{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T22:01:03Z","timestamp":1791928863307,"version":"4.3.4"},"reference-count":78,"publisher":"Association for Research in Vision and Ophthalmology (ARVO)","issue":"11","license":[{"start":{"date-parts":[[2025,8,11]],"date-time":"2025-08-11T00:00:00Z","timestamp":1754870400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Invest. Ophthalmol. Vis. Sci."],"published-print":{"date-parts":[[2025,8,11]]},"DOI":"10.1167\/iovs.66.11.26","type":"journal-article","created":{"date-parts":[[2025,8,11]],"date-time":"2025-08-11T12:30:36Z","timestamp":1754915436000},"page":"26","source":"Crossref","is-referenced-by-count":2,"title":["The Role of Retinal Antigen-Presenting Cells in Spontaneous Retinal Autoimmunity"],"prefix":"10.1167","volume":"66","author":[{"given":"Joe","family":"Sherman","sequence":"first","affiliation":[{"name":"Department of Ophthalmology and Visual Neurosciences, University of Minnesota, Minneapolis, Minnesota, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Burgstaler","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology and Visual Neurosciences, University of Minnesota, Minneapolis, Minnesota, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunan","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology and Visual Neurosciences, University of Minnesota, Minneapolis, Minnesota, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heidi","family":"Roehrich","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology and Visual Neurosciences, University of Minnesota, Minneapolis, Minnesota, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dale S.","family":"Gregerson","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology and Visual Neurosciences, University of Minnesota, Minneapolis, Minnesota, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott W.","family":"McPherson","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology and Visual Neurosciences, University of Minnesota, Minneapolis, Minnesota, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"27","reference":[{"issue":"11","key":"bib1","doi-asserted-by":"publisher","first-page":"778","DOI":"10.1016\/j.tins.2019.09.004","article-title":"Cien a\u00f1os de microgl\u00eda: milestones in a century of microglial research","volume":"42","author":"Sierra","year":"2019","journal-title":"Trends Neurosci"},{"issue":"6005","key":"bib2","doi-asserted-by":"publisher","first-page":"841","DOI":"10.1126\/science.1194637","article-title":"Fate mapping analysis reveals that adult microglia derive from primitive macrophages","volume":"330","author":"Ginhoux","year":"2010","journal-title":"Science"},{"issue":"3","key":"bib3","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1038\/nn.3318","article-title":"Microglia emerge from erythromyeloid precursors via Pu.1- and Irf8-dependent pathways","volume":"16","author":"Kierdorf","year":"2013","journal-title":"Nat Neurosci."},{"issue":"9","key":"bib4","doi-asserted-by":"publisher","first-page":"1142","DOI":"10.1038\/nn.2887","article-title":"Infiltrating monocytes trigger EAE progression, but do not contribute to the resident microglia pool","volume":"14","author":"Ajami","year":"2011","journal-title":"Nat Neurosci"},{"issue":"12","key":"bib5","doi-asserted-by":"publisher","first-page":"1538","DOI":"10.1038\/nn2014","article-title":"Local self-renewal can sustain CNS microglia maintenance and function throughout adult life","volume":"10","author":"Ajami","year":"2007","journal-title":"Nat Neurosci."},{"issue":"1","key":"bib6","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1016\/j.immuni.2015.06.012","article-title":"Genetic cell ablation reveals clusters of local self-renewing microglia in the mammalian central nervous system","volume":"43","author":"Bruttger","year":"2015","journal-title":"Immunity"},{"issue":"7540","key":"bib7","doi-asserted-by":"publisher","first-page":"547","DOI":"10.1038\/nature13989","article-title":"Tissue-resident macrophages originate from yolk-sac-derived erythro-myeloid progenitors","volume":"518","author":"Gomez Perdiguero","year":"2015","journal-title":"Nature"},{"issue":"4","key":"bib8","doi-asserted-by":"publisher","first-page":"792","DOI":"10.1016\/j.immuni.2013.04.004","article-title":"Tissue-resident macrophages self-maintain locally throughout adult life with minimal contribution from circulating monocytes","volume":"38","author":"Hashimoto","year":"2013","journal-title":"Immunity"},{"issue":"4","key":"bib9","doi-asserted-by":"publisher","first-page":"530","DOI":"10.1038\/s41593-018-0090-8","article-title":"Repopulated microglia are solely derived from the proliferation of residual microglia after acute depletion","volume":"21","author":"Huang","year":"2018","journal-title":"Nat Neurosci."