{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T22:01:50Z","timestamp":1791928910272,"version":"4.3.4"},"reference-count":22,"publisher":"Association for Research in Vision and Ophthalmology (ARVO)","issue":"11","license":[{"start":{"date-parts":[[2025,8,4]],"date-time":"2025-08-04T00:00:00Z","timestamp":1754265600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Invest. Ophthalmol. Vis. Sci."],"published-print":{"date-parts":[[2025,8,4]]},"DOI":"10.1167\/iovs.66.11.3","type":"journal-article","created":{"date-parts":[[2025,8,4]],"date-time":"2025-08-04T12:30:31Z","timestamp":1754310631000},"page":"3","source":"Crossref","is-referenced-by-count":13,"title":["Long-Term Durability of Ciliary Neurotrophic Factor\u2013Releasing Revakinagene Taroretcel-lwey in Individuals With Retinal Degenerative Disorders"],"prefix":"10.1167","volume":"66","author":[{"given":"Konrad","family":"Kauper","sequence":"first","affiliation":[{"name":"Neurotech Pharmaceuticals, Inc., Cumberland, Rhode Island, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arne","family":"Nystuen","sequence":"additional","affiliation":[{"name":"Neurotech Pharmaceuticals, Inc., Cumberland, Rhode Island, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa","family":"Orecchio","sequence":"additional","affiliation":[{"name":"Neurotech Pharmaceuticals, Inc., Cumberland, Rhode Island, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eugene","family":"Gonzalez-Lopez","sequence":"additional","affiliation":[{"name":"Neurotech Pharmaceuticals, Inc., Cumberland, Rhode Island, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alice","family":"Lee","sequence":"additional","affiliation":[{"name":"Neurotech Pharmaceuticals, Inc., Cumberland, Rhode Island, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacque L.","family":"Duncan","sequence":"additional","affiliation":[{"name":"University of California San Francisco, San Francisco, California, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jay M.","family":"Stewart","sequence":"additional","affiliation":[{"name":"University of California San Francisco, San Francisco, California, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr","given":"Thomas","family":"Aaberg","sequence":"additional","affiliation":[{"name":"Neurotech Pharmaceuticals, Inc., Cumberland, Rhode Island, United States"},{"name":"Retina Specialists of Michigan, Foundation for Vision Research, Grand Rapids, Michigan, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"27","reference":[{"key":"bib1","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1186\/s12967-024-05016-x","article-title":"Cell therapy for retinal degenerative disorders: a systematic review and three-level meta-analysis","volume":"22","author":"Khaboushan","year":"2024","journal-title":"J Transl Med."},{"key":"bib2","doi-asserted-by":"crossref","first-page":"513","DOI":"10.4103\/1673-5374.350192","article-title":"Inflammation and retinal degenerative diseases","volume":"18","author":"Kaur","year":"2023","journal-title":"Neural Regen Res."},{"key":"bib3","doi-asserted-by":"publisher","first-page":"15715","DOI":"10.1523\/JNEUROSCI.2841-12.2012","article-title":"Conditional M\u00fcller cell ablation causes independent neuronal and vascular pathologies in a novel transgenic model","volume":"32","author":"Shen","year":"2012","journal-title":"J Neurosci."},{"key":"bib4","doi-asserted-by":"publisher","first-page":"651","DOI":"10.1002\/glia.22477","article-title":"New functions of M\u00fcller cells","volume":"61","author":"Reichenbach","year":"2013","journal-title":"Glia."},{"key":"bib5","doi-asserted-by":"publisher","first-page":"423","DOI":"10.1016\/j.preteyeres.2009.07.001","article-title":"Cellular signaling and factors involved in M\u00fcller cell gliosis: neuroprotective and detrimental effects","volume":"28","author":"Bringmann","year":"2009","journal-title":"Prog Retin Eye Res."},{"key":"bib6","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1016\/j.preteyeres.2011.11.005","article-title":"CNTF and retina","volume":"31","author":"Wen","year":"2012","journal-title":"Prog Retin Eye Res."},{"key":"bib7","doi-asserted-by":"publisher","first-page":"540","DOI":"10.1016\/j.ophtha.2018.09.041","article-title":"Effect of ciliary neurotrophic factor on retinal neurodegeneration in patients with macular telangiectasia type 2: a randomized clinical trial","volume":"126","author":"Chew","year":"2019","journal-title":"Ophthalmology."},{"key":"bib8","doi-asserted-by":"publisher","first-page":"717","DOI":"10.1517\/14712598.6.7.717","article-title":"Application of encapsulated cell technology for retinal degenerative diseases","volume":"6","author":"Tao","year":"2006","journal-title":"Expert Opin Biol Ther."},{"key":"bib9","doi-asserted-by":"publisher","first-page":"6241","DOI":"10.1073\/pnas.1018987108","article-title":"Ciliary neurotrophic factor delivered by encapsulated cell intraocular implants for treatment of geographic atrophy in age-related macular degeneration","volume":"108","author":"Zhang","year":"2011","journal-title":"Proc Natl Acad Sci USA."