{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T14:33:52Z","timestamp":1793111632438,"version":"4.5.0"},"reference-count":32,"publisher":"Association for Research in Vision and Ophthalmology (ARVO)","issue":"3","license":[{"start":{"date-parts":[[2024,3,5]],"date-time":"2024-03-05T00:00:00Z","timestamp":1709596800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Invest. Ophthalmol. Vis. Sci."],"published-print":{"date-parts":[[2024,3,5]]},"DOI":"10.1167\/iovs.65.3.1","type":"journal-article","created":{"date-parts":[[2024,3,5]],"date-time":"2024-03-05T11:31:05Z","timestamp":1709638265000},"page":"1","source":"Crossref","is-referenced-by-count":7,"title":["Alteration of Neurotrophic Factors and Innervation in Extraocular Muscles of Individuals With Concomitant Esotropia"],"prefix":"10.1167","volume":"65","author":[{"given":"Jie","family":"Hao","sequence":"first","affiliation":[{"name":"Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing, China"},{"name":"Beijing Key Laboratory of Ophthalmology & Visual Sciences, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meixu","family":"Wang","sequence":"additional","affiliation":[{"name":"Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing, China"},{"name":"Beijing Key Laboratory of Ophthalmology & Visual Sciences, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiawen","family":"Liu","sequence":"additional","affiliation":[{"name":"Industrial Engineering and Operations Research, University of California, Berkeley, California, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mayinuer","family":"Yusufu","sequence":"additional","affiliation":[{"name":"Centre for Eye Research Australia, Royal Victorian Eye and Ear Hospital, East Melbourne, Australia"},{"name":"Department of Surgery (Ophthalmology), The University of Melbourne, Melbourne, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Cao","sequence":"additional","affiliation":[{"name":"Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing, China"},{"name":"Beijing Key Laboratory of Ophthalmology & Visual Sciences, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Fu","sequence":"additional","affiliation":[{"name":"Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing, China"},{"name":"Beijing Key Laboratory of Ophthalmology & Visual Sciences, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"27","reference":[{"key":"bib2","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1080\/09273972.2019.1604773","article-title":"Global and regional prevalence of strabismus: a comprehensive systematic review and meta-analysis","volume":"27","author":"Hashemi","year":"2019","journal-title":"Strabismus"},{"key":"bib3","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1007\/s40135-017-0141-4","article-title":"Extraocular muscle repair and regeneration","volume":"5","author":"Verma","year":"2017","journal-title":"Curr Ophthalmol Rep"},{"key":"bib4","doi-asserted-by":"publisher","first-page":"182","DOI":"10.1016\/j.exer.2019.03.022","article-title":"Gene expression profile of extraocular muscles following resection strabismus surgery","volume":"182","author":"Rodr\u00edguez","year":"2019","journal-title":"Exp Eye Res"},{"key":"bib5","doi-asserted-by":"publisher","first-page":"272","DOI":"10.1016\/j.ydbio.2021.04.006","article-title":"Oculomotor nerve guidance and terminal branching requires interactions with differentiating extraocular muscles","volume":"476","author":"Bjorke","year":"2021","journal-title":"Dev Biol"},{"key":"bib6","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1080\/2576117X.2021.1893585","article-title":"Childhood onset strabismus: a neurotrophic factor hypothesis","volume":"71","author":"Rudell","year":"2021","journal-title":"J Binocul Vis Ocul Motil"},{"key":"bib7","doi-asserted-by":"publisher","first-page":"5576","DOI":"10.1167\/iovs.16-20294","article-title":"Altered protein composition and gene expression in strabismic human extraocular muscles and tendons","volume":"57","author":"Agarwal","year":"2016","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib8","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1007\/s00424-011-0925-6","article-title":"How