"Sun","year":"2024","journal-title":"Exp Eye Res"},{"key":"bib98","doi-asserted-by":"publisher","first-page":"523","DOI":"10.1006\/nbdi.1999.0263","article-title":"Pigment epithelium-derived factor delays the death of photoreceptors in mouse models of inherited retinal degenerations","volume":"6","author":"Cayouette","year":"1999","journal-title":"Neurobiol Dis"},{"key":"bib99","first-page":"3079","article-title":"Photoreceptor rescue of pigment epithelium-derived factor-impregnated nanoparticles in Royal College of Surgeons rats","volume":"18","author":"Akiyama","year":"2012","journal-title":"Mol Vis"},{"key":"bib100","doi-asserted-by":"publisher","first-page":"560","DOI":"10.1038\/s41419-018-0613-y","article-title":"Pigment epithelium-derived factor hinders photoreceptor cell death by reducing intracellular calcium in the degenerating retina","volume":"9","author":"Comitato","year":"2018","journal-title":"Cell Death Dis"},{"key":"bib101","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1016\/j.exer.2019.04.008","article-title":"PEDF peptides promote photoreceptor survival in rd10 retina models","volume":"184","author":"Hern\u00e1ndez-Pinto","year":"2019","journal-title":"Exp Eye Res"},{"key":"bib102","doi-asserted-by":"publisher","first-page":"1503","DOI":"10.1038\/sj.gt.3302028","article-title":"Simian lentiviral vector-mediated retinal gene transfer of pigment epithelium-derived factor protects retinal degeneration and electrical defect in Royal College of Surgeons rats","volume":"10","author":"Miyazaki","year":"2003","journal-title":"Gene Ther"},{"key":"bib103","doi-asserted-by":"publisher","first-page":"1273","DOI":"10.1002\/jgm.1257","article-title":"Synergistic neuroprotective effect via simian lentiviral vector-mediated simultaneous gene transfer of human pigment epithelium-derived factor and human fibroblast growth factor-2 in rodent models of retinitis pigmentosa","volume":"10","author":"Miyazaki","year":"2008","journal-title":"J Gene Med"},{"key":"bib104","doi-asserted-by":"crossref","first-page":"e00126","DOI":"10.1042\/AN20130028","article-title":"Pigment epithelium-derived factor reduces apoptosis and pro-inflammatory cytokine gene expression in a murine model of focal retinal degeneration","volume":"5","author":"Wang","year":"2013","journal-title":"ASN Neuro"},{"key":"bib105","doi-asserted-by":"publisher","first-page":"570","DOI":"10.1002\/jcp.20155","article-title":"Intraocular gene transfer of pigment epithelium-derived factor rescues photoreceptors from light-induced cell death","volume":"202","author":"Imai","year":"2005","journal-title":"J Cell Physiol"},{"key":"bib106","first-page":"1646","article-title":"In vivo protection of photoreceptors from light damage by pigment epithelium-derived factor","volume":"42","author":"Cao","year":"2001","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib107","doi-asserted-by":"publisher","first-page":"e113798","DOI":"10.1371\/journal.pone.0113798","article-title":"A novel in vivo model of focal light emitting diode-induced cone-photoreceptor phototoxicity: neuroprotection afforded by brimonidine, BDNF, PEDF or bFGF","volume":"9","author":"Ort\u00edn-Mart\u00ednez","year":"2014","journal-title":"PLoS One"},{"key":"bib108","doi-asserted-by":"publisher","first-page":"7242","DOI":"10.3390\/ijms21197242","article-title":"Pigment epithelium-derived factor (PEDF) fragments prevent mouse cone photoreceptor cell loss induced by focal phototoxicity in vivo","volume":"21","author":"Valiente-Soriano","year":"2020","journal-title":"Int J Mol Sci"},{"key":"bib109","first-page":"438","article-title":"Anti-inflammatory effect of pigment epithelium-derived factor in DBA\/2J mice","volume":"15","author":"Zhou","year":"2009","journal-title":"Mol Vis"},{"key":"bib110","doi-asserted-by":"publisher","first-page":"212","DOI":"10.1016\/j.mcn.2015.08.001","article-title":"Eye drop delivery of pigment epithelium-derived factor-34 promotes retinal ganglion cell neuroprotection and axon regeneration","volume":"68","author":"Vigneswara","year":"2015","journal-title":"Mol Cell Neurosci"},{"key":"bib111","doi-asserted-by":"publisher","first-page":"2624","DOI":"10.1167\/iovs.13-11803","article-title":"Pigment epithelium-derived factor is retinal