{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T12:40:15Z","timestamp":1792586415867,"version":"4.5.0"},"reference-count":64,"publisher":"Association for Research in Vision and Ophthalmology (ARVO)","issue":"8","license":[{"start":{"date-parts":[[2024,7,19]],"date-time":"2024-07-19T00:00:00Z","timestamp":1721347200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Invest. Ophthalmol. Vis. Sci."],"published-print":{"date-parts":[[2024,7,19]]},"DOI":"10.1167\/iovs.65.8.35","type":"journal-article","created":{"date-parts":[[2024,7,19]],"date-time":"2024-07-19T16:35:48Z","timestamp":1721406948000},"page":"35","source":"Crossref","is-referenced-by-count":7,"title":["Independent Effects of Blood Pressure on Intraocular Pressure and Retinal Ganglion Cell Degeneration: A Mendelian Randomization Study"],"prefix":"10.1167","volume":"65","author":[{"given":"Skanda","family":"Rajasundaram","sequence":"first","affiliation":[{"name":"Faculty of Medicine, Imperial College London, London, United Kingdom"},{"name":"Department of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Boston, Massachusetts, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayellet V.","family":"Segr\u00e8","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Boston, Massachusetts, United States"},{"name":"Ocular Genomics Institute, Massachusetts Eye and Ear, Boston, Massachusetts, United States"},{"name":"Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dipender","family":"Gill","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin","family":"Woolf","sequence":"additional","affiliation":[{"name":"School of Psychological Science, University of Bristol, Bristol, United Kingdom"},{"name":"MRC Integrative Epidemiology Unit, University of Bristol, Bristol, United Kingdom"},{"name":"MRC Biostatistics Unit, University of Cambridge, Cambridge, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seyedeh M.","family":"Zekavat","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Boston, Massachusetts, United States"},{"name":"Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States"},{"name":"Yale University School of Medicine, New Haven, Connecticut, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen","family":"Burgess","sequence":"additional","affiliation":[{"name":"MRC Biostatistics Unit, University of Cambridge, Cambridge, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony P.","family":"Khawaja","sequence":"additional","affiliation":[{"name":"NIHR Biomedical Research Centre, Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nazlee","family":"Zebardast","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Boston, Massachusetts, United States"},{"name":"Ocular Genomics Institute, Massachusetts Eye and Ear, Boston, Massachusetts, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janey L.","family":"Wiggs","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Boston, Massachusetts, United States"},{"name":"Ocular Genomics Institute, Massachusetts Eye and Ear, Boston, Massachusetts, United States"},{"name":"Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"27","reference":[{"key":"bib1","doi-asserted-by":"publisher","first-page":"16067","DOI":"10.1038\/nrdp.2016.67","article-title":"Primary open-angle glaucoma","volume":"2","author":"Weinreb","year":"2016","journal-title":"Nat Rev Dis Primers"},{"key":"bib2","doi-asserted-by":"publisher","first-page":"4799","DOI":"10.1167\/iovs.16-19214","article-title":"Glaucoma diagnostic ability of layer-by-layer segmented ganglion cell complex by spectral-domain optical coherence tomography","volume":"57","author":"Kim","year":"2016","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib3","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1001\/archopht.121.1.41","article-title":"Macular thickness changes in glaucomatous optic neuropathy detected using optical coherence tomography","volume":"121","author":"Greenfield","year":"2003","journal-title":"Arch Ophthalmol"},{"key":"bib4","doi-asserted-by":"publisher","first-page":"939","DOI":"10.1016\/j.ophtha.2015.12.041","article-title":"Macular versus retinal nerve fiber layer parameters for diagnosing manifest glaucoma: a systematic review of diagnostic accuracy studies","volume":"123","author":"Oddone","year":"2016","journal-title":"Ophthalmology"},{"key":"bib5","doi-asserted-by":"publisher","first-page":"266","DOI":"10.3390\/diagnostics13020266","article-title":"Ganglion cell complex analysis: correlations with retinal nerve fiber layer on optical coherence tomography","volume":"13","author":"Ghita","year":"2023","journal-title":"Diagnostics (Basel)"},{"key":"bib6","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1001\/jamaophthalmol.2022.4973","article-title":"Association between rate of ganglion cell complex thinning and rate of central visual field loss","volume":"141","author":"Mahmoudinezhad","year":"2023","journal-title":"JAMA Ophthalmol"},{"key":"bib7","doi-asserted-by":"publisher","first-page":"632","DOI":"10.1167\/iovs.13-13130","article-title":"Early glaucoma involves both deep local, and shallow widespread, retinal nerve fiber damage of the macular region","volume":"55","author":"Hood","year":"2014","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"2","key":"bib8","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1167\/tvst.5.2.15","article-title":"The 24-2 visual field test misses central macular damage confirmed by the 10-2 visual field test and optical coherence tomography","volume":"5","author":"Grillo","year":"2016","journal-title":"Transl Vis Sci Technol"},{"issue":"6","key":"bib9","doi-asserted-by":"publisher","first-page":"714","DOI":"10.1001\/archopht.120.6.714","article-title":"The Ocular Hypertension Treatment Study: baseline factors that predict the onset of primary open-angle glaucoma","volume":"120","author":"Gordon","year":"2002","journal-title":"Arch Ophthalmol"},{"key":"bib10","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1016\/S0039-6257(98)00049-6","article-title":"Ophthalmoscopic evaluation of the optic nerve head","volume":"43","author":"Jonas","year":"1999","journal-title":"Surv Ophthalmol"},{"key":"bib11","doi-asserted-by":"publisher","first-page":"372","DOI":"10.1016\/j.ophtha.2018.10.016","article-title":"Eight-year incidence of open-angle glaucoma in the Tema Eye Survey","volume":"126","author":"Mwanza","year":"2019","journal-title":"Ophthalmology"},{"key":"bib12","doi-asserted-by":"publisher","first-page":"944","DOI":"10.1161\/HYPERTENSIONAHA.118.11507","article-title":"Glaucoma and blood pressure","volume":"73","author":"Leeman","year":"2019","journal-title":"Hypertension"},{"key":"bib13","doi-asserted-by":"publisher","first-page":"1101","DOI":"10.1007\/s10654-016-0191-1","article-title":"Associations with intraocular pressure across Europe: the European Eye Epidemiology (E3) Consortium","volume":"31","author":"Khawaja","year":"2016","journal-title":"Eur J Epidemiol"},{"key":"bib14","doi-asserted-by":"publisher","first-page":"771","DOI":"10.1016\/j.ophtha.2015.11.031","article-title":"UK Biobank Eye and Vision Consortium. Associations with intraocular pressure in a large cohort: results from the UK Biobank","volume":"123","author":"Chan","year":"2016","journal-title":"Ophthalmology"},{"issue":"1","key":"bib15","doi-asserted-by":"publisher","first-page":"17493","DOI":"10.1038\/s41598-022-22301-1","article-title":"Relationship between blood pressure and intraocular pressure in the JPHC-NEXT eye study","volume":"12","author":"Yasukawa","year":"2022","journal-title":"Sci Rep"},{"key":"bib16","doi-asserted-by":"publisher","first-page":"629","DOI":"10.1161\/HYPERTENSIONAHA.122.20364","article-title":"Effects of blood pressure and arterial stiffness on retinal neurodegeneration: cross-sectional and longitudinal evidence from UK Biobank and Chinese cohorts","volume":"80","author":"Huang","year":"2023","journal-title":"Hypertension"},{"key":"bib17","doi-asserted-by":"publisher","first-page":"3914","DOI":"10.1167\/iovs.19-27652","article-title":"Longitudinal changes in the peripapillary retinal nerve fiber layer thickness in hypertension: 4-year prospective observational study","volume":"60","author":"Lee","year":"2019","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib18","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1016\/j.ajo.2018.11.016","article-title":"Changes in ganglion cell-inner plexiform layer thickness and retinal microvasculature in hypertension: an optical coherence tomography angiography study","volume":"199","author":"Lim","year":"2019","journal-title":"Am J Ophthalmol"},{"issue":"2","key":"bib19","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1167\/tvst.12.2.3","article-title":"Associations of midlife and late-life blood pressure status with late-life retinal OCT measures","volume":"12","author":"Pan-Doh","year":"2023","journal-title":"Transl Vis Sci Technol"},{"key":"bib20","doi-asserted-by":"publisher","first-page":"1101","DOI":"10.1001\/archopht.126.8.1101","article-title":"SiMES Study Group. Determinants of the optic cup to disc ratio in an Asian population: the Singapore Malay Eye Study (SiMES)","volume":"126","author":"Amerasinghe","year":"2008","journal-title":"Arch