{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T22:00:47Z","timestamp":1791928847675,"version":"4.3.4"},"reference-count":72,"publisher":"Association for Research in Vision and Ophthalmology (ARVO)","issue":"5","license":[{"start":{"date-parts":[[2024,5,8]],"date-time":"2024-05-08T00:00:00Z","timestamp":1715126400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Invest. Ophthalmol. Vis. Sci."],"published-print":{"date-parts":[[2024,5,8]]},"DOI":"10.1167\/iovs.65.5.15","type":"journal-article","created":{"date-parts":[[2024,5,21]],"date-time":"2024-05-21T13:01:15Z","timestamp":1716296475000},"page":"15","source":"Crossref","is-referenced-by-count":5,"title":["TGF\u03b2 Signaling Dysregulation May Contribute to COL4A1-Related Glaucomatous Optic Nerve Damage"],"prefix":"10.1167","volume":"65","author":[{"given":"Mao","family":"Mao","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, University of California, San Francisco, San Francisco, California, United States"},{"name":"https:\/\/orcid.org\/0000-0001-7026-5790"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yien-Ming","family":"Kuo","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, University of California, San Francisco, San Francisco, California, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfred K.","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, University of California, San Francisco, San Francisco, California, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cassandre","family":"Labelle-Dumais","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, University of California, San Francisco, San Francisco, California, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yvonne","family":"Ou","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, University of California, San Francisco, San Francisco, California, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Douglas B.","family":"Gould","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, University of California, San Francisco, San Francisco, California, United States"},{"name":"Department of Anatomy, Institute for Human Genetics, Cardiovascular Research Institute, and Bakar Aging Research Institute, University of California, San Francisco, San Francisco, California, United States"},{"name":"https:\/\/orcid.org\/0000-0001-5127-5328"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"27","reference":[{"key":"bib1","doi-asserted-by":"publisher","first-page":"262","DOI":"10.1136\/bjo.2005.081224","article-title":"The number of people with glaucoma worldwide in 2010 and 2020","volume":"90","author":"Quigley","year":"2006","journal-title":"Br J Ophthalmol"},{"key":"bib2","doi-asserted-by":"publisher","first-page":"1015","DOI":"10.1387\/ijdb.041865dg","article-title":"Anterior segment development relevant to glaucoma","volume":"48","author":"Gould","year":"2004","journal-title":"Int J Dev Biol"},{"key":"bib3","doi-asserted-by":"publisher","first-page":"1185","DOI":"10.1093\/hmg\/11.10.1185","article-title":"Anterior segment dysgenesis and the developmental glaucomas are complex traits","volume":"11","author":"Gould","year":"2002","journal-title":"Hum Mol Genet"},{"key":"bib4","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1016\/j.survophthal.2006.02.006","article-title":"A review of anterior segment dysgeneses","volume":"51","author":"Idrees","year":"2006","journal-title":"Surv Ophthalmol"},{"key":"bib5","doi-asserted-by":"publisher","first-page":"899","DOI":"10.1007\/s00439-018-1935-7","article-title":"Phenotype-genotype correlations and emerging pathways in ocular anterior segment dysgenesis","volume":"138","author":"Ma","year":"2019","journal-title":"Hum Genet"},{"key":"bib6","doi-asserted-by":"publisher","first-page":"2293","DOI":"10.4103\/ijo.IJO_3223_21","article-title":"Anterior segment dysgenesis: insights into the genetics and pathogenesis","volume":"70","author":"Kaushik","year":"2022","journal-title":"Indian J Ophthalmol"},{"key":"bib7","doi-asserted-by":"publisher","first-page":"931","DOI":"10.1038\/eye.2014.140","article-title":"Childhood glaucoma surgery in the 21st century","volume":"28","author":"Papadopoulos","year":"2014","journal-title":"Eye (Lond)"},{"key":"bib8","doi-asserted-by":"publisher","first-page":"2278","DOI":"10.1038\/s41467-018-04555-4","article-title":"A multiethnic genome-wide association study of primary open-angle glaucoma identifies novel risk loci","volume":"9","author":"Choquet","year":"2018","journal-title":"Nat Commun"},{"key":"bib9","doi-asserted-by":"publisher","first-page":"dmm046953","DOI":"10.1242\/dmm.046953","article-title":"Genetic background modifies vulnerability to glaucoma-related phenotypes in Lmx1b