to make rapid eye movements \u201crapid\u201d: the role of growth factors for muscle contractile properties","volume":"461","author":"Li","year":"2011","journal-title":"Pfl\u00fcgers Arch"},{"key":"bib9","doi-asserted-by":"publisher","first-page":"3538","DOI":"10.1167\/iovs.04-0393","article-title":"Role of exogenous and endogenous trophic factors in the regulation of extraocular muscle strength during development","volume":"45","author":"Chen","year":"2004","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib10","doi-asserted-by":"publisher","first-page":"747","DOI":"10.3390\/cells9030747","article-title":"Muscle progenitors derived from extraocular muscles express higher levels of neurotrophins and their receptors than other cranial and limb muscles","volume":"9","author":"Carrero-Rojas","year":"2020","journal-title":"Cells"},{"key":"bib11","doi-asserted-by":"publisher","first-page":"399","DOI":"10.3389\/fnins.2017.00399","article-title":"Extraocular motor system exhibits a higher expression of neurotrophins when compared with other brainstem motor systems","volume":"11","author":"Hern\u00e1ndez","year":"2017","journal-title":"Front Neurosci"},{"key":"bib12","doi-asserted-by":"publisher","first-page":"228","DOI":"10.1016\/j.ghir.2011.06.001","article-title":"Expression of insulin-like growth factor 1 isoforms in the rabbit oculomotor system","volume":"21","author":"Feng","year":"2011","journal-title":"Growth Horm IGF Res"},{"key":"bib13","doi-asserted-by":"publisher","first-page":"3484","DOI":"10.1167\/iovs.15-16761","article-title":"Adaptability of the immature ocular motor control system: unilateral IGF-1 medial rectus treatment","volume":"56","author":"Willoughby","year":"2015","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib14","doi-asserted-by":"publisher","first-page":"11927","DOI":"10.1038\/s41598-020-68743-3","article-title":"Eye alignment changes caused by sustained GDNF treatment of an extraocular muscle in infant non-human primates","volume":"10","author":"Fleuriet","year":"2020","journal-title":"Sci Rep"},{"key":"bib15","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1167\/iovs.11-8356","article-title":"Effects of the sustained release of IGF-1 on extraocular muscle of the infant non-human primate: adaptations at the effector organ level","volume":"53","author":"Willoughby","year":"2012","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib16","doi-asserted-by":"publisher","first-page":"3467","DOI":"10.1167\/iovs.15-16852","article-title":"Adaptation of slow myofibers: the effect of sustained BDNF treatment of extraocular muscles in infant nonhuman primates","volume":"56","author":"Willoughby","year":"2015","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib17","doi-asserted-by":"publisher","first-page":"136","DOI":"10.3390\/ijms22010136","article-title":"How to build and to protect the neuromuscular junction: the role of the glial cell line-derived neurotrophic factor","volume":"22","author":"Stanga","year":"2020","journal-title":"Int J Mol Sci"},{"key":"bib18","doi-asserted-by":"publisher","first-page":"6070","DOI":"10.1167\/iovs.16-19739","article-title":"Improvement of eye alignment in adult strabismic monkeys by sustained IGF-1 treatment","volume":"57","author":"McLoon","year":"2016","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib19","doi-asserted-by":"publisher","first-page":"575","DOI":"10.1523\/JNEUROSCI.5312-08.2009","article-title":"Complementary actions of BDNF and neurotrophin-3 on the firing patterns and synaptic composition of motoneurons","volume":"29","author":"Davis-L\u00f3pez de Carrizosa","year":"2009","journal-title":"J Neurosci"},{"key":"bib20","doi-asserted-by":"publisher","first-page":"5168","DOI":"10.1167\/iovs.12-9785","article-title":"Differences in gene expression between strabismic and normal human extraocular muscles","volume":"53","author":"Altick","year":"2012","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib21","doi-asserted-by":"publisher","first-page":"e0202861","DOI":"10.1371\/journal.pone.0202861","article-title":"Changing muscle function with sustained glial derived neurotrophic factor treatment of rabbit extraocular