{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T22:01:16Z","timestamp":1791928876562,"version":"4.3.4"},"reference-count":35,"publisher":"Association for Research in Vision and Ophthalmology (ARVO)","issue":"1","license":[{"start":{"date-parts":[[2025,1,23]],"date-time":"2025-01-23T00:00:00Z","timestamp":1737590400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Invest. Ophthalmol. Vis. Sci."],"published-print":{"date-parts":[[2025,1,23]]},"DOI":"10.1167\/iovs.66.1.51","type":"journal-article","created":{"date-parts":[[2025,1,23]],"date-time":"2025-01-23T11:31:15Z","timestamp":1737631875000},"page":"51","source":"Crossref","is-referenced-by-count":8,"title":["ROCK Inhibitor Enhances Resilience Against Metabolic Stress Through Increasing Bioenergetic Capacity in Corneal Endothelial Cells"],"prefix":"10.1167","volume":"66","author":[{"given":"Wei-Ting","family":"Ho","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Far Eastern Memorial Hospital, New Taipei City, Taiwan"},{"name":"School of Medicine, National Yang Ming Chiao Tung University, Hsinchu, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jung-Shen","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, National Taiwan University Hospital, Taipei, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chia-Jen","family":"Lei","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, National Taiwan University Hospital, Taipei, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsan-Chi","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Far Eastern Memorial Hospital, New Taipei City, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia-Kang","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Far Eastern Memorial Hospital, New Taipei City, Taiwan"},{"name":"Department of Electrical Engineering, Yuan Ze University, Taoyuan, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shu-Wen","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Far Eastern Memorial Hospital, New Taipei City, Taiwan"},{"name":"College of Medicine, National Taiwan University, Taipei, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muh-Hwa","family":"Yang","sequence":"additional","affiliation":[{"name":"Institute of Clinical Medicine, National Yang Ming Chiao Tung University, Hsinchu, Taiwan"},{"name":"Division of Medical Oncology, Department of Oncology, Taipei Veterans General Hospital, Taipei, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tzuu-Shuh","family":"Jou","sequence":"additional","affiliation":[{"name":"College of Medicine, National Taiwan University, Taipei, Taiwan"},{"name":"Graduate Institute of Clinical Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan"},{"name":"Center of Precision Medicine, College of Medicine, National Taiwan University, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I-Jong","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, National Taiwan University Hospital, Taipei, Taiwan"},{"name":"College of Medicine, National Taiwan University, Taipei, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"27","reference":[{"key":"bib1","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1016\/j.exer.2011.06.004","article-title":"Molecular mechanisms underlying the corneal endothelial pump","volume":"95","author":"Bonanno","year":"2012","journal-title":"Exp Eye Res"},{"key":"bib2","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1016\/j.exer.2011.08.014","article-title":"Proliferative capacity of corneal endothelial cells","volume":"95","author":"Joyce","year":"2012","journal-title":"Exp Eye Res"},{"key":"bib3","doi-asserted-by":"publisher","first-page":"840","DOI":"10.1001\/archopht.121.6.840","article-title":"Human corneal endothelial cell expression of Na+, K+-adenosine triphosphatase isoforms","volume":"121","author":"Huang","year":"2003","journal-title":"Arch Ophthalmol"},{"key":"bib4","doi-asserted-by":"publisher","first-page":"1755","DOI":"10.1167\/iovs.05-1139","article-title":"The balance between corneal transparency and edema: the Proctor lecture","volume":"47","author":"Edelhauser","year":"2006","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib5","doi-asserted-by":"publisher","first-page":"5811","DOI":"10.1038\/s41598-020-62602-x","article-title":"Chronology of cellular events related to mitochondrial burnout leading to cell death in Fuchs endothelial corneal dystrophy","volume":"10","author":"Methot","year":"2020","journal-title":"Sci Rep"},{"key":"bib6","doi-asserted-by":"publisher","first-page":"3680","DOI":"10.1167\/iovs.08-2634","article-title":"Enhancement on primate corneal endothelial cell survival in vitro by a ROCK