{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T22:00:42Z","timestamp":1791928842624,"version":"4.3.4"},"reference-count":43,"publisher":"Association for Research in Vision and Ophthalmology (ARVO)","issue":"6","license":[{"start":{"date-parts":[[2024,6,27]],"date-time":"2024-06-27T00:00:00Z","timestamp":1719446400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Invest. Ophthalmol. Vis. Sci."],"published-print":{"date-parts":[[2024,6,27]]},"DOI":"10.1167\/iovs.65.6.37","type":"journal-article","created":{"date-parts":[[2024,6,27]],"date-time":"2024-06-27T11:02:08Z","timestamp":1719486128000},"page":"37","source":"Crossref","is-referenced-by-count":2,"title":["Alteration of Gene Expression in Pathological Keratinization of the Ocular Surface"],"prefix":"10.1167","volume":"65","author":[{"given":"Hokoru","family":"Yoshioka","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mayumi","family":"Ueta","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideki","family":"Fukuoka","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norihiko","family":"Yokoi","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katsura","family":"Mizushima","sequence":"additional","affiliation":[{"name":"Department of Human Immunology and Nutrition Science, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kamigyo-ku, Kyoto, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuji","family":"Naito","sequence":"additional","affiliation":[{"name":"Department of Human Immunology and Nutrition Science, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kamigyo-ku, Kyoto, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigeru","family":"Kinoshita","sequence":"additional","affiliation":[{"name":"Department of Frontier Medical Science and Technology for Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chie","family":"Sotozono","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"27","reference":[{"key":"bib1","doi-asserted-by":"publisher","first-page":"364","DOI":"10.1097\/ICO.0000000000001820","article-title":"Global consensus on definition, classification, diagnosis, and staging of limbal stem cell deficiency","volume":"38","author":"Deng","year":"2019","journal-title":"Cornea"},{"key":"bib2","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1016\/j.jtos.2016.02.001","article-title":"Acute and chronic ophthalmic involvement in Stevens-Johnson syndrome\/toxic epidermal necrolysis\u2014a comprehensive review and guide to therapy. II. Ophthalmic disease","volume":"14","author":"Kohanim","year":"2016","journal-title":"Ocul Surf"},{"key":"bib3","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1038\/eye.2016.284","article-title":"The 2016 Bowman Lecture Conjunctival curses: scarring conjunctivitis 30 years on","volume":"31","author":"Dart","year":"2017","journal-title":"Eye (Lond)"},{"key":"bib4","doi-asserted-by":"publisher","first-page":"745","DOI":"10.1097\/ICO.0000000000002263","article-title":"Long-term progression of ocular surface disease in Stevens-Johnson syndrome and toxic epidermal necrolysis","volume":"39","author":"Yoshikawa","year":"2020","journal-title":"Cornea"},{"key":"bib5","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1016\/j.survophthal.2016.01.004","article-title":"Stevens-Johnson syndrome: the role of an ophthalmologist","volume":"61","author":"Jain","year":"2016","journal-title":"Surv Ophthalmol"},{"key":"bib6","doi-asserted-by":"publisher","first-page":"292","DOI":"10.1136\/bjo.80.4.292","article-title":"Progression of disease in ocular cicatricial pemphigoid","volume":"80","author":"Elder","year":"1996","journal-title":"Br J Ophthalmol"},{"key":"bib7","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1016\/j.ajo.2005.03.022","article-title":"Survival analysis of conjunctival limbal grafts and amniotic membrane transplantation in eyes with total limbal stem cell