ganglion cell neuroprotective and axogenic after optic nerve crush injury","volume":"54","author":"Vigneswara","year":"2013","journal-title":"Invest Opthalmol Vis Sci"},{"key":"bib112","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1038\/s41419-019-1379-6","article-title":"Pigment epithelium-derived factor mediates retinal ganglion cell neuroprotection by suppression of caspase-2","volume":"10","author":"Vigneswara","year":"2019","journal-title":"Cell Death Dis"},{"key":"bib113","first-page":"382","article-title":"Neural stem cell-based intraocular administration of pigment epithelium-derived factor promotes retinal ganglion cell survival and axon regeneration after optic nerve crush injury in rat: an experimental study","volume":"41","author":"Zhang","year":"2016","journal-title":"Iran J Med Sci"},{"key":"bib114","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1038\/s41434-019-0089-0","article-title":"Effects of a combinatorial treatment with gene and cell therapy on retinal ganglion cell survival and axonal outgrowth after optic nerve injury","volume":"27","author":"Nascimento-Dos-Santos","year":"2020","journal-title":"Gene Ther"},{"key":"bib115","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1089\/hum.2010.132","article-title":"Pigment epithelium-derived factor gene therapy targeting retinal ganglion cell injuries: neuroprotection against loss of function in two animal models","volume":"22","author":"Miyazaki","year":"2011","journal-title":"Hum Gene Ther"},{"key":"bib116","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1076\/ceyr.22.4.245.5506","article-title":"Pigment epithelium derived factor as a neuroprotective agent against ischemic retinal injury","volume":"22","author":"Ogata","year":"2001","journal-title":"Curr Eye Res"},{"key":"bib117","doi-asserted-by":"publisher","first-page":"1116136","DOI":"10.3389\/fendo.2023.1116136","article-title":"Receptors that bind to PEDF and their therapeutic roles in retinal diseases","volume":"14","author":"Xu","year":"2023","journal-title":"Front Endocrinol (Lausanne)"},{"key":"bib118","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1002\/jcp.10212","article-title":"Putative role for EPC-1\/PEDF in the G0 growth arrest of human diploid fibroblasts","volume":"195","author":"Pignolo","year":"2003","journal-title":"J Cell Physiol"},{"key":"bib119","doi-asserted-by":"publisher","first-page":"769","DOI":"10.1517\/17460441.2013.794781","article-title":"The many facets of PEDF in drug discovery and disease: a diamond in the rough or split personality disorder?","volume":"8","author":"Craword","year":"2013","journal-title":"Expert Opin Drug Discov"},{"key":"bib120","doi-asserted-by":"publisher","first-page":"742","DOI":"10.1038\/s41419-019-1976-4","article-title":"The contrary intracellular and extracellular functions of PEDF in HCC development","volume":"10","author":"Li","year":"2019","journal-title":"Cell Death Dis"},{"key":"bib121","doi-asserted-by":"publisher","first-page":"108828","DOI":"10.1016\/j.exer.2021.108828","article-title":"PEDF is an endogenous inhibitor of VEGF-R2 angiogenesis signaling in endothelial cells","volume":"213","author":"Zhang","year":"2021","journal-title":"Exp Eye Res"},{"key":"bib122","doi-asserted-by":"publisher","first-page":"863845","DOI":"10.1155\/2015\/863845","article-title":"Antiangiogenic and neurogenic activities of sleeping beauty-mediated PEDF-transfected RPE cells in vitro and in vivo","volume":"2015","author":"Johnen","year":"2015","journal-title":"Biomed Res Int"},{"key":"bib123","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1124\/jpet.112.192575","article-title":"Polyethylene glycol-modified pigment epithelial-derived factor: new prospects for treatment of retinal neovascularization","volume":"342","author":"Bai","year":"2012","journal-title":"J Pharmacol Exp Ther"},{"key":"bib124","doi-asserted-by":"publisher","first-page":"2593","DOI":"10.1073\/pnas.031252398","article-title":"Prevention of ischemia-induced retinopathy by the natural ocular antiangiogenic agent pigment epithelium-derived factor","volume":"98","author":"Stellmach","year":"2001","journal-title":"Proc Natl Acad Sci USA"},{"key":"bib125","first-page":"1359","article-title":"The 67-kd laminin receptor