{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T05:15:37Z","timestamp":1792041337986,"version":"4.4.0"},"reference-count":63,"publisher":"Association for Research in Vision and Ophthalmology (ARVO)","issue":"4","license":[{"start":{"date-parts":[[2024,4,18]],"date-time":"2024-04-18T00:00:00Z","timestamp":1713398400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Invest. Ophthalmol. Vis. Sci."],"published-print":{"date-parts":[[2024,4,18]]},"DOI":"10.1167\/iovs.65.4.29","type":"journal-article","created":{"date-parts":[[2024,5,21]],"date-time":"2024-05-21T12:30:58Z","timestamp":1716294658000},"page":"29","source":"Crossref","is-referenced-by-count":14,"title":["Training in Cortically Blinded Fields Appears to Confer Patient-Specific Benefit Against Retinal Thinning"],"prefix":"10.1167","volume":"65","author":[{"given":"Berkeley K.","family":"Fahrenthold","sequence":"first","affiliation":[{"name":"Flaum Eye Institute and Center for Visual Science, University of Rochester, Rochester, New York, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew R.","family":"Cavanaugh","sequence":"additional","affiliation":[{"name":"Flaum Eye Institute and Center for Visual Science, University of Rochester, Rochester, New York, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madhura","family":"Tamhankar","sequence":"additional","affiliation":[{"name":"Scheie Eye Institute, University of Pennsylvania, Philadelphia, Pennsylvania, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Byron L.","family":"Lam","sequence":"additional","affiliation":[{"name":"Bascom Palmer Eye Institute, University of Miami, Miami, Florida, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven E.","family":"Feldon","sequence":"additional","affiliation":[{"name":"Flaum Eye Institute and Center for Visual Science, University of Rochester, Rochester, New York, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brent A.","family":"Johnson","sequence":"additional","affiliation":[{"name":"Department of Biostatistics and Computational Biology, University of Rochester, Rochester, New York, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krystel R.","family":"Huxlin","sequence":"additional","affiliation":[{"name":"Flaum Eye Institute and Center for Visual Science, University of Rochester, Rochester, New York, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"27","reference":[{"key":"bib1","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1093\/ageing\/18.6.419","article-title":"Recovery of visual fields in acute stroke: homonymous hemianopia associated with adverse prognosis","volume":"18","author":"Gray","year":"1989","journal-title":"Age Ageing"},{"key":"bib2","doi-asserted-by":"crossref","first-page":"bcr2013010494","DOI":"10.1136\/bcr-2013-010494","article-title":"Perimetric demonstration of spontaneous visual field recovery following occipital lobe haemorrhage","volume":"2013","author":"Lin","year":"2013","journal-title":"BMJ Case Rep"},{"key":"bib3","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1097\/01.wno.0000235587.41040.39","article-title":"Homonymous hemianopia in stroke","volume":"26","author":"Zhang","year":"2006","journal-title":"J Neuroophthalmol"},{"key":"bib4","doi-asserted-by":"publisher","first-page":"901","DOI":"10.1212\/01.wnl.0000203338.54323.22","article-title":"Natural history of homonymous hemianopia","volume":"66","author":"Zhang","year":"2006","journal-title":"Neurology"},{"key":"bib5","doi-asserted-by":"publisher","first-page":"82","DOI":"10.3389\/fnint.2014.00082","article-title":"Rehabilitation of homonymous hemianopia: insight into blindsight","volume":"8","author":"Perez","year":"2014","journal-title":"Front Integr Neurosci"},{"key":"bib6","doi-asserted-by":"publisher","first-page":"453","DOI":"10.1097\/00006324-200009000-00006","article-title":"Field expansion for homonymous hemianopia by optically induced peripheral exotropia","volume":"77","author":"Peli","year":"2000","journal-title":"Optom Vis Sci"},{"key":"bib7","doi-asserted-by":"publisher","first-page":"5186461","DOI":"10.1155\/2016\/5186461","article-title":"Use of NeuroEyeCoach to improve eye movement efficacy in patients with homonymous visual field Loss","volume":"2016","author":"Sahraie","year":"2016","journal-title":"BioMed Res