deficiency","volume":"140","author":"Santos","year":"2005","journal-title":"Am J Ophthalmol"},{"key":"bib8","doi-asserted-by":"publisher","first-page":"101148","DOI":"10.1016\/j.preteyeres.2022.101148","article-title":"Cell identity changes in ocular surface Epithelia","volume":"95","author":"Di Girolamo","year":"2022","journal-title":"Prog Retin Eye Res"},{"key":"bib9","doi-asserted-by":"publisher","first-page":"1998","DOI":"10.3390\/nu13061998","article-title":"A review of topical and systemic vitamin supplementation in ocular surface diseases","volume":"13","author":"Fogagnolo","year":"2021","journal-title":"Nutrients"},{"key":"bib10","doi-asserted-by":"publisher","first-page":"1355","DOI":"10.1136\/bjophthalmol-2020-318547","article-title":"Long-term outcome of cultivated oral mucosal epithelial transplantation for fornix reconstruction in chronic cicatrising diseases","volume":"106","author":"Komai","year":"2021","journal-title":"Br J Ophthalmol"},{"key":"bib11","doi-asserted-by":"publisher","first-page":"e21892","DOI":"10.1097\/MD.0000000000021892","article-title":"Histopathological examination of congenital corneal staphyloma and prognosis after penetrating keratoplasty","volume":"99","author":"Wan","year":"2020","journal-title":"Medicine (Baltimore)"},{"key":"bib12","doi-asserted-by":"publisher","first-page":"452","DOI":"10.1038\/bmt.2012.244","article-title":"Investigation of the freely available easy-to-use software `EZR' for medical statistics","volume":"48","author":"Kanda","year":"2013","journal-title":"Bone Marrow Transplant"},{"key":"bib13","first-page":"1702","article-title":"Changes in conjunctival clusterin expression in severe ocular surface disease","volume":"43","author":"Nakamura","year":"2002","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib14","doi-asserted-by":"publisher","first-page":"1703","DOI":"10.3390\/nu13051703","article-title":"Vitamin A update: forms, sources, kinetics, detection, function, deficiency, therapeutic use and toxicity","volume":"13","author":"Carazo","year":"2021","journal-title":"Nutrients"},{"key":"bib15","doi-asserted-by":"publisher","first-page":"385","DOI":"10.3390\/nu3040385","article-title":"Vitamin A in reproduction and development","volume":"3","author":"Clagett-Dame","year":"2011","journal-title":"Nutrients"},{"key":"bib16","doi-asserted-by":"publisher","first-page":"2723","DOI":"10.1242\/dev.120.10.2723","article-title":"Function of the retinoic acid receptors (RARs) during development (I). Craniofacial and skeletal abnormalities in RAR double mutants","volume":"120","author":"Lohnes","year":"1994","journal-title":"Development"},{"key":"bib17","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1016\/j.ydbio.2008.04.039","article-title":"Impairing retinoic acid signalling in the neural crest cells is sufficient to alter entire eye morphogenesis","volume":"320","author":"Matt","year":"2008","journal-title":"Dev Biol"},{"key":"bib18","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1016\/j.survophthal.2014.10.001","article-title":"Retinoic acid and the ocular surface","volume":"60","author":"Samarawickrama","year":"2015","journal-title":"Surv Ophthalmol"},{"key":"bib19","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1016\/j.pharmthera.2017.01.004","article-title":"Cellular retinoid binding-proteins, CRBP, CRABP, FABP5: effects on retinoid metabolism, function and related diseases","volume":"173","author":"Napoli","year":"2017","journal-title":"Pharmacol Ther"},{"key":"bib20","doi-asserted-by":"publisher","first-page":"6105","DOI":"10.1007\/s11033-020-05686-y","article-title":"Analysis of CRABP2 and FABP5 genes in primary and recurrent pterygium tissues","volume":"47","author":"Celik","year":"2020","journal-title":"Mol Biol Rep"},{"key":"bib21","doi-asserted-by":"publisher","first-page":"35621","DOI":"10.1074\/jbc.M706372200","article-title":"Overproduction