is preferentially expressed by proliferating retinal vessels in a murine model of ischemic retinopathy","volume":"152","author":"Stitt","year":"1998","journal-title":"Am J Pathol"},{"key":"bib126","doi-asserted-by":"publisher","first-page":"1534","DOI":"10.1097\/00029330-200709010-00013","article-title":"Role of pigment epithelium-derived factor on proliferation and migration of choroidal capillary endothelium induced by vascular endothelial growth factor in vitro","volume":"120","author":"Wang","year":"2007","journal-title":"Chin Med J (Engl)"},{"key":"bib127","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1038\/nm0402-349","article-title":"Inducer-stimulated Fas targets activated endothelium for destruction by anti-angiogenic thrombospondin-1 and pigment epithelium\u2013derived factor","volume":"8","author":"Volpert","year":"2002","journal-title":"Nat Med"},{"key":"bib128","doi-asserted-by":"publisher","first-page":"2787","DOI":"10.3390\/ijms24032787","article-title":"PEDF protects endothelial barrier integrity during acute myocardial infarction via 67LR","volume":"24","author":"Liang","year":"2023","journal-title":"Int J Mol Sci"},{"key":"bib129","doi-asserted-by":"publisher","first-page":"e21164","DOI":"10.1371\/journal.pone.0021164","article-title":"PEDF regulates vascular permeability by a ?-secretase-mediated pathway","volume":"6","author":"Cai","year":"2011","journal-title":"PLoS One"},{"key":"bib130","doi-asserted-by":"publisher","first-page":"3273","DOI":"10.1167\/iovs.08-2878","article-title":"Antipermeability function of PEDF involves blockade of the MAP kinase\/GSK\/\u00df-catenin signaling pathway and uPAR expression","volume":"51","author":"Yang","year":"2010","journal-title":"Invest Opthalmol Vis Sci"},{"key":"bib131","doi-asserted-by":"publisher","first-page":"6605","DOI":"10.1073\/pnas.0308342101","article-title":"Identification of the antivasopermeability effect of pigment epithelium-derived factor and its active site","volume":"101","author":"Liu","year":"2004","journal-title":"Proc Natl Acad Sci USA"},{"key":"bib132","doi-asserted-by":"publisher","first-page":"20213","DOI":"10.1074\/jbc.M602110200","article-title":"Pigment epithelium-derived factor inhibits advanced glycation end product-induced retinal vascular hyperpermeability by blocking reactive oxygen species-mediated vascular endothelial growth factor expression","volume":"281","author":"Yamagishi","year":"2006","journal-title":"J Biol Chem"},{"key":"bib133","doi-asserted-by":"publisher","first-page":"105323","DOI":"10.1016\/j.bioorg.2021.105323","article-title":"Exploration of novel anti-angiogenic PEDF-derived peptides with improved activitives by inhibiting proliferation, suppressing migration, and inducing 67LR internalization","volume":"116","author":"Shi","year":"2021","journal-title":"Bioorg Chem"},{"key":"bib134","doi-asserted-by":"publisher","first-page":"512","DOI":"10.1159\/000492990","article-title":"Pigment epithelium-derived factor and its phosphomimetic mutant induce JNK-dependent apoptosis and P38-mediated migration arrest","volume":"49","author":"Konson","year":"2018","journal-title":"Cell Physiol Biochem"},{"key":"bib135","doi-asserted-by":"publisher","first-page":"805","DOI":"10.1042\/CS20130463","article-title":"PEDF and its roles in physiological and pathological conditions: implication in diabetic and hypoxia-induced angiogenic diseases","volume":"128","author":"He","year":"2015","journal-title":"Clin Sci (Lond)"},{"key":"bib136","doi-asserted-by":"publisher","first-page":"1513","DOI":"10.1084\/jem.20040474","article-title":"Nuclear factor of activated T cells balances angiogenesis activation and inhibition","volume":"199","author":"Zaichuk","year":"2004","journal-title":"J Exp Med"},{"key":"bib137","doi-asserted-by":"publisher","first-page":"13517","DOI":"10.1074\/jbc.M110.117374","article-title":"Natural angiogenesis inhibitor signals through Erk5 activation of peroxisome proliferator-activated receptor gamma (PPARgamma)","volume":"285","author":"Biyashev","year":"2010","journal-title":"J Biol Chem"},{"key":"bib138","doi-asserted-by":"publisher","first-page":"475","DOI":"10.1182\/blood-2009-07-232132","article-title":"NF-kappaB balances vascular regression and angiogenesis via