{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T18:51:28Z","timestamp":1793040688927,"version":"4.5.0"},"reference-count":59,"publisher":"Association for Research in Vision and Ophthalmology (ARVO)","issue":"1","license":[{"start":{"date-parts":[[2025,1,14]],"date-time":"2025-01-14T00:00:00Z","timestamp":1736812800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Invest. Ophthalmol. Vis. Sci."],"published-print":{"date-parts":[[2025,1,14]]},"DOI":"10.1167\/iovs.66.1.35","type":"journal-article","created":{"date-parts":[[2025,1,14]],"date-time":"2025-01-14T10:54:52Z","timestamp":1736852092000},"page":"35","source":"Crossref","is-referenced-by-count":20,"title":["S100A8\/A9 Promotes Dendritic Cell\u2013Mediated Th17 Cell Response in Sj\u00f6gren's Dry Eye Disease by Regulating the Acod1\/STAT3 Pathway"],"prefix":"10.1167","volume":"66","author":[{"given":"Yankai","family":"Wei","sequence":"first","affiliation":[{"name":"Tianjin Key Laboratory of Retinal Functions and Diseases, Tianjin Branch of National Clinical Research Center for Ocular Disease, Eye Institute and School of Optometry, Tianjin Medical University Eye Hospital, Tianjin, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mei","family":"Sun","sequence":"additional","affiliation":[{"name":"Tianjin Key Laboratory of Retinal Functions and Diseases, Tianjin Branch of National Clinical Research Center for Ocular Disease, Eye Institute and School of Optometry, Tianjin Medical University Eye Hospital, Tianjin, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyu","family":"Zhang","sequence":"additional","affiliation":[{"name":"Tianjin Key Laboratory of Retinal Functions and Diseases, Tianjin Branch of National Clinical Research Center for Ocular Disease, Eye Institute and School of Optometry, Tianjin Medical University Eye Hospital, Tianjin, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengyuan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Tianjin Key Laboratory of Retinal Functions and Diseases, Tianjin Branch of National Clinical Research Center for Ocular Disease, Eye Institute and School of Optometry, Tianjin Medical University Eye Hospital, Tianjin, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Yang","sequence":"additional","affiliation":[{"name":"Tianjin Key Laboratory of Retinal Functions and Diseases, Tianjin Branch of National Clinical Research Center for Ocular Disease, Eye Institute and School of Optometry, Tianjin Medical University Eye Hospital, Tianjin, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Nian","sequence":"additional","affiliation":[{"name":"Tianjin Key Laboratory of Retinal Functions and Diseases, Tianjin Branch of National Clinical Research Center for Ocular Disease, Eye Institute and School of Optometry, Tianjin Medical University Eye Hospital, Tianjin, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bei","family":"Du","sequence":"additional","affiliation":[{"name":"Tianjin Key Laboratory of Retinal Functions and Diseases, Tianjin Branch of National Clinical Research Center for Ocular Disease, Eye Institute and School of Optometry, Tianjin Medical University Eye Hospital, Tianjin, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruihua","family":"Wei","sequence":"additional","affiliation":[{"name":"Tianjin Key Laboratory of Retinal Functions and Diseases, Tianjin Branch of National Clinical Research Center for Ocular Disease, Eye Institute and School of Optometry, Tianjin Medical University Eye Hospital, Tianjin, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"27","reference":[{"key":"bib1","doi-asserted-by":"publisher","first-page":"DES71","DOI":"10.1167\/iovs.17-23750","article-title":"Sj\u00f6gren's