},{"key":"bib10","doi-asserted-by":"publisher","first-page":"100298","DOI":"10.1016\/j.xops.2023.100298","article-title":"Phase I NT-501 ciliary neurotrophic factor implant trial for primary open-angle glaucoma: safety, neuroprotection, and neuroenhancement","volume":"3","author":"Goldberg","year":"2023","journal-title":"Ophthalmol Sci."},{"key":"bib11","doi-asserted-by":"publisher","first-page":"9282","DOI":"10.1523\/JNEUROSCI.18-22-09282.1998","article-title":"Intraocular gene transfer of ciliary neurotrophic factor prevents death and increases responsiveness of rod photoreceptors in the retinal degeneration slow mouse","volume":"18","author":"Cayouette","year":"1998","journal-title":"J Neurosci."},{"key":"bib12","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1006\/mthe.2000.0252","article-title":"AAV-mediated delivery of ciliary neurotrophic factor prolongs photoreceptor survival in the rhodopsin knockout mouse","volume":"3","author":"Liang","year":"2001","journal-title":"Mol Ther."},{"key":"bib13","doi-asserted-by":"publisher","first-page":"461","DOI":"10.1006\/mthe.2001.0473","article-title":"Long-term protection of retinal structure but not function using RAAV.CNTF in animal models of retinitis pigmentosa","volume":"4","author":"Liang","year":"2001","journal-title":"Mol Ther."},{"key":"bib14","doi-asserted-by":"publisher","first-page":"7484","DOI":"10.1167\/iovs.12-9970","article-title":"Two-year intraocular delivery of ciliary neurotrophic factor by encapsulated cell technology implants in patients with chronic retinal degenerative diseases","volume":"53","author":"Kauper","year":"2012","journal-title":"Invest Ophthalmol Vis Sci."},{"key":"bib15","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1159\/000285777","article-title":"Use of encapsulated stem cells to overcome the bottleneck of cell availability for cell therapy approaches","volume":"37","author":"Freimark","year":"2010","journal-title":"Transfus Med Hemother."},{"key":"bib16","first-page":"3292","article-title":"Encapsulated cell-based delivery of CNTF reduces photoreceptor degeneration in animal models of retinitis pigmentosa","volume":"43","author":"Tao","year":"2002","journal-title":"Invest Ophthalmol Vis Sci."},{"key":"bib18","doi-asserted-by":"publisher","first-page":"1617","DOI":"10.1089\/ten.2004.10.1617","article-title":"Sustained secretion of ciliary neurotrophic factor to the vitreous, using the encapsulated cell therapy-based NT-501 intraocular device","volume":"10","author":"Thanos","year":"2004","journal-title":"Tissue Eng."},{"key":"bib19","doi-asserted-by":"publisher","first-page":"3896","DOI":"10.1073\/pnas.0600236103","article-title":"Ciliary neurotrophic factor (CNTF) for human retinal degeneration: phase I trial of CNTF delivered by encapsulated cell intraocular implants","volume":"103","author":"Sieving","year":"2006","journal-title":"Proc Natl Acad Sci USA."},{"key":"bib20","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1016\/j.ajo.2013.03.021","article-title":"Randomized trial of ciliary neurotrophic factor delivered by encapsulated cell intraocular implants for retinitis pigmentosa","volume":"156","author":"Birch","year":"2013","journal-title":"Am J Ophthalmol."},{"key":"bib21","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1002\/jcp.1041400219","article-title":"Establishment and characterization of a unique human cell line that proliferates dependently on GM-CSF, IL-3, or erythropoietin","volume":"140","author":"Kitamura","year":"1989","journal-title":"J Cell Physiol."},{"key":"bib22","doi-asserted-by":"publisher","first-page":"122123","DOI":"10.1016\/j.biomaterials.2023.122123","article-title":"An electrospun macrodevice for durable encapsulation of human cells with consistent secretion of therapeutic antibodies","volume":"298","author":"Imaichi-Kobayashi","year":"2023","journal-title":"Biomaterials."},{"key":"bib17","first-page":"EVIDoa2400481","article-title":"Cell-based ciliary neurotrophic factor therapy for macular telangiectasia type 2.","volume-title":"NEJM Evid.","author":"Chew","year":"2025"}],"container-title":["Investigative Ophthalmology & Visual Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/iovs.arvojournals.org\/article.aspx?articleid=2810621","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:32:02Z","timestamp":1791927122000},"score":1,"resource":{"primary":{"URL":"https:\/\/iovs.arvojournals.org\/article.aspx?articleid=2810621"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,4]]},"references-count":22,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2025,8,1]]}},"URL":"https:\/\/doi.org\/10.1167\/iovs.66.11.3","relation":{},"ISSN":["1552-5783"],"issn-type":[{"value":"1552-5783","type":"print"}],"subject":[],"published":{"date-parts":[[2025,8,4]]}}}