{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T22:01:20Z","timestamp":1791928880172,"version":"4.3.4"},"reference-count":37,"publisher":"Association for Research in Vision and Ophthalmology (ARVO)","issue":"5","license":[{"start":{"date-parts":[[2024,5,21]],"date-time":"2024-05-21T00:00:00Z","timestamp":1716249600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Invest. Ophthalmol. Vis. Sci."],"published-print":{"date-parts":[[2024,5,21]]},"DOI":"10.1167\/iovs.65.5.30","type":"journal-article","created":{"date-parts":[[2024,5,21]],"date-time":"2024-05-21T11:31:05Z","timestamp":1716291065000},"page":"30","source":"Crossref","is-referenced-by-count":5,"title":["The Role of Aquaporin 4 in Lacrimal Gland Ductal Fluid Secretion in Mice"],"prefix":"10.1167","volume":"65","author":[{"given":"Gr\u00e9ta","family":"Elekes","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, University of Szeged, Szeged, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vir\u00e1g","family":"Csap\u00f3","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, University of Szeged, Szeged, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D\u00f3ra","family":"Szarka","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, University of Szeged, Szeged, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L\u00e1szl\u00f3","family":"Szalay","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, University of Szeged, Szeged, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marietta Margar\u00e9ta","family":"Kors\u00f3s","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Pharmacotherapy, University of Szeged, Szeged, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dorottya","family":"T\u00e1losi","sequence":"additional","affiliation":[{"name":"Albert Szent-Gyorgyi Medical School, University of Szeged, Szeged, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D\u00e9nes","family":"T\u00f6r\u00f6k","sequence":"additional","affiliation":[{"name":"Department of Anatomy, University of Szeged, Szeged, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edit","family":"T\u00f3th-Moln\u00e1r","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, University of Szeged, Szeged, Hungary"},{"name":"Faculty of Health Sciences and Social Studies, University of Szeged, Szeged, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"27","reference":[{"key":"bib1","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1007\/BF00586647","article-title":"Water and electrolyte secretion by the exorbital lacrimal gland of the rat studied by micropuncture and catheterization techniques","volume":"337","author":"Alexander","year":"1972","journal-title":"Pflugers Arch"},{"key":"bib2","doi-asserted-by":"publisher","first-page":"557","DOI":"10.1113\/jphysiol.1981.sp014002","article-title":"Lacrimal gland electrolyte and water secretion in the rabbit: localization and role of (Na+\/K+)-activated ATP-ase","volume":"321","author":"Dartt","year":"1981","journal-title":"J Physiol"},{"key":"bib3","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1016\/j.preteyeres.2009.04.003","article-title":"Neural regulation of lacrimal gland secretory processes: relevance in dry eye diseases","volume":"28","author":"Dartt","year":"2009","journal-title":"Prog Retin Eye Res"},{"key":"bib4","doi-asserted-by":"publisher","first-page":"1876","DOI":"10.1167\/iovs.05-0363","article-title":"Gene expression in rat lacrimal gland duct cells collected using laser capture microdissection: evidence for K+ secretion by the duct cells","volume":"47","author":"Ubels","year":"2006","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib5","doi-asserted-by":"publisher","first-page":"2960","DOI":"10.1167\/iovs.09-4687","article-title":"Duct system of the rabbit lacrimal gland: structural characteristics and role in lacrimal secretion","volume":"51","author":"Ding","year":"2010","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib6","doi-asserted-by":"publisher","first-page":"3746","DOI":"10.1167\/iovs.06-1291","article-title":"New experimental method to study acid\/base transporters and their regulation in lacrimal gland ductal epithelia","volume":"48","author":"T\u00f3th-Moln\u00e1r","year":"2007","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib7","doi-asserted-by":"publisher","first-page":"4360","DOI":"10.1167\/iovs.14-14025","article-title":"Experimental evidence of fluid secretion of rabbit lacrimal gland duct epithelium","volume":"55","author":"Katona","year":"2014","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib8","doi-asserted-by":"publisher","first-page":"3828","DOI":"10.1167\/iovs.15-18462","article-title":"Characterization