syndrome, non-Sj\u00f6gren's syndrome, and graft-versus-host disease related dry eye","volume":"59","author":"Ogawa","year":"2018","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib2","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1136\/annrheumdis-2019-216114","article-title":"EULAR recommendations for the management of Sj\u00f6gren's syndrome with topical and systemic therapies","volume":"79","author":"Ramos-Casals","year":"2020","journal-title":"Ann Rheum Dis"},{"key":"bib3","doi-asserted-by":"publisher","first-page":"147","DOI":"10.3390\/pharmaceutics15010147","article-title":"Management of Sjogren's dry eye disease-advances in ocular drug delivery offering a new hope","volume":"15","author":"Wu","year":"2022","journal-title":"Pharmaceutics"},{"key":"bib4","doi-asserted-by":"publisher","first-page":"102933","DOI":"10.1016\/j.autrev.2021.102933","article-title":"Autoimmunity in dry eye disease \u2013 an updated review of evidence on effector and memory Th17 cells in disease pathogenicity","volume":"20","author":"Chen","year":"2021","journal-title":"Autoimmun Rev"},{"key":"bib5","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1167\/iovs.64.11.3","article-title":"Thymosin \u00df4 alleviates autoimmune dacryoadenitis via suppressing Th17 cell response","volume":"64","author":"Zhao","year":"2023","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib6","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1016\/j.jtos.2020.05.009","article-title":"The role of Th17 immunity in chronic ocular surface disorders","volume":"19","author":"Fan","year":"2021","journal-title":"Ocul Surf"},{"key":"bib7","doi-asserted-by":"publisher","first-page":"759","DOI":"10.1146\/annurev-immunol-101819-025146","article-title":"Dendritic cell regulation of T helper cells","volume":"39","author":"Yin","year":"2021","journal-title":"Annu Rev Immunol"},{"key":"bib8","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1186\/s13578-022-00780-z","article-title":"Aryl hydrocarbon receptor activation ameliorates experimental colitis by modulating the tolerogenic dendritic and regulatory T cell formation","volume":"12","author":"Cui","year":"2022","journal-title":"Cell Biosci"},{"key":"bib9","doi-asserted-by":"publisher","first-page":"587","DOI":"10.1038\/s41423-020-0465-0","article-title":"Antigen presentation by dendritic cells and their instruction of CD4+ T helper cell responses","volume":"17","author":"Hilligan","year":"2020","journal-title":"Cell Mol Immunol"},{"key":"bib10","doi-asserted-by":"publisher","first-page":"346","DOI":"10.1038\/s41423-018-0005-3","article-title":"Chemokine and chemotactic signals in dendritic cell migration","volume":"15","author":"Tiberio","year":"2018","journal-title":"Cell Mol Immunol"},{"key":"bib11","doi-asserted-by":"publisher","first-page":"6198","DOI":"10.1038\/s41467-021-26477-4","article-title":"Optineurin modulates the maturation of dendritic cells to regulate autoimmunity through JAK2-STAT3 signaling","volume":"12","author":"Wang","year":"2021","journal-title":"Nat Commun"},{"key":"bib12","doi-asserted-by":"publisher","first-page":"222","DOI":"10.1016\/j.chom.2020.12.016","article-title":"Induction of alarmin S100A8\/A9 mediates activation of aberrant neutrophils in the pathogenesis of COVID-19","volume":"29","author":"Guo","year":"2021","journal-title":"Cell Host Microbe"},{"key":"bib13","doi-asserted-by":"publisher","first-page":"751","DOI":"10.1161\/CIRCULATIONAHA.118.039262","article-title":"S100a8\/a9 signaling causes mitochondrial dysfunction and cardiomyocyte death in response to ischemic\/reperfusion