Int"},{"key":"bib8","first-page":"479","article-title":"Visual scanning training effect on reading-related tasks in acquired right brain damage","volume":"58","author":"Weinberg","year":"1977","journal-title":"Arch Phys Med Rehabil"},{"key":"bib9","first-page":"CD008388","article-title":"Interventions for visual field defects in people with stroke","volume":"5","author":"Pollock","year":"2019","journal-title":"Cochrane Database Syst Rev"},{"key":"bib10","doi-asserted-by":"publisher","first-page":"681","DOI":"10.3389\/fneur.2017.00681","article-title":"Segregation of spontaneous and training induced recovery from visual field defects in subacute stroke patients","volume":"8","author":"Bergsma","year":"2017","journal-title":"Front Neurol"},{"key":"bib11","doi-asserted-by":"publisher","first-page":"1856","DOI":"10.1212\/WNL.0000000000003921","article-title":"Visual discrimination training improves Humphrey perimetry in chronic cortically induced blindness","volume":"88","author":"Cavanaugh","year":"2017","journal-title":"Neurology"},{"key":"bib12","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1167\/15.10.9","article-title":"Visual recovery in cortical blindness is limited by high internal noise","volume":"15","author":"Cavanaugh","year":"2015","journal-title":"J Vis"},{"key":"bib13","first-page":"305","article-title":"From blindsight to sight: cognitive rehabilitation of visual field defects","volume":"26","author":"Chokron","year":"2008","journal-title":"Restor Neurol Neurosci"},{"key":"bib14","doi-asserted-by":"publisher","first-page":"11652","DOI":"10.1523\/JNEUROSCI.1076-14.2014","article-title":"Beyond blindsight: properties of visual relearning in cortically blind fields","volume":"34","author":"Das","year":"2014","journal-title":"J Neurosci"},{"key":"bib15","doi-asserted-by":"publisher","first-page":"3981","DOI":"10.1523\/JNEUROSCI.4882-08.2009","article-title":"Perceptual relearning of complex visual motion after V1 damage in humans","volume":"29","author":"Huxlin","year":"2009","journal-title":"J Neurosci"},{"key":"bib16","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1177\/1073858415621035","article-title":"Relearning to see in cortical blindness","volume":"22","author":"Melnick","year":"2016","journal-title":"Neuroscientist"},{"key":"bib17","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1136\/jnnp.2006.099366","article-title":"Temporal sensitivity in a hemianopic visual field can be improved by long-term training using flicker stimulation","volume":"78","author":"Raninen","year":"2007","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"bib18","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1007\/s00221-010-2395-z","article-title":"Improved detection following neuro-eye therapy in patients with post-geniculate brain damage","volume":"206","author":"Sahraie","year":"2010","journal-title":"Exp Brain Res"},{"key":"bib19","doi-asserted-by":"publisher","first-page":"1857","DOI":"10.1093\/brain\/awaa128","article-title":"Functional preservation and enhanced capacity for visual restoration in subacute occipital stroke","volume":"143","author":"Saionz","year":"2020","journal-title":"Brain"},{"key":"bib20","doi-asserted-by":"publisher","first-page":"29","DOI":"10.5709\/acp","article-title":"Evidence for perceptual learning with repeated stimulation after partial and total cortical blindness","volume":"8","author":"Trevethan","year":"2012","journal-title":"Adv Cogn Psychol"},{"key":"bib21","doi-asserted-by":"publisher","first-page":"1266","DOI":"10.1162\/jocn_a_00538","article-title":"Reorganization of retinotopic maps after occipital lobe infarction","volume":"26","author":"Vaina","year":"2014","journal-title":"J Cogn Neurosci"},{"key":"bib22","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1167\/17.15.51a","article-title":"Natural progression of perimetric visual field defects after V1 stroke","volume":"17","author":"Wang","year":"2017","journal-title":"J Vis"},{"key":"bib24","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1136\/jnnp.45.2.143","article-title":"Direct demonstration of transsynaptic degeneration in the human visual system: a comparison of retrograde and anterograde