},{"key":"bib10","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1038\/s41421-018-0011-8","article-title":"Dual extra-retinal origins of microglia in the model of retinal microglia repopulation","volume":"4","author":"Huang","year":"2018","journal-title":"Cell Discov"},{"issue":"1","key":"bib11","doi-asserted-by":"publisher","first-page":"8433","DOI":"10.1038\/s41598-017-08702-7","article-title":"Monocyte infiltration and proliferation reestablish myeloid cell homeostasis in the mouse retina following retinal pigment epithelial cell injury","volume":"7","author":"Ma","year":"2017","journal-title":"Sci Rep"},{"key":"bib12","doi-asserted-by":"publisher","first-page":"20636","DOI":"10.1038\/srep20636","article-title":"Fate mapping reveals that microglia and recruited monocyte-derived macrophages are definitively distinguishable by phenotype in the retina","volume":"6","author":"O'Koren","year":"2016","journal-title":"Sci Rep"},{"issue":"1","key":"bib13","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1186\/s40478-018-0571-8","article-title":"Optic nerve as a source of activated retinal microglia post-injury","volume":"6","author":"Heuss","year":"2018","journal-title":"Acta Neuropathol Commun"},{"issue":"1","key":"bib14","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1016\/j.nbd.2010.05.022","article-title":"Dendritic cells are early responders to retinal injury","volume":"40","author":"Lehmann","year":"2010","journal-title":"Neurobiol Dis"},{"key":"bib15","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1016\/j.mcn.2017.09.002","article-title":"A subpopulation of activated retinal macrophages selectively migrated to regions of cone photoreceptor stress, but had limited effect on cone death in a mouse model for type 2 Leber congenital amaurosis","volume":"85","author":"Tang","year":"2017","journal-title":"Mol Cell Neurosci"},{"issue":"1","key":"bib16","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1186\/s12974-019-1546-9","article-title":"The retinal environment induces microglia-like properties in recruited myeloid cells","volume":"16","author":"McPherson","year":"2019","journal-title":"J Neuroinflammation"},{"issue":"3","key":"bib17","doi-asserted-by":"publisher","first-page":"eaap8492","DOI":"10.1126\/sciadv.aap8492","article-title":"Repopulating retinal microglia restore endogenous organization and function under CX3CL1-CX3CR1 regulation","volume":"4","author":"Zhang","year":"2018","journal-title":"Sci Adv"},{"issue":"1","key":"bib18","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1186\/s12974-022-02652-2","article-title":"Structural and functional distinctions of co-resident microglia and monocyte-derived macrophages after retinal degeneration","volume":"19","author":"Ronning","year":"2022","journal-title":"J Neuroinflammation"},{"issue":"1","key":"bib19","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1084\/jem.20101202","article-title":"Neuroprotection and progenitor cell renewal in the injured adult murine retina requires healing monocyte-derived macrophages","volume":"208","author":"London","year":"2011","journal-title":"J Exp Med"},{"issue":"48","key":"bib20","doi-asserted-by":"publisher","first-page":"E11359","DOI":"10.1073\/pnas.1807123115","article-title":"Permanent neuroglial remodeling of the retina following infiltration of CSF1R inhibition-resistant peripheral monocytes","volume":"115","author":"Paschalis","year":"2018","journal-title":"Proc Natl Acad Sci USA"},{"issue":"7","key":"bib21","doi-asserted-by":"publisher","first-page":"1580","DOI":"10.1016\/j.ajpath.2018.03.005","article-title":"The role of microglia and peripheral monocytes in retinal damage after corneal chemical injury","volume":"188","author":"Paschalis","year":"2018","journal-title":"Am J Pathol"},{"key":"bib22","doi-asserted-by":"publisher","first-page":"1753","DOI":"10.3389\/fimmu.2018.01753","article-title":"The