of bioactive retinoic acid in cells expressing disease-associated mutants of retinol dehydrogenase 12","volume":"282","author":"Lee","year":"2007","journal-title":"J Biol Chem"},{"key":"bib22","doi-asserted-by":"publisher","first-page":"758","DOI":"10.1038\/modpathol.2011.191","article-title":"Overexpression and oncogenic function of aldo-keto reductase family 1B10 (AKR1B10) in pancreatic carcinoma","volume":"25","author":"Chung","year":"2012","journal-title":"Mod Pathol"},{"key":"bib23","doi-asserted-by":"publisher","first-page":"106113","DOI":"10.1016\/j.jsbmb.2022.106113","article-title":"Porcine aldo-keto reductase 1C subfamily members AKR1C1 and AKR1C4: substrate specificity, inhibitor sensitivity and activators","volume":"221","author":"Endo","year":"2022","journal-title":"J Steroid Biochem Mol Biol"},{"key":"bib24","doi-asserted-by":"publisher","first-page":"e3000719","DOI":"10.1371\/journal.pbio.3000719","article-title":"Discovery of genes required for body axis and limb formation by global identification of retinoic acid-regulated epigenetic marks","volume":"18","author":"Berenguer","year":"2020","journal-title":"PLoS Biol"},{"key":"bib25","doi-asserted-by":"publisher","first-page":"819","DOI":"10.1001\/jamadermatol.2018.1373","article-title":"Association of retinoic acid receptor beta gene with onset and progression of lichen sclerosus-associated vulvar squamous cell carcinoma","volume":"154","author":"Rotondo","year":"2018","journal-title":"JAMA Dermatol"},{"key":"bib26","doi-asserted-by":"publisher","first-page":"2411","DOI":"10.1158\/0008-5472.CAN-03-0164","article-title":"Hypermethylation and silencing of the putative tumor suppressor Tazarotene-induced gene 1 in human cancers","volume":"64","author":"Youssef","year":"2004","journal-title":"Cancer Res"},{"key":"bib27","first-page":"3518","article-title":"Overexpression of retinoic acid receptor beta in head and neck squamous cell carcinoma cells increases their sensitivity to retinoid-induced suppression of squamous differentiation by retinoids","volume":"59","author":"Wan","year":"1999","journal-title":"Cancer Res"},{"key":"bib28","doi-asserted-by":"publisher","first-page":"4050","DOI":"10.1167\/iovs.05-0627","article-title":"Effect of retinoic acid on gene expression in human conjunctival epithelium: secretory phospholipase A2 mediates retinoic acid induction of MUC16","volume":"46","author":"Hori","year":"2005","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib29","doi-asserted-by":"publisher","first-page":"160","DOI":"10.1016\/j.jtos.2023.09.002","article-title":"Retinol palmitate in management of chronic Steven-Johnson Syndrome with ocular surface keratinization","volume":"30","author":"Ravindra","year":"2023","journal-title":"Ocul Surf"},{"key":"bib30","doi-asserted-by":"publisher","first-page":"1015","DOI":"10.1136\/bjophthalmol-2018-312849","article-title":"Altered retinoid metabolism gene expression in chronic Stevens-Johnson syndrome","volume":"103","author":"Srividya","year":"2019","journal-title":"Br J Ophthalmol"},{"key":"bib31","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1016\/j.exer.2004.09.011","article-title":"A retrospective on topical retinoids occasioned by observation of unexpected interactions of retinoic acid with androgens and glucocorticoids in immortalized lacrimal acinar cells","volume":"80","author":"Ubels","year":"2005","journal-title":"Exp Eye Res"},{"key":"bib32","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1111\/j.0022-202X.2005.23668.x","article-title":"Stratum corneum defensive functions: an integrated view","volume":"125","author":"Elias","year":"2005","journal-title":"J Invest Dermatol"},{"key":"bib33","doi-asserted-by":"publisher","first-page":"412","DOI":"10.1016\/S0022-2275(20)33902-X","article-title":"Parallel regulation of sterol