injury","volume":"140","author":"Li","year":"2019","journal-title":"Circulation"},{"key":"bib14","doi-asserted-by":"publisher","first-page":"2002732","DOI":"10.1183\/13993003.02732-2020","article-title":"The antimicrobial peptide S100A8\/A9 produced by airway epithelium functions as a potent and direct regulator of macrophage phenotype and function","volume":"59","author":"Skronska-Wasek","year":"2022","journal-title":"Eur Respir J"},{"key":"bib15","doi-asserted-by":"publisher","first-page":"29629","DOI":"10.1038\/srep29629","article-title":"Proteomics analysis of human tears from aqueous-deficient and evaporative dry eye patients","volume":"6","author":"Perumal","year":"2016","journal-title":"Sci Rep"},{"key":"bib16","doi-asserted-by":"publisher","first-page":"2385","DOI":"10.1167\/iovs.11-8751","article-title":"Alterations in the tear proteome of dry eye patients\u2014a matter of the clinical phenotype","volume":"54","author":"Boehm","year":"2013","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib17","doi-asserted-by":"publisher","first-page":"435","DOI":"10.18240\/ijo.2024.03.04","article-title":"Dry environment on the expression of lacrimal gland S100A9, Anxa1, and Clu in rats via proteomics","volume":"17","author":"Sun","year":"2024","journal-title":"Int J Ophthalmol"},{"key":"bib18","doi-asserted-by":"publisher","first-page":"110052","DOI":"10.1016\/j.exer.2024.110052","article-title":"S100A9-TLR4 axis aggravates dry eye through the blockage of autophagy","volume":"247","author":"Liang","year":"2024","journal-title":"Exp Eye Res"},{"key":"bib19","doi-asserted-by":"publisher","first-page":"702755","DOI":"10.3389\/fimmu.2021.702755","article-title":"Differentially expressed gene pathways in the conjunctiva of Sj\u00f6gren syndrome keratoconjunctivitis sicca","volume":"12","author":"de Paiva","year":"2021","journal-title":"Front Immunol"},{"key":"bib20","doi-asserted-by":"publisher","first-page":"2469","DOI":"10.1002\/pmic.201200230","article-title":"Proteomic analysis revealed the altered tear protein profile in a rabbit model of Sj\u00f6gren's syndrome-associated dry eye","volume":"13","author":"Zhou","year":"2013","journal-title":"Proteomics"},{"key":"bib21","doi-asserted-by":"publisher","first-page":"713","DOI":"10.1038\/nm.2150","article-title":"The Toll-like receptor 4 ligands Mrp8 and Mrp14 are crucial in the development of autoreactive CD8+ T cells","volume":"16","author":"Loser","year":"2010","journal-title":"Nat Med"},{"key":"bib22","doi-asserted-by":"publisher","first-page":"1332","DOI":"10.1167\/iovs.17-23127","article-title":"Local S100A8 levels correlate with recurrence of experimental autoimmune uveitis and promote pathogenic T cell activity","volume":"59","author":"Yun","year":"2018","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib23","doi-asserted-by":"publisher","first-page":"505","DOI":"10.4049\/jimmunol.2000087","article-title":"Deletion of S100a8 and S100a9 enhances skin hyperplasia and promotes the Th17 response in imiquimod-induced psoriasis","volume":"206","author":"Defr\u00eane","year":"2021","journal-title":"J Immunol"},{"key":"bib24","doi-asserted-by":"publisher","first-page":"539","DOI":"10.1016\/j.jtos.2017.05.001","article-title":"TFOS DEWS II Diagnostic Methodology report","volume":"15","author":"Wolffsohn","year":"2017","journal-title":"Ocul Surf"},{"key":"bib25","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1136\/annrheumdis-2016-210571","article-title":"2016 American College of Rheumatology\/European League Against Rheumatism classification criteria for primary Sj\u00f6gren's syndrome: a consensus and data-driven methodology involving three international patient cohorts","volume":"76","author":"Shiboski","year":"2017","journal-title":"Ann Rheum