mutant mice","volume":"14","author":"Tolman","year":"2021","journal-title":"Dis Model Mech"},{"key":"bib10","doi-asserted-by":"publisher","first-page":"109603","DOI":"10.1016\/j.exer.2023.109603","article-title":"The molecular genetics of anterior segment dysgenesis","volume":"234","author":"Kuang","year":"2023","journal-title":"Exp Eye Res"},{"key":"bib11","doi-asserted-by":"publisher","first-page":"1310","DOI":"10.1038\/sj.eye.6702852","article-title":"Molecular and developmental mechanisms of anterior segment dysgenesis","volume":"21","author":"Sowden","year":"2007","journal-title":"Eye (Lond)"},{"key":"bib12","doi-asserted-by":"publisher","first-page":"314","DOI":"10.1097\/ICU.0b013e328349412b","article-title":"Genetics of anterior segment dysgenesis disorders","volume":"22","author":"Reis","year":"2011","journal-title":"Curr Opin Ophthalmol"},{"key":"bib13","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.matbio.2016.12.009","article-title":"The nature and biology of basement membranes","volume":"57\u201358","author":"Pozzi","year":"2017","journal-title":"Matrix Biol"},{"key":"bib14","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1002\/jemt.v71:5","article-title":"Mammalian Collagen IV","volume":"71","author":"Khoshnoodi","year":"2008","journal-title":"Microsc Res Tech"},{"key":"bib15","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1016\/bs.ctm.2015.09.002","article-title":"Type IV collagens and basement membrane diseases: cell biology and pathogenic mechanisms","volume":"76","author":"Mao","year":"2015","journal-title":"Curr Top Membr"},{"key":"bib16","doi-asserted-by":"publisher","first-page":"R97","DOI":"10.1093\/hmg\/dds346","article-title":"COL4A1 and COL4A2 mutations and disease: insights into pathogenic mechanisms and potential therapeutic targets","volume":"21","author":"Kuo","year":"2012","journal-title":"Hum Mol Genet"},{"key":"bib17","doi-asserted-by":"publisher","first-page":"ra76","DOI":"10.1126\/scisignal.2005347","article-title":"Type IV collagen is an activating ligand for the adhesion G protein-coupled receptor GPR126","volume":"7","author":"Paavola","year":"2014","journal-title":"Sci Signal"},{"key":"bib18","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1038\/nature07214","article-title":"Type IV collagens regulate BMP signalling in Drosophila","volume":"455","author":"Wang","year":"2008","journal-title":"Nature"},{"key":"bib19","doi-asserted-by":"publisher","first-page":"164","DOI":"10.1016\/j.cell.2011.06.016","article-title":"Assembly of lamina-specific neuronal connections by slit bound to type IV collagen","volume":"146","author":"Xiao","year":"2011","journal-title":"Cell"},{"key":"bib20","first-page":"898","article-title":"Novel COL4A2 mutation causing familial malformations of cortical development","volume":"25","author":"Neri","year":"2021","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"bib21","doi-asserted-by":"publisher","first-page":"e025629","DOI":"10.1161\/JAHA.121.025629","article-title":"Systematic review of cerebral phenotypes associated with monogenic cerebral small-vessel disease","volume":"11","author":"Whittaker","year":"2022","journal-title":"J Am Heart Assoc"},{"key":"bib22","doi-asserted-by":"publisher","first-page":"e2078","DOI":"10.1212\/WNL.0000000000006567","article-title":"Neurologic phenotypes associated with COL4A1\/2 mutations: expanding the spectrum of disease","volume":"91","author":"Zagaglia","year":"2018","journal-title":"Neurology"},{"key":"bib23","doi-asserted-by":"publisher","first-page":"3007","DOI":"10.1161\/STROKEAHA.120.029517","article-title":"Beyond the brain: systematic review of extracerebral phenotypes associated with monogenic cerebral small vessel disease","volume":"51","author":"Rannikmae","year":"2020","journal-title":"Stroke"},{"key":"bib24","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1016\/j.matbio.2016.10.003","article-title":"Genotype-phenotype correlations in pathology caused by collagen type IV alpha 1 and 2 mutations","volume":"57-58","author":"Jeanne","year":"2017","journal-title":"Matrix Biol"},{"key":"bib25","doi-asserted-by":"publisher","first-page":"dmm048231","DOI":"10.1242\/dmm.048231","article-title":"Identification of fibronectin 1 as a candidate genetic modifier in a Col4a1 mutant mouse model of Gould syndrome","volume":"14","author":"Mao","year":"2021","journal-title":"Dis Model Mech"},{"key":"bib26","doi-asserted-by":"publisher","first-page":"108365","DOI":"10.1016\/j.yebeh.2021.108365","article-title":"Epilepsy and related challenges in children with COL4A1 and COL4A2 mutations: a Gould syndrome patient registry","volume":"125","author":"Boyce","year":"2021","journal-title":"Epilepsy