inhibitor","volume":"50","author":"Okumura","year":"2009","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib7","doi-asserted-by":"publisher","first-page":"1006","DOI":"10.1136\/bjo.2010.194571","article-title":"Enhancement of corneal endothelium wound healing by Rho-associated kinase (ROCK) inhibitor eye drops","volume":"95","author":"Okumura","year":"2011","journal-title":"Br J Ophthalmol"},{"key":"bib8","doi-asserted-by":"publisher","first-page":"268","DOI":"10.1016\/j.ajpath.2012.03.033","article-title":"ROCK inhibitor converts corneal endothelial cells into a phenotype capable of regenerating in vivo endothelial tissue","volume":"181","author":"Okumura","year":"2012","journal-title":"Am J Pathol"},{"key":"bib9","doi-asserted-by":"publisher","first-page":"995","DOI":"10.1056\/NEJMoa1712770","article-title":"Injection of cultured cells with a ROCK inhibitor for bullous keratopathy","volume":"378","author":"Kinoshita","year":"2018","journal-title":"N Engl J Med"},{"key":"bib10","doi-asserted-by":"publisher","first-page":"504","DOI":"10.1016\/j.ophtha.2020.09.002","article-title":"Five-year follow-up of first 11 patients undergoing injection of cultured corneal endothelial cells for corneal endothelial failure","volume":"128","author":"Numa","year":"2021","journal-title":"Ophthalmology"},{"key":"bib11","doi-asserted-by":"publisher","first-page":"e22397","DOI":"10.1096\/fj.202101442RR","article-title":"Inhibition of Rho-associated protein kinase activity enhances oxidative phosphorylation to support corneal endothelial cell migration","volume":"36","author":"Ho","year":"2022","journal-title":"FASEB J"},{"key":"bib12","doi-asserted-by":"publisher","first-page":"765","DOI":"10.1007\/s00249-016-1173-7","article-title":"Comparison of fluorescence probes for intracellular sodium imaging in prostate cancer cell lines","volume":"45","author":"Iamshanova","year":"2016","journal-title":"Eur Biophys J"},{"key":"bib13","doi-asserted-by":"publisher","first-page":"e0152016","DOI":"10.1371\/journal.pone.0152016","article-title":"Determining maximum glycolytic capacity using extracellular flux measurements","volume":"11","author":"Mookerjee","year":"2016","journal-title":"PLoS One"},{"key":"bib14","doi-asserted-by":"publisher","first-page":"7189","DOI":"10.1074\/jbc.M116.774471","article-title":"Quantifying intracellular rates of glycolytic and oxidative ATP production and consumption using extracellular flux measurements","volume":"292","author":"Mookerjee","year":"2017","journal-title":"J Biol Chem"},{"key":"bib15","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1042\/CS20140101","article-title":"The bioenergetic health index: a new concept in mitochondrial translational research","volume":"127","author":"Chacko","year":"2014","journal-title":"Clin Sci (Lond)"},{"key":"bib16","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1167\/iovs.61.14.10","article-title":"Mitochondria as a platform for dictating the cell fate of cultured human corneal endothelial cells","volume":"61","author":"Numa","year":"2020","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib17","doi-asserted-by":"publisher","first-page":"7189","DOI":"10.1074\/jbc.M116.774471","article-title":"Quantifying intracellular rates of glycolytic and oxidative ATP production and consumption using extracellular flux measurements","volume":"292","author":"Mookerjee","year":"2017","journal-title":"J Biol Chem"},{"key":"bib18","doi-asserted-by":"crossref","first-page":"161","DOI":"10.3390\/cells10081888","article-title":"Mitochondrial dysfunction and mitophagy in Fuchs endothelial corneal dystrophy","volume":"10","author":"Kumar","year":"2021","journal-title":"Cells"},{"key":"bib19","doi-asserted-by":"publisher","first-page":"eaaz5195","DOI":"10.1126\/sciadv.aaz5195","article-title":"Pathological processes in aqueous humor due to iris atrophy predispose to early corneal graft failure in humans and mice","volume":"6","author":"Yamaguchi","year":"2020","journal-title":"Sci Adv"},{"key":"bib20","doi-asserted-by":"publisher","first-page":"3175","DOI":"10.1158\/1535-7163.MCT-10-0368","article-title":"Monensin is a potent inducer of oxidative stress and inhibitor of androgen signaling leading to apoptosis in prostate cancer cells","volume":"9","author":"Ketola","year":"2010","journal-title":"Mol Cancer Ther"},{"key":"bib21","doi-asserted-by":"publisher","first-page":"574","DOI":"10.1038\/s42003-023-04946-4","article-title":"Boosting intracellular sodium selectively kills hepatocarcinoma cells and induces hepatocellular carcinoma tumor shrinkage in mice","volume":"6","author":"Clemente","year":"2023","journal-title":"Commun