changes","volume":"45","author":"Beatty","year":"1982","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"bib25","doi-asserted-by":"publisher","first-page":"382","DOI":"10.1167\/iovs.10-5708","article-title":"Imaging reveals optic tract degeneration in hemianopia","volume":"52","author":"Bridge","year":"2011","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib26","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1016\/0306-4522(89)90333-3","article-title":"Transneuronal retrograde degeneration of retinal ganglion cells after damage to striate cortex in macaque monkeys: selective loss of P beta cells","volume":"29","author":"Cowey","year":"1989","journal-title":"Neuroscience"},{"key":"bib27","doi-asserted-by":"publisher","first-page":"2149","DOI":"10.1093\/brain\/awr125","article-title":"Transneuronal retrograde degeneration of retinal ganglion cells and optic tract in hemianopic monkeys and humans","volume":"134","author":"Cowey","year":"2011","journal-title":"Brain"},{"key":"bib28","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.2147\/OPTH.S81749","article-title":"Retrograde degeneration of retinal ganglion cells in homonymous hemianopsia","volume":"9","author":"Herro","year":"2015","journal-title":"Clin Ophthalmol"},{"key":"bib29","doi-asserted-by":"publisher","first-page":"628","DOI":"10.1093\/brain\/awp001","article-title":"Retrograde trans-synaptic retinal ganglion cell loss identified by optical coherence tomography","volume":"132","author":"Jindahra","year":"2009","journal-title":"Brain"},{"key":"bib30","doi-asserted-by":"publisher","first-page":"534","DOI":"10.1093\/brain\/awr324","article-title":"The time course of retrograde trans-synaptic degeneration following occipital lobe damage in humans","volume":"135","author":"Jindahra","year":"2012","journal-title":"Brain"},{"key":"bib31","doi-asserted-by":"publisher","first-page":"1292","DOI":"10.1016\/j.ophtha.2012.11.021","article-title":"Transneuronal retrograde degeneration of the retinal ganglion cells in patients with cerebral infarction","volume":"120","author":"Park","year":"2013","journal-title":"Ophthalmology"},{"issue":"2","key":"bib32","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1097\/WNO.0000000000000182","article-title":"Homonymous ganglion cell layer thinning after isolated occipital lesion: macular OCT demonstrates transsynaptic retrograde retinal degeneration","volume":"35","author":"Meier","year":"2015","journal-title":"J Neuroophthalmol"},{"key":"bib33","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1136\/jnnp-2013-306577","article-title":"Quantifying the pattern of optic tract degeneration in human hemianopia","volume":"85","author":"Millington","year":"2014","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"bib34","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2016\/2394957","article-title":"Retinal ganglion cell atrophy in homonymous hemianopia due to acquired occipital lesions observed using cirrus high-definition-OCT","volume":"2016","author":"Yamashita","year":"2016","journal-title":"J Ophthalmol"},{"key":"bib35","doi-asserted-by":"publisher","first-page":"3642","DOI":"10.1161\/STROKEAHA.121.034738","article-title":"Optic tract shrinkage limits visual restoration after occipital stroke","volume":"52","author":"Fahrenthold","year":"2021","journal-title":"Stroke"},{"key":"bib36","first-page":"9","article-title":"Survival of retinal ganglion cells after damage to the occipital lobe in humans is activity dependent","volume":"286","author":"Schneider","year":"2019","journal-title":"Proc R Soc B Biol Sci"},{"key":"bib37","doi-asserted-by":"publisher","first-page":"745","DOI":"10.1007\/s00417-015-3181-1","article-title":"Sectoral analysis of the retinal nerve fiber layer thinning and its association with visual field loss in homonymous hemianopia caused by post-geniculate lesions using spectral-domain optical coherence tomography","volume":"254","author":"Goto","year":"2016","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"key":"bib38","doi-asserted-by":"publisher","first-page":"e97444","DOI":"10.1371\/journal.pone.0097444","article-title":"Lesions in the posterior visual pathway promote trans-synaptic degeneration of retinal ganglion cells","volume":"9","author":"Keller","year":"2014","journal-title":"PLoS