Behav"},{"key":"bib27","doi-asserted-by":"publisher","first-page":"843","DOI":"10.1038\/gim.2014.210","article-title":"The expanding phenotype of COL4A1 and COL4A2 mutations: clinical data on 13 newly identified families and a review of the literature","volume":"17","author":"Meuwissen","year":"2015","journal-title":"Genet Med"},{"key":"bib28","doi-asserted-by":"publisher","first-page":"475","DOI":"10.1111\/cge.2014.86.issue-5","article-title":"Whole exome analysis identifies dominant COL4A1 mutations in patients with complex ocular phenotypes involving microphthalmia","volume":"86","author":"Deml","year":"2014","journal-title":"Clin Genet"},{"key":"bib29","doi-asserted-by":"publisher","first-page":"483","DOI":"10.1001\/archophthalmol.2010.42","article-title":"Ophthalmological features associated with COL4A1 mutations","volume":"128","author":"Coupry","year":"2010","journal-title":"Arch Ophthalmol"},{"key":"bib30","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1002\/ana.v62:2","article-title":"COL4A1 mutation in Axenfeld-Rieger anomaly with leukoencephalopathy and stroke","volume":"62","author":"Sibon","year":"2007","journal-title":"Ann Neurol"},{"key":"bib31","doi-asserted-by":"publisher","first-page":"35872","DOI":"10.1074\/jbc.M109.060384","article-title":"Abnormal expression of collagen IV in lens activates unfolded protein response resulting in cataract","volume":"284","author":"Firtina","year":"2009","journal-title":"J Biol Chem"},{"key":"bib32","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1242\/dmm.021741","article-title":"ER stress and basement membrane defects combine to cause glomerular and tubular renal disease resulting from Col4a1 mutations in mice","volume":"9","author":"Jones","year":"2016","journal-title":"Dis Model Mech"},{"key":"bib33","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1016\/j.matbio.2022.05.001","article-title":"Elevated TGF\u00df signaling contributes to ocular anterior segment dysgenesis in Col4a1 mutant mice","volume":"110","author":"Mao","year":"2022","journal-title":"Matrix Biol"},{"key":"bib34","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1016\/j.matbio.2022.11.007","article-title":"Elevated TGF\u00df signaling contributes to cerebral small vessel disease in mouse models of Gould syndrome","volume":"115","author":"Branyan","year":"2023","journal-title":"Matrix Biol"},{"key":"bib35","doi-asserted-by":"publisher","first-page":"e2217327120","DOI":"10.1073\/pnas.2217327120","article-title":"Faulty TRPM4 channels underlie age-dependent cerebral vascular dysfunction in Gould syndrome","volume":"120","author":"Yamasaki","year":"2023","journal-title":"Proc Natl Acad Sci USA"},{"key":"bib36","doi-asserted-by":"publisher","first-page":"a022053","DOI":"10.1101\/cshperspect.a022053","article-title":"Signaling receptors for TGF-\u00df family members.","volume":"8","author":"Heldin","year":"2016","journal-title":"Cold Spring Harb Perspect Biol"},{"key":"bib37","doi-asserted-by":"publisher","first-page":"725","DOI":"10.1534\/genetics.106.064733","article-title":"Type IV procollagen missense mutations associated with defects of the eye, vascular stability, the brain, kidney function and embryonic or postnatal viability in the mouse, Mus musculus: an extension of the Col4a1 allelic series and the identification of the first two Col4a2 mutant alleles","volume":"175","author":"Favor","year":"2007","journal-title":"Genetics"},{"key":"bib38","doi-asserted-by":"publisher","first-page":"1709","DOI":"10.1093\/hmg\/ddt560","article-title":"Allelic heterogeneity contributes to variability in ocular dysgenesis, myopathy and brain malformations caused by Col4a1 and Col4a2 mutations","volume":"23","author":"Kuo","year":"2014","journal-title":"Hum Mol Genet"},{"key":"bib39","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1002\/gene.v32:2","article-title":"Conditional inactivation of the TGF-\u00df type II receptor using Cre:Lox","volume":"32","author":"Chytil","year":"2002","journal-title":"Genesis"},{"key":"bib40","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1101\/SQB.1997.062.01.021","article-title":"Analysis of Fgf8 gene function in vertebrate development","volume":"62","author":"Lewandoski","year":"1997","journal-title":"Cold Spring Harb Symp Quant Biol"},{"key":"bib41","doi-asserted-by":"publisher","first-page":"e1007244","DOI":"10.1371\/journal.pgen.1007244","article-title":"Muller glia-derived PRSS56 is required to sustain ocular axial growth and prevent refractive error","volume":"14","author":"Paylakhi","year":"2018","journal-title":"PLoS Genet"},{"key":"bib42","first-page":"10.3791\/61588","article-title":"In vivo structural assessments of