kaleidoscope of microglial phenotypes","volume":"9","author":"Dubbelaar","year":"2018","journal-title":"Front Immunol"},{"issue":"17","key":"bib23","doi-asserted-by":"publisher","first-page":"e101997","DOI":"10.15252\/embj.2019101997","article-title":"Microglial subtypes: diversity within the microglial community","volume":"38","author":"Stratoulias","year":"2019","journal-title":"EMBO J"},{"issue":"1","key":"bib24","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1186\/s13064-019-0137-x","article-title":"Microglia in the developing retina","volume":"14","author":"Li","year":"2019","journal-title":"Neural Dev"},{"issue":"3","key":"bib25","doi-asserted-by":"publisher","first-page":"723","DOI":"10.1016\/j.immuni.2019.02.007","article-title":"Microglial function is distinct in different anatomical locations during retinal homeostasis and degeneration","volume":"50","author":"O'Koren","year":"2019","journal-title":"Immunity"},{"issue":"1","key":"bib26","doi-asserted-by":"publisher","first-page":"4858","DOI":"10.1038\/s41598-019-41141-0","article-title":"Molecular profiling of resident and infiltrating mononuclear phagocytes during rapid adult retinal degeneration using single-cell RNA sequencing","volume":"9","author":"Ronning","year":"2019","journal-title":"Sci Rep"},{"issue":"2","key":"bib27","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1016\/S1074-7613(02)00365-5","article-title":"In vivo depletion of CD11c+ dendritic cells abrogates priming of CD8+ T cells by exogenous cell-associated antigens","volume":"17","author":"Jung","year":"2002","journal-title":"Immunity"},{"issue":"3","key":"bib28","doi-asserted-by":"publisher","first-page":"1191","DOI":"10.4049\/jimmunol.1101621","article-title":"Local activation of dendritic cells alters the pathogenesis of autoimmune disease in the retina","volume":"188","author":"Heuss","year":"2012","journal-title":"J Immunol"},{"key":"bib29","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1186\/s12974-014-0205-4","article-title":"Retinal antigen-specific regulatory T cells protect against spontaneous and induced autoimmunity and require local dendritic cells","volume":"11","author":"McPherson","year":"2014","journal-title":"J Neuroinflammation"},{"issue":"1","key":"bib30","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1186\/s12974-022-02660-2","article-title":"Parabiosis reveals the correlation between the recruitment of circulating antigen presenting cells to the retina and the induction of spontaneous autoimmune uveoretinitis","volume":"19","author":"McPherson","year":"2022","journal-title":"J Neuroinflammation"},{"issue":"8","key":"bib31","doi-asserted-by":"publisher","first-page":"e72161","DOI":"10.1371\/journal.pone.0072161","article-title":"Comparative analysis of induced vs. spontaneous models of autoimmune uveitis targeting the interphotoreceptor retinoid binding protein","volume":"8","author":"Chen","year":"2013","journal-title":"PLoS One"},{"issue":"6","key":"bib32","doi-asserted-by":"publisher","first-page":"511","DOI":"10.2174\/1566524015666150731095201","article-title":"Spontaneous ocular autoimmunity in mice expressing a transgenic t cell receptor specific to retina: a tool to dissect mechanisms of uveitis","volume":"15","author":"Horai","year":"2015","journal-title":"Curr Mol Med"},{"key":"bib33","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1016\/j.jaut.2013.06.003","article-title":"Breakdown of immune privilege and spontaneous autoimmunity in mice expressing a transgenic T cell receptor specific for a retinal autoantigen","volume":"44","author":"Horai","year":"2013","journal-title":"J Autoimmun"},{"key":"bib34","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1007\/978-1-60761-421-0","article-title":"Defining in vivo dendritic cell functions using CD11c-DTR transgenic mice","volume":"595","author":"Bar-On","year":"2010","journal-title":"Methods Mol Biol"},{"issue":"1","key":"bib35","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1111\/j.0105-2896.2009.00875.x","article-title":"Defining dendritic cells by conditional and constitutive cell ablation","volume":"234","author":"Bar-On","year":"2010","journal-title":"Immunol Rev"},{"issue":"6","key":"bib36","doi-asserted-by":"publisher","first-page":"2921","DOI":"10.1167\/iovs.12-9662","article-title":"The Rd8 