Ophthalmol"},{"issue":"9","key":"bib21","doi-asserted-by":"publisher","first-page":"e0239071","DOI":"10.1371\/journal.pone.0239071","article-title":"Association between metabolic risk factors and optic disc cupping identified by deep learning method","volume":"15","author":"Shin","year":"2020","journal-title":"PLoS One"},{"key":"bib22","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1093\/ije\/dyg070","article-title":"\u201cMendelian randomization\u201d: can genetic epidemiology contribute to understanding environmental determinants of disease?","volume":"32","author":"Smith","year":"2003","journal-title":"Int J Epidemiol"},{"key":"bib23","doi-asserted-by":"publisher","first-page":"1383","DOI":"10.1093\/ije\/dys141","article-title":"The effect of non-differential measurement error on bias, precision and power in Mendelian randomization studies","volume":"41","author":"Pierce","year":"2012","journal-title":"Int J Epidemiol"},{"key":"bib24","doi-asserted-by":"publisher","first-page":"864","DOI":"10.1001\/jamaophthalmol.2022.2762","article-title":"Association between myopic refractive error and primary open-angle glaucoma: a 2-sample mendelian randomization study","volume":"140","author":"Choquet","year":"2022","journal-title":"JAMA Ophthalmol"},{"key":"bib25","doi-asserted-by":"publisher","first-page":"847","DOI":"10.1186\/s12967-023-04737-9","article-title":"TIE1 and TEK signalling, intraocular pressure, and primary open-angle glaucoma: a Mendelian randomization study","volume":"21","author":"Rajasundaram","year":"2023","journal-title":"J Transl Med"},{"key":"bib26","doi-asserted-by":"publisher","first-page":"396","DOI":"10.1038\/s41467-023-44380-y","article-title":"Integrating genetic regulation and single-cell expression with GWAS prioritizes causal genes and cell types for glaucoma","volume":"15","author":"Hamel","year":"2024","journal-title":"Nat Commun"},{"key":"bib27","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1016\/j.ophtha.2020.06.027","article-title":"Impact of intraocular pressure control on rates of retinal nerve fiber layer loss in a large clinical population","volume":"128","author":"Jammal","year":"2021","journal-title":"Ophthalmology"},{"key":"bib28","doi-asserted-by":"publisher","first-page":"1412","DOI":"10.1038\/s41588-018-0205-x","article-title":"Genetic analysis of over 1\u00a0million people identifies 535 new loci associated with blood pressure traits","volume":"50","author":"Evangelou","year":"2018","journal-title":"Nat Genet"},{"key":"bib29","doi-asserted-by":"publisher","first-page":"778","DOI":"10.1038\/s41588-018-0126-8","article-title":"Genome-wide analyses identify 68 new loci associated with intraocular pressure and improve risk prediction for primary open-angle glaucoma","volume":"50","author":"Khawaja","year":"2018","journal-title":"Nat Genet"},{"issue":"731","key":"bib30","doi-asserted-by":"publisher","first-page":"eadg4517","DOI":"10.1126\/scitranslmed.adg4517","article-title":"Phenome- and genome-wide analyses of retinal optical coherence tomography images identify links between ocular and systemic health","volume":"16","author":"Zekavat","year":"2024","journal-title":"Sci Transl Med"},{"key":"bib31","doi-asserted-by":"publisher","first-page":"1204","DOI":"10.1016\/j.ajhg.2021.05.005","article-title":"Automated AI labeling of optic nerve head enables insights into cross-ancestry glaucoma risk and genetic discovery in >280,000 images from UKB and CLSA","volume":"108","author":"Han","year":"2021","journal-title":"Am J Hum Genet"},{"key":"bib32","doi-asserted-by":"publisher","first-page":"1118","DOI":"10.1136\/bjo.82.10.1118","article-title":"Vertical cup\/disc ratio in relation to optic disc size: its value in the assessment of the glaucoma suspect","volume":"82","author":"Garway-Heath","year":"1998","journal-title":"Br J Ophthalmol"},{"key":"bib33","doi-asserted-by":"publisher","first-page":"1258","DOI":"10.1038\/s41467-020-20851-4","article-title":"Genome-wide meta-analysis identifies 127 open-angle glaucoma loci with consistent effect across ancestries","volume":"12","author":"Gharahkhani","year":"2021","journal-title":"Nat Commun"},{"issue":"3","key":"bib34","doi-asserted-by":"publisher","first-page":"e1001779","DOI":"10.1371\/journal.pmed.1001779","article-title":"UK biobank: an open access resource for identifying the causes of a wide range of complex diseases of middle and old age","volume":"12","author":"Sudlow","year":"2015","journal-title":"PLoS Med"},{"key":"bib35","doi-asserted-by":"crossref","first-page":"n2233","DOI":"10.1136\/bmj.n2233","article-title":"Strengthening the reporting of observational studies in epidemiology using mendelian randomisation (STROBE-MR): explanation