chromatin remodeling and NFAT displacement","volume":"116","author":"Aurora","year":"2010","journal-title":"Blood"},{"key":"bib139","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1167\/iovs.09-3511","article-title":"Inhibition of JAK2\/STAT3-mediated VEGF upregulation under high glucose conditions by PEDF through a mitochondrial ROS pathway in vitro","volume":"51","author":"Zheng","year":"2010","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib140","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1016\/j.yjmcc.2004.04.007","article-title":"Pigment epithelium-derived factor inhibits TNF-alpha-induced interleukin-6 expression in endothelial cells by suppressing NADPH oxidase-mediated reactive oxygen species generation","volume":"37","author":"Yamagishi","year":"2004","journal-title":"J Mol Cell Cardiol"},{"key":"bib141","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1677\/jme.1.02008","article-title":"Pigment epithelium-derived factor downregulates vascular endothelial growth factor (VEGF) expression and inhibits VEGF\u2013VEGF receptor 2 binding in diabetic retinopathy","volume":"37","author":"Zhang","year":"2006","journal-title":"J Mol Endocrinol"},{"key":"bib142","doi-asserted-by":"publisher","first-page":"30177","DOI":"10.1074\/jbc.M109.032391","article-title":"Pigment epithelium-derived factor maintains retinal pigment epithelium function by inhibiting vascular endothelial growth factor-R2 signaling through ?-secretase","volume":"284","author":"Ablonczy","year":"2009","journal-title":"J Biol Chem"},{"key":"bib143","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1016\/j.bbrc.2013.10.074","article-title":"Pigment epithelium-derived factor (PEDF) binds to caveolin-1 and inhibits the pro-inflammatory effects of caveolin-1 in endothelial cells","volume":"441","author":"Matsui","year":"2013","journal-title":"Biochem Biophys Res Commun"},{"key":"bib144","first-page":"681","article-title":"Pigment epithelium-derived factor inhibits angiogenesis and growth of gastric carcinoma by down-regulation of VEGF","volume":"26","author":"Zhang","year":"2011","journal-title":"Oncol Rep"},{"key":"bib145","doi-asserted-by":"publisher","first-page":"943","DOI":"10.1161\/CIRCRESAHA.110.223750","article-title":"The role of wnt signaling in physiological and pathological angiogenesis","volume":"107","author":"Dejana","year":"2010","journal-title":"Circ Res"},{"key":"bib146","doi-asserted-by":"publisher","first-page":"2676","DOI":"10.2353\/ajpath.2009.080945","article-title":"Activation of the Wnt pathway plays a pathogenic role in diabetic retinopathy in humans and animal models","volume":"175","author":"Chen","year":"2009","journal-title":"Am J Pathol"},{"key":"bib147","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1167\/iovs.12-10281","article-title":"Pathogenic role of the Wnt signaling pathway activation in laser-induced choroidal neovascularization","volume":"54","author":"Hu","year":"2013","journal-title":"Invest Opthalmol Vis Sci"},{"key":"bib148","doi-asserted-by":"publisher","first-page":"11877","DOI":"10.3390\/ijms222111877","article-title":"Wnt signaling in inner blood\u2013retinal barrier maintenance","volume":"22","author":"Yemanyi","year":"2021","journal-title":"Int J Mol Sci"},{"key":"bib149","doi-asserted-by":"publisher","first-page":"6656","DOI":"10.1073\/pnas.131067798","article-title":"Endothelial cell surface F1-F0 ATP synthase is active in ATP synthesis and is inhibited by angiostatin","volume":"98","author":"Moser","year":"2001","journal-title":"Proc Natl Acad Sci USA"},{"key":"bib150","first-page":"931","article-title":"Possible role of cell surface H+ -ATP synthase in the extracellular ATP synthesis and proliferation of human umbilical vein endothelial cells","volume":"1","author":"Arakaki","year":"2003","journal-title":"Mol Cancer Res"},{"key":"bib151","doi-asserted-by":"publisher","first-page":"3151","DOI":"10.1167\/iovs.07-1249","article-title":"TEM7 (PLXDC1) in neovascular endothelial cells of fibrovascular membranes from patients with proliferative diabetic retinopathy","volume":"49","author":"Yamaji","year":"2008","journal-title":"Invest Opthalmol Vis Sci"},{"key":"bib152","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1016\/j.mvr.2011.09.004","article-title":"Tumor