mutation of the Crb1 gene is present in vendor lines of C57BL\/6N mice and embryonic stem cells, and confounds ocular induced mutant phenotypes","volume":"53","author":"Mattapallil","year":"2012","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib37","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1007\/978-1-4939-8938-6","article-title":"Clinical and functional evaluation of ocular inflammatory disease using the model of experimental autoimmune uveitis","volume":"1899","author":"Chen","year":"2019","journal-title":"Methods Mol Biol"},{"issue":"5","key":"bib38","first-page":"1004","article-title":"Experimental induction of retinal ganglion cell death in adult mice","volume":"40","author":"Li","year":"1999","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib39","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1186\/s12974-014-0143-1","article-title":"Retinal dendritic cell recruitment, but not function, was inhibited in MyD88 and TRIF deficient mice","volume":"11","author":"Heuss","year":"2014","journal-title":"J Neuroinflammation"},{"issue":"10","key":"bib40","doi-asserted-by":"publisher","first-page":"5751","DOI":"10.4049\/jimmunol.151.10.5751","article-title":"Oral tolerance in experimental autoimmune uveoretinitis. Distinct mechanisms of resistance are induced by low dose vs high dose feeding protocols","volume":"151","author":"Gregerson","year":"1993","journal-title":"J Immunol"},{"issue":"9","key":"bib41","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1038\/laban1005-39","article-title":"A rapid, simple, and humane method for submandibular bleeding of mice using a lancet","volume":"34","author":"Golde","year":"2005","journal-title":"Lab Anim (NY)"},{"issue":"10","key":"bib42","doi-asserted-by":"publisher","first-page":"4971","DOI":"10.4049\/jimmunol.1202625","article-title":"Local \u201con-demand\u201d generation and function of antigen-specific Foxp3+ regulatory T cells","volume":"190","author":"McPherson","year":"2013","journal-title":"J Immunol"},{"issue":"12","key":"bib43","doi-asserted-by":"publisher","first-page":"519","DOI":"10.1016\/j.it.2007.08.011","article-title":"DC ablation in mice: promises, pitfalls, and challenges","volume":"28","author":"Bennett","year":"2007","journal-title":"Trends Immunol"},{"issue":"7","key":"bib44","doi-asserted-by":"publisher","first-page":"1114","DOI":"10.1002\/eji.201847527","article-title":"DTR-mediated conditional cell ablation\u2014progress and challenges","volume":"48","author":"Ruedl","year":"2018","journal-title":"Eur J Immunol"},{"issue":"3-4","key":"bib45","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1159\/000119871","article-title":"Mouse models of experimental autoimmune uveitis","volume":"40","author":"Caspi","year":"2008","journal-title":"Ophthalmic Res"},{"issue":"6","key":"bib46","doi-asserted-by":"publisher","first-page":"550","DOI":"10.2174\/1566524015666150731100318","article-title":"Mouse models of experimental autoimmune uveitis: comparative analysis of adjuvant-induced vs spontaneous models of uveitis","volume":"15","author":"Chen","year":"2015","journal-title":"Curr Mol Med"},{"issue":"18","key":"bib47","doi-asserted-by":"publisher","first-page":"2453","DOI":"10.2174\/1381612821666150316122928","article-title":"Mouse models of autoimmune uveitis","volume":"21","author":"Klaska","year":"2015","journal-title":"Curr Pharm Des"},{"issue":"4","key":"bib48","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1111\/j.1750-3639.1992.tb00703.x","article-title":"Drainage of brain extracellular fluid into blood and deep cervical lymph and its immunological significance","volume":"2","author":"Cserr","year":"1992","journal-title":"Brain Pathol"},{"key":"bib49","doi-asserted-by":"publisher","first-page":"783163","DOI":"10.1155\/2012\/783163","article-title":"Lymphatics and lymphangiogenesis in the eye","volume":"2012","author":"Nakao","year":"2012","journal-title":"J Ophthalmol"},{"issue":"4 pt 2","key":"bib50","first-page":"H1197","article-title":"Albumin outflow into deep cervical lymph from different regions of rabbit brain","volume":"261","author":"Yamada","year":"1991","journal-title":"Am J Physiol"},{"issue":"8006","key":"bib51","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1038\/s41586-024-07130-8","article-title":"Compartmentalized ocular lymphatic system mediates eye-brain immunity","volume":"628","author":"Yin","year":"2024","journal-title":"Nature"},{"key":"bib52","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1111\/j.1600-065X.2006.00439.x","article-title":"Ocular autoimmunity: the price of privilege?","volume":"213","author":"Caspi","year":"2006","journal-title":"Immunol Rev."