{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T13:06:52Z","timestamp":1793192812652,"version":"4.5.0"},"reference-count":55,"publisher":"Association for Research in Vision and Ophthalmology (ARVO)","issue":"8","license":[{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Invest. Ophthalmol. Vis. Sci."],"published-print":{"date-parts":[[2024,7,1]]},"DOI":"10.1167\/iovs.65.8.1","type":"journal-article","created":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T10:32:05Z","timestamp":1719829925000},"page":"1","source":"Crossref","is-referenced-by-count":10,"title":["Protective Effect of Nicotinamide Riboside on Glucocorticoid-Induced Glaucoma: Mitigating Mitochondrial Damage and Extracellular Matrix Deposition"],"prefix":"10.1167","volume":"65","author":[{"given":"Nan","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pengyu","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xizhi","family":"Deng","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yixin","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongxiao","family":"Ji","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China"},{"name":"Department of Ophthalmology, Huaihai Hospital of Henan University, Kaifeng, Henan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lufan","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen","family":"Zeng","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Ke","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"27","reference":[{"issue":"1","key":"bib1","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1016\/j.tem.2017.10.010","article-title":"Therapeutic mechanisms of glucocorticoids","volume":"29","author":"Vandewalle","year":"2018","journal-title":"Trends Endocrinol Metab"},{"issue":"4","key":"bib2","first-page":"358","article-title":"Treatment with vonoprazan for 3 weeks is not inferior to 8 weeks for the management of gastric ESD: a multicenter noninferiority randomized study","volume":"58","author":"Kato","year":"2023","journal-title":"J Gastroenterol"},{"issue":"5","key":"bib3","doi-asserted-by":"publisher","first-page":"2993","DOI":"10.1167\/iovs.15-16744","article-title":"Aqueous humor outflow: dynamics and disease","volume":"56","author":"Roy Chowdhury","year":"2015","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib4","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1016\/j.preteyeres.2016.09.003","article-title":"Steroid-induced ocular hypertension\/glaucoma: focus on pharmacogenomics and implications for precision medicine","volume":"56","author":"Fini","year":"2017","journal-title":"Prog Retin Eye Res"},{"key":"bib5","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/j.exer.2016.07.011","article-title":"Trabecular meshwork stiffness in glaucoma","volume":"158","author":"Wang","year":"2017","journal-title":"Exp Eye Res"},{"issue":"2","key":"bib6","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1080\/02713683.2019.1657462","article-title":"Mitochondria and autophagy dysfunction in glucocorticoid-induced ocular hypertension\/glaucoma mice model","volume":"45","author":"Zeng","year":"2020","journal-title":"Curr Eye Res"},{"issue":"9","key":"bib7","doi-asserted-by":"publisher","first-page":"6586","DOI":"10.1007\/s12035-019-1559-5","article-title":"Rapamycin removes damaged mitochondria and protects human trabecular meshwork (TM-1) cells from chronic oxidative stress","volume":"56","author":"He","year":"2019","journal-title":"Mol Neurobiol"},{"issue":"Pt 15","key":"bib8","doi-asserted-by":"crossref","first-page":"jeb222513","DOI":"10.1242\/jeb.222513","article-title":"Increased glucocorticoid concentrations in early life cause mitochondrial inefficiency and short telomeres","volume":"223","author":"Casagrande","year":"2020","journal-title":"J Exp Biol"},{"issue":"1-2","key":"bib9","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1016\/j.pbiomolbio.2013.04.001","article-title":"Glucocorticoids and their receptors: insights into specific roles in mitochondria","volume":"112","author":"Lee","year":"2013","journal-title":"Prog Biophys Mol Biol"},{"issue":"2","key":"bib10","doi-asserted-by":"publisher","first-page":"2240707","DOI":"10.1080\/07853890.2023.2240707","article-title":"Ageing of skeletal muscle extracellular matrix and mitochondria: finding a potential link","volume":"55","author":"Cai","year":"2023","journal-title":"Ann Med"},{"issue":"4","key":"bib11","doi-asserted-by":"publisher","first-page":"101224","DOI":"10.1016\/j.jbc.2021.101224","article-title":"Mitochondrial respiratory chain function promotes extracellular