ocular disease in rodent models using optical coherence tomography","volume":"161","author":"Allen","year":"2020","journal-title":"J Vis Exp"},{"key":"bib43","first-page":"475","article-title":"Genetic dissection of anterior segment dysgenesis caused by a Col4a1 mutation in mouse","volume":"10","author":"Mao","year":"2017","journal-title":"Dis Model Mech"},{"key":"bib44","doi-asserted-by":"publisher","first-page":"970","DOI":"10.1038\/nrm2297","article-title":"TGF\u00df-SMAD signal transduction: molecular specificity and functional flexibility","volume":"8","author":"Schmierer","year":"2007","journal-title":"Nat Rev Mol Cell Biol"},{"key":"bib45","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1016\/j.ejpb.2015.04.029","article-title":"The aqueous humor outflow pathways in glaucoma: a unifying concept of disease mechanisms and causative treatment","volume":"95","author":"Braunger","year":"2015","journal-title":"Eur J Pharm Biopharm"},{"key":"bib46","doi-asserted-by":"publisher","first-page":"798","DOI":"10.1093\/hmg\/ddm024","article-title":"Col4a1 mutation causes endoplasmic reticulum stress and genetically modifiable ocular dysgenesis","volume":"16","author":"Gould","year":"2007","journal-title":"Hum Mol Genet"},{"key":"bib47","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1167\/iovs.63.2.12","article-title":"Consensus recommendation for mouse models of ocular hypertension to study aqueous humor outflow and its mechanisms","volume":"63","author":"McDowell","year":"2022","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib48","doi-asserted-by":"publisher","first-page":"8754","DOI":"10.1167\/iovs.10-6654","article-title":"Longitudinal and simultaneous imaging of retinal ganglion cells and inner retinal layers in a mouse model of glaucoma induced by N-methyl-d-aspartate","volume":"52","author":"Nakano","year":"2011","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib49","first-page":"1258","article-title":"Retinal morphology and ERG response in the DBA\/2NNia mouse model of angle-closure glaucoma","volume":"42","author":"Bayer","year":"2001","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib50","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1001\/archopht.118.2.235","article-title":"Swelling and loss of photoreceptors in chronic human and experimental glaucomas","volume":"118","author":"Nork","year":"2000","journal-title":"Arch Ophthalmol"},{"key":"bib51","doi-asserted-by":"publisher","first-page":"4200","DOI":"10.1167\/iovs.05-0691","article-title":"Fate maps of neural crest and mesoderm in the mammalian eye","volume":"46","author":"Gage","year":"2005","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib52","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1186\/jbiol29","article-title":"Compound developmental eye disorders following inactivation of TGF\u00df signaling in neural-crest stem cells","volume":"4","author":"Ittner","year":"2005","journal-title":"J Biol"},{"key":"bib53","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1006\/dbio.2001.0480","article-title":"TGF\u00df2 in corneal morphogenesis during mouse embryonic development","volume":"240","author":"Saika","year":"2001","journal-title":"Dev Biol"},{"key":"bib54","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1002\/dvdy.v225:2","article-title":"Disruption of anterior segment development by TGF-\u00df1 overexpression in the eyes of transgenic mice","volume":"225","author":"Flugel-Koch","year":"2002","journal-title":"Dev Dyn"},{"key":"bib55","doi-asserted-by":"publisher","first-page":"308","DOI":"10.1167\/iovs.09-3380","article-title":"Ocular gene transfer of active TGF-\u00df induces changes in anterior segment morphology and elevated IOP in rats","volume":"51","author":"Robertson","year":"2010","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib56","doi-asserted-by":"publisher","first-page":"625","DOI":"10.1172\/JCI1360","article-title":"Lens-specific expression of transforming growth factor beta1 in transgenic mice causes anterior subcapsular cataracts","volume":"101","author":"Srinivasan","year":"1998","journal-title":"J Clin Invest"},{"key":"bib57","first-page":"612","article-title":"Aqueous humor TGF-\u00df2 levels in patients with open-angle glaucoma: a meta-analysis","volume":"21","author":"Agarwal","year":"2015","journal-title":"Mol Vis"},{"key":"bib58","doi-asserted-by":"publisher","first-page":"680","DOI":"10.1136\/bjophthalmol-2011-301132","article-title":"The role of transforming growth factor beta in glaucoma and the therapeutic implications","volume":"97","author":"Prendes","year":"2013","journal-title":"Br J Ophthalmol"},{"key":"bib59","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1167\/iovs.03-0796","article-title":"Effects