},{"issue":"2-3","key":"bib53","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1080\/08830180212062","article-title":"Peripheral expression of ocular antigens in regulation and therapy of ocular autoimmunity","volume":"21","author":"Gregerson","year":"2002","journal-title":"Int Rev Immunol"},{"issue":"1","key":"bib54","doi-asserted-by":"publisher","first-page":"14226","DOI":"10.1038\/s41598-017-14618-z","article-title":"Ocular antigen does not cause disease unless presented in the context of inflammation","volume":"7","author":"Voigt","year":"2017","journal-title":"Sci Rep"},{"key":"bib55","doi-asserted-by":"publisher","first-page":"37","DOI":"10.3389\/fimmu.2016.00037","article-title":"Ocular immune privilege and transplantation","volume":"7","author":"Taylor","year":"2016","journal-title":"Front Immunol"},{"issue":"12","key":"bib56","doi-asserted-by":"publisher","first-page":"E1738","DOI":"10.1073\/pnas.1525528113","article-title":"New tools for studying microglia in the mouse and human CNS","volume":"113","author":"Bennett","year":"2016","journal-title":"Proc Natl Acad Sci USA"},{"issue":"1","key":"bib57","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1038\/nn.3599","article-title":"Identification of a unique TGF-\u00df-dependent molecular and functional signature in microglia","volume":"17","author":"Butovsky","year":"2014","journal-title":"Nat Neurosci"},{"issue":"2","key":"bib58","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1111\/bcpt.12657","article-title":"Pharmacological value of murine delayed-type hypersensitivity arthritis: a robust mouse model of rheumatoid arthritis in C57BL\/6 mice","volume":"120","author":"Atkinson","year":"2017","journal-title":"Basic Clin Pharmacol Toxicol"},{"key":"bib59","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1159\/000060492","article-title":"Genetic factors regulating experimental arthritis in mice and rats","volume":"1","author":"Wilder","year":"1999","journal-title":"Curr Dir Autoimmun"},{"key":"bib60","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1007\/978-1-60761-720-4","article-title":"Rodent models of experimental autoimmune uveitis","volume":"900","author":"Agarwal","year":"2012","journal-title":"Methods Mol Biol"},{"issue":"4","key":"bib61","doi-asserted-by":"publisher","first-page":"799","DOI":"10.1084\/jem.20071258","article-title":"Either a Th17 or a Th1 effector response can drive autoimmunity: conditions of disease induction affect dominant effector category","volume":"205","author":"Luger","year":"2008","journal-title":"J Exp Med"},{"issue":"6","key":"bib62","doi-asserted-by":"publisher","first-page":"1101","DOI":"10.1189\/jlb.3A1014-466RR","article-title":"Recovery from experimental autoimmune uveitis promotes induction of antiuveitic inducible Tregs","volume":"97","author":"Lee","year":"2015","journal-title":"J Leukoc Biol"},{"issue":"7","key":"bib63","doi-asserted-by":"publisher","first-page":"3011","DOI":"10.4049\/jimmunol.1402650","article-title":"Retina-specific T regulatory cells bring about resolution and maintain remission of autoimmune uveitis","volume":"194","author":"Silver","year":"2015","journal-title":"J Immunol"},{"issue":"4","key":"bib64","doi-asserted-by":"publisher","first-page":"1742","DOI":"10.4049\/jimmunol.1102415","article-title":"The living eye \u201cdisarms\u201d uncommitted autoreactive T cells by converting them to Foxp3+ regulatory cells following local antigen recognition","volume":"188","author":"Zhou","year":"2012","journal-title":"J Immunol"},{"key":"bib65","doi-asserted-by":"publisher","first-page":"2304","DOI":"10.3389\/fimmu.2018.02304","article-title":"Tolerance induction in relation to the eye","volume":"9","author":"Gery","year":"2018","journal-title":"Front Immunol"},{"issue":"2","key":"bib66","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1016\/j.immuni.2015.07.014","article-title":"Microbiota-dependent activation of an autoreactive T cell receptor provokes autoimmunity in an immunologically