{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T22:01:50Z","timestamp":1791928910251,"version":"4.3.4"},"reference-count":33,"publisher":"Association for Research in Vision and Ophthalmology (ARVO)","issue":"1","license":[{"start":{"date-parts":[[2025,1,16]],"date-time":"2025-01-16T00:00:00Z","timestamp":1736985600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Invest. Ophthalmol. Vis. Sci."],"published-print":{"date-parts":[[2025,1,16]]},"DOI":"10.1167\/iovs.66.1.40","type":"journal-article","created":{"date-parts":[[2025,1,16]],"date-time":"2025-01-16T11:31:16Z","timestamp":1737027076000},"page":"40","source":"Crossref","is-referenced-by-count":1,"title":["The Value of Orbital Exenteration for Eyelid Sebaceous Carcinoma in Stages II to IV: A Cohort Study of 78 Patients"],"prefix":"10.1167","volume":"66","author":[{"given":"Jie","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China"},{"name":"Shanghai Key Laboratory of Orbital Diseases and Ocular Oncology, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianyu","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China"},{"name":"Shanghai Key Laboratory of Orbital Diseases and Ocular Oncology, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziyue","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China"},{"name":"Shanghai Key Laboratory of Orbital Diseases and Ocular Oncology, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renbing","family":"Jia","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China"},{"name":"Shanghai Key Laboratory of Orbital Diseases and Ocular Oncology, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiqiong","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China"},{"name":"Shanghai Key Laboratory of Orbital Diseases and Ocular Oncology, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"27","reference":[{"issue":"15","key":"bib1","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1167\/iovs.64.15.16","article-title":"Establishment and characterization of a TP53-mutated eyelid sebaceous carcinoma cell line","volume":"64","author":"Gu","year":"2023","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"6","key":"bib2","doi-asserted-by":"publisher","first-page":"756","DOI":"10.1136\/bjophthalmol-2021-320547","article-title":"Diffuse pattern, orbital invasion, perineural invasion and Ki-67 are associated with nodal metastasis in patients with eyelid sebaceous carcinoma","volume":"107","author":"Gu","year":"2023","journal-title":"Br J Ophthalmol"},{"issue":"2","key":"bib3","first-page":"143","article-title":"Clinical and pathological analysis of 2734 cases of eyelid neoplasms","volume":"44","author":"Chen","year":"2008","journal-title":"Zhonghua Yan Ke Za Zhi"},{"issue":"3","key":"bib4","doi-asserted-by":"publisher","first-page":"324","DOI":"10.1136\/bjophthalmol-2021-319789","article-title":"Intraepithelial growth pattern for eyelid sebaceous carcinoma: a cohort of 214 patients from a single institution","volume":"107","author":"Zhou","year":"2023","journal-title":"Br J Ophthalmol"},{"issue":"3","key":"bib5","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1038\/eye.2016.218","article-title":"Orbital exenteration for advanced periorbital non-melanoma skin cancer: prognostic factors and survival","volume":"31","author":"Gerring","year":"2017","journal-title":"Eye (Lond)."},{"issue":"5","key":"bib6","doi-asserted-by":"publisher","first-page":"1078","DOI":"10.1016\/j.ophtha.2011.11.006","article-title":"American Joint Committee on Cancer T category for eyelid sebaceous carcinoma correlates with nodal metastasis and survival","volume":"119","author":"Esmaeli","year":"2012","journal-title":"Ophthalmology"},{"issue":"7","key":"bib7","doi-asserted-by":"publisher","first-page":"980","DOI":"10.1136\/bjophthalmol-2018-312635","article-title":"Prognostic factors for local recurrence, metastasis and survival for sebaceous carcinoma of the eyelid: observations in 100 patients","volume":"103","author":"Sa","year":"2019","journal-title":"Br J Ophthalmol"},{"issue":"6","key":"bib8","doi-asserted-by":"publisher","first-page":"887","DOI":"10.1038\/s41433-019-0454-7","article-title":"Eyelid sebaceous carcinoma: Validation of the 8th edition of the American Joint Committee on cancer T staging system and the prognostic factors for local recurrence, nodal metastasis, and survival","volume":"33","author":"Hsia","year":"2019","journal-title":"Eye (Lond)."