of Na+-K+-2Cl- cotransporter activity in rabbit lacrimal gland duct cells","volume":"57","author":"Vizv\u00e1ri","year":"2016","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"1","key":"bib9","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1167\/iovs.17-22533","article-title":"Novel insight into the role of CFTR in lacrimal gland duct function in mice","volume":"59","author":"Berczeli","year":"2018","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"14","key":"bib10","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1167\/iovs.61.14.3","article-title":"Alpha-adrenergic agonists stimulate ductal fluid secretion in lacrimal gland ducts","volume":"61","author":"Szarka","year":"2020","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"4","key":"bib11","doi-asserted-by":"publisher","first-page":"595","DOI":"10.1016\/j.jtos.2020.07.002","article-title":"New insight into lacrimal gland function: role of the duct epithelium in tear secretion","volume":"18","author":"T\u00f3th-Moln\u00e1r","year":"2020","journal-title":"Ocul Surf"},{"issue":"Suppl.","key":"bib12","doi-asserted-by":"crossref","first-page":"179","DOI":"10.2152\/jmi.56.179","article-title":"Aquaporin water channels in transepithelial fluid transport","volume":"56","author":"Tradtrantip","year":"2009","journal-title":"J Med Invest"},{"key":"bib13","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1007\/978-94-024-1057-0","article-title":"Aquaporins and gland secretion","volume":"969","author":"Delporte","year":"2017","journal-title":"Adv Exp Med Biol"},{"issue":"5Pt1","key":"bib14","doi-asserted-by":"crossref","first-page":"C1332","DOI":"10.1152\/ajpcell.1998.274.5.C1332","article-title":"Aquaporins in complex tissues: distribution of aquaporins 1-5 in human and rat eye","volume":"274","author":"Hamann","year":"1998","journal-title":"Am J Physiol"},{"key":"bib15","doi-asserted-by":"publisher","first-page":"420","DOI":"10.1016\/j.preteyeres.2008.04.001","article-title":"Functions of aquaporins in the eye","volume":"27","author":"Verkman","year":"2008","journal-title":"Prog Ret Eye Res"},{"key":"bib16","doi-asserted-by":"publisher","first-page":"109557","DOI":"10.1016\/j.exer.2023.109557","article-title":"Aquaporin 5 in the eye: expression, function, and roles in ocular diseases","volume":"233","author":"Zhang","year":"2023","journal-title":"Exp Eye Res"},{"key":"bib17","doi-asserted-by":"publisher","first-page":"891","DOI":"10.1006\/bbrc.1997.7396","article-title":"Immunolocalization of aquaporin homologs in mouse lacrimal glands","volume":"238","author":"Ishida","year":"1997","journal-title":"Biochem Biophys Res Commun"},{"key":"bib18","doi-asserted-by":"publisher","first-page":"571","DOI":"10.3109\/02713683.2011.574330","article-title":"Changes of aquaporins in the lacrimal glands of a rabbit model of Sjogren's syndrome","volume":"36","author":"Ding","year":"2011","journal-title":"Curr Eye Res"},{"key":"bib19","first-page":"2847","article-title":"Changes of the ocular surface and aquaporins in the lacrimal glands of rabbits during pregnancy","volume":"17","author":"Ding","year":"2011","journal-title":"Mol Vis"},{"key":"bib20","doi-asserted-by":"publisher","first-page":"557","DOI":"10.1006\/exer.1999.0814","article-title":"Tear secretion by lacrimal glands in transgenic mice lacking water channels AQP1, AQP3, AQP4 and AQP5","volume":"70","author":"Moore","year":"2000","journal-title":"Exp Eye Res"},{"key":"bib21","doi-asserted-by":"publisher","first-page":"923","DOI":"10.1080\/02713680701733076","article-title":"The difference of aquaporin 5 distribution in acinar and ductal cells in lacrimal and parotid glands","volume":"32","author":"Sasaki","year":"2007","journal-title":"Curr Eye Res"},{"key":"bib22","first-page":"679","article-title":"Lacrimal gland homeostasis is maintained by the AQP5 pathway by attenuating endoplasmic reticulum stress inflammation in the lacrimal gland of AQP5 knockout mice","volume":"27","author":"Hu","year":"2021","journal-title":"Mol Vis"},{"key":"bib23","doi-asserted-by":"publisher","first-page":"621","DOI":"10.1080\/02713680802262819","article-title":"Altered distribution of aquaporin 5 and its C-terminal binding protein in the lacrimal glands of a mouse model for Sj\u00f6gren's syndrome","volume":"33","author":"Ohashi","year":"2008","journal-title":"Curr Eye Res"},{"key":"bib24","doi-asserted-by":"publisher","first-page":"688","DOI":"10.1016\/S0140-6736(00)04140-4","article-title":"Defective cellular trafficking of