regulatory element binding protein-2 and the enzymes of cholesterol and fatty acid synthesis but not ceramide synthesis in cultured human keratinocytes and murine epidermis","volume":"39","author":"Harris","year":"1998","journal-title":"J Lipid Res"},{"key":"bib34","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1002\/jcp.v220:2","article-title":"Retinoid-responsive transcriptional changes in epidermal keratinocytes","volume":"220","author":"Lee","year":"2009","journal-title":"J Cell Physiol"},{"key":"bib35","doi-asserted-by":"publisher","first-page":"e2895","DOI":"10.1038\/cddis.2017.244","article-title":"MYBL2 (B-Myb): a central regulator of cell proliferation, cell survival and differentiation involved in tumorigenesis","volume":"8","author":"Musa","year":"2017","journal-title":"Cell Death Dis"},{"key":"bib36","doi-asserted-by":"crossref","first-page":"2383516","DOI":"10.1155\/2020\/2383516","article-title":"Identification of functional genes in pterygium based on bioinformatics analysis","volume":"2020","author":"Xu","year":"2020","journal-title":"Biomed Res Int"},{"key":"bib37","doi-asserted-by":"publisher","first-page":"2505","DOI":"10.1038\/s41467-021-22779-9","article-title":"Single-keratinocyte transcriptomic analyses identify different clonal types and proliferative potential mediated by FOXM1 in human epidermal stem cells","volume":"12","author":"Enzo","year":"2021","journal-title":"Nat Commun"},{"key":"bib38","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1016\/j.survophthal.2021.04.008","article-title":"Molecular mechanisms and treatments for ocular symblephara","volume":"67","author":"Swarup","year":"2022","journal-title":"Surv Ophthalmol"},{"key":"bib39","doi-asserted-by":"publisher","first-page":"2191","DOI":"10.3390\/molecules23092191","article-title":"ELF3, ELF5, EHF and SPDEF transcription factors in tissue homeostasis and cancer","volume":"23","author":"Luk","year":"2018","journal-title":"Molecules"},{"key":"bib40","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1016\/j.diff.2023.02.002","article-title":"Corneal epithelial development and homeostasis","volume":"132","author":"Swamynathan","year":"2023","journal-title":"Differentiation"},{"key":"bib41","doi-asserted-by":"publisher","first-page":"943275","DOI":"10.3389\/fendo.2022.943275","article-title":"Expression profiling suggests the involvement of hormone-related, metabolic, and Wnt signaling pathways in pterygium progression","volume":"13","author":"Li","year":"2022","journal-title":"Front Endocrinol (Lausanne)"},{"key":"bib42","doi-asserted-by":"publisher","first-page":"e000254","DOI":"10.1136\/bmjophth-2018-000254","article-title":"Gene expression analysis of conjunctival epithelium of patients with Stevens-Johnson syndrome in the chronic stage","volume":"4","author":"Ueta","year":"2019","journal-title":"BMJ Open Ophthalmol"},{"key":"bib43","doi-asserted-by":"crossref","first-page":"e87001","DOI":"10.1172\/jci.insight.87001","article-title":"Aldehyde dehydrogenase inhibition blocks mucosal fibrosis in human and mouse ocular scarring","volume":"1","author":"Ahadome","year":"2016","journal-title":"JCI Insight"}],"container-title":["Investigative Ophthalmology &amp; Visual Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/iovs.arvojournals.org\/article.aspx?articleid=2793793","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:31:53Z","timestamp":1791927113000},"score":1,"resource":{"primary":{"URL":"https:\/\/iovs.arvojournals.org\/article.aspx?articleid=2793793"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6,27]]},"references-count":43,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2024,6,3]]}},"URL":"https:\/\/doi.org\/10.1167\/iovs.65.6.37","relation":{},"ISSN":["1552-5783"],"issn-type":[{"value":"1552-5783","type":"print"}],"subject":[],"published":{"date-parts":[[2024,6,27]]}}}