matrix integrity in cartilage","volume":"297","author":"Bubb","year":"2021","journal-title":"J Biol Chem"},{"key":"bib12","doi-asserted-by":"publisher","first-page":"101509","DOI":"10.1016\/j.redox.2020.101509","article-title":"Mitochondria dysfunction and metabolic reprogramming as drivers of idiopathic pulmonary fibrosis","volume":"33","author":"Bueno","year":"2020","journal-title":"Redox Biol"},{"key":"bib13","doi-asserted-by":"publisher","first-page":"9932442","DOI":"10.1155\/2021\/9932442","article-title":"The role of interaction between mitochondria and the extracellular matrix in the development of idiopathic pulmonary fibrosis","volume":"2021","author":"Siekacz","year":"2021","journal-title":"Oxid Med Cell Longev"},{"key":"bib14","doi-asserted-by":"publisher","first-page":"1006","DOI":"10.3389\/fphar.2020.01006","article-title":"Protective effects of rapamycin on trabecular meshwork cells in glucocorticoid-induced glaucoma mice","volume":"11","author":"Zhu","year":"2020","journal-title":"Front Pharmacol"},{"issue":"3","key":"bib15","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1016\/j.cmet.2017.11.002","article-title":"NAD(+) intermediates: the biology and therapeutic potential of NMN and NR","volume":"27","author":"Yoshino","year":"2018","journal-title":"Cell Metab"},{"issue":"6","key":"bib16","doi-asserted-by":"publisher","first-page":"1076","DOI":"10.1016\/j.cmet.2021.04.003","article-title":"Evolving concepts in NAD(+) metabolism","volume":"33","author":"Chini","year":"2021","journal-title":"Cell Metab"},{"issue":"1","key":"bib17","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1186\/s13395-018-0154-1","article-title":"A need for NAD+ in muscle development, homeostasis, and aging","volume":"8","author":"Goody","year":"2018","journal-title":"Skelet Muscle"},{"issue":"16","key":"bib18","doi-asserted-by":"publisher","first-page":"4205","DOI":"10.1158\/0008-5472.CAN-21-0086","article-title":"Genetic determinants of somatic selection of mutational processes in 3,566 human cancers","volume":"81","author":"Guo","year":"2021","journal-title":"Cancer Res"},{"issue":"3","key":"bib19","doi-asserted-by":"publisher","first-page":"108660","DOI":"10.1016\/j.celrep.2020.108660","article-title":"NAD(+) boosting reduces age-associated amyloidosis and restores mitochondrial homeostasis in muscle","volume":"34","author":"Romani","year":"2021","journal-title":"Cell Rep"},{"key":"bib20","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1016\/j.redox.2018.04.006","article-title":"Nicotinamide riboside attenuates alcohol induced liver injuries via activation of SirT1\/PGC-1alpha\/mitochondrial biosynthesis pathway","volume":"17","author":"Wang","year":"2018","journal-title":"Redox Biol"},{"issue":"11","key":"bib21","doi-asserted-by":"publisher","first-page":"6054","DOI":"10.1172\/JCI138538","article-title":"Boosting NAD level suppresses inflammatory activation of PBMCs in heart failure","volume":"130","author":"Zhou","year":"2020","journal-title":"J Clin Invest"},{"issue":"9","key":"bib22","doi-asserted-by":"publisher","first-page":"2451","DOI":"10.1016\/j.bbadis.2019.06.009","article-title":"Nicotinamide riboside, an NAD+ precursor, attenuates the development of liver fibrosis in a diet-induced mouse model of liver fibrosis","volume":"1865","author":"Pham","year":"2019","journal-title":"Biochim Biophys Acta Mol Basis Dis"},{"issue":"1","key":"bib23","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1093\/ndt\/gfaa124","article-title":"Differential role of nicotinamide adenine dinucleotide deficiency in acute and chronic kidney disease","volume":"36","author":"Faivre","year":"2021","journal-title":"Nephrol Dial Transplant"},{"issue":"6","key":"bib24","doi-asserted-by":"publisher","first-page":"893","DOI":"10.3390\/pharmaceutics13060893","article-title":"Systemic treatment with nicotinamide riboside is protective in two mouse models of retinal ganglion cell damage","volume":"13","author":"Zhang","year":"2021","journal-title":"Pharmaceutics"},{"issue":"7","key":"bib25","first-page":"2375-A0059\u20132375-A0059","article-title":"Oral supplementary nicotinamide riboside treats several components of the DBA\/2J murine model of pigment dispersion glaucoma","volume":"63","author":"Li","year":"2022","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"7","key":"bib26","first-page":"2717-A0081\u20132717-A0081","article-title":"Systemic nicotinamide riboside treatment protects retinal ganglion cells in an aged optic nerve crush mouse