privileged site","volume":"43","author":"Horai","year":"2015","journal-title":"Immunity"},{"issue":"11","key":"bib67","doi-asserted-by":"publisher","first-page":"1573","DOI":"10.1093\/intimm\/dxh158","article-title":"The fate of autoreactive, GFP+ T cells in rat models of uveitis analyzed by intravital fluorescence microscopy and FACS","volume":"16","author":"Thurau","year":"2004","journal-title":"Int Immunol"},{"issue":"6","key":"bib68","doi-asserted-by":"publisher","first-page":"393","DOI":"10.1038\/nri2550","article-title":"Autoimmune T cell responses in the central nervous system","volume":"9","author":"Goverman","year":"2009","journal-title":"Nat Rev Immunol"},{"issue":"5","key":"bib69","first-page":"754","article-title":"T cell traffic and the inflammatory response in experimental autoimmune uveoretinitis","volume":"39","author":"Prendergast","year":"1998","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"20","key":"bib70","doi-asserted-by":"publisher","first-page":"9989","DOI":"10.1073\/pnas.1820387116","article-title":"Retinal microglia initiate neuroinflammation in ocular autoimmunity","volume":"116","author":"Okunuki","year":"2019","journal-title":"Proc Natl Acad Sci USA"},{"key":"bib71","doi-asserted-by":"publisher","first-page":"103417","DOI":"10.1016\/j.jaut.2025.103417","article-title":"Preventing the antigen-presenting function of retinal microglia blocks autoimmune neuroinflammation by dendritic cell-primed CD4+ T cells","volume":"153","author":"Shirahama","year":"2025","journal-title":"J Autoimmun"},{"issue":"10","key":"bib72","doi-asserted-by":"publisher","first-page":"6123","DOI":"10.4049\/jimmunol.178.10.6123","article-title":"Pertussis toxin by inducing IL-6 promotes the generation of IL-17-producing CD4 cells","volume":"178","author":"Chen","year":"2007","journal-title":"J Immunol"},{"issue":"12","key":"bib73","first-page":"2898","article-title":"The requirement for pertussis to induce EAU is strain-dependent: B10.RIII, but not B10.A, mice develop EAU and Th1 responses to IRBP without pertussis treatment","volume":"40","author":"Silver","year":"1999","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"1-2","key":"bib74","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1016\/S0165-5728(02)00203-5","article-title":"Pertussis toxin alters the innate and the adaptive immune responses in a pertussis-dependent model of autoimmunity","volume":"129","author":"Agarwal","year":"2002","journal-title":"J Neuroimmunol"},{"issue":"1","key":"bib75","doi-asserted-by":"publisher","first-page":"250","DOI":"10.4049\/jimmunol.167.1.250","article-title":"Pertussis toxin inhibits induction of tissue-specific autoimmune disease by disrupting G protein-coupled signals","volume":"167","author":"Su","year":"2001","journal-title":"J Immunol"},{"issue":"2","key":"bib76","doi-asserted-by":"publisher","first-page":"1004","DOI":"10.4049\/jimmunol.159.2.1004","article-title":"Genetic susceptibility to experimental autoimmune uveitis involves more than a predisposition to generate a T helper-1-like or a T helper-2-like response","volume":"159","author":"Sun","year":"1997","journal-title":"J Immunol"},{"issue":"6","key":"bib77","doi-asserted-by":"publisher","first-page":"1021","DOI":"10.1002\/jnr.24224","article-title":"Animal models of multiple sclerosis: focus on experimental autoimmune encephalomyelitis","volume":"96","author":"Bjelobaba","year":"2018","journal-title":"J Neurosci Res"},{"issue":"5-6","key":"bib78","first-page":"469","article-title":"Initiation and regulation of CNS autoimmunity","volume":"17","author":"Goverman","year":"1997","journal-title":"Crit Rev Immunol"}],"container-title":["Investigative Ophthalmology &amp; Visual Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/iovs.arvojournals.org\/article.aspx?articleid=2810654","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:32:01Z","timestamp":1791927121000},"score":1,"resource":{"primary":{"URL":"https:\/\/iovs.arvojournals.org\/article.aspx?articleid=2810654"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,11]]},"references-count":78,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2025,8,1]]}},"URL":"https:\/\/doi.org\/10.1167\/iovs.66.11.26","relation":{},"ISSN":["1552-5783"],"issn-type":[{"value":"1552-5783","type":"print"}],"subject":[],"published":{"date-parts":[[2025,8,11]]}}}