muscle","volume":"13","author":"Fitzpatrick","year":"2018","journal-title":"PLoS One"},{"key":"bib22","doi-asserted-by":"publisher","first-page":"478","DOI":"10.1002\/mus.v41:4","article-title":"Schwann cells as a source of insulin-like growth factor-1 for extraocular muscles","volume":"41","author":"Feng","year":"2010","journal-title":"Muscle Nerve"},{"key":"bib23","doi-asserted-by":"publisher","first-page":"217","DOI":"10.3892\/mmr.2012.1149","article-title":"Abnormal expression of seven myogenesis-related genes in extraocular muscles of patients with concomitant strabismus","volume":"7","author":"Zhu","year":"2013","journal-title":"Mol Med Rep"},{"key":"bib24","doi-asserted-by":"publisher","first-page":"2016","DOI":"10.3390\/ijms17122016","article-title":"Functional diversity of neurotrophin actions on the oculomotor system","volume":"17","author":"Ben\u00edtez-Temi\u00f1o","year":"2016","journal-title":"Int J Mol Sci"},{"key":"bib25","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1006\/mcne.2001.1069","article-title":"Target-derived cardiotrophin-1 and insulin-like growth factor-I promote neurite growth and survival of developing oculomotor neurons","volume":"19","author":"Rind","year":"2002","journal-title":"Mol Cell Neurosci"},{"key":"bib26","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1002\/mus.v41:3","article-title":"Effect of locally delivered IGF-1 on nerve regeneration during aging: an experimental study in rats","volume":"41","author":"Apel","year":"2010","journal-title":"Muscle Nerve"},{"key":"bib27","doi-asserted-by":"publisher","first-page":"6831","DOI":"10.1167\/iovs.16-20074","article-title":"Unchanged neurotrophic factors and their receptors correlate with sparing in extraocular muscles in amyotrophic lateral sclerosis","volume":"57","author":"Harandi","year":"2016","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib28","doi-asserted-by":"publisher","first-page":"1725","DOI":"10.1126\/science.279.5357.1725","article-title":"Hyperinnervation of neuromuscular junctions caused by GDNF overexpression in muscle","volume":"279","author":"Nguyen","year":"1998","journal-title":"Science"},{"key":"bib29","doi-asserted-by":"publisher","first-page":"8308","DOI":"10.1523\/JNEUROSCI.0719-10.2010","article-title":"Nerve growth factor regulates the firing patterns and synaptic composition of motoneurons","volume":"30","author":"Davis-L\u00f3pez de Carrizosa","year":"2010","journal-title":"J Neurosci"},{"key":"bib30","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1038\/s41434-018-0009-8","article-title":"AAV1.NT-3 gene therapy increases muscle fiber diameter through activation of mTOR pathway and metabolic remodeling in a CMT mouse model","volume":"25","author":"Yalvac","year":"2018","journal-title":"Gene Ther"},{"key":"bib31","doi-asserted-by":"publisher","first-page":"1017","DOI":"10.1038\/sj.npp.1300112","article-title":"Post-mortem interval effects on the phosphorylation of signaling proteins","volume":"28","author":"Li","year":"2003","journal-title":"Neuropsychopharmacology"},{"key":"bib32","doi-asserted-by":"publisher","first-page":"1412","DOI":"10.4067\/S0717-95022021000501412","article-title":"Overall distribution pattern of the intramuscular nerves of the extraocular muscles and its clinical implications","volume":"39","author":"Zhou","year":"2021","journal-title":"Int J Morphol"},{"key":"bib1","article-title":"Esotropia","volume-title":"StatPearls [Internet]","author":"Kaur","year":"2023"}],"container-title":["Investigative Opthalmology & Visual Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/iovs.arvojournals.org\/article.aspx?articleid=2793424","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:31:46Z","timestamp":1791927106000},"score":1,"resource":{"primary":{"URL":"https:\/\/iovs.arvojournals.org\/article.aspx?articleid=2793424"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3,5]]},"references-count":32,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2024,3,5]]}},"URL":"https:\/\/doi.org\/10.1167\/iovs.65.3.1","relation":{},"ISSN":["1552-5783"],"issn-type":[{"value":"1552-5783","type":"print"}],"subject":[],"published":{"date-parts":[[2024,3,5]]}}}