of TGF-\u00df2 in perfused human eyes","volume":"45","author":"Gottanka","year":"2004","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib60","doi-asserted-by":"publisher","first-page":"226","DOI":"10.1167\/iovs.05-1060","article-title":"TGF\u00df2-induced changes in human trabecular meshwork: implications for intraocular pressure","volume":"47","author":"Fleenor","year":"2006","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib61","doi-asserted-by":"publisher","first-page":"2067","DOI":"10.1167\/iovs.09-4567","article-title":"Adenoviral gene transfer of active human transforming growth factor-\u00df2 elevates intraocular pressure and reduces outflow facility in rodent eyes","volume":"51","author":"Shepard","year":"2010","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib62","doi-asserted-by":"publisher","first-page":"2183","DOI":"10.1016\/S0140-6736(17)31469-1","article-title":"Glaucoma","volume":"390","author":"Jonas","year":"2017","journal-title":"Lancet"},{"key":"bib63","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1136\/bjo.83.2.209","article-title":"Transforming growth factor \u00df isoforms in human optic nerve heads","volume":"83","author":"Pena","year":"1999","journal-title":"Br J Ophthalmol"},{"key":"bib64","doi-asserted-by":"publisher","first-page":"568","DOI":"10.1167\/iovs.04-0649","article-title":"Transforming growth factor-\u00df2 modulated extracellular matrix component expression in cultured human optic nerve head astrocytes","volume":"46","author":"Fuchshofer","year":"2005","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib65","first-page":"1745","article-title":"Transforming growth factor-\u00df2 increases extracellular matrix proteins in optic nerve head cells via activation of the Smad signaling pathway","volume":"17","author":"Zode","year":"2011","journal-title":"Mol Vis"},{"key":"bib66","first-page":"2303","article-title":"Increased elastin expression in astrocytes of the lamina cribrosa in response to elevated intraocular pressure","volume":"42","author":"Pena","year":"2001","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib67","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1242\/dev.111.1.131","article-title":"Embryonic gene expression patterns of TGF \u00df1, \u00df2 and \u00df3 suggest different developmental functions in vivo","volume":"111","author":"Millan","year":"1991","journal-title":"Development"},{"key":"bib68","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1016\/0012-1606(91)90081-D","article-title":"Transforming growth factor beta type 1 binds to collagen IV of basement membrane matrix: implications for development","volume":"143","author":"Paralkar","year":"1991","journal-title":"Dev Biol"},{"key":"bib69","doi-asserted-by":"publisher","first-page":"296","DOI":"10.1016\/j.devcel.2010.07.019","article-title":"Hemocyte-secreted type IV collagen enhances BMP signaling to guide renal tubule morphogenesis in Drosophila","volume":"19","author":"Bunt","year":"2010","journal-title":"Dev Cell"},{"key":"bib70","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1083\/jcb.113.2.417","article-title":"The NC1 domain of type IV collagen promotes axonal growth in sympathetic neurons through interaction with the alpha 1 beta 1 integrin","volume":"113","author":"Lein","year":"1991","journal-title":"J Cell Biol"},{"key":"bib71","doi-asserted-by":"publisher","first-page":"3593","DOI":"10.1242\/dev.121.11.3593","article-title":"Integrin alpha 2 beta 1 mediates interactions between developing embryonic retinal cells and collagen","volume":"121","author":"Bradshaw","year":"1995","journal-title":"Development"},{"key":"bib72","doi-asserted-by":"publisher","first-page":"3295","DOI":"10.1172\/JCI71668","article-title":"Integrin-mediated type II TGF-\u00df receptor tyrosine dephosphorylation controls SMAD-dependent profibrotic signaling","volume":"124","author":"Chen","year":"2014","journal-title":"J Clin Invest"}],"container-title":["Investigative Ophthalmology & Visual Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/iovs.arvojournals.org\/article.aspx?articleid=2793649","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:31:47Z","timestamp":1791927107000},"score":1,"resource":{"primary":{"URL":"https:\/\/iovs.arvojournals.org\/article.aspx?articleid=2793649"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5,8]]},"references-count":72,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2024,5,1]]}},"URL":"https:\/\/doi.org\/10.1167\/iovs.65.5.15","relation":{},"ISSN":["1552-5783"],"issn-type":[{"value":"1552-5783","type":"print"}],"subject":[],"published":{"date-parts":[[2024,5,8]]}}}