ONE"},{"key":"bib39","doi-asserted-by":"publisher","first-page":"727","DOI":"10.1016\/j.ajo.2005.03.059","article-title":"Optical coherence tomography (OCT) findings in congenital\/long-standing homonymous hemianopia","volume":"140","author":"Mehta","year":"2005","journal-title":"Am J Ophthalmol"},{"key":"bib40","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1097\/WNO.0000000000000268","article-title":"Corresponding ganglion cell atrophy in patients with postgeniculate homonymous visual field loss","volume":"35","author":"Mitchell","year":"2015","journal-title":"J Neuroophthalmol"},{"key":"bib41","doi-asserted-by":"publisher","first-page":"1739","DOI":"10.1016\/S0042-6989(98)00272-7","article-title":"Retinal ganglion cell dysfunction in humans following post-geniculate lesions: specific spatio\u2013temporal losses revealed by pattern ERG","volume":"39","author":"Porrello","year":"1999","journal-title":"Vis Res"},{"key":"bib42","doi-asserted-by":"publisher","first-page":"1501","DOI":"10.1007\/s00417-014-2706-3","article-title":"Macular ganglion cell\u2013inner plexiform layer thinning in patients with visual field defect that respects the vertical meridian","volume":"252","author":"Shin","year":"2014","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"key":"bib43","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1167\/iovs.63.9.18","article-title":"Lateral geniculate nucleus volume determined on MRI correlates with corresponding ganglion cell layer loss in acquired human postgeniculate lesions","volume":"63","author":"Simmen","year":"2022","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib44","doi-asserted-by":"publisher","first-page":"236","DOI":"10.1080\/01658107.2019.1686764","article-title":"Evaluation of significance maps and the analysis of the longitudinal time course of the macular ganglion cell complex thicknesses in acquired occipital homonymous hemianopia using spectral-domain optical coherence tomography","volume":"44","author":"Yamashita","journal-title":"Neuroophthalmology"},{"key":"bib45","doi-asserted-by":"publisher","first-page":"214","DOI":"10.1111\/cxo.12478","article-title":"Reconciling visual field defects and retinal nerve fibre layer asymmetric patterns in retrograde degeneration: an extended case series: retinal nerve fibre layer defects in retrograde degeneration","volume":"100","author":"Zangerl","year":"2017","journal-title":"Clin Exp Optom"},{"key":"bib47","doi-asserted-by":"publisher","first-page":"1719","DOI":"10.1523\/JNEUROSCI.4249-08.2009","article-title":"In vivo voltage-sensitive dye imaging in adult mice reveals that somatosensory maps lost to stroke are replaced over weeks by new structural and functional circuits with prolonged modes of activation within both the peri-infarct zone and distant sites","volume":"29","author":"Brown","year":"2009","journal-title":"J Neurosci"},{"key":"bib48","doi-asserted-by":"publisher","first-page":"4101","DOI":"10.1523\/JNEUROSCI.4295-06.2007","article-title":"Extensive turnover of dendritic spines and vascular remodeling in cortical tissues recovering from stroke","volume":"27","author":"Brown","year":"2007","journal-title":"J Neurosci"},{"key":"bib49","doi-asserted-by":"publisher","first-page":"2300","DOI":"10.1161\/STROKEAHA.113.001272","article-title":"Displacement of sensory maps and disorganization of motor cortex after targeted stroke in mice","volume":"44","author":"Harrison","year":"2013","journal-title":"Stroke"},{"key":"bib50","doi-asserted-by":"publisher","first-page":"1091","DOI":"10.1016\/j.ophtha.2020.11.020","article-title":"Efficacy of visual retraining in the hemianopic field after stroke: results of a randomized clinical trial","volume":"128","author":"Cavanaugh","year":"2021","journal-title":"Ophthalmology"},{"key":"bib51","doi-asserted-by":"publisher","first-page":"6102","DOI":"10.1038\/s41467-021-26345-1","article-title":"Spared perilesional V1 activity underlies training-induced recovery of luminance detection sensitivity in cortically-blind patients","volume":"12","author":"Barbot","year":"2021","journal-title":"Nat Commun"},{"key":"bib52","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1016\/j.exer.2012.10.008","article-title":"A mathematical model for describing the retinal nerve fiber bundle trajectories in the human eye: average