lacrimal gland aquaporin-5 in Sj\u00f6gren's syndrome","volume":"357","author":"Tsubota","year":"2001","journal-title":"Lancet"},{"issue":"7","key":"bib25","doi-asserted-by":"publisher","first-page":"676","DOI":"10.1038\/nmeth.2019","article-title":"Fiji: an open-source platform for biological-image analysis","volume":"9","author":"Schindelin","year":"2012","journal-title":"Nature Methods"},{"issue":"5","key":"bib26","doi-asserted-by":"publisher","first-page":"1603","DOI":"10.3390\/ijms21051603","article-title":"Regulation of AQP4 in the central nervous system","volume":"21","author":"Vandeborek","year":"2020","journal-title":"Int J Mol Sci"},{"key":"bib27","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1159\/000440846","article-title":"Nitric oxide increases the expression of aquaporin-4 protein in rat optic nerve astrocytes through the cyclic guanosine monophosphate\/protein kinase G pathway","volume":"54","author":"Hidehiro","year":"2015","journal-title":"Ophthalmic Res"},{"key":"bib28","doi-asserted-by":"publisher","first-page":"2127","DOI":"10.1167\/iovs.11-8471","article-title":"Stimulation of aquaporin-mediated fluid transport by cyclic GMP in human retinal pigment epithelium in vitro","volume":"53","author":"Baetz","year":"2012","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib29","doi-asserted-by":"publisher","first-page":"1971","DOI":"10.2147\/DDDT.S309675","article-title":"Inhibitory effect of Lactococcus lactis subsp. Lactis HFY14 on diphenoxylate-induced constipation in mice by regulating the VIP-cAMP-PKA-AQP3 signaling pathway","volume":"15","author":"Tan","year":"2021","journal-title":"Drug Des Devel Ther"},{"key":"bib30","doi-asserted-by":"publisher","first-page":"13199","DOI":"10.1073\/pnas.1404493111","article-title":"Overactivation of corticotropin-releasing factor receptor type 1 and aquaporin-4 by hypoxia induces cerebral edema","volume":"111","author":"Chen","year":"2014","journal-title":"Proc Nat Acad Sci"},{"key":"bib31","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1093\/toxsci\/kfv055","article-title":"Morphine-induced constipation develops with increased Aquaporin-3 expression in the colon via increased serotonin secretion","volume":"145","author":"Kon","year":"2015","journal-title":"Toxicol Sci"},{"key":"bib32","doi-asserted-by":"publisher","first-page":"1047","DOI":"10.2741\/4357","article-title":"Expression of AQP3 protein in hAECs is regulated by camp-PKA-CREB signaling pathway","volume":"20","author":"Zhu","year":"2015","journal-title":"Front Biosci"},{"key":"bib33","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1016\/j.preteyeres.2009.04.003","article-title":"Neural regulation of lacrimal gland secretory processes: relevance in dry eye diseases","volume":"28","author":"Dartt","year":"2009","journal-title":"Prog Retin Eye Res"},{"key":"bib34","doi-asserted-by":"publisher","first-page":"619","DOI":"10.3109\/02713688908995762","article-title":"Signal transduction and control of lacrimal gland protein secretion: a review","volume":"8","author":"Dartt","year":"1989","journal-title":"Curr Eye Res"},{"key":"bib35","first-page":"780","article-title":"The regulatory role of vasoactive intestinal peptide in lacrimal gland ductal fluid secretion: a new piece of the puzzle in tear production","volume":"26","author":"Berczeli","year":"2020","journal-title":"Mol Vis"},{"key":"bib36","doi-asserted-by":"publisher","first-page":"109676","DOI":"10.1016\/j.exer.2023.109676","article-title":"Aquaporins in lacrimal glands and their role in dry eye disease","volume":"236","author":"Bai","year":"2023","journal-title":"Exp Eye Res"},{"key":"bib37","doi-asserted-by":"publisher","first-page":"103268","DOI":"10.1016\/j.autrev.2023.103268","article-title":"Involvement of aquaporin 5 in Sjogren's syndrome","volume":"22","author":"Chivasso","year":"2023","journal-title":"Autoimmunity Rev"}],"container-title":["Investigative Ophthalmology & Visual Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/iovs.arvojournals.org\/article.aspx?articleid=2793679","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:31:51Z","timestamp":1791927111000},"score":1,"resource":{"primary":{"URL":"https:\/\/iovs.arvojournals.org\/article.aspx?articleid=2793679"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5,21]]},"references-count":37,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2024,5,1]]}},"URL":"https:\/\/doi.org\/10.1167\/iovs.65.5.30","relation":{},"ISSN":["1552-5783"],"issn-type":[{"value":"1552-5783","type":"print"}],"subject":[],"published":{"date-parts":[[2024,5,21]]}}}