},{"issue":"1","key":"bib9","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1111\/aos.15204","article-title":"Eyelid sebaceous gland carcinoma, validation of AJCC 8th edition T staging \u2013 a retrospective study from North India","volume":"101","author":"Sen","year":"2023","journal-title":"Acta Ophthalmol"},{"issue":"21","key":"bib10","doi-asserted-by":"publisher","first-page":"4887","DOI":"10.1158\/1078-0432.CCR-24-1327","article-title":"Multiomics profiling distinguishes sebaceous carcinoma from benign sebaceous neoplasms and provides insight into the genetic evolution of sebaceous carcinogenesis","volume":"30","author":"Starrett","year":"2024","journal-title":"Clin Cancer Res"},{"issue":"2","key":"bib11","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1007\/s00428-019-02644-3","article-title":"Potentially actionable FGFR2 high-level amplification in thymic sebaceous carcinoma","volume":"476","author":"Porubsky","year":"2020","journal-title":"Virchows Arch"},{"issue":"5","key":"bib12","first-page":"730","article-title":"S1-guideline sebaceous carcinoma","volume":"22","author":"Utikal","year":"2024","journal-title":"J Dtsch Dermatol Ges"},{"issue":"6","key":"bib13","doi-asserted-by":"publisher","first-page":"726","DOI":"10.1111\/ijd.17045","article-title":"Periocular sebaceous carcinoma: updates in the diagnosis, treatment, staging, and management","volume":"63","author":"Dini","year":"2024","journal-title":"Int J Dermatol"},{"issue":"6","key":"bib14","doi-asserted-by":"publisher","first-page":"1123","DOI":"10.1016\/j.jaad.2023.05.012","article-title":"Sebaceous neoplasms and the Muir-Torre syndrome","volume":"89","author":"Elston","year":"2023","journal-title":"J Am Acad Dermatol"},{"issue":"12","key":"bib16","doi-asserted-by":"publisher","first-page":"2149","DOI":"10.1016\/j.ophtha.2004.10.019","article-title":"Sebaceous carcinoma of the eyelids","volume":"111","author":"Hornblass","year":"2004","journal-title":"Ophthalmology"},{"issue":"5","key":"bib17","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1097\/ICU.0000000000000505","article-title":"Current review of sebaceous cell carcinoma","volume":"29","author":"Orr","year":"2018","journal-title":"Curr Opin Ophthalmol"},{"issue":"4","key":"bib18","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1097\/APO.0000000000000105","article-title":"Sebaceous carcinoma of the ocular region: the 2014 Professor Winifred Mao Lecture","volume":"4","author":"Shields","year":"2015","journal-title":"Asia Pac J Ophthalmol (Phila)"},{"issue":"2","key":"bib19","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1111\/aos.14552","article-title":"Sebaceous carcinoma of the eyelid: 21-year experience in a Nordic country","volume":"99","author":"Niinim\u00e4ki","year":"2021","journal-title":"Acta Ophthalmol"},{"issue":"1","key":"bib20","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1016\/j.jaad.2023.01.049","article-title":"Positive surgical margins in sebaceous carcinoma: risk factors and prognostic impact","volume":"89","author":"Maloney","year":"2023","journal-title":"J Am Acad Dermatol"},{"issue":"12","key":"bib21","doi-asserted-by":"publisher","first-page":"e699","DOI":"10.1016\/S1470-2045(19)30673-4","article-title":"Sebaceous carcinoma: evidence-based clinical practice guidelines","volume":"20","author":"Owen","year":"2019","journal-title":"Lancet Oncol"},{"issue":"10","key":"bib22","doi-asserted-by":"publisher","first-page":"1877","DOI":"10.1016\/S0161-6420(01)00719-9","article-title":"Outcome of patients with periocular sebaceous gland carcinoma with and without conjunctival intraepithelial