endothelial marker 7 (TEM-7): a novel target for antiangiogenic therapy","volume":"82","author":"Bagley","year":"2011","journal-title":"Microvasc Res"},{"key":"bib153","doi-asserted-by":"publisher","first-page":"2883","DOI":"10.1172\/JCI118746","article-title":"Accelerated death of retinal microvascular cells in human and experimental diabetic retinopathy","volume":"97","author":"Mizutani","year":"1996","journal-title":"J Clin Invest"},{"key":"bib154","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1038\/s41574-020-00451-4","article-title":"Current understanding of the molecular and cellular pathology of diabetic retinopathy","volume":"17","author":"Antonetti","year":"2021","journal-title":"Nat Rev Endocrinol"},{"key":"bib155","first-page":"197","article-title":"Pigment epithelium-derived factor is a pericyte mitogen secreted by microvascular endothelial cells: possible participation of angiotensin II-elicited PEDF downregulation in diabetic retinopathy","volume":"27","author":"Yamagishi","year":"2005","journal-title":"Int J Tissue React"},{"key":"bib156","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1016\/j.mvr.2005.04.001","article-title":"Pigment epithelium-derived factor (PEDF) promotes growth of pericytes through autocrine production of platelet-derived growth factor-B","volume":"69","author":"Yamagishi","year":"2005","journal-title":"Microvasc Res"},{"key":"bib157","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1016\/j.mvr.2004.11.001","article-title":"Pigment epithelium-derived factor inhibits oxidative stress-induced apoptosis and dysfunction of cultured retinal pericytes","volume":"69","author":"Amano","year":"2005","journal-title":"Microvasc Res"},{"key":"bib158","first-page":"505","article-title":"Pigment epithelium-derived factor inhibits advanced glycation end-products-induced cytotoxicity in retinal pericytes","volume":"37","author":"Sheikpranbabu","year":"2011","journal-title":"Diabetes Metab"},{"key":"bib160","doi-asserted-by":"publisher","first-page":"789","DOI":"10.1002\/(SICI)1097-4547(19990915)57:6<789::AID-JNR4>3.0.CO;2-M","article-title":"Pigment epithelium-derived factor protects cultured retinal neurons against hydrogen peroxide-induced cell death","volume":"57","author":"Cao","year":"1999","journal-title":"J Neurosci Res"},{"key":"bib162","doi-asserted-by":"publisher","first-page":"1411","DOI":"10.1159\/000485537","article-title":"M\u00fcller cell-derived PEDF mediates neuroprotection via STAT3 activation","volume":"44","author":"Eichler","year":"2017","journal-title":"Cell Physiol Biochem"},{"key":"bib163","doi-asserted-by":"publisher","first-page":"1524","DOI":"10.1007\/s11064-012-0747-8","article-title":"Pigment epithelium-derived factor released by M\u00fcller glial cells exerts neuroprotective effects on retinal ganglion cells","volume":"37","author":"Unterlauft","year":"2012","journal-title":"Neurochem Res"},{"key":"bib165","doi-asserted-by":"publisher","first-page":"100358","DOI":"10.1016\/j.jlr.2023.100358","article-title":"Ablation of pigment epithelium-derived factor receptor (PEDF-R\/Pnpla2) causes photoreceptor degeneration","volume":"64","author":"Bernardo-Col\u00f3n","year":"2023","journal-title":"J Lipid Res"},{"key":"bib166","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1167\/iovs.62.2.30","article-title":"Degradation of photoreceptor outer segments by the retinal pigment epithelium requires pigment epithelium-derived factor receptor (PEDF-R)","volume":"62","author":"Bullock","year":"2021","journal-title":"Invest Opthalmol Vis Sci"},{"key":"bib167","doi-asserted-by":"publisher","first-page":"23928","DOI":"10.1074\/jbc.M113.487884","article-title":"Pigment epithelium-derived factor (PEDF) prevents retinal cell death via PEDF receptor (PEDF-R)","volume":"288","author":"Subramanian","year":"2013","journal-title":"J Biol Chem"},{"key":"bib168","doi-asserted-by":"publisher","first-page":"18486","DOI":"10.1074\/jbc.M117.801472","article-title":"Defining a mechanistic link between pigment epithelium\u2013derived factor, docosahexaenoic acid, and corneal nerve regeneration","volume":"292","author":"Pham","year":"2017","journal-title":"J Biol