Dis"},{"key":"bib26","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1016\/j.exer.2013.06.005","article-title":"Amniotic membrane extract ameliorates benzalkonium chloride-induced dry eye in a murine model","volume":"115","author":"Xiao","year":"2013","journal-title":"Exp Eye Res"},{"key":"bib27","doi-asserted-by":"publisher","first-page":"9478","DOI":"10.3390\/ijms21249478","article-title":"Toll-like receptor 7 is required for lacrimal gland autoimmunity and type 1 diabetes development in male nonobese diabetic mice","volume":"21","author":"Debreceni","year":"2020","journal-title":"Int J Mol Sci"},{"key":"bib28","doi-asserted-by":"publisher","first-page":"3767","DOI":"10.3390\/ijms22073767","article-title":"Characterization of type I interferon-associated chemokines and cytokines in lacrimal glands of nonobese diabetic mice","volume":"22","author":"Allred","year":"2021","journal-title":"Int J Mol Sci"},{"key":"bib29","doi-asserted-by":"publisher","first-page":"1693","DOI":"10.1084\/jem.176.6.1693","article-title":"Generation of large numbers of dendritic cells from mouse bone marrow cultures supplemented with granulocyte\/macrophage colony-stimulating factor","volume":"176","author":"Inaba","year":"1992","journal-title":"J Exp Med"},{"key":"bib30","doi-asserted-by":"publisher","first-page":"e23277","DOI":"10.1096\/fj.202300893R","article-title":"Mettl3 induced miR-338-3p expression in dendritic cells promotes antigen-specific Th17 cell response via regulation of Dusp16","volume":"37","author":"Wei","year":"2023","journal-title":"FASEB J"},{"key":"bib31","doi-asserted-by":"publisher","first-page":"5697","DOI":"10.2147\/JIR.S440263","article-title":"Integrated DNA methylation and transcriptomics analyses of lacrimal glands identify the potential genes implicated in the development of Sj\u00f6gren's syndrome-related dry eye","volume":"16","author":"Sun","year":"2023","journal-title":"J Inflamm Res"},{"key":"bib32","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1038\/s41385-021-00462-y","article-title":"Irg1\/itaconate metabolic pathway is a crucial determinant of dendritic cells immune-priming function and contributes to resolute allergen-induced airway inflammation","volume":"15","author":"Jaiswal","year":"2022","journal-title":"Mucosal Immunol"},{"key":"bib33","doi-asserted-by":"publisher","first-page":"5798","DOI":"10.1038\/ncomms6798","article-title":"STAT3 restrains RANK- and TLR4-mediated signalling by suppressing expression of the E2 ubiquitin-conjugating enzyme Ubc13","volume":"5","author":"Zhang","year":"2014","journal-title":"Nat Commun"},{"key":"bib34","doi-asserted-by":"publisher","first-page":"188891","DOI":"10.1016\/j.bbcan.2023.188891","article-title":"S100A8 and S100A9 in cancer","volume":"1878","author":"Chen","year":"2023","journal-title":"Biochim Biophys Acta Rev Cancer"},{"key":"bib35","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1186\/s40364-023-00548-8","article-title":"S100A8\/A9 as a risk factor for breast cancer negatively regulated by DACH1","volume":"11","author":"Zhang","year":"2023","journal-title":"Biomark Res"},{"key":"bib36","doi-asserted-by":"publisher","first-page":"1400","DOI":"10.1136\/annrheumdis-2022-222229","article-title":"Keratinocyte-derived S100A9 modulates neutrophil infiltration and affects psoriasis-like skin and joint disease","volume":"81","author":"Mellor","year":"2022","journal-title":"Ann Rheum Dis"},{"key":"bib37","doi-asserted-by":"publisher","first-page":"1171","DOI":"10.1016\/j.immuni.2013.11.011","article-title":"S100A8-S100A9 protein complex mediates psoriasis by regulating the expression of complement factor