invasion","volume":"108","author":"Chao","year":"2001","journal-title":"Ophthalmology"},{"issue":"12","key":"bib23","doi-asserted-by":"publisher","first-page":"2151","DOI":"10.1016\/j.ophtha.2004.07.031","article-title":"Sebaceous carcinoma of the eyelids: personal experience with 60 cases","volume":"111","author":"Shields","year":"2004","journal-title":"Ophthalmology"},{"issue":"6","key":"bib24","doi-asserted-by":"publisher","first-page":"1608","DOI":"10.1016\/j.jaad.2018.12.053","article-title":"Mohs micrographic surgery for eyelid sebaceous carcinoma: a multicenter cohort of 360 patients","volume":"80","author":"Zhou","year":"2019","journal-title":"J Am Acad Dermatol"},{"issue":"6","key":"bib25","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1167\/tvst.10.6.34","article-title":"Establishment and characterization of a novel human ocular adnexal sebaceous carcinoma cell line","volume":"10","author":"Rong","year":"2021","journal-title":"Transl Vis Sci Technol"},{"issue":"12","key":"bib27","doi-asserted-by":"publisher","first-page":"1723","DOI":"10.1136\/bjophthalmol-2017-311533","article-title":"14-year case series of eyelid sebaceous gland carcinoma in Chinese patients and review of management","volume":"102","author":"Lam","year":"2018","journal-title":"Br J Ophthalmol"},{"issue":"5","key":"bib28","doi-asserted-by":"publisher","first-page":"1095","DOI":"10.2214\/ajr.160.5.8470584","article-title":"Lesions causing a mass in the medial canthus of the orbit: CT and MR features","volume":"160","author":"Friedman","year":"1993","journal-title":"AJR Am J Roentgenol"},{"issue":"10","key":"bib29","doi-asserted-by":"publisher","first-page":"1335","DOI":"10.1136\/bjo.2004.062471","article-title":"Orbital exenteration: a 13 year Manchester experience","volume":"89","author":"Rahman","year":"2005","journal-title":"Br J Ophthalmol"},{"key":"bib30","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1016\/j.ajo.2016.08.028","article-title":"Risk factors for local recurrence or metastasis of eyelid sebaceous gland carcinoma after wide excision with paraffin section control","volume":"171","author":"Takahashi","year":"2016","journal-title":"Am J Ophthalmol"},{"issue":"6","key":"bib31","doi-asserted-by":"publisher","first-page":"848","DOI":"10.1136\/bjophthalmol-2017-311283","article-title":"Immunohistochemical evaluation of stress-responsive protein sestrin2 and its correlation with p53 mutational status in eyelid sebaceous gland carcinoma","volume":"102","author":"Jayaraj","year":"2018","journal-title":"Br J Ophthalmol"},{"issue":"2","key":"bib32","doi-asserted-by":"publisher","first-page":"284","DOI":"10.1136\/bjo.2009.177204","article-title":"Does \u00df-catenin have a role in pathogenesis of sebaceous cell carcinoma of the eyelid?","volume":"95","author":"Jayaraj","year":"2011","journal-title":"Br J Ophthalmol"},{"issue":"6","key":"bib33","doi-asserted-by":"publisher","first-page":"879","DOI":"10.1136\/bjophthalmol-2018-313285","article-title":"Vimentin overexpression as a novel poor prognostic biomarker in eyelid sebaceous gland carcinoma","volume":"104","author":"Bhardwaj","year":"2020","journal-title":"Br J Ophthalmol"},{"key":"bib15","volume-title":"AJCC Cancer Staging Manual","author":"Edge","year":"2017","edition":"7th ed"},{"key":"bib26","first-page":"1165","article-title":"Orbital exenteration for invasive skin tumours","volume-title":"Eye (Lond)","author":"Tyers","year":"2006"}],"container-title":["Investigative Ophthalmology & Visual Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/iovs.arvojournals.org\/article.aspx?articleid=2802480","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:32:04Z","timestamp":1791927124000},"score":1,"resource":{"primary":{"URL":"https:\/\/iovs.arvojournals.org\/article.aspx?articleid=2802480"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,16]]},"references-count":33,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,1,2]]}},"URL":"https:\/\/doi.org\/10.1167\/iovs.66.1.40","relation":{},"ISSN":["1552-5783"],"issn-type":[{"value":"1552-5783","type":"print"}],"subject":[],"published":{"date-parts":[[2025,1,16]]}}}