model","volume":"63","author":"Zhang","year":"2022","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"7","key":"bib27","doi-asserted-by":"publisher","first-page":"903","DOI":"10.1111\/ceo.v48.7","article-title":"Improvement in inner retinal function in glaucoma with nicotinamide (vitamin B3) supplementation: a crossover randomized clinical trial","volume":"48","author":"Hui","year":"2020","journal-title":"Clin Exp Ophthalmol"},{"issue":"14","key":"bib28","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1167\/iovs.64.14.34","article-title":"Nicotinamide prevents retinal vascular dropout in a rat model of ocular hypertension and supports ocular blood supply in glaucoma patients","volume":"64","author":"Gustavsson","year":"2023","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"1","key":"bib29","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1186\/s13063-021-05968-1","article-title":"Nicotinamide riboside as a neuroprotective therapy for glaucoma: study protocol for a randomized, double-blind, placebo-control trial","volume":"23","author":"Leung","year":"2022","journal-title":"Trials"},{"issue":"3","key":"bib30","doi-asserted-by":"publisher","first-page":"316","DOI":"10.1016\/j.exer.2011.02.012","article-title":"Real-time measurements of nicotinamide adenine dinucleotide in live human trabecular meshwork cells: effects of acute oxidative stress","volume":"93","author":"Masihzadeh","year":"2011","journal-title":"Exp Eye Res"},{"issue":"4","key":"bib31","doi-asserted-by":"publisher","first-page":"713","DOI":"10.1016\/j.ajpath.2016.12.003","article-title":"Dexamethasone-induced ocular hypertension in mice: effects of myocilin and route of administration","volume":"187","author":"Patel","year":"2017","journal-title":"Am J Pathol"},{"issue":"10","key":"bib32","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1167\/iovs.61.10.38","article-title":"Osthole reduces mouse IOP associated with ameliorating extracellular matrix expression of trabecular meshwork cell","volume":"61","author":"Fan","year":"2020","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib33","doi-asserted-by":"publisher","first-page":"164","DOI":"10.1016\/j.exer.2018.03.001","article-title":"Consensus recommendations for trabecular meshwork cell isolation, characterization and culture","volume":"171","author":"Keller","year":"2018","journal-title":"Exp Eye Res"},{"issue":"8","key":"bib34","first-page":"1769","article-title":"Glucocorticoid induction of the glaucoma gene MYOC in human and monkey trabecular meshwork cells and tissues","volume":"42","author":"Clark","year":"2001","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"3","key":"bib35","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1016\/j.acthis.2017.03.001","article-title":"A simple ImageJ macro tool for analyzing mitochondrial network morphology in mammalian cell culture","volume":"119","author":"Valente","year":"2017","journal-title":"Acta Histochem"},{"key":"bib36","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1016\/j.exer.2017.12.013","article-title":"Genomic loci modulating retinal ganglion cell death following elevated IOP in the mouse","volume":"169","author":"Struebing","year":"2018","journal-title":"Exp Eye Res"},{"issue":"8","key":"bib37","doi-asserted-by":"publisher","first-page":"736","DOI":"10.1080\/02713683.2023.2206067","article-title":"Simvastatin attenuates glucocorticoid-induced human trabecular meshwork cell dysfunction via YAP\/TAZ inactivation","volume":"48","author":"Yoo","year":"2023","journal-title":"Curr Eye Res"},{"issue":"5","key":"bib38","first-page":"1091","article-title":"Aqueous humor stimulates the migration of human trabecular meshwork cells in vitro","volume":"41","author":"Hogg","year":"2000","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib39","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1016\/j.tox.2017.07.019","article-title":"Mitochondrial fusion, fission, and mitochondrial toxicity","volume":"391","author":"Meyer","year":"2017","journal-title":"Toxicology"},{"issue":"6","key":"bib40","doi-asserted-by":"publisher","first-page":"1967","DOI":"10.1167\/iovs.18-26383","article-title":"Glucocorticoid receptor transactivation is required for glucocorticoid-induced ocular hypertension and glaucoma","volume":"60","author":"Patel","year":"2019","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"20","key":"bib41","doi-asserted-by":"publisher","first-page":"2452","DOI":"10.3390\/cells12202452","article-title":"Role of glucocorticoids and glucocorticoid receptors in glaucoma