and elaboration","volume":"375","author":"Skrivankova","year":"2021","journal-title":"BMJ"},{"key":"bib36","doi-asserted-by":"publisher","first-page":"597","DOI":"10.1002\/gepi.2016.40.issue-7","article-title":"Bias due to participant overlap in two-sample Mendelian randomization","volume":"40","author":"Burgess","year":"2016","journal-title":"Genet Epidemiol"},{"key":"bib37","doi-asserted-by":"publisher","first-page":"2333","DOI":"10.1177\/0962280215597579","article-title":"A review of instrumental variable estimators for Mendelian randomization","volume":"26","author":"Burgess","year":"2017","journal-title":"Stat Methods Med Res"},{"key":"bib38","doi-asserted-by":"publisher","first-page":"1639","DOI":"10.1093\/ije\/dyaa266","article-title":"Bias in two-sample Mendelian randomization when using heritable covariable-adjusted summary associations","volume":"50","author":"Hartwig","year":"2021","journal-title":"Int J Epidemiol"},{"key":"bib40","doi-asserted-by":"publisher","first-page":"1209","DOI":"10.1093\/ije\/dyac233","article-title":"An empirical investigation into the impact of winner's curse on estimates from Mendelian randomization","volume":"52","author":"Jiang","year":"2023","journal-title":"Int J Epidemiol"},{"issue":"2","key":"bib41","doi-asserted-by":"publisher","first-page":"a038984","DOI":"10.1101\/cshperspect.a038984","article-title":"Multivariable mendelian randomization and mediation","volume":"11","author":"Sanderson","year":"2021","journal-title":"Cold Spring Harb Perspect Med"},{"key":"bib42","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1093\/aje\/kwu283","article-title":"Multivariable mendelian randomization: the use of pleiotropic genetic variants to estimate causal effects","volume":"181","author":"Burgess","year":"2015","journal-title":"Am J Epidemiol"},{"key":"bib43","doi-asserted-by":"publisher","first-page":"713","DOI":"10.1093\/ije\/dyy262","article-title":"An examination of multivariable mendelian randomization in the single-sample and two-sample summary data settings","volume":"48","author":"Sanderson","year":"2019","journal-title":"Int J Epidemiol"},{"key":"bib44","doi-asserted-by":"publisher","first-page":"717","DOI":"10.1136\/bjo.59.12.717","article-title":"Intraocular pressure and systemic blood pressure in the elderly","volume":"59","author":"Bulpitt","year":"1975","journal-title":"Br J Ophthalmol"},{"issue":"6","key":"bib45","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1167\/iovs.63.6.29","article-title":"High blood pressure and intraocular pressure: a mendelian randomization study","volume":"63","author":"Plotnikov","year":"2022","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib46","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1016\/j.ophtha.2020.06.067","article-title":"Cardiovascular disease predicts structural and functional progression in early glaucoma","volume":"128","author":"Marshall","year":"2021","journal-title":"Ophthalmology"},{"issue":"3","key":"bib47","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1001\/jamaophthalmol.2022.6092","article-title":"Association of blood pressure with rates of macular ganglion cell complex thinning in patients with glaucoma","volume":"141","author":"Mohammadzadeh","year":"2023","journal-title":"JAMA Ophthalmol"},{"key":"bib48","doi-asserted-by":"publisher","first-page":"3399","DOI":"10.1167\/iovs.09-4867","article-title":"Distribution of ocular perfusion pressure and its relationship with open-angle glaucoma: the Singapore Malay Eye Study","volume":"51","author":"Zheng","year":"2010","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib49","doi-asserted-by":"publisher","first-page":"2872","DOI":"10.1167\/iovs.08-2956","article-title":"Blood pressure, perfusion pressure, and open-angle glaucoma: the Los Angeles Latino Eye Study","volume":"51","author":"Memarzadeh","year":"2010","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib50","doi-asserted-by":"publisher","first-page":"1077","DOI":"10.1093\/ajh\/hpv016","article-title":"Circadian variation in arterial blood pressure and glaucomatous optic neuropathy\u2014a systematic review and meta-analysis","volume":"28","author":"Bowe","year":"2015","journal-title":"Am J Hypertens"},{"key":"bib51","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1097\/ICU.0000000000000245","article-title":"Vascular and autonomic dysregulation in primary open-angle glaucoma","volume":"27","author":"Pasquale","year":"2016","journal-title":"Curr Opin Ophthalmol"},{"key":"bib52","doi-asserted-by":"publisher","first-page":"615","DOI":"10.1016\/j.ajo.2014.05.029","article-title":"The association of