Chem"},{"key":"bib169","doi-asserted-by":"publisher","first-page":"3505","DOI":"10.1167\/iovs.15-16755","article-title":"The PEDF neuroprotective domain plus DHA induces corneal nerve regeneration after experimental surgery","volume":"56","author":"He","year":"2015","journal-title":"Invest Opthalmol Vis Sci"},{"key":"bib170","doi-asserted-by":"publisher","first-page":"13152","DOI":"10.1073\/pnas.0705949104","article-title":"Neurotrophins enhance retinal pigment epithelial cell survival through neuroprotectin D1 signaling","volume":"104","author":"Mukherjee","year":"2007","journal-title":"Proc Natl Acad Sci"},{"key":"bib171","doi-asserted-by":"publisher","first-page":"43313","DOI":"10.1074\/jbc.M107831200","article-title":"NF?B activation is required for the neuroprotective effects of pigment epithelium-derived factor (PEDF) on cerebellar granule neurons","volume":"276","author":"Yabe","year":"2001","journal-title":"J Biol Chem"},{"key":"bib172","doi-asserted-by":"publisher","first-page":"691","DOI":"10.1016\/j.neuroscience.2005.03.007","article-title":"Pigment epithelium-derived factor induces pro-survival genes through cyclic AMP-responsive element binding protein and nuclear factor kappa B activation in rat cultured cerebellar granule cells: implication for its neuroprotective effect","volume":"133","author":"Yabe","year":"2005","journal-title":"Neuroscience"},{"key":"bib173","doi-asserted-by":"publisher","first-page":"369","DOI":"10.3390\/ijms22010369","article-title":"Pigment epithelium-derived factor (PEDF) receptors are involved in survival of retinal neurons","volume":"22","author":"B\u00fcrger","year":"2020","journal-title":"Int J Mol Sci"},{"key":"bib174","doi-asserted-by":"publisher","first-page":"545","DOI":"10.1016\/j.lfs.2006.01.041","article-title":"Pigment epithelium-derived factor inhibits oxidative stress-induced cell death by activation of extracellular signal-regulated kinases in cultured retinal pigment epithelial cells","volume":"79","author":"Tsao","year":"2006","journal-title":"Life Sci"},{"key":"bib175","doi-asserted-by":"publisher","first-page":"372","DOI":"10.1016\/j.bbrc.2006.01.164","article-title":"Pigment epithelium-derived factor protects retinal pigment epithelium from oxidant-mediated barrier dysfunction","volume":"342","author":"Ho","year":"2006","journal-title":"Biochem Biophys Res Commun"},{"key":"bib176","doi-asserted-by":"publisher","first-page":"6742","DOI":"10.1167\/iovs.14-14696","article-title":"improves mitochondrial function in RPE cells during oxidative stress","volume":"55","author":"He","year":"2014","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib178","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1007\/s00441-021-03514-8","article-title":"Subretinal fibrosis in neovascular age-related macular degeneration: current concepts, therapeutic avenues, and future perspectives","volume":"387","author":"Tenbrock","year":"2022","journal-title":"Cell Tissue Res"},{"key":"bib179","doi-asserted-by":"publisher","first-page":"688","DOI":"10.1016\/j.ajpath.2010.10.014","article-title":"Overexpression of pigment epithelium\u2013derived factor inhibits retinal inflammation and neovascularization","volume":"178","author":"Park","year":"2011","journal-title":"Am J Pathol"},{"key":"bib180","doi-asserted-by":"publisher","first-page":"e41511","DOI":"10.1371\/journal.pone.0041511","article-title":"Long-term retinal PEDF overexpression prevents neovascularization in a murine adult model of retinopathy","volume":"7","author":"Haurigot","year":"2012","journal-title":"PLoS One"},{"key":"bib181","doi-asserted-by":"publisher","first-page":"e22878","DOI":"10.1096\/fj.202201664RR","article-title":"N-cadherin cleavage: a critical function that induces diabetic retinopathy fibrosis via regulation of \u00df-catenin translocation","volume":"37","author":"Xiang","year":"2023","journal-title":"FASEB J"},{"key":"bib182","first-page":"1","article-title":"Pigment epithelium-derived factor as a possible treatment agent for choroidal neovascularization","volume":"2020","author":"Xi","year":"2020","journal-title":"Oxid Med Cell Longev"},{"key":"bib183","doi-asserted-by":"publisher","first-page":"41932","DOI":"10.1038\/srep41932","article-title":"Pigment epithelium-derived factor attenuates myocardial fibrosis via