Biol"},{"key":"bib22","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1016\/j.tibs.2009.10.006","article-title":"Glycolysis: a bioenergetic or a survival pathway?","volume":"35","author":"Bola\u00f1os","year":"2010","journal-title":"Trends Biochem Sci"},{"key":"bib23","doi-asserted-by":"publisher","first-page":"2049","DOI":"10.1242\/jeb.00241","article-title":"Isozymes of mammalian hexokinase: Structure, subcellular localization and metabolic function","volume":"206","author":"Wilson","year":"2003","journal-title":"J Exp Biol"},{"key":"bib24","doi-asserted-by":"publisher","first-page":"13106","DOI":"10.1096\/fj.202000767R","article-title":"Mitochondrial spare respiratory capacity: mechanisms, regulation, and significance in non-transformed and cancer cells","volume":"34","author":"Marchetti","year":"2020","journal-title":"FASEB J"},{"key":"bib25","doi-asserted-by":"publisher","first-page":"292","DOI":"10.1016\/j.ebiom.2017.01.004","article-title":"Glutaminolysis is essential for energy production and ion transport in human corneal endothelium","volume":"16","author":"Zhang","year":"2017","journal-title":"EBioMedicine"},{"key":"bib26","first-page":"17","article-title":"Hsp47-dependent and -independent intracellular trafficking of type I collagen in corneal endothelial cells","volume":"5","author":"Ko","year":"1999","journal-title":"Mol Vis"},{"key":"bib27","doi-asserted-by":"publisher","first-page":"2143","DOI":"10.1242\/jcs.080762","article-title":"Increased ER-mitochondrial coupling promotes mitochondrial respiration and bioenergetics during early phases of ER stress","volume":"124","author":"Bravo","year":"2011","journal-title":"J Cell Sci"},{"key":"bib28","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1038\/nrm.2017.95","article-title":"AMPK: Guardian of metabolism and mitochondrial homeostasis","volume":"19","author":"Herzig","year":"2018","journal-title":"Nat Rev Mol Cell Biol"},{"key":"bib29","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1038\/s41467-019-13781-3","article-title":"ROCK inhibitors upregulate the neuroprotective Parkin-mediated mitophagy pathway","volume":"11","author":"Moskal","year":"2020","journal-title":"Nat Commun"},{"key":"bib30","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1186\/2049-3002-2-7","article-title":"Separation of metabolic supply and demand: Aerobic glycolysis as a normal physiological response to fluctuating energetic demands in the membrane","volume":"2","author":"Epstein","year":"2014","journal-title":"Cancer Metab"},{"key":"bib31","doi-asserted-by":"publisher","first-page":"521","DOI":"10.1038\/sj.cdd.4402285","article-title":"Akt mediates mitochondrial protection in cardiomyocytes through phosphorylation of mitochondrial hexokinase-II","volume":"15","author":"Miyamoto","year":"2008","journal-title":"Cell Death Differ"},{"key":"bib32","doi-asserted-by":"publisher","first-page":"1261","DOI":"10.1016\/j.molcel.2022.02.028","article-title":"Hexokinase 1 cellular localization regulates the metabolic fate of glucose","volume":"82","author":"De Jesus","year":"2022","journal-title":"Mol Cell"},{"key":"bib33","doi-asserted-by":"publisher","first-page":"e17674","DOI":"10.1371\/journal.pone.0017674","article-title":"Subcellular localization of hexokinases I and II directs the metabolic fate of glucose","volume":"6","author":"John","year":"2011","journal-title":"PLoS One"},{"key":"bib34","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1038\/cdd.2014.173","article-title":"Hexokinase II integrates energy metabolism and cellular protection: Akting on mitochondria and TORCing to autophagy","volume":"22","author":"Roberts","year":"2015","journal-title":"Cell Death Differ"},{"key":"bib35","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1042\/BJ20090934","article-title":"Importance of the bioenergetic reserve capacity in response to cardiomyocyte stress induced by 4-hydroxynonenal","volume":"424","author":"Hill","year":"2009","journal-title":"Biochem J"}],"container-title":["Investigative Ophthalmology &amp; Visual Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/iovs.arvojournals.org\/article.aspx?articleid=2802496","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:32:07Z","timestamp":1791927127000},"score":1,"resource":{"primary":{"URL":"https:\/\/iovs.arvojournals.org\/article.aspx?articleid=2802496"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,23]]},"references-count":35,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,1,2]]}},"URL":"https:\/\/doi.org\/10.1167\/iovs.66.1.51","relation":{},"ISSN":["1552-5783"],"issn-type":[{"value":"1552-5783","type":"print"}],"subject":[],"published":{"date-parts":[[2025,1,23]]}}}