C3","volume":"39","author":"Schonthaler","year":"2013","journal-title":"Immunity"},{"key":"bib38","doi-asserted-by":"publisher","first-page":"1678","DOI":"10.1016\/j.jid.2023.02.026","article-title":"S100A9 drives the chronification of psoriasiform inflammation by inducing IL-23\/type 3 immunity","volume":"143","author":"Silva de Melo","year":"2023","journal-title":"J Invest Dermatol"},{"key":"bib39","doi-asserted-by":"publisher","first-page":"155376","DOI":"10.1016\/j.metabol.2022.155376","article-title":"Inhibition of S100A8\/A9 ameliorates renal interstitial fibrosis in diabetic nephropathy","volume":"144","author":"Du","year":"2023","journal-title":"Metabolism"},{"key":"bib40","doi-asserted-by":"publisher","first-page":"1001025","DOI":"10.3389\/fimmu.2022.1001025","article-title":"From bench to bedside: calprotectin (S100A8\/S100A9) as a biomarker in rheumatoid arthritis","volume":"13","author":"Inciarte-Mundo","year":"2022","journal-title":"Front Immunol"},{"key":"bib41","doi-asserted-by":"publisher","first-page":"113006","DOI":"10.1016\/j.celrep.2023.113006","article-title":"S100A8\/A9-alarmin promotes local myeloid-derived suppressor cell activation restricting severe autoimmune arthritis","volume":"42","author":"von Wulffen","year":"2023","journal-title":"Cell Rep"},{"key":"bib42","doi-asserted-by":"publisher","first-page":"1970","DOI":"10.1002\/art.39656","article-title":"Platelet-derived S100A8\/A9 and cardiovascular disease in systemic lupus erythematosus","volume":"68","author":"Lood","year":"2016","journal-title":"Arthritis Rheumatol"},{"key":"bib43","doi-asserted-by":"publisher","first-page":"1326751","DOI":"10.3389\/fimmu.2023.1326751","article-title":"Serum S100A8\/A9 and MMP-9 levels are elevated in systemic lupus erythematosus patients with cognitive impairment","volume":"14","author":"Mu\u00f1oz-Grajales","year":"2023","journal-title":"Front Immunol"},{"key":"bib44","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1007\/s00018-024-05155-w","article-title":"MDSC-derived S100A8\/9 contributes to lupus pathogenesis by promoting TLR7-mediated activation of macrophages and dendritic cells","volume":"81","author":"Yang","year":"2024","journal-title":"Cell Mol Life Sci"},{"key":"bib45","first-page":"129","article-title":"Phagocyte-specific S100A8\/A9 is upregulated in primary Sj\u00f6gren's syndrome and triggers the secretion of pro-inflammatory cytokines in vitro","volume":"35","author":"Nicaise","year":"2017","journal-title":"Clin Exp Rheumatol"},{"key":"bib46","doi-asserted-by":"publisher","first-page":"1003","DOI":"10.1002\/art.41195","article-title":"Poly(ADP-ribose) polymerase enhances infiltration of mononuclear cells in primary Sj\u00f6gren's syndrome through interferon-induced protein with tetratricopeptide repeats 1-mediated up-regulation of CXCL10","volume":"72","author":"Tian","year":"2020","journal-title":"Arthritis Rheumatol"},{"key":"bib47","doi-asserted-by":"publisher","first-page":"4889","DOI":"10.1021\/pr900686s","article-title":"Identification of tear fluid biomarkers in dry eye syndrome using iTRAQ quantitative proteomics","volume":"8","author":"Zhou","year":"2009","journal-title":"J Proteome Res"},{"key":"bib48","doi-asserted-by":"publisher","first-page":"557","DOI":"10.1038\/cmi.2016.65","article-title":"Deficiency of the G protein Gaq ameliorates experimental autoimmune encephalomyelitis with impaired DC-derived IL-6 production and Th17 differentiation","volume":"14","author":"Lai","year":"2017","journal-title":"Cell Mol Immunol"},{"key":"bib49","doi-asserted-by":"publisher","first-page":"e20","DOI":"10.1038\/emm.2013.39","article-title":"MRP8 promotes Th17 differentiation via upregulation of IL-6 production by fibroblast-like synoviocytes in rheumatoid