course, variability, and influence of refraction, optic disc size and optic disc position","volume":"105","author":"Jansonius","year":"2012","journal-title":"Exp Eye Res"},{"key":"bib53","doi-asserted-by":"publisher","first-page":"2149","DOI":"10.1093\/brain\/awr125","article-title":"Transneuronal retrograde degeneration of retinal ganglion cells and optic tract in hemianopic monkeys and humans","volume":"134","author":"Cowey","year":"2011","journal-title":"Brain"},{"key":"bib54","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1068\/p030257","article-title":"Atrophy of retinal ganglion cells after removal of striate cortex in a rhesus monkey","volume":"3","author":"Cowey","year":"1974","journal-title":"Perception"},{"key":"bib55","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1007\/s002210000384","article-title":"Transneuronal retrograde degeneration of retinal ganglion cells following restricted lesions of striate cortex in the monkey","volume":"132","author":"Johnson","year":"2000","journal-title":"Exp Brain Res"},{"key":"bib56","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1136\/jnnp.26.5.402","article-title":"Trans-synaptic retrograde degeneration in the visual system of primates","volume":"26","author":"Buren","year":"1963","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"bib57","doi-asserted-by":"publisher","first-page":"21683","DOI":"10.1038\/s41598-020-77760-1","article-title":"Dynamic changes in cell size and corresponding cell fate after optic nerve injury","volume":"10","author":"Davis","year":"2020","journal-title":"Sci Rep"},{"key":"bib58","doi-asserted-by":"publisher","first-page":"393","DOI":"10.1016\/j.tcb.2017.02.006","article-title":"Mitochondrial function and cell size: an allometric relationship","volume":"27","author":"Miettinen","year":"2017","journal-title":"Trends Cell Biol"},{"key":"bib59","first-page":"1","article-title":"Longitudinal and cross-sectional analyses of age effects on retinal nerve fiber layer and ganglion cell complex thickness by Fourier-domain OCT","volume":"5","author":"Zhang","year":"2016","journal-title":"Transl Vis Sci Technol"},{"key":"bib60","doi-asserted-by":"publisher","first-page":"1224","DOI":"10.1016\/j.neuroimage.2010.05.060","article-title":"Topographic organization of V1 projections through the corpus callosum in humans","volume":"52","author":"Saenz","year":"2010","journal-title":"NeuroImage"},{"key":"bib61","doi-asserted-by":"publisher","first-page":"2329","DOI":"10.1523\/JNEUROSCI.1419-14.2015","article-title":"Characteristic patterns of dendritic remodeling in early-stage glaucoma: evidence from genetically identified retinal ganglion cell types","volume":"35","author":"El-Danaf","year":"2015","journal-title":"J Neurosci"},{"key":"bib62","doi-asserted-by":"publisher","first-page":"106516","DOI":"10.1016\/j.phrs.2022.106516","article-title":"Morpho-functional analysis of the early changes induced in retinal ganglion cells by the onset of diabetic retinopathy: the effects of a neuroprotective strategy","volume":"185","author":"Amato","year":"2022","journal-title":"Pharmacol Res"},{"key":"bib63","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.preteyeres.2015.06.003","article-title":"Glia\u2013neuron interactions in the mammalian retina","volume":"51","author":"Vecino","year":"2016","journal-title":"Prog Retin Eye Res"},{"key":"bib23","author":"Saionz"},{"key":"bib46","first-page":"357","article-title":"Rehabilitation of visual perception in cortical blindness","volume-title":"Handbook of Clinical Neurology","author":"Saionz","year":"2022:"}],"container-title":["Investigative Ophthalmology &amp; Visual Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/iovs.arvojournals.org\/article.aspx?articleid=2793588","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:31:51Z","timestamp":1791927111000},"score":1,"resource":{"primary":{"URL":"https:\/\/iovs.arvojournals.org\/article.aspx?articleid=2793588"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4,18]]},"references-count":63,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2024,4,1]]}},"URL":"https:\/\/doi.org\/10.1167\/iovs.65.4.29","relation":{},"ISSN":["1552-5783"],"issn-type":[{"value":"1552-5783","type":"print"}],"subject":[],"published":{"date-parts":[[2024,4,18]]}}}