inhibiting endothelial-to-mesenchymal transition in rats with acute myocardial infarction","volume":"7","author":"Zhang","year":"2017","journal-title":"Sci Rep"},{"key":"bib184","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1186\/s12931-022-02027-4","article-title":"PEDF is an antifibrosis factor that inhibits the activation of fibroblasts in a bleomycin-induced pulmonary fibrosis rat model","volume":"23","author":"Qin","year":"2022","journal-title":"Respir Res"},{"key":"bib185","doi-asserted-by":"publisher","first-page":"3004","DOI":"10.1016\/j.ijcard.2013.04.003","article-title":"Pigment epithelium-derived factor (PEDF) blocks high glucose-induced inflammatory reactions in endothelial cells through its anti-oxidative properties","volume":"168","author":"Nakashima","year":"2013","journal-title":"Int J Cardiol"},{"key":"bib186","doi-asserted-by":"publisher","first-page":"42846","DOI":"10.1038\/srep42846","article-title":"PEDF mediates pathological neovascularization by regulating macrophage recruitment and polarization in the mouse model of oxygen-induced retinopathy","volume":"7","author":"Gao","year":"2017","journal-title":"Sci Rep"},{"key":"bib187","doi-asserted-by":"publisher","first-page":"1045613","DOI":"10.3389\/fphys.2022.1045613","article-title":"Pigment epithelium-derived factor is an interleukin-6 antagonist in the RPE: Insight of structure-function relationships","volume":"13","author":"Bernardo-Col\u00f3n","year":"2022","journal-title":"Front Physiol"},{"key":"bib188","doi-asserted-by":"publisher","first-page":"768","DOI":"10.1002\/glia.23727","article-title":"Glia of the human retina","volume":"68","author":"Reichenbach","year":"2020","journal-title":"Glia"},{"key":"bib189","doi-asserted-by":"publisher","first-page":"710","DOI":"10.1002\/(SICI)1097-4547(19970915)49:6<710::AID-JNR5>3.0.CO;2-A","article-title":"Pigment epithelium-derived factor (PEDF) has direct effects on the metabolism and proliferation of microglia and indirect effects on astrocytes","volume":"49","author":"Sugita","year":"1997","journal-title":"J Neurosci Res"},{"key":"bib190","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1016\/j.neulet.2005.01.035","article-title":"The regulation of pro-inflammatory gene expression induced by pigment epithelium-derived factor in rat cultured microglial cells","volume":"380","author":"Sanagi","year":"2005","journal-title":"Neurosci Lett"},{"key":"bib191","doi-asserted-by":"publisher","first-page":"266","DOI":"10.1002\/glia.20203","article-title":"Pigment epithelium-derived factor induces the production of chemokines by rat microglia","volume":"51","author":"Takanohashi","year":"2005","journal-title":"Glia"},{"key":"bib192","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1002\/glia.20171","article-title":"Pigment epithelium-derived factor induces pro-inflammatory genes in neonatal astrocytes through activation of NF-?B and CREB","volume":"50","author":"Yabe","year":"2005","journal-title":"Glia"},{"key":"bib193","doi-asserted-by":"publisher","first-page":"S29","DOI":"10.1097\/00006982-200512001-00011","article-title":"Surmountable challenges in translating pigment epithelium-derived factor (PEDF) therapy from animal models to clinical trials for retinal degenerations","volume":"25","author":"Chader","year":"2005","journal-title":"Retina"},{"key":"bib194","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1089\/hum.2006.17.167","article-title":"Adenoviral vector-delivered pigment epithelium-derived factor for neovascular age-related macular degeneration: results of a phase I clinical trial","volume":"17","author":"Campochiaro","year":"2006","journal-title":"Hum Gene Ther"},{"key":"bib195","doi-asserted-by":"publisher","first-page":"538","DOI":"10.1016\/j.jconrel.2022.08.040","article-title":"Long-acting formulation strategies for protein and peptide delivery in the treatment of PSED","volume":"350","author":"Garkal","year":"2022","journal-title":"J Control Release"},{"key":"bib196","doi-asserted-by":"publisher","first-page":"5344","DOI":"10.3390\/ijms22105344","article-title":"Delivery systems of retinoprotective proteins in the retina","volume":"22","author":"Rebustini","year":"2021","journal-title":"Int J Mol