arthritis","volume":"45","author":"Lee","year":"2013","journal-title":"Exp Mol Med"},{"key":"bib50","doi-asserted-by":"publisher","first-page":"518","DOI":"10.4049\/jimmunol.2300101","article-title":"The dual role of ACOD1 in inflammation","volume":"211","author":"Wu","year":"2023","journal-title":"J Immunol"},{"key":"bib51","doi-asserted-by":"publisher","first-page":"1352165","DOI":"10.3389\/fimmu.2024.1352165","article-title":"Control of immune cell signaling by the immuno-metabolite itaconate","volume":"15","author":"Lang","year":"2024","journal-title":"Front Immunol"},{"key":"bib52","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1038\/s42003-024-05814-5","article-title":"S100A8\/A9 promotes endometrial fibrosis via regulating RAGE\/JAK2\/STAT3 signaling pathway","volume":"7","author":"Xin","year":"2024","journal-title":"Commun Biol"},{"key":"bib53","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1097\/ICO.0000000000000019","article-title":"Effects of topical Janus kinase inhibition on ocular surface inflammation and immunity","volume":"33","author":"Stevenson","year":"2014","journal-title":"Cornea"},{"key":"bib54","doi-asserted-by":"publisher","first-page":"1328","DOI":"10.1016\/j.ophtha.2012.01.028","article-title":"Tofacitinib (CP-690,550), a Janus kinase inhibitor for dry eye disease: results from a phase 1\/2 trial","volume":"119","author":"Liew","year":"2012","journal-title":"Ophthalmology"},{"key":"bib55","doi-asserted-by":"publisher","first-page":"3776","DOI":"10.1167\/iovs.19-26928","article-title":"Therapeutic effects of STAT3 inhibition on experimental murine dry eye","volume":"60","author":"Qu","year":"2019","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib56","doi-asserted-by":"publisher","first-page":"298","DOI":"10.3389\/fendo.2020.00298","article-title":"Low serum IL-17A in pregnancy during second trimester is associated with an increased risk of subclinical hypothyroidism","volume":"11","author":"He","year":"2020","journal-title":"Front Endocrinol (Lausanne)"},{"key":"bib57","doi-asserted-by":"publisher","first-page":"1985","DOI":"10.1016\/j.jid.2024.02.012","article-title":"S100A9 exacerbates the inflammation in rosacea through Toll-like receptor 4\/MyD88\/NF-?B signaling pathway","volume":"144","author":"Le","year":"2024","journal-title":"J Invest Dermatol"},{"key":"bib58","doi-asserted-by":"publisher","first-page":"1659","DOI":"10.7150\/thno.67174","article-title":"Overexpression of S100A9 in obesity impairs macrophage differentiation via TLR4-NFkB-signaling worsening inflammation and wound healing","volume":"12","author":"Franz","year":"2022","journal-title":"Theranostics"},{"key":"bib59","doi-asserted-by":"publisher","first-page":"1077914","DOI":"10.3389\/fimmu.2022.1077914","article-title":"S100A8 alarmin supports IL-6 and metalloproteinase-9 production by fibroblasts in the synovial microenvironment of peripheral spondyloarthritis","volume":"13","author":"Arias","year":"2022","journal-title":"Front Immunol"}],"container-title":["Investigative Ophthalmology &amp; Visual Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/iovs.arvojournals.org\/article.aspx?articleid=2802466","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:32:03Z","timestamp":1791927123000},"score":1,"resource":{"primary":{"URL":"https:\/\/iovs.arvojournals.org\/article.aspx?articleid=2802466"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,14]]},"references-count":59,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,1,2]]}},"URL":"https:\/\/doi.org\/10.1167\/iovs.66.1.35","relation":{},"ISSN":["1552-5783"],"issn-type":[{"value":"1552-5783","type":"print"}],"subject":[],"published":{"date-parts":[[2025,1,14]]}}}