pathogenesis","volume":"12","author":"Patel","year":"2023","journal-title":"Cells"},{"issue":"11","key":"bib42","doi-asserted-by":"publisher","first-page":"6054","DOI":"10.3390\/ijms22116054","article-title":"Mitochondrial glucocorticoid receptors and their actions","volume":"22","author":"Kokkinopoulou","year":"2021","journal-title":"Int J Mol Sci"},{"issue":"2","key":"bib43","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1016\/j.exer.2006.09.022","article-title":"Dexamethasone inhibition of trabecular meshwork cell phagocytosis and its modulation by glucocorticoid receptor beta","volume":"84","author":"Zhang","year":"2007","journal-title":"Exp Eye Res"},{"key":"bib44","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1016\/j.exer.2016.07.009","article-title":"The many faces of the trabecular meshwork cell","volume":"158","author":"Stamer","year":"2017","journal-title":"Exp Eye Res"},{"issue":"1","key":"bib45","doi-asserted-by":"publisher","first-page":"5848","DOI":"10.1038\/s41598-018-24165-w","article-title":"The relationship between outflow resistance and trabecular meshwork stiffness in mice","volume":"8","author":"Wang","year":"2018","journal-title":"Sci Rep"},{"issue":"17","key":"bib46","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22179446","article-title":"Fibrotic changes to Schlemm's canal endothelial cells in glaucoma","volume":"22","author":"Kelly","year":"2021","journal-title":"Int J Mol Sci"},{"key":"bib47","first-page":"237","article-title":"Genomic\/proteomic analyses of dexamethasone-treated human trabecular meshwork cells reveal a role for GULP1 and ABR in phagocytosis","volume":"25","author":"Faralli","year":"2019","journal-title":"Mol Vis"},{"issue":"2","key":"bib48","doi-asserted-by":"publisher","first-page":"237","DOI":"10.3892\/etm.2012.595","article-title":"Mitochondria are the primary source of the H(2)O(2) signal for glucocorticoid-induced apoptosis of lymphoma cells","volume":"4","author":"Tome","year":"2012","journal-title":"Exp Ther Med"},{"issue":"7","key":"bib49","doi-asserted-by":"publisher","first-page":"680","DOI":"10.3390\/cells8070680","article-title":"Mitochondria in health and disease","volume":"8","author":"Annesley","year":"2019","journal-title":"Cells"},{"key":"bib50","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1146\/physiol.2017.79.issue-1","article-title":"Mitochondrial dysfunction in lung pathogenesis","volume":"79","author":"Piantadosi","year":"2017","journal-title":"Annu Rev Physiol"},{"issue":"1","key":"bib51","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1007\/s000110300012","article-title":"Dose-dependent effects of corticosteroids on the expression of matrix-related genes in normal and cytokine-treated articular chondrocytes","volume":"52","author":"Richardson","year":"2003","journal-title":"Inflamm Res"},{"issue":"3","key":"bib52","doi-asserted-by":"publisher","first-page":"406","DOI":"10.1016\/j.immuni.2015.02.002","article-title":"Mitochondria in the regulation of innate and adaptive immunity","volume":"42","author":"Weinberg","year":"2015","journal-title":"Immunity"},{"issue":"1","key":"bib53","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1007\/s40266-022-00989-0","article-title":"Importance of NAD+ anabolism in metabolic, cardiovascular and neurodegenerative disorders","volume":"40","author":"Helman","year":"2023","journal-title":"Drugs Aging"},{"issue":"19","key":"bib54","doi-asserted-by":"publisher","first-page":"3889","DOI":"10.3390\/nu14193889","article-title":"Emerging role of nicotinamide riboside in health and diseases","volume":"14","author":"Sharma","year":"2022","journal-title":"Nutrients"},{"key":"bib55","doi-asserted-by":"publisher","first-page":"149590","DOI":"10.1016\/j.bbrc.2024.149590","article-title":"The therapeutic perspective of NAD(+) precursors in age-related diseases","volume":"702","author":"Iqbal","year":"2024","journal-title":"Biochem Biophys Res Commun"}],"container-title":["Investigative Ophthalmology &amp; Visual Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/iovs.arvojournals.org\/article.aspx?articleid=2800204","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:31:46Z","timestamp":1791927106000},"score":1,"resource":{"primary":{"URL":"https:\/\/iovs.arvojournals.org\/article.aspx?articleid=2800204"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7,1]]},"references-count":55,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2024,7,1]]}},"URL":"https:\/\/doi.org\/10.1167\/iovs.65.8.1","relation":{},"ISSN":["1552-5783"],"issn-type":[{"value":"1552-5783","type":"print"}],"subject":[],"published":{"date-parts":[[2024,7,1]]}}}