Sci"},{"key":"bib197","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1208\/s12249-023-02673-x","article-title":"Trends in formulation approaches for sustained drug delivery to the posterior segment of the eye","volume":"24","author":"Biswas","year":"2023","journal-title":"AAPS PharmSciTech"},{"key":"bib198","first-page":"3680","article-title":"Continuous intraocular drug delivery lasting over a decade: ciliary neurotrophic factor (CNTF) secreted from Neurotech's NT-501 implanted in subjects with retinal degenerative disorders","volume":"64","author":"Kauper","year":"2023","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib199","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1016\/j.omtm.2023.08.007","article-title":"Toward lentiviral vectors for antiangiogenic ocular gene therapy","volume":"30","author":"Askou","year":"2023","journal-title":"Mol Ther Methods Clin Dev"},{"key":"bib200","doi-asserted-by":"publisher","first-page":"107939","DOI":"10.1016\/j.isci.2023.107939","article-title":"Chimpanzee adenovirus-mediated multiple gene therapy for age-related macular degeneration","volume":"26","author":"Wei-Zhang","year":"2023","journal-title":"iScience"},{"key":"bib201","doi-asserted-by":"publisher","first-page":"511","DOI":"10.1038\/s41434-024-00461-1","article-title":"Stable inhibition of choroidal neovascularization by adeno-associated virus 2\/8-vectored bispecific molecules","volume":"31","author":"Bai","year":"2024","journal-title":"Gene Ther"},{"key":"bib202","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1016\/j.omtn.2019.01.012","article-title":"Suppression of choroidal neovascularization by AAV-based dual-acting antiangiogenic gene therapy","volume":"16","author":"Askou","year":"2019","journal-title":"Mol Ther Nucleic Acids"},{"key":"bib203","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1016\/j.omtn.2020.08.036","article-title":"Dual-acting antiangiogenic gene therapy reduces inflammation and regresses neovascularization in diabetic mouse retina","volume":"22","author":"Ara\u00fajo","year":"2020","journal-title":"Mol Ther Nucleic Acids"},{"key":"bib204","doi-asserted-by":"publisher","first-page":"e100811","DOI":"10.15252\/embj.2018100811","article-title":"A single-cell transcriptome atlas of the adult human retina","volume":"38","author":"Lukowski","year":"2019","journal-title":"Embo J"},{"key":"bib8","first-page":"223","volume-title":"Structure-Function Studies on PEDF","author":"Becerra","year":"1997"},{"key":"bib38","doi-asserted-by":"crossref","DOI":"10.1016\/B978-0-443-13820-1.00007-4","article-title":"Pigment epithelium derived factor in ocular vascular development, neovascularization and function","volume-title":"Reference Module in Neuroscience and Biobehavioral Psychology","author":"Sorenson","year":"2024"},{"key":"bib159","first-page":"445","volume-title":"Signaling Mechanisms Involved in PEDF-Mediated Retinoprotection","author":"Pagan-Mercado","year":"2019"},{"key":"bib161","first-page":"813","volume-title":"Pigment Epithelium-Derived Factor Protects Cone Photoreceptor-Derived 661W Cells from Light Damage Through Akt Activation","author":"Rapp","year":"2014"},{"key":"bib164","first-page":"29","volume-title":"Pigment Epithelium-derived Factor Receptor (PEDF-R): A Plasma Membrane-linked Phospholipase with PEDF Binding Affinity","author":"Subramanian","year":"2010"},{"key":"bib177","first-page":"457","volume-title":"Pigment Epithelium-derived Factor Protects Retinal Pigment Epithelial Cells Against Cytotoxicity \u201cIn Vitro\u201d","author":"Nadal-Nicolas","year":"2018"}],"container-title":["Investigative Ophthalmology & Visual Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/iovs.arvojournals.org\/article.aspx?articleid=2802393","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:31:54Z","timestamp":1791927114000},"score":1,"resource":{"primary":{"URL":"https:\/\/iovs.arvojournals.org\/article.aspx?articleid=2802393"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,27]]},"references-count":204,"journal-issue":{"issue":"14","published-print":{"date-parts":[[2024,12,2]]}},"URL":"https:\/\/doi.org\/10.1167\/iovs.65.14.41","relation":{},"ISSN":["1552-5783"],"issn-type":[{"value":"1552-5783","type":"print"}],"subject":[],"published":{"date-parts":[[2024,12,27]]}}}