blood pressure and primary open-angle glaucoma: a meta-analysis","volume":"158","author":"Zhao","year":"2014","journal-title":"Am J Ophthalmol"},{"issue":"13","key":"bib53","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1167\/iovs.63.13.3","article-title":"Blood pressure measures and incident primary open-angle glaucoma","volume":"63","author":"Macri","year":"2022","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"8","key":"bib54","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1167\/iovs.61.8.35","article-title":"Risk factors associated with structural progression in normal-tension glaucoma: intraocular pressure, systemic blood pressure, and myopia","volume":"61","author":"Lee","year":"2020","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"2","key":"bib55","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1167\/tvst.7.2.16","article-title":"Validation of the UNC OCT Index for the Diagnosis of Early Glaucoma","volume":"7","author":"Mwanza","year":"2018","journal-title":"Transl Vis Sci Technol"},{"issue":"6","key":"bib56","doi-asserted-by":"publisher","first-page":"e0199134","DOI":"10.1371\/journal.pone.0199134","article-title":"Diagnostic accuracy of macular ganglion cell-inner plexiform layer thickness for glaucoma detection in a population-based study: comparison with optic nerve head imaging parameters","volume":"13","author":"Koh","year":"2018","journal-title":"PLoS One"},{"issue":"1","key":"bib57","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1016\/j.ophtha.2007.03.017","article-title":"Risk factors for incident open-angle glaucoma: the Barbados Eye Studies","volume":"115","author":"Leske","year":"2008","journal-title":"Ophthalmology"},{"key":"bib58","doi-asserted-by":"publisher","first-page":"308","DOI":"10.1093\/ajh\/hpy186","article-title":"Nonlinear relationship between blood pressure and glaucoma in US adults","volume":"32","author":"Kim","year":"2019","journal-title":"Am J Hypertens"},{"issue":"3","key":"bib59","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1016\/j.joco.2019.06.002","article-title":"The Distribution of Vertical Cup-to-Disc Ratio and its Determinants in the Iranian Adult Population","volume":"32","author":"Hashemi","year":"2020","journal-title":"J Curr Ophthalmol"},{"issue":"5","key":"bib60","doi-asserted-by":"publisher","first-page":"336","DOI":"10.3341\/kjo.2015.29.5.336","article-title":"Epidemiologic Survey Committee of the Korean Ophthalmological Society. Associations between optic cup-to-disc ratio and systemic factors in the healthy Korean population","volume":"29","author":"Kim","year":"2015","journal-title":"Korean J Ophthalmol"},{"key":"bib61","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1097\/IJG.0000000000002149","article-title":"Risk factors associated with a large vertical cup-to-disc ratio: Korean National Health and Nutritional Examination Survey","volume":"32","author":"Lee","year":"2023","journal-title":"J Glaucoma"},{"issue":"6","key":"bib62","doi-asserted-by":"publisher","first-page":"e1010823","DOI":"10.1371\/journal.pgen.1010823","article-title":"Relaxing parametric assumptions for non-linear Mendelian randomization using a doubly-ranked stratification method","volume":"19","author":"Tian","year":"2023","journal-title":"PLoS Genet"},{"key":"bib63","doi-asserted-by":"publisher","first-page":"8094","DOI":"10.1167\/iovs.11-7833","article-title":"Macular and retinal nerve fiber layer thickness: which is more helpful in the diagnosis of glaucoma?","volume":"52","author":"Na","year":"2011","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib64","doi-asserted-by":"publisher","first-page":"267","DOI":"10.4274\/tjo","article-title":"Are all retinal nerve fiber layer defects on optic coherence tomography glaucomatous?","volume":"47","author":"G\u00fcr G\u00fcng\u00f6r","year":"2017","journal-title":"Turk J Ophthalmol"},{"key":"bib39","author":"Elsworth lab: UK Biobank GWAS Results"}],"container-title":["Investigative Ophthalmology & Visual Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/iovs.arvojournals.org\/article.aspx?articleid=2800594","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:31:53Z","timestamp":1791927113000},"score":1,"resource":{"primary":{"URL":"https:\/\/iovs.arvojournals.org\/article.aspx?articleid=2800594"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7,19]]},"references-count":64,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2024,7,1]]}},"URL":"https:\/\/doi.org\/10.1167\/iovs.65.8.35","relation":{},"ISSN":["1552-5783"],"issn-type":[{"value":"1552-5783","type":"print"}],"subject":[],"published":{"date-parts":[[2024,7,19]]}}}